Dual detection channel acute kidney injury rapid test device

Abstract

The utility model relates to the technical field of biotechnologies diagnosis technique, and disclose a double detection channel's acute renal injury rapid testing device, including box body, the opening is set up in the box body front wall or bottom, and the inside of opening is provided with the shunt structure for respectively guiding urine in test tube into two sides recess, the utility model discloses a urine in the drainage groove inside starts to inject the channel formed to two drainage holes, and then a urine is divided into two and respectively contacts the recess in two channels another end access of drainage hole, and then contacts the test paper detection area of NGAL and interleukin-18 test paper, NGAL and interleukin-18 test paper start to react at this moment, and a moment of waiting NGAL and interleukin-18 test paper draw the test result can observe the test result of acute renal injury from the both sides of box, reaches the use two -way synchronous detection acute renal injury's NGAL and interleukin-18 two data time fast efficiency high advantage.

Description

Technical Field

[0001] This utility model relates to the field of biotechnology diagnostic technology, specifically to a rapid testing device for acute kidney injury with dual detection channels. Background Technology

[0002] Acute kidney injury (AKI) is a clinical syndrome caused by a sudden decline in kidney function over a short period (hours to days) due to various reasons. It is a common disease that threatens the lives of critically ill patients. However, AKI is not a difficult condition to detect. On the contrary, it can be easily detected using a kit. Existing technology CN207894937U, in its instruction manual, paragraph 0016, discloses that "first, open the box cover, then take out the sampling device and test card, then insert the test card into the test chamber, and then move the movable plate to the left to expose the positioning hole by the operating block. The sampling device here can directly sample the patient's urine." Sampling: First, press the top cover and loosen it to separate it from the sampling cylinder. Then, insert the bottom of the sampling head into the urine. Slowly release the top cover; under the action of the spring, the piston will move upward, drawing urine into the sampling cylinder, thus greatly improving the sampling effect. Finally, insert the sampling head into the positioning hole and press the top cover down to allow urine in the sampling device to drip into the detection area on the test card, thus greatly improving the accuracy of the test. After a period of time, the test card can be removed to view the test results, effectively preventing the occurrence of acute kidney injury. The use of test strips for rapid detection of acute kidney injury has been publicly disclosed.

[0003] However, the aforementioned technical solution can only test one test strip at a time. Acute kidney injury requires at least two sets of data: NGAL and interleukin-18. When acute kidney injury occurs, the renal tubular epithelial cells are stimulated by damage, and the NGAL gene is rapidly expressed, causing its concentration in blood and urine to rise significantly 2-6 hours after the injury, much earlier than traditional indicators such as serum creatinine and blood urea nitrogen, which usually change several hours to days after kidney function is impaired. This facilitates early detection of acute kidney injury. When renal tubular epithelial cells are damaged by ischemia and hypoxia, caspase-1 is activated, causing a large amount of interleukin-18 to be produced and released into the blood and urine. Generally, the level of interleukin-18 in urine begins to rise 4-6 hours after the onset of acute kidney injury, which can reflect the condition of renal tubular damage in the early stage. Although the above technical solution allows for the re-insertion of a test strip into the detection chamber for a second test, the previous test also requires reaction time. Inserting and removing the test strip and dripping urine all take time, resulting in a significant time loss. Utility Model Content

[0004] (a) Technical problems to be solved To address the shortcomings of existing technologies, this invention provides a rapid testing device for acute kidney injury with dual detection channels. It has the advantages of fast detection time and high efficiency in using dual channels to simultaneously detect NGAL and interleukin-18 data for acute kidney injury, thus solving the aforementioned technical problems.

