A cell wax block gel top-up device

Abstract

The utility model discloses a cell wax block gel adds the appliance to overcome prior art inconvenient operation, gel quantitative inaccuracy, the quality of cell wax block prepared is not good and the shortage that sample is easy to lose. The appliance includes syringe, sleeve and quantitative adding structure. Syringe is used for preloading and discharging gel, sleeve is fixed syringe through containing structure, and its extension part is connected fixing piece through limiting rod and forms support frame, quantitative adding structure is limited syringe according to hand's push process through the cooperation of movable limiting part and the limiting hole on adding structure, thereby realizes the accurate quantitative adding of gel, and effectively solves the problem that gel dose is not accurate in traditional operation, the quality of cell wax block prepared is not good and sample is easy to lose.

Description

Technical Field

[0001] This utility model relates to the field of cell pathology technology, specifically to a cell paraffin block gel injection device. Background Technology

[0002] Cell block preparation technology is a key platform technology in the field of cytopathology, widely used in the processing of body fluid samples such as pleural and peritoneal fluid, serous cavity irrigation fluid, and urine, as well as fine-needle aspiration samples. This technology uses gelling agents to coagulate enriched cells into clusters and prepare cell blocks for paraffin sectioning and immunohistochemical staining, thereby significantly improving the accuracy of cytological diagnosis.

[0003] However, in the practical application of this technology, accurately and conveniently adding an appropriate amount of cell-enriched paraffin blocks to test tubes to prepare gels remains a technical challenge. Currently, common practices include direct addition using a dropper bottle or pre-packaging in small-capacity centrifuge tubes (such as 0.2 ml or 1.5 ml). The former, due to the viscosity of the gel itself, makes it difficult to control the dosage, leading to an uncontrolled gel-to-cell volume ratio between different samples, directly affecting the quality of paraffin block preparation. The latter, while providing a fixed dosage, cannot flexibly match the differences in cell quantity in different cases; more importantly, during use, whether transferring cells to pre-packed gel centrifuge tubes or transferring gel to centrifuge tubes containing cells, the viscous nature of the gel makes the operation cumbersome and inefficient, and easily results in the loss of valuable cell samples during the transfer process.

[0004] Therefore, the existing technology lacks a special instrument that can pre-fill gel and flexibly and quantitatively add it according to cell volume, which restricts the efficiency and quality improvement of cell wax block preparation technology. Utility Model Content

[0005] The purpose of this invention is to provide a cell paraffin block gel dispensing device to overcome the shortcomings of existing technologies, such as inconvenient operation, inaccurate quantification, and easy sample loss.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: This utility model provides a cell paraffin block gel dispensing device, comprising: a syringe, including an outer sleeve, a core rod disposed within the outer sleeve, a piston fixed to one end of the core rod, and a handle fixed to the other end of the core rod; a sleeve, on which a syringe receiving structure is provided, an extension portion is provided on one side of the syringe receiving structure, the extension portion being connected to a fixing member via a limiting rod; a quantitative dispensing structure, disposed on the limiting rod, including a limiting member and a dispensing structure, the limiting member being movably disposed on the limiting rod, the end of the dispensing structure having a limiting hole that mates with the limiting member, and a syringe fixing structure being provided on the side of the dispensing structure near the sleeve, wherein the syringe fixing structure is connected to the handle during use.

[0007] According to one embodiment of the present invention, the outer sleeve is provided with an outer sleeve rolled edge, and the syringe receiving structure is provided with a syringe axial limiting groove, so that the outer sleeve rolled edge is placed in the syringe axial limiting groove during use.

[0008] According to one embodiment of the present invention, the syringe receiving structure is a U-shaped structure, the syringe axial limiting groove is an ear chamber, and the ear chamber is formed on the opening side of the sleeve.

[0009] According to one embodiment of the present invention, the internal dimensions of the U-shaped structure are adapted to the dimensions of the outer jacket.

[0010] According to one embodiment of the present invention, the top plate of the ear chamber extends outward from both sides to form the extension portion, and the extension portion is provided with a sleeve bolt fixing hole, and the limiting rod is fixed to the sleeve bolt fixing hole.

[0011] According to one embodiment of the present invention, the injection structure is a hand-operated card plate, and the syringe fixing structure is a hand-operated cavity.

[0012] According to one embodiment of the present invention, the dispensing structure is provided with a pressing hole on the side away from the syringe fixing structure.

[0013] According to one embodiment of the present invention, at least two limiting rods are provided, and each limiting rod is provided with a limiting member, and the limiting rods are parallel to each other.

