An endoscopic pre-filled cell perfusion device

Abstract

The utility model discloses an endoscopic pre-filled cell perfusion device. It includes push rod, syringe, tee and perfusion hose, the first interface of tee is connected with the injection outlet of the front end of syringe, the second interface of tee is connected with the tail end of perfusion hose, and the third interface of tee is equipped with detachable tee cap, the front end of push rod is equipped with sealed piston, and sealed piston is located in syringe, and the tail part of syringe is equipped with screw hole channel, the rod body of push rod is equipped with the screw thread that cooperates with screw hole channel, and the tail part of push rod is located outside syringe and is connected with rotating handle, the syringe is transparent syringe, the entrance of screw hole channel on syringe is equipped with reference scale line or scale display window, and the first milliliter scale line is equipped on push rod.

Description

Technical Field

[0001] This utility model relates to a cell perfusion device, and in particular discloses an endoscopic pre-filled cell perfusion device. Background Technology

[0002] Currently, due to genetic factors, environmental factors, and lifestyle habits, the number of people suffering from lung diseases is gradually increasing. Electronic bronchoscopic perfusion cell therapy for lung diseases is a precision medicine technology closely related to the treatment needs of lung diseases, the development of cell therapy technology, and advancements in endoscopic techniques. As a core tool in respiratory intervention, the electronic bronchoscope's high-definition imaging and navigation can precisely locate lesion areas. Electronic bronchoscopic perfusion cell therapy delivers cells directly to the lesion area, reducing systemic side effects. Furthermore, it is repeatable, allowing for multiple procedures to maintain cell viability or dosage.

[0003] Currently, commonly used cell aspiration tools consist of a standard syringe connected to a drug injection tubing. The syringe structure includes a syringe body and a plunger. The plunger's front end has a single layer of sealant, and its rear end has a push-pull handle. During cell aspiration, the following problems exist: During aspiration, the plunger is pushed or pulled forward or backward to aspirate cells. To ensure a tight seal while facilitating syringe pushing and pulling, insufficient friction between the single layer of sealant and the syringe wall is detrimental to sealing, while excessive friction makes pushing and pulling difficult. Therefore, in actual aspiration, the pushing and pulling force of current syringes is difficult to control. Even slight over-pushing or pulling can cause air to enter the syringe, and excessively fast aspiration can lead to a large number of air bubbles due to turbulence. Furthermore, aspiration can waste cells, easily causing cell contamination and damage to cell viability. It also requires strict environmental and temperature control, increasing the risk of cell contamination and waste. Existing syringes require a high level of operator skill for cell aspiration.

[0004] Secondly, the existing syringe cell extraction procedure is cumbersome. When aspirating cells, it is necessary to select a syringe with an appropriate dosage, insert the tip of the syringe into the opening of the cell bag, gently shake the cell bag, and aspirate the corresponding amount of cells. Attention should also be paid to the aspiration speed and force. Novice operators may damage the cells or generate a large number of air bubbles due to turbulence if they aspirate too quickly. The generation of air bubbles can also cause inaccurate judgment of the injection dosage during the injection process, thereby increasing the workload of the operator.

[0005] During perfusion, it is impossible to accurately control the injection dosage. One reason is the visual difference caused by the angle. The syringe of the existing cell injector only has the scale lines on the syringe body. If the normal injection angle is downward, it is impossible to accurately control the injection dosage. The syringe must be observed at eye level. Another reason is that the syringe must be kept fixed during the perfusion process. Otherwise, if the doctor applies even a slight negative pressure during the operation, the cells will be sucked away by the negative pressure, resulting in cell waste.

[0006] The existing syringe and dosing tube are designed as separate parts, which increases the risk of contamination during manual connection.

[0007] During cell perfusion, tracheal stenosis increases perfusion pressure, and the connection points are prone to detachment, causing cell spillage, resulting in cell waste and increasing the risk of infection for medical staff.