[0005] (II) Technical Solution To achieve the above objectives, the present invention provides the following technical solution: a box body, wherein an opening is provided on the front wall or bottom surface of the box body, and grooves are symmetrically provided on both sides of the outer surface of the box body, wherein the positions of the two grooves do not overlap with the opening, and test strips for NGAL and interleukin-18 are placed in the two grooves respectively, wherein the detection areas of the test strips for NGAL and interleukin-18 face upward and are attached to one side of the box body. The opening is provided with a diversion structure for guiding the urine in the test tube into the grooves on both sides respectively. It includes a test tube set inside the opening to contain urine, a sleeve inserted into the bottom of the test tube, and a cover plate connected to the outer surface of the sleeve to cover the opening. The bottom of the cover plate is hinged to the opening in the box to form an opening and closing mechanism. Includes a top block, which is fixedly installed on the top of the inner side of the opening; It includes two drainage holes, which are symmetrically opened on both sides of the inner wall of the opening and on the same side as the two grooves. The drainage holes are located above or below the top block, with one end of the drainage hole located inside the opening and the other end connected to the top of the inner side of the groove.

[0006] As a preferred embodiment of this utility model, a medical cotton ball is installed inside the groove and below the opening at the other end of the drainage hole. The position of the medical cotton ball is lower than the detection area of ​​the NGAL and interleukin-18 test strips.

[0007] As a preferred embodiment of this invention, the surface of the groove is covered with transparent plastic.

[0008] As a preferred embodiment of this utility model, the opening is formed on the front wall of the box and extends into its interior. The cover plate covers the front wall of the box. The bottom of the cover plate opens and closes with the opening in the box via a hinge. A sleeve is fixedly installed on the side of the cover plate near the opening. The sleeve is larger at the top and smaller at the bottom, forming an inverted triangle. The sleeve is larger at the top and smaller at the bottom, and it is larger at the top and smaller at the bottom along the direction of the opening. The bottom of the test tube is inserted into the sleeve and is simultaneously located inside the opening when it is attached to the surface of the opening with the cover plate. The drainage hole is located below the top block and is located at the left and right ends of the bottom inside the opening.

[0009] As a preferred technical solution of this utility model, the diversion structure further includes a diversion groove, which is fixedly installed at the bottom inside the opening, and the thickness of the diversion groove is less than half the distance between the inner wall of the opening and the test tube. The diversion groove is a hollow rectangular body, the top of the diversion groove is located directly below the top block, and the two ends of its inner bottom respectively encompass one end of two diversion holes.

[0010] As a preferred technical solution of this utility model, the opening is opened on the bottom surface of the box and extends into its interior. The diversion structure also includes a sponge sleeve, which is inserted into the inside of the opening from bottom to top, and the inside of the sponge sleeve is vertically inserted into the bottom of the test tube with the opening facing upward. The bottom surface of the sponge sleeve is fixedly connected to the top surface of the cover plate by means of glue. After the cover plate covers the opening, it is located directly below the box. The drainage hole is located at the top of the inside of the opening and above the top block.

[0011] Compared with the prior art, this utility model provides a rapid testing device for acute kidney injury with dual detection channels, which has the following beneficial effects: This invention involves flipping open a cover to reveal an opening on the front wall of the box. As the cover flips backward, it pulls out a connected sleeve, exposing the test tube inside. The test tube is then pulled out from the sleeve and used to collect urine from the person being tested. The urine volume should not exceed one-third of the test tube's capacity. The outer surface of the test tube is then wiped clean and reinserted into the sleeve. The cover is then flipped back to close in front of the opening and seal the box. The entire box is then laid flat with the cover facing upward for five seconds, then returned to its original position, and then laid flat for another five seconds. When the box is laid flat with the cover facing upward, gravity causes the urine in the test tube to flow downward. As the urine flows downward, it contacts the top block and the inner wall of the opening, after which the box returns to its original position. At this point, the urine flows downward into the drainage channel due to gravity. Inside, urine is injected into the channel formed by two drainage holes within the drainage groove. Then, one portion of urine is divided into two parts, which contact the grooves connected to the other end of the drainage holes in the two channels. They then contact the detection areas of the NGAL and interleukin-18 test strips. At this point, the NGAL and interleukin-18 test strips begin to react. The excess urine flows along the NGAL and interleukin-18 test strips into the grooves and comes into contact with a medical cotton ball. The medical cotton ball absorbs the excess urine. After a short wait, the NGAL and interleukin-18 test strips produce the test results, which can be observed from both sides of the box. This achieves the advantages of fast and efficient dual-channel simultaneous detection of NGAL and interleukin-18 data for acute kidney injury. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the overall structure of the box in Embodiment 1 of this utility model; Figure 2 This is a schematic diagram of the box structure according to Embodiment 1 of this utility model; Figure 3 This is a schematic diagram of the unfolded box structure according to Embodiment 1 of this utility model; Figure 4 This is a front sectional view of the box structure according to Embodiment 1 of this utility model; Figure 5 This is a schematic diagram of the overall structure of the box body in Embodiment 2 of this utility model; Figure 6 This is a front sectional view of the box structure in Embodiment 2 of this utility model.