[0014] According to one embodiment of the present invention, the limiting rod is a D-type column bolt, the limiting component is a stepped nut, and the stepped nut is provided with a limiting step.

[0015] According to one embodiment of the present invention, the limiting rod is provided with scale lines.

[0016] Compared with the prior art, the present invention has the following beneficial technical effects: This invention provides a cell block gel dispensing device that effectively overcomes the shortcomings of existing technologies by using a syringe pre-filled with gel and combining it with a sleeve and a quantitative dispensing structure. The device utilizes an adjustable limiting element along a limiting rod, which, in conjunction with the upper limit hole of the dispensing structure, precisely limits the push stroke of the hand, thereby achieving quantitative gel dispensing and solving the problem of inaccurate dosage. The entire dispensing process is completed within a stable frame structure, requiring only a single press during operation. This avoids the repeated transfer of gel and cell sample in traditional methods, significantly simplifying the operation process and reducing the risk of inaccurate gel dosage or cell sample loss due to viscous transfer. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of a cell wax block gel injection device according to an embodiment of the present invention.

[0018] Figure 2 This is a cross-sectional view of a cell wax block gel injection device according to an embodiment of the present invention.

[0019] Figure 3 This is a cross-sectional view of the extension in an embodiment of this utility model.

[0020] In the diagram, 1. Syringe; 2. Sleeve; 3. D-bolt; 4. Stepped nut; 5. Hand-operated plate; 6. Fixing plate; 7. Outer sleeve; 8. Outer sleeve rolled edge; 9. Piston; 10. Core rod; 11. Hand-operated plate; 12. Cone; 13. Cone cap; 14. Needle tube; 15. Ear chamber; 16. Extension; 17. Sleeve bolt fixing hole; 18. Scale line; 19. Hand-operated plate cavity; 20. Nut hole; 21. Pressing hole; 22. Fixing plate bolt fixing hole. Detailed Implementation

[0021] Cell block preparation technology is a key technique in cytopathology for embedding cells enriched in various body fluid samples. Currently, there are two main methods for adding cell blocks to cell-containing test tubes to prepare gels: first, direct addition using a dropper bottle, which leads to inaccurate dosage control due to the viscosity of the gel; second, using pre-filled gel centrifuge tubes, which, while providing a fixed dosage, cannot flexibly match different cell volumes, and the transfer of cells or gel is cumbersome and prone to cell loss. Existing technologies lack a dedicated instrument that can simultaneously provide pre-storage, accurate quantification, and flexible dispensing, thus limiting the efficiency and effectiveness of this technology.

[0022] Based on the above background, this invention proposes a cell paraffin block gel dispensing device. By pre-loading the gel into the syringe, the transfer operation is avoided, fundamentally preventing sample loss. The adjustable limiting component, in conjunction with the dispensing structure, precisely limits the push-button stroke, thereby ensuring the accuracy of the gel dispensing dosage. This integrated structure makes the operation simple and direct, effectively solving the dosage control difficulties and cumbersome transfer problems caused by the viscosity of the gel in traditional methods.

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0025] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installed," "equipped with," "sleeved / connected," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0026] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "several" means two or more, unless otherwise explicitly specified.

[0027] The cell paraffin block gel dispensing device provided in this specific embodiment of the present invention includes: The syringe 1 includes an outer casing 7, a core rod 10 disposed within the outer casing 7, a piston 9 fixed to one end of the core rod 10, and a handle 11 fixed to the other end of the core rod 10; Sleeve 2, sleeve 2 is provided with syringe 1 receiving structure, syringe 1 receiving structure is provided with an extension 16 on one side, the extension 16 is connected to a fixing member through a limiting rod; A quantitative dispensing structure is provided on a limiting rod, including a limiting member and a dispensing structure. The limiting member is movably provided on the limiting rod. The end of the dispensing structure has a limiting hole that cooperates with the limiting member. A syringe 1 fixing structure is provided on the side of the dispensing structure near the sleeve. When in use, the syringe 1 fixing structure is connected to the handle 11.

[0028] In this specific embodiment, syringe 1 is used to preload and discharge cell wax blocks to prepare gel. Its core rod 10 drives piston 9 to move within the outer sleeve to complete the fluid operation. Sleeve 2 provides stable support and positioning for syringe 1 through the syringe 1 housing structure. Extension 16, together with limiting rod and fixing member, forms a rigid frame to ensure that the components maintain a stable relative position during operation. In the quantitative dispensing structure, the limiting member, which can move along the limiting rod, cooperates with the limiting hole on the dispensing structure to form an adjustable mechanical limiting mechanism. This mechanism can precisely control the maximum displacement of the dispensing structure. The dispensing structure is connected to syringe handle 11 through syringe 1 fixing structure, transmitting the operator's pressing pressure to the core rod 10 of syringe 1. All components work together, sleeve 2 and frame provide structural stability, limiting member achieves precise stroke control, and dispensing structure completes force transmission, jointly realizing stable and quantitative gel dispensing operation.