[0008] Uneven pressure during infusion can generate air bubbles, affecting the field of vision of the bronchoscopy. Summary of the Invention

[0009] The purpose of this invention is to overcome the defects in the existing technology and provide an endoscopic pre-filled cell perfusion device that reduces cell loss, lowers the difficulty of operation, reduces the probability of contamination, and shortens the operation time.

[0010] This invention is implemented as follows: An endoscopic pre-filled cell perfusion device includes a push rod, a syringe, a three-way connector, and a perfusion tubing. The first port of the three-way connector is connected to the injection outlet at the front end of the syringe, the second port of the three-way connector is connected to the tail end of the perfusion tubing, and the third port of the three-way connector is provided with a detachable three-way cap. The front end of the push rod is provided with a sealing piston, which is located inside the syringe. A threaded channel is provided inside the syringe near the tail end. The push rod has a thread that mates with the threaded channel. The tail end of the push rod is located outside the syringe and is connected to a rotating handle. The syringe is a transparent syringe, and a reference scale line or scale display window is provided on the syringe facing the entrance of the threaded channel. The push rod has a first milliliter scale line.

[0011] The front end of the push rod is rotatably connected to the sealing piston.

[0012] The push rod has a rotating convex ring on its four sides at the front end, and a rotating mounting seat is provided at the rear end of the sealing piston. The rotating mounting seat has a circular cylindrical hole in the middle, and a groove that mates with the rotating convex ring is provided on the inner wall of the circular cylindrical hole. The front end of the push rod is located in the circular cylindrical hole, and the rotating convex ring is located in the groove.

[0013] The syringe has a gripping protrusion on the outer side of the middle section.

[0014] The front end sidewall of the infusion hose is provided with several through holes evenly distributed.

[0015] The sealing piston is a silicone piston.

[0016] The syringe is equipped with a second milliliter graduation mark.

[0017] The beneficial effects of this invention are as follows: The push rod is threadedly connected to the screw hole channel inside the syringe, allowing the push rod to advance spirally. This makes the pushing distance controllable, avoiding over-pushing due to excessive force, thus achieving precise dosage control. The syringe, tee, and infusion tubing are integrated into one unit, facilitating infusion while preventing the infusion tubing from detaching, thereby avoiding secondary contamination and making it safer and more reliable to use. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of this utility model.

[0019] Figure 2 This is a schematic diagram showing the connection relationship between the syringe, tee, and infusion hose of this utility model.

[0020] Figure 3 This is a schematic diagram of the internal structure of the injection cylinder of this utility model.

[0021] Figure 4 This is a schematic diagram of the internal structure of the sealing piston of this utility model.

[0022] Figure 5 This is a schematic diagram of the structural connection relationship when the push rod of this utility model retracts.

[0023] Figure 6 This is a schematic diagram showing the connection relationship between the push rod and the sealing piston of this utility model.

[0024] The components include: 1. Push rod; 2. Injector; 3. T-joint; 4. Infusion hose; 5. Injection outlet; 6. Removable t-joint cap; 7. Sealing piston; 8. Screw hole channel; 9. Thread; 10. Rotary handle; 11. Reference scale line; 12. First milliliter scale line; 13. Rotating convex ring; 14. Rotary mounting base; 15. Circular cylindrical hole; 16. Groove; 17. Grip protrusion; 18. Second milliliter scale line; 19. Through hole. Detailed Implementation

