A fixture for mouse blood collection

CN224911361UActive Publication Date: 2026-10-30JINAN UNIVERSITY
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Patent Information

Application Number
CN202521014518.0
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-05-22
Publication Date
2026-10-30
Estimated Expiration
2035-05-22

AI Technical Summary

Technical Problem

然而,现有固定器或人工固定在实验应用中仍存在诸多问题和缺点,尤其是小鼠眼球的突出、体位的调节和小鼠头部的固定方面面临挑战

Benefits of technology

[0016]本实用新型通过肢体固定机构的固定通道、固定板及固定带,配合颈部夹持机构和尾部夹持机构,可全方位固定小鼠的肢体、颈部和尾部,解决现有固定器稳定性差、易滑脱的问题;同时,各部件可适配不同体型小鼠,降低动物应激,避免因应激或溶血影响血液成分,满足精准实验需求。摒弃人工提拉颈部皮肤的不稳定固定方式,采用颈部夹持机构,卡住小鼠头部防止移位同时能够提拉颈部皮肤,使其眼球稳定突出,便于取血。可转动的平板搭配带锁止环的转动杆,能够根据实验操作需求调整小鼠体位,克服传统设备结构固定、体位调节受限的缺陷,为多样化实验操作提供便利。固定通道两侧的通孔结合加压机构,通过下压压板促使小鼠自然伸出四肢,再通过固定带固定,无需借助胶带、细绳等外部设施,简化操作流程,且避免实验过程中四肢固定脱落的问题。防咬机构的防护罩可有效防止小鼠咬伤操作者,解决现有固定方式存在的安全隐患,提升实验操作的安全性。

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Abstract

The utility model provides a kind of fixing device for mouse blood taking, comprising: support;Rotatably arranged on the support flat plate;Limb fixation mechanism is arranged on the flat plate, the limb fixation mechanism includes fixed seat and the pair of arc-shaped plate being arranged on the fixed seat, the fixed seat and the pair of arc-shaped plate define the fixed channel for accommodating mouse limbs;Neck clamping mechanism, the neck clamping mechanism includes rotatably arranged on the fixed seat one side first clamping plate and second clamping plate;Slidably arranged on the flat plate anti-bite mechanism, the anti-bite mechanism corresponds with the neck clamping mechanism, it is used to be fitted in mouse head to prevent bite injury user.The utility model can fix mouse stably and comprehensively by fixing device, adapt to different body shape and reduce mouse stress, prevent blood from sticking to mouse hair, cause hemolysis or affect blood composition.
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Description

Technical Field

[0001] This utility model relates to the field of mouse fixation technology, specifically to a fixation device for blood collection from mice. Background Technology

[0002] In biomedical research, mice are core experimental animals, and their blood samples are crucial for revealing physiological mechanisms, evaluating disease models, and validating drug efficacy. Their blood components (such as red blood cells, white blood cells, and platelets) and physiological parameters are frequently used to simulate human disease mechanisms. By detecting blood biochemical indicators (glucose, blood lipids), routine blood parameters (hemoglobin, white blood cell differential count), and inflammatory factor levels, the progression of metabolic diseases, immune diseases, and tumor models can be assessed, playing an irreplaceable role. The scientific and standardized nature of blood collection directly affects the accuracy and reproducibility of experimental data. However, existing restraint devices or artificial fixation still have many problems and shortcomings in experimental applications, especially in addressing challenges related to mouse eyeball protrusion, body position adjustment, and head fixation. In practice, the following problems are often encountered: (1) Difficulty in protruding mouse eyeballs: During the process of fixing mice for blood collection, the mice experience stress and their eyes are closed, making it difficult to expose the eyeballs and collect blood; (2) Inability to adjust body position: Traditional equipment has a fixed structure and rigid materials, which restricts the adjustment of the mouse's body position and makes it difficult for blood to flow into the EP tube; (3) Poor applicability: Poor fixation and large range of struggle by the mice lead to easy shedding of mouse fur during blood collection, posing risks such as hemolysis and affecting blood testing, making it difficult to meet experimental requirements; (4) Poor stability: Existing fixation devices rely on manual lifting to fix the neck skin, which is unstable and easy to slip off, and may even bite the operator; (5) Poor limb fixation: Existing fixation devices require the use of external facilities (such as tape, thin rope, etc.) to fix the mouse's limbs, which is too cumbersome and may fall off during the experiment. Therefore, how to develop a mouse fixation device with good fixation and low stress is an urgent problem to be solved. Utility Model Content

[0003] To address the problems existing in the prior art, the purpose of this utility model is to provide a fixation device for blood collection from mice. Through the cooperation of a limb fixation mechanism, a neck clamping mechanism, a tail clamping mechanism, and a pressure mechanism, the mouse can be fixed in a comprehensive and stable manner before blood collection is performed. This device is suitable for different body sizes, reduces stress on mice, and avoids hemolysis or affecting blood components.