[0013] The components are: 1. Box body; 101. Groove; 2. Opening; 201. Card sleeve; 202. Sponge sleeve; 3. Cover plate; 4. Top block; 5. Drainage hole; 6. Medical cotton ball; 7. Drainage groove. Detailed Implementation

[0014] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are for illustrative purposes only and should not be construed as limiting the scope of this utility model.

[0015] In the description of this utility model, unless otherwise stated, "a plurality of" means two or more; the terms "upper," "lower," "left," "right," "inner," "outer," "front end," "rear end," "head," "tail," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. In addition, the terms "first," "second," "third," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0016] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0017] Please see Figure 1-6 A rapid testing device for acute kidney injury with dual detection channels includes a box body 1. An opening 2 is opened on the front wall or bottom surface of the box body 1. Grooves 101 are symmetrically opened on both sides of the outer surface of the box body 1. The positions of the two grooves 101 do not overlap with the opening 2. Test strips of NGAL and interleukin-18 are placed in the two grooves 101 respectively. The detection areas of the NGAL and interleukin-18 test strips face upward and are attached to one side of the box body 1. The inner side of the opening 2 is provided with a diversion structure for guiding the urine in the test tube into the grooves 101 on both sides respectively; It includes a test tube set inside the opening 2 to contain urine, with a sleeve 201 inserted into the bottom of the test tube, and a cover plate 3 that covers the opening 2 connected to the outer surface of the sleeve 201. Includes top block 4, which is fixedly installed on the top of the inner side of opening 2; It includes two drainage holes 5, which are symmetrically opened on both sides of the inner wall of the opening 2, on the same side as the two grooves 101. The drainage holes 5 are located above or below the top block 4. One end of the drainage hole 5 is located inside the opening 2 and the other end is connected to the top of the inner side of the groove 101.

[0018] Furthermore, except where otherwise described, the overall structure of this application is made of polycarbonate, which is a medical material and can be recycled after single use.

[0019] The medical cotton ball 6 is a commercially available cotton ball, and it is not glued or double-sided tape. It is simply held between the groove 101 and the NGAL and interleukin-18 test strips by its own shape, and is lower than the detection area of ​​the NGAL and interleukin-18 test strips, and is located below the other end opening of the drainage hole 5.

[0020] Furthermore, the surface of the groove 101 is covered with transparent plastic.

[0021] The transparent plastic in this application is made of polycarbonate, which is a medical material. The current market price is about 20 yuan per kilogram. It is a finished product that can be purchased directly on the market, so this application will not discuss it in detail. The transparent plastic is glued to the surface of the groove 101 to seal it. The glue is a cyanoacrylate glue or epoxy resin glue. The transparent plastic ensures that the test strips of NGAL and interleukin-18 can be observed without falling out of the groove 101.

[0022] The sponge sleeve 202 is made of polyurethane sponge and has compression expansion properties. The adhesive used for the sponge sleeve 202 is neoprene rubber adhesive.

[0023] Hinges are the type of hinges commonly used by those skilled in the art, as shown in the appendix to the specification. Figure 2 As shown, the hinge is used only as a structural component for flipping in this application and does not participate in the structural improvement of this application. It is worth noting that the hinge model used in this application is GY-30, but it is not limited to this model of hinge. Other hinges of similar size can also be used.