[0029] A specific embodiment of this utility model also provides a cell wax block gel injection device, such as... Figure 1 and Figure 2 As shown, the cell wax block gel dispensing device consists of a syringe 1, a sleeve 2, a D-shaped column bolt 3, a stepped nut 4, a hand-operated clamping plate 5, and a fixing plate 6. The sleeve 2, D-shaped column bolt 3, stepped nut 4, hand-operated clamping plate 5, and fixing plate 6 can be made of metal or non-metal materials to meet the needs of different usage scenarios.

[0030] The syringe 1 is a disposable syringe with a capacity of 1ml to 10ml. In this specific embodiment, a disposable syringe with a capacity of 5ml is used. One end of the outer casing 7 of the disposable syringe is the outlet end, which is provided with an outer casing flange 8. The other end of the outer casing 7 is provided with a hollow cone head 12. The cone head 12 can be selectively connected to a cone head cap 13 or a needle tube 14. In this specific embodiment, the needle tube 14 is a 18G specification flat-head needle tube. A core rod 10 is movably disposed inside the outer casing 7. A piston 9 is fixedly disposed at one end of the core rod 10 near the cone head 12. A handle 11 is fixedly disposed at the other end of the core rod 10. By moving the handle 11, the core rod 10 and the piston 9 can be driven to slide along the inner wall of the outer casing 7 to realize the extraction and discharge of gel.

[0031] like Figure 3As shown, the sleeve 2 has a U-shaped syringe 1 fixing structure in the middle, that is, the sleeve 2 is a sleeve-shaped component with a U-shaped cross section. The inner diameter of the sleeve-shaped component matches the outer diameter of the disposable syringe outer sleeve 7, ensuring that the outer sleeve 7 can be stably embedded in the sleeve 2 without radial shaking. On the two side walls of the opening side of the sleeve 2, there are ear chambers 15 perpendicular to the axis of the sleeve 2 as axial limiting grooves for the syringe 1. The shape and size of the ear chambers 15 match the rolled edge 8 of the outer sleeve of the syringe 1, which is used to axially limit the syringe 1 and prevent the syringe 1 from axially displacing during use. The top plate of each ear chamber 15 extends outward on both sides to form an extension 16. The two extensions 16 are respectively provided with symmetrically arranged sleeve bolt fixing holes 17, which are used to connect with D-type column bolts 3 to ensure the connection stability between the components.

[0032] In this specific embodiment, the limiting rod is a D-type column bolt 3, and two D-type column bolts 3 are provided. The specifications of the two D-type column bolts 3 are exactly the same, and both are provided with external threads on their outer peripheral walls. One end of the two D-type column bolts 3 is respectively fixedly installed in the sleeve bolt fixing hole 17 of the sleeve extension 16, and the two D-type column bolts 3 are kept parallel to each other to ensure the coaxiality of subsequent component installation. A scale line 18 is engraved on the plane where the axis of the D-type column bolt 3 is located. The smallest unit of measurement of the scale line 18 is millimeters. The position of the stepped nut 4 can be accurately read through the scale line 18, thereby realizing the precise adjustment of the injection dosage.

[0033] The limiting component is a stepped nut 4, the number of which corresponds to the number of D-type column bolts 3, that is, one stepped nut 4 is fitted on each D-type column bolt 3. All stepped nuts 4 have the same specifications and parameters, and internal threads are provided on their inner circumferential walls. The internal threads of the stepped nuts 4 mesh with the external threads of the D-type column bolts 3. By rotating the stepped nuts 4, the stepped nuts 4 can move up and down along the axis of the D-type column bolts 3, thereby adjusting the limiting position. In order to realize the limiting function of the hand-operated clamping plate 5, the stepped nuts 4 are divided into upper and lower sections along the axis. The side closer to the sleeve 2 is the lower section of the stepped nuts 4, and the side farther away from the sleeve 2 is the upper section of the stepped nuts 4. The outer diameter of the upper section of the stepped nuts 4 is smaller than the outer diameter of the lower section of the stepped nuts 4, forming a stepped structure for axially limiting the hand-operated clamping plate 5, ensuring that the hand-operated clamping plate 5 can be accurately limited after it is moved to the designated position.

