NMR sample tube removal device

Abstract

This utility model provides a sample tube removal device for an NMR spectrometer, comprising: a retainer capable of being locked within the probe cavity of the NMR spectrometer; and a push rod, the upper section of which is a rigid section capable of pushing the sample tube within the NMR spectrometer sample cavity, the upper section of which passes through the retainer, and the lower section of which is a flexible section capable of passing through the NMR spectrometer probe cavity and applying upward force. This removal device has a simple structure, enables quick and flexible removal of the sample tube, has high versatility, and good durability.

Description

Technical Field

[0001] This utility model belongs to the field of laboratory equipment, and in particular relates to a sample tube removal device for nuclear magnetic resonance spectrometers. Background Technology

[0002] Nuclear magnetic resonance (NMR) is a commonly used instrument for biochemical analysis of samples. During biochemical analysis experiments, the upper section of the sample tube is typically mounted on a rotor. Under the influence of airflow, the rotor suspends within the sample chamber of the NMR spectrometer, while the lower section of the sample tube is detected by the probe within the probe chamber. After detection, the rotor, driven by airflow, moves the sample tube upwards within the sample chamber, ultimately ejecting the sample tube.

[0003] However, existing experiments often encounter problems such as excessive sample loading leading to overly heavy sample tubes, uneven sample distribution within the tube due to insertion into glass capillaries, insufficient air compressor pressure, and rotor aging. These issues can cause the rotor on the sample tube to become stuck inside the NMR spectrometer's sample chamber, making it impossible to remove. The NMR spectrometer's sample chamber is long and narrow, making direct observation impossible. If the sample tube is stuck, it is difficult to remove it using ordinary tools. Since high-field Fourier transform NMR spectrometers are precision instruments, any ferromagnetic metal tool will interfere with its superconducting magnetic field. Furthermore, as the field strength increases, the height and volume of the magnet increase, further limiting the operable space above and below the chamber. Therefore, it is difficult to remove the stuck sample tube and rotor using conventional tools. Utility Model Content

[0004] To address the technical problem that sample tubes in existing nuclear magnetic resonance (NMR) instruments are difficult to remove, the present invention aims to provide a sample tube removal device for NMR instruments.

[0005] The sample tube removal device for nuclear magnetic resonance spectrometer of this utility model includes:

[0006] A limiter that can be installed inside the probe cavity of an MRI scanner;

[0007] A push rod, wherein the upper section of the push rod is a hard section capable of pushing the sample tube inside the sample chamber of the nuclear magnetic resonance spectrometer, the upper section of the push rod is inserted into the limiter, and the lower section of the push rod is a soft section capable of being inserted into the probe chamber of the nuclear magnetic resonance spectrometer and being able to apply upward force.

[0008] Preferably, the outer diameter of the limiter is consistent with the inner diameter of the MRI scanner probe cavity.

[0009] Preferably, the limiter has a central through hole that extends vertically through the middle, and the upper section of the push rod passes through the central through hole.

[0010] Preferably, the length of the pusher is greater than or equal to the sum of the length of the sample cavity and the probe cavity of the nuclear magnetic resonance spectrometer.

[0011] Preferably, the pusher comprises:

[0012] A flexible tube, the lower section of which is the lower section of a push rod;

[0013] A rigid rod is inserted through the upper section of the hose to form the upper section of the push rod, preferably the upper end of the hose is an open end.

[0014] Preferably, the outer diameter of the rigid rod is the same as the inner diameter of the upper section of the flexible tube.

[0015] Preferably, the rigid rod is a glass rod or a wooden rod; the flexible tube is an air tube or a rubber tube; and the limiter is a foam limiter.

[0016] Preferably, the length of the hose is greater than the length of the rigid rod.

[0017] Preferably, the rigid rod is 10 to 30 cm long, and after being embedded in the upper section of the flexible tube, it is 0.5 to 1 cm away from the opening end.

[0018] Preferably, the upper section of the push rod passes through the limiter and protrudes a certain distance, preferably 7 to 10 cm, from the top surface of the limiter.

