Cellular product culture sterile isolator

Abstract

The application discloses a cell product culture sterile isolator and relates to the technical field of cell product culture.The application comprises a rack, a power distribution box is mounted on the inner side of the rack, an isolator body is mounted on the top of the rack, an observation window is mounted on the outer side of the isolator body, sterile glove devices are symmetrically mounted on the outer side of the isolator body, cleaning mechanisms are symmetrically arranged on the outer side of the isolator body, a rotating motor is started to drive a threaded rod to rotate, the threaded rod is in threaded connection with a moving seat, the moving seat moves along the threaded rod in a horizontal direction, and the moving seat moves to drive a cleaning cloth to clean the observation window, thereby reducing the inconvenience of cleaning by hand of a worker.

Description

Technical Field

[0001] This application relates to the field of cell culture technology, and in particular to a sterile isolator for cell culture. Background Technology

[0002] Aseptic isolators are commonly used equipment in modern biomedical laboratories and are widely used in cell culture, bacteriological research, drug development and other fields, providing reliable aseptic protection for high-risk operations.

[0003] The existing Chinese patent (authorization announcement number: CN222357055U) mentions an intelligent aseptic piglet feeding isolator that can achieve a more thorough disinfection effect by directly spraying vaporized hydrogen peroxide into the working area, allowing the vaporized hydrogen peroxide to more fully cover all surfaces of the working area. Simultaneously, since it no longer relies on gas circulation, the entire disinfection process time is greatly shortened, significantly improving work efficiency. Furthermore, the inclusion of an electrically operated airtight transfer port and a circular operating port makes the operator's work more convenient and flexible. Combined with the design of the jetting, gas output, and gas spraying components, the vaporized hydrogen peroxide can be fully atomized, resulting in a more uniform distribution within the working area and better disinfection. In summary, this isolator provides more thorough disinfection, shorter circulation time, and more flexible operation, comprehensively improving the performance of the VHP aseptic inspection isolator.

[0004] Currently, when culturing cell products, staff mostly observe through the observation window. Although this is simple and easy, the outside of the observation window is in direct contact with the laboratory environment. In areas with frequent personnel movement or large airflow disturbances, dust particles can easily settle on the glass surface, which may require staff to use tools such as cloths and brushes to clean it, making the operation rather inconvenient. Utility Model Content

[0005] The purpose of this application is to address the problem that dust particles tend to settle on glass surfaces in areas with frequent foot traffic or significant airflow disturbances, requiring workers to use tools such as cloths and brushes for cleaning. This application provides a sterile isolator for cell culture.

[0006] To achieve the above objectives, this application specifically adopts the following technical solution: A sterile isolator for cell culture includes a frame, an electrical distribution box installed on the inner side of the frame, an isolator body installed on the top of the frame, an observation window installed on the outer side of the isolator body, sterile glove devices symmetrically installed on the outer side of the isolator body, and cleaning mechanisms symmetrically arranged on the outer side of the isolator body.

[0007] By adopting the above technical solution, the automatic disinfection mode can be selected through the control panel of the power distribution box. The hands are put into the sterile glove device, and the consumables are placed in the cabin according to the operation requirements. During the operation, the situation inside the cabin is observed through the observation window to ensure that the movements are gentle. Finally, the operation process is recorded in real time. After the operation is completed, the samples that need to be retained can be placed in the sterile storage device. The cleaning mechanism makes it easy for staff to clean the observation window.

[0008] Furthermore, the cleaning mechanism includes vertical plates symmetrically and fixedly connected to the outside of the isolator body, a threaded rod rotatably connected between the two vertical plates, a rotary motor fixedly connected to the outside of one of the vertical plates, the output shaft of the rotary motor passing through the vertical plate and fixedly connected to the threaded rod, the output shaft of the rotary motor rotatably connected to the vertical plate, a movable seat threadedly connected to the outside of the threaded rod, a wiping cloth slidably disposed below the movable seat, and the wiping cloth slidably disposed with the observation window when moving.

[0009] By adopting the above technical solution, the rotating motor is started to drive the threaded rod to rotate. The threaded rod is threadedly connected to the moving seat, so that the moving seat moves horizontally along the threaded rod. The movement of the moving seat will drive the wiping cloth to clean the observation window.

[0010] Furthermore, guide seats are symmetrically fixedly connected to the outer side of the isolator body, and a guide rod is fixedly connected between the two guide seats. One end of the guide rod passes through the movable seat, and the guide rod is slidably connected to the movable seat.

[0011] By adopting the above technical solution, the guide rod provides an additional support point for the moving seat, so that the moving seat can remain stable when moving.

[0012] Furthermore, the inner side of the movable seat is provided with a slot, and springs are symmetrically fixedly connected to the inner side of the slot. A movable plate is fixedly connected to the bottom end of the spring, and the movable plate is slidably connected to the slot. The bottom of the movable plate is connected to the wiping cloth by Velcro.

[0013] By adopting the above technical solution, the elastic potential energy of the spring is used to maintain a certain pressure between the rag and the observation window, thereby improving the cleaning effect of the rag.