[0034] The dispensing structure is a hand-operated clamping plate 5, with a hand-operated cavity 19 at its center. The shape and size of the hand-operated cavity 19 match the hand-operated handle 11 of the syringe 1, and is used to fix the hand-operated handle 11, so that the movement of the hand-operated clamping plate 5 can synchronously drive the hand-operated handle 11 to move. Nut holes 20 are respectively opened on both sides of the hand-operated clamping plate 5. The inner diameter of the nut holes 20 matches the outer diameter of the upper section of the stepped nut 4 on the D-type column bolt 3, so that the hand-operated clamping plate 5 can be sleeved on the upper section of the stepped nut 4 through the nut holes 20, and the hand-operated clamping plate 5 can move freely along the axial direction of the upper section of the stepped nut 4. The upper surface of the hand-operated clamping plate 5 is also provided with a pressing hole 21, which is used by the operator to apply pushing force, so as to facilitate the operator to perform pressing operation.

[0035] The fastener is a fixing plate 6, which is a flat plate structure with symmetrically arranged fixing plate bolt fixing holes 22 on both sides. The positions of the fixing plate bolt fixing holes 22 correspond one-to-one with the positions of the sleeve bolt fixing holes 17 on the extension 16 of the sleeve 2, ensuring that the D-type column bolts 3 can be accurately installed. One end of the D-type column bolt 3 is fixedly installed in the sleeve bolt fixing hole 17, and the other end is fixedly installed in the fixing plate bolt fixing hole 22. A stepped nut 4 is fitted on the D-type column bolt 3. The fixing plate 6 achieves axial fixation of the D-type column bolt 3, preventing axial movement of the D-type column bolt 3 during use and ensuring the stability of the entire frame structure.

[0036] To further clarify the cell wax block gel dispensing device and its beneficial effects provided by this utility model, a specific embodiment of using this device in the cell wax block preparation process is provided below. In this specific embodiment, the assembly method of the device is as follows: Two D-type column bolts 3 are respectively inserted into the sleeve bolt fixing holes 17 on the extension 16 of the sleeve 2, and the relative fixation of the D-type column bolts 3 and the sleeve 2 is ensured by welding or threaded connection. Two stepped nuts 4 are respectively fitted onto two D-type column bolts 3. Rotate the stepped nuts 4 to ensure that they can rotate freely along the D-type column bolts 3 without jamming. The hand-operated clamp 5 is inserted through the nut holes 20 on both sides and fitted onto the upper section of the two stepped nuts 4. The position of the hand-operated clamp 5 is adjusted to ensure that it can move smoothly along the axial direction of the upper section of the stepped nuts 4. The fixing plate 6 is securely connected to the other end of the two D-type column bolts 3 by means of threaded connection or riveting through the fixing plate bolt fixing holes 22 on both sides, so that the sleeve 2, the two D-type column bolts 3 and the fixing plate 6 form a stable integrated rectangular frame structure, ensuring that no relative displacement occurs between the components during subsequent use.