[0024] Example 1 In this embodiment, the box 1 is placed upright and sealed with heat-shrink film on the outside. When the user needs to perform a rapid test for acute kidney injury on themselves or others, they simply tear open the heat-shrink film on the outside of the box 1 to expose the box 1 and flip open the cover 3 to expose the opening on the front wall of the box 1. As the cover 3 flips backward, it brings out the attached sleeve 201, and the test tube inside the sleeve 201 is also exposed to the outside. Then, the test tube is pulled out from the inside of the sleeve 201. The test tube detached from the sleeve 201 is used to collect the urine of the person being tested. The urine should not exceed one-third of the test tube's capacity. Then, the outer surface of the test tube is wiped clean and reinserted into the sleeve 201. Furthermore, the sleeve 201 in this embodiment is also made of polyurethane foam, which is elastic and can initially limit the insertion of the test tube. Further, as per the attached instruction manual... Figure 2 As shown, the sleeve 201 is an inverted triangle, wider at the top and narrower at the bottom. This design causes the test tube to tilt downwards by approximately 15-20 degrees after being inserted back into the sleeve 201. Then, the cover 3 is flipped over to close again in front of the opening 2, forming a seal with the box body 1. At this point, as per the instruction manual... Figure 3 As shown, the test tube with the cover 3 closed is tilted at an angle of 105-110 degrees. Then, the entire box 1 is placed flat with the cover 3 facing upwards for five seconds, then returned to its original position, and then flattened again for five seconds. When the box 1 is placed flat with the cover 3 facing upwards, the urine in the test tube flows downwards due to gravity, and there is also a probability that the test tube will slide down. However, when the test tube actually starts to slide down, it will be blocked by the top block 4 and thus cannot disengage from the sleeve 201. Furthermore, as the urine flows down and contacts the top block 4 and the inner wall of the opening 2, the box 1 is then reset. At this time, the urine flows down into the drainage groove 7 due to gravity, as shown in the instruction manual. Figure 3 As shown, the bottom of the drainage channel 7 includes two drainage holes 5. When the box 1 is laid flat again after resetting, the urine flows in the direction indicated in the instruction manual. Figure 4The pressure difference of the "U"-shaped drainage holes, as shown, allows urine to begin flowing into the channel formed by the two drainage holes 5 within the drainage groove 7. Then, one portion of urine is divided into two parts, each contacting the groove 101 connected to the other end of the drainage hole 5 within the two channels. This then contacts the detection area of ​​the NGAL and interleukin-18 test strips, at which point the NGAL and interleukin-18 test strips begin to react. The excess urine, flowing along the NGAL and interleukin-18 test strips into the groove 101, contacts the medical cotton ball 6. The medical cotton ball 6 absorbs the excess urine. After a short wait, the NGAL and interleukin-18 test strips... Once the test results are obtained, the results of the acute kidney injury test can be observed from both sides of the box 1. In this embodiment, the NGAL test strip is the one disclosed in CN102955036B. The interleukin-18 test strip has also been disclosed in CN204422546U, which uses one of the five test strips for interleukin-18. Since this application simply applies the test strip directly without improving its structure, the existing test strip will not be described in detail. After observing the test results of the NGAL and interleukin-18 test strips through the transparent plastic, the box 1 can be thrown into the medical waste collection bin for recycling.