[0019] The positive and progressive effects of this utility model are as follows: When the sample tube of the nuclear magnetic resonance (NMR) instrument is locked in the probe cavity of the NMR instrument by the limiter in the extraction device, the sample tube in the NMR instrument sample cavity is pushed upward by pushing the soft section at the lower end of the push rod, so that the hard section at the upper end of the push rod pushes the sample tube upward into the sample cavity. The structure is simple, the operation is convenient, it can be reused multiple times, it is highly durable, has a long service life, is easy to disassemble and assemble, occupies little space and is easy to store, and has strong versatility and can be adapted to different models of NMR instrument cavities. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the sample tube removal device for a nuclear magnetic resonance spectrometer according to the present invention.

[0021] Figure 2 This is a schematic diagram of the working operation of the sample tube removal device for the nuclear magnetic resonance spectrometer of this utility model. Detailed Implementation

[0022] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model.

[0023] like Figure 1 As shown, this utility model discloses a sample tube removal device 10 for an NMR spectrometer. The removal device 10 includes a limiter 11 and a pusher 12. The upper section of the pusher 12 passes through the limiter 11, and the top of the pusher 12 abuts against the bottom of the sample tube. By pushing the removal device upwards, the pusher 12 can push the sample tube out of the NMR spectrometer from bottom to top. It features a simple structure, easy operation, convenient disassembly and assembly, small footprint for easy storage, reusability, high durability, and long service life.

[0024] like Figure 2 As shown, the outer diameter of the limiter 11 is the same as the inner diameter of the MRI probe cavity 21, allowing the limiter 11 to move up and down within the MRI probe cavity 21 under external force. That is, after the limiter 11 is inserted into the MRI probe cavity 21 from the bottom, it can be pushed upwards within the cavity. Since the inner diameter of the MRI probe cavity 21 is much larger than the inner diameter of the MRI sample cavity 22, the limiter 11 will stop moving when pushed to the junction of the MRI probe cavity 21 and the MRI sample cavity 22. In this example, the limiter 11 is a foam limiter, which is soft and lightweight, will not scratch the inner wall of the MRI probe cavity 21, is easy to push without effort, and has strong versatility, adaptable to different models of MRI cavities. It should be noted that the material of the limiter 11 is not a magnetic material such as iron. The specific material is not particularly limited, as long as it can move within the MRI probe cavity 21 without damaging the inner wall of the MRI probe cavity 21.

[0025] The limiter 11 has a central through-hole 111 in its middle, and the upper section of the pusher 12 passes through this central through-hole 111. During use, after the limiter 11 is inserted into the NMR probe cavity 21 from the bottom of the NMR spectrometer, the pusher 12 can be pushed upwards, thus pushing the limiter 11 upwards along with it until the limiter 11 reaches the junction of the NMR probe cavity 21 and the NMR sample cavity 22, at which point the movement of the limiter 11 is restricted. Under the action of the pushing force, the pusher 12 will continue to move upwards relative to the limiter 11, and then the top of the pusher 12 will abut against the bottom of the sample tube 30, pushing the sample tube 30 upwards out of the NMR sample cavity 22. Furthermore, the upper section of the pusher 12, after passing through the central through-hole 111 of the limiter 11, protrudes a certain distance from the top surface of the limiter 11, preferably 7-10 cm. It should be noted that this distance is not limited.

[0026] Continue as Figure 1As shown, the upper section of the pusher 12 is a rigid section 121, which is not easily deformed. After the rigid section 121 passes through the central through hole 111 of the limiter 11, it can be located at the exact center of the NMR probe cavity 21. At this time, the top of the rigid section 121 can just abut against the bottom of the sample tube 30 located at the exact center, and can push the sample tube 30 upward in the NMR sample cavity 22. The limiter limits the rigid section 121 to prevent it from shifting. The lower section of the pusher 12 is a flexible section 122 that can pass through the NMR sample cavity 22 and can apply upward force. The flexible section 122 can be folded to avoid the inability to send the pusher 12 into the NMR probe cavity 21 due to insufficient space at the bottom of the NMR instrument. The length of the pusher 12 is greater than or equal to the sum of the length of the NMR probe cavity 21 and the length of the sample cavity 22, which facilitates the complete upward push of the sample tube 30 into the NMR sample cavity 22.

