A segmented collision device for mass spectrometry

Abstract

This invention discloses a segmented collision device for mass spectrometry, which mainly consists of a first collision chamber, an ion source, a second collision chamber, and an ion transport channel. The first collision chamber receives the ion beam from the ion source and collides it with a first gas, thus performing preliminary processing of the ion beam. The ion source, as the ion beam generation source, is connected to the first collision chamber to ensure the ion beam can smoothly enter the first collision chamber. The second collision chamber is connected to the first collision chamber, improving collision efficiency. Through the segmented design, ions collide with different gases in the first and second collision chambers respectively, allowing for optimization of gas type and pressure for different stages of collision, thereby improving collision efficiency. Precise control of collision conditions is achieved through a gas inlet tube and a pressure control tube, allowing for precise control of the gas type and pressure in each collision chamber, providing the optimal collision environment for the ions.

Description

Technical Field

[0001] This utility model relates to the field of analytical instrument technology, specifically to a segmented collision device for mass spectrometry. Background Technology

[0002] Mass spectrometry is an important material analysis technique widely used in chemistry, biology, medicine, and other fields. In mass spectrometry, ions undergo acceleration, separation, and detection to determine their mass and structural information. The collision device is one of the key components of a mass spectrometer, used to collide ions with gas molecules to achieve ion fragmentation and energy transfer, thereby obtaining more structural information.

[0003] Traditional collision devices typically employ a single collision chamber, resulting in low collision and ion transport efficiencies, and making precise control of the collision process difficult. Therefore, a novel collision device is needed to improve collision and ion transport efficiencies while simultaneously achieving precise control of the collision process. Utility Model Content

[0004] The purpose of this invention is to provide a segmented collision device for mass spectrometry to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a segmented collision device for mass spectrometry, which mainly consists of a first collision chamber, an ion source, a second collision chamber, and an ion transmission channel. The first collision chamber receives the ion beam from the ion source and collides it with a first gas, thereby performing preliminary processing of the ion beam. The ion source, as the ion beam generation source, is connected to the first collision chamber to ensure that the ion beam can smoothly enter the first collision chamber. The second collision chamber is connected to the first collision chamber and receives the ion beam processed by the first collision chamber, colliding it with a second gas for further processing. The ion transmission channel is located between the first and second collision chambers, and its main function is to transmit the ion beam, ensuring that the ion beam can be smoothly transmitted from the first collision chamber to the second collision chamber, forming a complete ion transmission path.

[0006] In this apparatus, both the first and second collision chambers are equipped with gas inlet pipes. The outer ends of these gas inlet pipes are connected to gas inlet devices to introduce gas, thereby creating the desired collision gas environment within the collision chambers. In this way, the type and concentration of the collision gas can be precisely controlled to meet different analytical needs.

[0007] To further optimize the working environment within the collision chambers, pressure control tubes are installed in both the first and second collision chambers. These tubes are connected to pressure control devices, allowing operators to adjust and control the pressure within the collision chambers as needed for experiments. Precise pressure control improves the efficiency of the collision process and the quality of the ion beam.

[0008] In its design, this device specifically considers the length ratio of the first and second collision chambers, which is set between 1:1 and 1:3. This design ratio helps ensure that the ion beam receives appropriate processing time in both collision chambers, thereby achieving optimal collision results.

[0009] Structurally, both the first and second collision chambers are cylindrical. This design helps to uniformly distribute the collision gas and allows the ion beam to collide with the gas evenly within the chambers. Furthermore, the ion transport channel is designed to be located on the central axis of the first and second collision chambers. This arrangement helps maintain the ion beam's transport direction and reduces scattering during transport.

[0010] To improve the transmission efficiency and quality of the ion beam, an ion lens is specially installed in the ion transmission channel. The function of the ion lens is to focus and guide the ion beam, ensuring that the ion beam maintains a good focused state during transmission, thereby improving the analytical accuracy and sensitivity of the entire device.

[0011] Compared with the prior art, the beneficial effects of this utility model are: improved collision efficiency. Through the segmented design, ions collide with different gases in the first and second collision chambers respectively. The gas type and pressure can be optimized for the collision requirements at different stages, thereby improving collision efficiency.

[0012] By precisely controlling the collision conditions through gas inlet pipes and pressure control pipes, the type and pressure of gas in each collision chamber can be precisely controlled, providing the best collision environment for ions.

[0013] The device offers flexibility and adaptability, as the conditions in the two collision chambers can be controlled separately, allowing it to adapt to different types of analytical needs, such as optimization for ions with different mass ranges.

[0014] It has high ion transmission efficiency. The ion transmission channel is located on the central axis of the two collision chambers. With the use of ion lenses, it can effectively focus and guide the ion beam, reduce ion loss, and improve transmission efficiency.

[0015] Its compact structure reduces space requirements and facilitates integration into existing mass spectrometry instruments.

[0016] Improving analytical sensitivity and resolution can be achieved by optimizing the collision gas environment and pressure, which can enhance ion activation efficiency and thus improve the sensitivity and resolution of mass spectrometry analysis. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 for Figure 1 A magnified structural diagram of point A in the middle.

[0018] In the diagram: 1. First collision chamber; 2. Ion source; 3. Second collision chamber; 4. Ion transmission channel; 5. Gas inlet tube; 6. Pressure control tube; 7. Ion lens. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] Please see Figure 1-2 This invention provides a technical solution: a segmented collision device for mass spectrometry, which mainly consists of a first collision chamber 1, an ion source 2, a second collision chamber 3, and an ion transmission channel 4. The first collision chamber 1 receives the ion beam from the ion source 2 and collides it with a first gas, thus performing preliminary processing of the ion beam. The ion source 2, as the ion beam generation source, is connected to the first collision chamber 1 to ensure that the ion beam can smoothly enter the first collision chamber. The second collision chamber 3 is connected to the first collision chamber 1 and receives the ion beam processed in the first collision chamber, colliding it with a second gas for further processing. The ion transmission channel 4 is located between the first collision chamber 1 and the second collision chamber 3, and its main function is to transmit the ion beam, ensuring that the ion beam can be smoothly transmitted from the first collision chamber to the second collision chamber, forming a complete ion transmission path.