[0014] Furthermore, the inner side of the empty slot is symmetrically provided with sliding grooves, and the outer side of the movable plate is symmetrically fixedly connected with sliders, which are slidably connected to the sliding grooves.

[0015] By adopting the above technical solution, the slider and the groove provide a guiding function for the moving plate, so that the moving plate remains stable when moving.

[0016] Furthermore, mounting plates are symmetrically fixedly connected to the outer side of the isolator body, and connecting blocks are fixedly connected to the top of each of the two mounting plates. A placement seat is fixedly connected to the top of the connecting block, and a buffer pad is fixedly connected to the top of the placement seat.

[0017] By adopting the above technical solution, the support seat can support the arms of the staff and reduce the soreness of the user's arms during long-term use.

[0018] In summary, this application includes at least one of the following beneficial effects; 1. In this application, when cleaning the observation window, the first step is to start the rotary motor to drive the moving seat to move horizontally along the threaded rod. The movement of the moving seat will drive the rag to clean the observation window, which reduces the inconvenience of cleaning with hand tools, reduces the workload, and improves the work efficiency.

[0019] 2. In this application, when culturing cell products, the arm is first placed on the support seat. The support seat can support the arm of the staff, reduce the soreness of the arm during long-term use, and facilitate the use of the staff. Attached Figure Description

[0020] Figure 1 This is a three-dimensional structural diagram of the isolator body in this application; Figure 2 This is a schematic diagram of the three-dimensional structure of the cleaning mechanism in this application; Figure 3 This is a schematic diagram of the cross-sectional structure of the movable seat in this application; Figure 4 This application Figure 1 Enlarged structural diagram at point A in the middle.

[0021] Explanation of reference numerals in the attached figures: 1. Frame; 2. Distribution box; 3. Isolator body; 4. Observation window; 5. Sterile glove device; 6. Vertical plate; 7. Threaded rod; 8. Rotary motor; 9. Moving seat; 10. Wiping cloth; 11. Guide seat; 12. Guide rod; 13. Empty slot; 14. Spring; 15. Moving plate; 16. Slide; 17. Mounting plate; 18. Connecting block; 19. Placement seat; 20. Buffer pad. Detailed Implementation

[0022] The following is in conjunction with the appendix Figure 1-4 This application will be described in further detail.

[0023] This application discloses a sterile isolator for cell product culture.

[0024] Reference Figure 1A sterile isolator for cell product culture includes a frame 1, an electrical distribution box 2 installed on the inner side of the frame 1, an isolator body 3 installed on the top of the frame 1, an observation window 4 installed on the outer side of the isolator body 3, sterile glove devices 5 symmetrically installed on the outer side of the isolator body 3, and cleaning mechanisms symmetrically arranged on the outer side of the isolator body 3.

[0025] When culturing cell products, first select the automatic disinfection mode through the operation panel of the power distribution box 2, put both hands into the sterile glove device 5, and place the consumables in the chamber according to the operation requirements. During the operation, observe the situation in the chamber through the observation window 4 to ensure that the movements are gentle. Finally, record the operation process in real time. After the operation is completed, put the samples that need to be retained into the sterile storage device. The cleaning mechanism makes it convenient for staff to clean the observation window 4, reducing the inconvenience of staff cleaning with hand tools.

[0026] Reference Figure 1 and Figure 2 The cleaning mechanism includes vertical plates 6 that are symmetrically fixedly connected to the outside of the isolator body 3. A threaded rod 7 is rotatably connected between the two vertical plates 6. A rotary motor 8 is fixedly connected to the outside of one of the vertical plates 6. The output shaft of the rotary motor 8 passes through the vertical plate 6 and is fixedly connected to the threaded rod 7. The output shaft of the rotary motor 8 is rotatably connected to the vertical plate 6. A movable seat 9 is threadedly connected to the outside of the threaded rod 7. A wiping cloth 10 is slidably arranged below the movable seat 9. When the wiping cloth 10 moves, it is slidably arranged with the observation window 4.

[0027] Among them, guide seats 11 are symmetrically fixedly connected to the outer side of the isolator body 3, and guide rods 12 are fixedly connected between the two guide seats 11. One end of the guide rod 12 passes through the movable seat 9, and the guide rod 12 is slidably connected to the movable seat 9.

[0028] In addition, a slot 13 is provided on the inner side of the movable seat 9. A spring 14 is symmetrically fixedly connected to the inner side of the slot 13. A movable plate 15 is fixedly connected to the bottom end of the spring 14. The movable plate 15 is slidably connected to the slot 13. The bottom of the movable plate 15 is connected to the wiping cloth 10 by Velcro.

[0029] Furthermore, the inner side of the empty groove 13 is symmetrically provided with sliding grooves 16, and the outer side of the movable plate 15 is symmetrically fixedly connected with sliders, which are slidably connected to the sliding grooves 16.