[0027] In this example, the push rod 12 is composed of a flexible tube 13 and a rigid rod 14. The rigid rod 14 passes through the upper section of the flexible tube 13 to form the upper section (rigid section) 121 of the push rod 12, and the lower section (flexible section) 122 of the flexible tube 13 forms the lower section 122 of the push rod 12. The outer diameter of the rigid rod 14 is the same as the inner diameter of the upper section of the flexible tube 13, so that the rigid rod 14 is just embedded inside the upper section of the flexible tube 13. The length of the flexible tube 13 is greater than the length of the rigid rod 14. In this example, the length of the rigid rod 14 is 10-30 cm, preferably 20 cm. The upper end of the flexible tube 13 is an open end, and the bottom of the sample tube 30 can be locked inside the open end of the flexible tube 13 to prevent the sample tube 30 from detaching from the flexible tube 13. Furthermore, the distance between the rigid rod 14 embedded in the upper end of the flexible tube 13 and the open end of the flexible tube is 0.5-1 cm, and the upper end of the rigid rod 14 abuts against the bottom of the sample tube 30 inside the open end, thereby pushing the sample tube 30 upward. In a further example, the rigid rod 14 is a glass rod or a wooden rod, and the flexible tube 13 is a trachea or rubber tube, both of which are common laboratory items and easily accessible. It should be noted that the materials of the rigid rod and the flexible tube are not particularly limited, as long as the rigid rod is made of a hard material and the flexible tube is made of a soft material.

[0028] The present invention has been described in detail above with reference to the accompanying drawings and embodiments. Those skilled in the art can make various modifications to the present invention based on the above description. Therefore, certain details in the embodiments should not be construed as limiting the present invention, and the scope of protection of the present invention shall be defined by the appended claims.

Claims

1. A sample tube removal device for an nuclear magnetic resonance spectrometer, characterized in that, The extraction device includes: A limiter that can be installed inside the probe cavity of an MRI scanner; A push rod, wherein the upper section of the push rod is a hard section that can push the sample tube inside the sample chamber of the NMR spectrometer, the upper section of the push rod is inserted into the limiter, and the lower section of the push rod is a soft section that can be inserted into the probe chamber of the NMR spectrometer and can apply upward force.

2. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that, The outer diameter of the limiter is consistent with the inner diameter of the MRI scanner probe cavity.

3. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that, The limiter has a central through hole running vertically through its middle section, and the upper section of the push rod passes through the central through hole.

4. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that, The length of the pusher is greater than or equal to the sum of the length of the sample cavity and the probe cavity of the nuclear magnetic resonance spectrometer.

5. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 1, characterized in that, The push rod includes: A flexible tube, the lower section of which is the lower section of a push rod; A rigid rod, which passes through the upper section of the hose to form the upper section of the push rod.

6. The sample tube removal device for an NMR spectrometer as described in claim 5, characterized in that, The upper end of the hose is an open end.

7. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 5, characterized in that, The outer diameter of the rigid rod is the same as the inner diameter of the upper section of the flexible tube.

8. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 7, characterized in that, The rigid rod is a glass rod or a wooden rod; the flexible tube is an air tube or a rubber tube; and the limiter is a foam limiter.

9. The sample tube removal device for an NMR spectrometer as described in claim 7, characterized in that, The length of the hose is greater than the length of the rigid rod.

10. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 7, characterized in that, The rigid rod is 10-30cm in length, and after being embedded in the upper section of the flexible tube, it is 0.5-1cm away from the opening end.

11. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 7, characterized in that, The upper section of the push rod passes through the limiter and protrudes a certain distance from the top surface of the limiter.

12. The sample tube removal device for a nuclear magnetic resonance spectrometer as described in claim 11, characterized in that, The upper section of the push rod passes through the limiter and protrudes 7-10 cm beyond the top surface of the limiter.

Images