[0025] according to Figure 1-6This invention relates to an endoscopic pre-filled cell perfusion device, comprising a push rod 1, an injection cylinder 2, a three-way connector 3, and a perfusion tubing 4. The first port of the three-way connector 3 is connected to the injection outlet 5 at the front end of the injection cylinder 2, the second port of the three-way connector 3 is connected to the tail end of the perfusion tubing 4, and the third port of the three-way connector 3 is provided with a detachable three-way cap 6. The front end of the push rod 1 is provided with a sealing piston 7, which is located inside the injection cylinder 2. The injection cylinder 2 has a screw hole channel 8 near its tail end, and the push rod 1 has a thread 9 that mates with the screw hole channel 8. The tail end of the push rod 1 is located outside the injection cylinder 2 and is connected to a rotating handle 10. The injection cylinder 2 is a transparent injection cylinder, and a reference scale line 11 or a scale display window is provided on the injection cylinder 2 facing the entrance of the screw hole channel 8. The push rod 1 has a first milliliter scale line 12. The scale display window is used to display the value of the first milliliter scale line 12. The value of the first milliliter scale line 12, which is pointed to by the reference scale line 11 or displayed in the scale display window, is the volume value from the front end of the sealed piston 7 to the front end of the syringe 2.

[0026] The front end of the push rod 1 is rotatably connected to the sealing piston 7. Specifically, the front end of the push rod 1 has a rotating protruding ring 13 on its four side walls, and the rear end of the sealing piston 7 has a rotating mounting seat 14. The rotating mounting seat 14 has a circular cylindrical hole 15 in the middle, and the inner wall of the circular cylindrical hole 15 has a groove 16 that mates with the rotating protruding ring 13. The front end of the push rod 1 is located in the circular cylindrical hole 15, and the rotating protruding ring 13 is located in the groove 16. The sealing piston 7 is a silicone piston. The push rod 1 is threadedly connected to the screw hole channel 8 in the syringe 2. In use, rotating the rotating handle 10 drives the push rod 1 to advance spirally. Under the action of the thread, the push rod 1 advances a constant distance with each rotation, thus making the advancement distance of the push rod 1 controllable and avoiding over-push due to excessive force, thereby achieving precise dosage control.

[0027] The syringe 2 has a gripping protrusion 17 on its outer side at the middle. The syringe 2 has a second milliliter scale line 18. The infusion tubing 4 has several through holes 19 evenly distributed on its front end sidewall. The end face of the front end of the infusion tubing 4 is beveled.

Claims

1. An endoscopic pre-filled cell perfusion device, characterized in that: The device includes a push rod, a syringe, a tee, and an infusion tubing. The first port of the tee is connected to the injection outlet at the front end of the syringe, the second port of the tee is connected to the tail end of the infusion tubing, and the third port of the tee is equipped with a detachable tee cap. The front end of the push rod is equipped with a sealing piston located inside the syringe. A threaded hole channel is provided inside the syringe near the tail end. The push rod has threads that mate with the threaded hole channel. The tail end of the push rod is located outside the syringe and is connected to a rotating handle. The syringe is a transparent syringe with a reference scale line or scale display window at the entrance of the threaded hole channel. The push rod has a first milliliter scale line.

2. The endoscopic pre-filled cell perfusion device according to claim 1, characterized in that: The front end of the push rod is rotatably connected to the sealing piston.

3. The endoscopic pre-filled cell perfusion device according to claim 2, characterized in that: The push rod has a rotating convex ring on its four sides at the front end, and a rotating mounting seat is provided at the rear end of the sealing piston. The rotating mounting seat has a circular cylindrical hole in the middle, and a groove that mates with the rotating convex ring is provided on the inner wall of the circular cylindrical hole. The front end of the push rod is located in the circular cylindrical hole, and the rotating convex ring is located in the groove.

4. The endoscopic pre-filled cell perfusion device according to claim 1, characterized in that: The syringe has a gripping protrusion on the outer side of the middle section.

5. An endoscopic pre-filled cell perfusion device according to claim 1, characterized in that: The front end sidewall of the infusion hose is provided with several through holes evenly distributed.

6. The endoscopic pre-filled cell perfusion device according to claim 1, characterized in that: The sealing piston is a silicone piston.

7. An endoscopic pre-filled cell perfusion device according to claim 1, characterized in that: The syringe is provided with a second milliliter graduation mark.

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