[0021] In this apparatus, both the first collision chamber 1 and the second collision chamber 3 are equipped with gas inlet pipes 5. The outer ends of these gas inlet pipes 5 are connected to gas inlet devices, the purpose of which is to introduce gas, thereby creating the required collision gas environment within the collision chamber. In this way, the type and concentration of the collision gas can be precisely controlled to meet different analytical needs.

[0022] To further optimize the working environment within the collision chambers, pressure control tubes 6 are also installed in both the first and second collision chambers 1 and 3. The outer ends of these pressure control tubes 6 are connected to pressure control devices, allowing operators to adjust and control the pressure within the collision chambers according to experimental needs. Precise pressure control can improve the efficiency of the collision process and the quality of the ion beam.

[0023] In its design, this device specifically considers the length ratio of the first collision chamber 1 and the second collision chamber 3, which is set between 1:1 and 1:3. This design ratio helps ensure that the ion beam receives appropriate processing time in both collision chambers, thereby achieving optimal collision results.

[0024] Structurally, both the first collision chamber 1 and the second collision chamber 3 are cylindrical in shape. This design helps to distribute the collision gas evenly and allows the ion beam to collide uniformly with the gas within the collision chamber. Furthermore, the ion transmission channel 4 is designed to be located on the central axis of the first collision chamber 1 and the second collision chamber 3. This arrangement helps to maintain the transmission direction of the ion beam and reduce scattering of the ion beam during transmission.

[0025] To improve the transmission efficiency and quality of the ion beam, an ion lens 7 is specially provided in the ion transmission channel 4. The function of the ion lens 7 is to focus and guide the ion beam, ensuring that the ion beam maintains a good focused state during transmission, thereby improving the analytical accuracy and sensitivity of the entire device.

[0026] Working principle: When this utility model is in operation, the ion source 2 generates ion beams, which are then transmitted to the first collision chamber 1.

[0027] Inside the first collision chamber 1, the ion beam collides with a pre-introduced collision gas introduced through the gas inlet tube 5. These collisions cause energy and momentum transfer in the ions within the ion beam, thereby generating fragment ions or excited-state ions.

[0028] The ion beam after collision is transmitted to the second collision chamber 3 through the ion transmission channel 4. The ion transmission channel 4 may contain an ion lens 7 for focusing and guiding the ion beam, ensuring the transmission efficiency and quality of the ion beam.

[0029] In the second collision chamber 3, the ion beam collides again with another collision gas introduced through another gas inlet tube 5. This step allows for further analysis or preparation of the ions, for example, by generating more fragment ions through further collision-induced dissociation (CID).

[0030] The pressure inside the collision chamber is regulated by pressure control tube 6 and connected pressure control device to optimize the collision process and ion transport efficiency.

[0031] The length ratio of the first collision chamber 1 to the second collision chamber 3 is 1:1 to 1:3, which helps to control the collision process and the transmission of the ion beam.

[0032] The first collision chamber 1 and the second collision chamber 3 are both cylindrical in shape, and the ion transport channel 4 is located on their central axis. This helps to maintain a straight transport path for the ion beam and reduce scattering and loss.

[0033] Through the above steps, this segmented collision device can effectively perform multi-stage collision processing on the ion beam, thereby providing richer information for mass spectrometry analysis.

[0034] In the description of this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0035] All standard parts used in this invention can be purchased from the market, and irregular parts can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art, and the circuit connection adopts conventional connection methods in the prior art, which will not be described in detail here.

[0036] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A segmented collision device for mass spectrometry, characterized in that, include: The first collision chamber (1) is used to receive the ion beam from the ion source (2) and to collide with the first gas; The second collision chamber (3) is connected to the first collision chamber (1) and is used to receive the ion beam after collision in the first collision chamber and to collide with the second gas. An ion transport channel (4) is provided between the first collision chamber (1) and the second collision chamber (3) for transmitting ion beams; The ion source (2), the first collision chamber (1), the ion transmission channel (4), and the second collision chamber (3) are connected in sequence to form an ion transmission path.

2. The segmented collision device for mass spectrometry according to claim 1, characterized in that: The first collision chamber (1) and the second collision chamber (3) are respectively provided with gas inlet pipes (5), and the outer end of the gas inlet pipes (5) is connected to a gas inlet device for introducing gas to form a collision gas environment.

3. The segmented collision device for mass spectrometry according to claim 1, characterized in that: Pressure control tubes (6) are respectively provided in the first collision chamber (1) and the second collision chamber (3). The outer end of the pressure control tube (6) is connected to a pressure control device to control the pressure inside the collision chamber.

4. A segmented collision device for mass spectrometry according to claim 1, characterized in that: The length ratio of the first collision chamber (1) to the second collision chamber (3) is 1:1 to 1:

3.

5. A segmented collision device for mass spectrometry according to claim 1, characterized in that: The first collision chamber (1) and the second collision chamber (3) are both cylindrical in shape, and the ion transport channel (4) is located on the central axis of the first collision chamber (1) and the second collision chamber (3).

6. A segmented collision device for mass spectrometry according to claim 5, characterized in that: The ion transmission channel (4) is equipped with an ion lens (7) for focusing and guiding the ion beam.

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