[0030] When cleaning the observation window 4, the rotary motor 8 is started to drive the threaded rod 7 to rotate. The threaded rod 7 is threadedly connected to the movable seat 9, which causes the movable seat 9 to move horizontally along the threaded rod 7. The movement of the movable seat 9 will drive the wiping cloth 10 to clean the observation window 4, reducing the inconvenience of cleaning with hand tools, reducing the workload, and improving work efficiency.

[0031] When the movable seat 9 moves, the guide rod 12 provides an additional support point for the movable seat 9, so that the movable seat 9 can remain stable when moving.

[0032] When the rag 10 comes into contact with the observation window 4, the reaction force will cause the rag 10 to move. The movement of the rag 10 will cause the moving plate 15 to move. The movement of the moving plate 15 will squeeze the spring 14, causing the spring 14 to compress and generate elastic potential energy. The elastic potential energy of the spring 14 will maintain a certain pressure between the rag 10 and the observation window 4, thereby improving the cleaning effect of the rag 10.

[0033] When the movable plate 15 moves, the slider and the groove 16 provide guidance for the movable plate 15, so that the movable plate 15 remains stable during movement.

[0034] Reference Figure 2 and Figure 4 The isolator body 3 is symmetrically fixedly connected with mounting plates 17 on its outer side. The top of each mounting plate 17 is fixedly connected with a connecting block 18. The top of the connecting block 18 is fixedly connected with a placement seat 19. The top of the placement seat 19 is fixedly connected with a buffer pad 20.

[0035] When culturing cell products, the arm is first placed on the placement seat 19, and then the sterile glove device 5 is worn to operate the items inside the isolator body 3. The placement seat 19 can support the arm of the staff, reduce the soreness of the user's arm during long-term use, and make it convenient for the user to use. The cushioning pad 20 is made of rubber, which has a certain degree of flexibility, further improving the comfort of use.

[0036] Working principle: Select the automatic disinfection mode through the operation panel of the power distribution box 2, put your hands into the sterile glove device 5, and place the consumables in the chamber according to the operation requirements. During the operation, observe the situation in the chamber through the observation window 4 to ensure that the movements are gentle. Finally, record the operation process in real time. After the operation is completed, put the samples to be retained into the sterile storage device. Start the rotary motor 8 to drive the threaded rod 7 to rotate. The threaded rod 7 is threadedly connected to the moving seat 9, so that the moving seat 9 moves horizontally along the threaded rod 7. The movement of the moving seat 9 will drive the wiping cloth 10 to clean the observation window 4, reducing the inconvenience of cleaning with hand tools.

Claims

1. A sterile isolator for cell product culture, comprising a frame (1), characterized in that: A power distribution box (2) is installed on the inner side of the frame (1), an isolator body (3) is installed on the top of the frame (1), an observation window (4) is installed on the outer side of the isolator body (3), sterile glove devices (5) are symmetrically installed on the outer side of the isolator body (3), and cleaning mechanisms are symmetrically arranged on the outer side of the isolator body (3).

2. The aseptic isolator for cell product culture according to claim 1, characterized in that: The cleaning mechanism includes vertical plates (6) that are symmetrically fixedly connected to the outside of the isolator body (3). A threaded rod (7) is rotatably connected between the two vertical plates (6). A rotary motor (8) is fixedly connected to the outside of one of the vertical plates (6). The output shaft of the rotary motor (8) passes through the vertical plate (6) and is fixedly connected to the threaded rod (7). The output shaft of the rotary motor (8) is rotatably connected to the vertical plate (6). A movable seat (9) is threadedly connected to the outside of the threaded rod (7). A wiping cloth (10) is slidably arranged below the movable seat (9). When the wiping cloth (10) moves, it is slidably arranged with the observation window (4).

3. The aseptic isolator for cell product culture according to claim 2, characterized in that: The isolator body (3) is symmetrically and fixedly connected with guide seats (11) on the outside. A guide rod (12) is fixedly connected between the two guide seats (11). One end of the guide rod (12) passes through the movable seat (9). The guide rod (12) is slidably connected to the movable seat (9).

4. The aseptic isolator for cell product culture according to claim 2, characterized in that: The inner side of the movable seat (9) is provided with a slot (13), and a spring (14) is symmetrically fixedly connected to the inner side of the slot (13). A movable plate (15) is fixedly connected to the bottom end of the spring (14). The movable plate (15) is slidably connected to the slot (13), and the bottom of the movable plate (15) is connected to the rag (10) by Velcro.

5. A sterile isolator for cell product culture according to claim 4, characterized in that: The inner side of the empty groove (13) is symmetrically provided with a sliding groove (16), and the outer side of the movable plate (15) is symmetrically fixedly connected with a slider, which is slidably connected to the sliding groove (16).

6. The aseptic isolator for cell product culture according to claim 1, characterized in that: The isolator body (3) is symmetrically fixedly connected with mounting plates (17) on the outside. The top of each of the two mounting plates (17) is fixedly connected with a connecting block (18). The top of the connecting block (18) is fixedly connected with a placement seat (19). The top of the placement seat (19) is fixedly connected with a buffer pad (20).

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