[0025] In use, flip open the cover 3 to reveal the opening on the front wall of the box 1. As the cover 3 flips backward, it brings out the attached sleeve 201, exposing the test tube inside the sleeve 201. Then, pull the test tube out from the inside of the sleeve 201. The test tube detached from the sleeve 201 is used to collect the urine of the person being tested. The urine should not exceed one-third of the test tube's capacity. Then, wipe the outer surface of the test tube clean and reinsert it into the sleeve 201. Next, flip the cover 3 to close it again in front of the opening 2 and form a seal with the box 1. Then, place the entire box 1 with the cover 3 facing upward for five seconds and then return it to its original position. When the box 1 with the cover 3 facing upward is placed flat, the urine in the test tube will flow down due to gravity. As the urine flows down, it will contact the top block 4 and the opening 2. After the inner wall is closed and the box 1 is reset, the urine flows down into the drainage groove 7 due to gravity. The urine begins to flow into the channel formed by the two drainage holes 5 inside the drainage groove 7. Then, one part of the urine is divided into two parts and comes into contact with the groove 101 connected to the other end of the drainage hole 5 in the two channels. Then, it comes into contact with the test strip detection area of ​​the NGAL and interleukin-18 test strips. At this time, the NGAL and interleukin-18 test strips begin to react. The excess urine flows along the NGAL and interleukin-18 test strips into the groove 101 and comes into contact with the medical cotton ball 6. The medical cotton ball 6 absorbs the excess urine. After a short while, the NGAL and interleukin-18 test strips produce test results, and the test results of acute kidney injury can be observed from both sides of the box 1.

[0026] Example 2 In this embodiment, the opening 2 is directly made on the bottom surface of the box 1. The sponge sleeve 202 is inserted into the opening 2. Utilizing the elasticity of the sponge sleeve 202, the cover plate 3 simultaneously covers the opening 2, forming a snap-fit. Furthermore, in this embodiment, after removing the heat-shrink film from the surface of the box 1, the cover plate 3 is directly pulled off from the bottom of the box 1, bringing out the sponge sleeve 202 and the test tube inserted inside. The subsequent urine collection steps are the same as in Embodiment 1. After cleaning the test tube containing urine, the bottom is reinserted above the sponge sleeve 202. Then, the cover plate 3 is lifted and moved upwards so that the sponge sleeve 202 is completely submerged inside the box 1. The corresponding test tube containing urine is also submerged into the opening 2. Then, the box 1 is completely inverted, as shown in the attached instruction manual. Figure 6 As shown, the inverted test tube releases all the urine inside, directly contacting the top of opening 2. At this point, because the box 1 is flipped, the top inside opening 2 is actually the bottom. Then, as per the instruction manual... Figure 6 As shown, at this time, the drainage holes 5 on both sides of the opening begin to receive urine. One part of urine is divided into two parts and comes into contact with the groove 101 connected to the other end of the drainage hole 5 in the two channels, and then comes into contact with the test strip detection area of ​​NGAL and interleukin-18 test strips. At this time, NGAL and interleukin-18 test strips begin to react. The excess urine flows along NGAL and interleukin-18 test strips into the groove 101 and comes into contact with the medical cotton ball 6. At this time, the medical cotton ball 6 absorbs the excess urine. After a while, the NGAL and interleukin-18 test strips produce test results, and the test results of acute kidney injury can be observed from both sides of the box 1.

[0027] In use, simply pull off the cover plate 3 from the bottom of the box 1, bringing out the sponge sleeve 202 and the test tube inserted inside. The subsequent urine collection steps are the same as in Example 1. After cleaning the test tube containing urine, reinsert the bottom of the sponge sleeve 202. Then, lift the cover plate 3 upwards so that the sponge sleeve 202 is completely submerged inside the box 1, and the corresponding test tube containing urine is also submerged into the opening 2. Then, simply invert the entire box 1, as per the instruction manual. Figure 6 As shown, the inverted test tube releases all the urine inside, directly contacting the top of opening 2. At this point, because the box 1 is flipped, the top inside opening 2 is actually the bottom. Then, as per the instruction manual... Figure 6As shown, at this time, the drainage holes 5 on both sides of the opening begin to receive urine. One part of urine is divided into two parts and comes into contact with the groove 101 connected to the other end of the drainage hole 5 in the two channels, and then comes into contact with the test strip detection area of ​​NGAL and interleukin-18 test strips. At this time, NGAL and interleukin-18 test strips begin to react. The excess urine flows along NGAL and interleukin-18 test strips into the groove 101 and comes into contact with the medical cotton ball 6. At this time, the medical cotton ball 6 absorbs the excess urine. After a while, the NGAL and interleukin-18 test strips produce test results, and the test results of acute kidney injury can be observed from both sides of the box 1.