[0037] In the process of preparing cell paraffin blocks, the cell paraffin block gel dispensing device provided by this invention is used to pre-load cell paraffin blocks to prepare gel and to achieve quantitative dispensing of the gel. Its specific operation is as follows: First, a pre-loading operation is performed. The cell wax block preparation gel is pre-loaded into the outer shell 7 of the syringe 1 through the cone 12 of the syringe 1. After the gel is full, the cone 12 of the syringe 1 is sealed with the cone cap 13 to prevent leakage of the gel during storage or transportation. In this specific embodiment, the cell wax block preparation gel is specifically a paraffin preparation gel. Next, the instrument is installed. The syringe 1, which is pre-filled with paraffin to prepare the gel, is positioned with the outlet end facing the sleeve 2. The outer sleeve 7's outer sleeve edge 8 is aligned with the ear chamber 15 of the sleeve 2 and appropriate pressure is applied to make the outer sleeve edge 8 completely embedded in the ear chamber 15. At the same time, it is ensured that the part of the outer sleeve 7 near the outer sleeve edge 8 is completely embedded in the U-shaped cavity of the sleeve 2, thereby achieving relative fixation between the syringe 1 and the sleeve 2. Then, the handle 11 at the end of the syringe 1 rod 10 is aligned with the handle cavity 19 of the handle plate 5 and pressure is applied so that the handle 11 is fully embedded in the handle cavity 19, thereby achieving synchronous connection between the syringe 1 and the handle plate 5. Based on the amount of paraffin required to be added during the preparation of the cell wax block, refer to the scale line 18 on the D-type column bolt 3, and adjust the position of the stepped nut 4 on the D-type column bolt 3 by rotating it so that the stepped structure of the stepped nut 4 is at the scale position corresponding to the required dose, so as to limit the maximum movement distance of the hand-operated card plate 5 and ensure the accuracy of subsequent dose addition. Remove the cone cap 13 from the cone 12 of syringe 1, connect the 18G flat-head syringe 14 coaxially with the cone 12, and ensure a sealed connection between the syringe 14 and the cone 12 to prevent leakage of gel during the injection process. The operator inserts their thumb into the pressing hole 21 on the hand-operated plate 5, while their index and middle fingers grip the extension 16 of the sleeve 2. A uniform downward thrust is applied to the pressing hole 21, causing the hand-operated plate 5 to move downwards along the axis of the D-shaped bolt 3 until the lower surface of the hand-operated plate 5 contacts and is stopped by the stepped structure of the stepped nut 4. During this process, the hand-operated plate 5 drives the hand 11 to move downwards synchronously. The hand 11 drives the core rod 10 and piston 9 to slide downwards along the inner wall of the outer sleeve 7. The piston 9 applies pressure to the paraffin gel inside the outer sleeve 7, causing the paraffin gel to be squeezed out from the needle tube 14 at the front end of the cone 12 and precisely injected into the designated test tube. Following the above operating steps, the quantitative addition of paraffin gel can be repeated according to the actual needs of cell block preparation until the gel addition work of all designated test tubes is completed, thus meeting the needs of batch preparation of cell blocks.

[0038] Based on the above, the cell wax block gel dispensing device proposed in this utility model has an ingenious design, simple structure, low cost, and convenient use. Using this device, not only can it be used for dispensing pre-loaded cell wax blocks to prepare gel, but it can also accurately dispense the required dosage of cell wax block gel at any time according to the volume of cells to be treated obtained through enrichment, thus effectively overcoming the shortcomings of existing cell wax block dispensing devices, such as inaccurate dosage and low efficiency.

[0039] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A cell paraffin block gel dispensing device, characterized in that, include: Sleeve (2), a syringe (1) receiving structure is provided on sleeve (2), an extension (16) is provided on one side of syringe (1) receiving structure, and the extension (16) is connected to a fixing member by a limiting rod; A quantitative dispensing structure is set on a limiting rod, including a limiting member and a dispensing structure. The limiting member is movably set on the limiting rod. The end of the dispensing structure has a limiting hole that cooperates with the limiting member. A syringe (1) fixing structure is set on the side of the dispensing structure near the sleeve (2). When in use, the syringe (1) fixing structure is connected to the handle (11).

2. The cell wax block gel infusion device according to claim 1, characterized in that, The syringe (1) has an outer sleeve (7) with a rolled edge (8) on the outside. The syringe (1) accommodating structure is provided with an axial limiting groove for the syringe (1). When in use, the rolled edge (8) is placed in the axial limiting groove for the syringe (1).

3. The cell wax block gel infusion device according to claim 2, characterized in that, The syringe (1) has a U-shaped accommodating structure, and the syringe (1) has an axial limiting groove called an ear chamber (15), which is formed on the opening side of the sleeve (2).

4. The cell wax block gel infusion device according to claim 3, characterized in that, The internal dimensions of the U-shaped structure are adapted to the dimensions of the outer jacket (7).

5. The cell wax block gel infusion device according to claim 3, characterized in that, The top plate of the ear chamber (15) extends outward from both sides to form the extension (16), and the extension (16) is provided with a sleeve bolt fixing hole (17), and the limiting rod is fixed in the sleeve bolt fixing hole (17).

6. The cell wax block gel infusion device according to claim 1, characterized in that, The injection structure is a hand-operated card plate (5), and the syringe (1) fixing structure is a hand-operated cavity (19).

7. The cell wax block gel infusion device according to claim 1, characterized in that, The dispensing structure has a pressing hole (21) on the side away from the syringe (1) fixing structure.

8. The cell wax block gel infusion device according to claim 1, characterized in that, The limiting rods are provided in at least two, and each limiting rod is provided with a limiting component, and the limiting rods are parallel to each other.

9. The cell paraffin block gel infusion device according to claim 1, characterized in that, The limiting rod is a D-type column bolt (3), the limiting component is a stepped nut (4), and the stepped nut (4) is provided with a limiting step.

10. The cell paraffin block gel dispensing device according to claim 1, characterized in that, The limiting rod is provided with scale lines (18).

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