[0028] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A rapid testing device for acute kidney injury with dual detection channels, comprising a housing (1), characterized in that: The box body (1) has an opening (2) on the front wall or bottom surface, and grooves (101) are symmetrically opened on both sides of the outer surface of the box body (1). The two grooves (101) do not overlap with the opening (2). The two grooves (101) respectively place test strips of NGAL and interleukin-18. The detection areas of the test strips of NGAL and interleukin-18 face upward and are attached to one side of the box body (1). The opening (2) is provided with a diversion structure inside to guide the urine in the test tube into the grooves (101) on both sides respectively; Includes a test tube set inside the opening (2) for containing urine, with a sleeve (201) inserted into the bottom of the test tube, and a cover plate (3) that covers the opening (2) connected to the outer surface of the sleeve (201). The bottom of the cover plate (3) is connected to the opening of the box body (1) by a hinge to form an opening and closing mechanism. Includes a top block (4), which is fixedly installed on the top of the inside of the opening (2); Includes drainage holes (5), there are two drainage holes (5), which are symmetrically opened on both sides of the inner wall of the opening (2) and on the same side as the two grooves (101). The drainage holes (5) are located above or below the top block (4). One end of the drainage hole (5) is located inside the opening (2) and the other end is connected to the top of the inner side of the groove (101).

2. The rapid testing device for acute kidney injury with dual detection channels according to claim 1, characterized in that: A medical cotton ball (6) is also installed inside the groove (101) and below the opening at the other end of the drainage hole (5). The position of the medical cotton ball (6) is lower than the test strip detection area of ​​NGAL and interleukin-18.

3. The rapid testing device for acute kidney injury with dual detection channels according to claim 1 or 2, characterized in that: The surface of the groove (101) is covered with transparent plastic.

4. The rapid testing device for acute kidney injury with dual detection channels according to claim 3, characterized in that: The opening (2) is opened on the front wall of the box body (1) and extends into its interior. The cover plate (3) covers the front wall of the box body (1). The bottom of the cover plate (3) is hinged to open and close with the opening (2) of the box body (1). A sleeve (201) is fixedly installed on the side of the cover plate (3) near the opening (2). The sleeve (201) is larger at the top and smaller at the bottom, forming an inverted triangle. It is larger at the top and smaller at the bottom along the direction of the opening (2). The bottom of the test tube is inserted into the sleeve (201) and is simultaneously located inside the opening (2) when it is attached to the surface of the opening (2) with the cover plate (3). The drainage hole (5) is located below the top block (4) and is located at the left and right ends of the bottom inside the opening (2).

5. The rapid testing device for acute kidney injury with dual detection channels according to claim 4, characterized in that: The diversion structure also includes a diversion groove (7), which is fixedly installed at the bottom inside the opening (2). The thickness of the diversion groove (7) is less than half the distance between the inner wall of the opening (2) and the test tube. The diversion groove (7) is a hollow rectangular body. The top of the diversion groove (7) is located directly below the top block (4), and the two ends of its inner bottom respectively encompass one end of two diversion holes (5).

6. The rapid testing device for acute kidney injury with dual detection channels according to claim 3, characterized in that: The opening (2) is opened on the bottom surface of the box body (1) and extends into its interior. The diversion structure also includes a sponge sleeve (202). The sponge sleeve (202) is inserted into the inside of the opening (2) from bottom to top, and the inside of the sponge sleeve (202) is vertically inserted into the bottom of the test tube with the opening facing upward. The bottom surface of the sponge sleeve (202) is fixedly connected to the top surface of the cover plate (3) by means of glue. The cover plate (3) is located directly below the box body (1) after covering the opening (2). The drainage hole (5) is located at the top of the inside of the opening (2) and above the top block (4).

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