[0004] To achieve the above objectives, the present invention adopts the following technical solution:

[0005] A fixation device for blood collection from mice includes: a support; a plate rotatably mounted on the support; a limb fixation mechanism mounted on the plate, the limb fixation mechanism including a fixing seat and a pair of arc-shaped plates mounted on the fixing seat, the fixing seat and the pair of arc-shaped plates defining a fixation channel for receiving mouse limbs, the two ends of the fixation channel forming an entrance for receiving the mouse and an exit for the mouse's head to extend out, and the two sides of the fixation channel forming through holes for receiving the mouse's limbs; a neck clamping mechanism including a first clamping plate and a second clamping plate rotatably mounted on one side of the fixing seat, the first clamping plate and the second clamping plate forming a locking space between them for clamping the mouse's neck when rotated closer; and a bite-proof mechanism slidably mounted on the plate, the bite-proof mechanism corresponding to the neck clamping mechanism, which is used to fit over the mouse's head to prevent it from biting the user.

[0006] According to one example, the support has a mounting opening for accommodating the plate, and rotating rods are respectively provided on both sides of the plate. The rotating rods are rotatably connected to the inner sidewall of the mounting opening, wherein one end of the rotating rod has a locking ring for fixing the rotation angle of the plate relative to the support.

[0007] According to one example, a first clamping plate is provided at one end of the first clamping plate, and a second clamping plate is provided at one end of the second clamping plate to cooperate with the first clamping plate, and a clamping space for clamping the skin of the mouse neck is formed between the first clamping plate and the second clamping plate.

[0008] According to one example, multiple fixing plates corresponding to the through holes are provided on both sides of the fixing channel, and fixing straps for binding the limbs of mice are provided across the fixing plates.

[0009] According to one example, the anti-bite mechanism includes a slide bar and a protective cover disposed at the upper end of the slide bar, and a first slide groove is provided on the plate along its length direction, and the slide bar is slidably connected to the first slide groove.

[0010] According to one example, a pressure mechanism is provided between the pair of arc-shaped plates, the pressure mechanism including a connecting rod horizontally disposed between the pair of arc-shaped plates and a pressure plate slidably disposed below the connecting rod, the pressure plate being located within the fixed channel.

[0011] According to one example, a pressure rod is vertically mounted on the top of the pressure plate. The upper end of the pressure rod passes through the connecting rod and extends upward to a certain height. An elastic component is provided on the portion of the pressure rod above the connecting rod. The elastic component includes a cylinder disposed on the upper surface of the connecting rod. The cylinder has a central hole through which the pressure rod passes. A compression spring is disposed inside the cylinder and sleeved on the outside of the pressure rod. An annular baffle is provided on the circumferential wall of the pressure rod, and the annular baffle abuts against the upper end face of the compression spring.

[0012] According to one example, a tail clamping mechanism is also provided on the other side of the fixing base. The tail clamping mechanism includes a pair of clamping blocks arranged symmetrically. A second sliding groove is provided on the other side of the fixing base. The clamping blocks are slidably connected in the second sliding groove. One side of the clamping block has an arc-shaped groove. When the two clamping blocks are close together, the two arc-shaped grooves form a clamping opening for clamping the tail.

[0013] According to one example, the mounting base is provided with multiple vent holes.

[0014] According to one example, the base of the support has four supporting legs that lift the support off the ground at a certain distance.

[0015] This utility model has the following advantages:

[0016] This invention utilizes a limb fixation mechanism with a fixed channel, a fixed plate, and a fixed strap, combined with a neck clamping mechanism and a tail clamping mechanism, to comprehensively fix the limbs, neck, and tail of mice, solving the problems of poor stability and easy slippage in existing fixation devices. Simultaneously, each component can be adapted to mice of different sizes, reducing animal stress and preventing stress or hemolysis from affecting blood components, thus meeting the needs of precise experiments. It abandons the unstable fixation method of manually pulling the neck skin, employing a neck clamping mechanism to hold the mouse's head in place to prevent displacement while simultaneously lifting the neck skin, ensuring stable protrusion of the eyeballs for easy blood collection. A rotatable plate combined with a rotating rod with a locking ring allows adjustment of the mouse's position according to experimental needs, overcoming the shortcomings of traditional equipment with fixed structures and limited position adjustment, providing convenience for diverse experimental operations. Through holes on both sides of the fixation channel, combined with a pressure mechanism, use a downward pressure plate to encourage the mouse to naturally extend its limbs, which are then fixed by the straps, eliminating the need for external facilities such as tape or rope, simplifying the operation process and preventing limbs from slipping off during experiments. The protective shield of the anti-bite mechanism can effectively prevent mice from biting the operator, solve the safety hazards of existing fixation methods, and improve the safety of experimental operations. Attached Figure Description

[0017] Figure 1 This is a three-dimensional structural diagram of the fixation device for blood collection from mice according to this utility model.

[0018] Figure 2 yes Figure 1 A magnified view of part A.

[0019] Figure 3 This is a three-dimensional structural diagram of the fixation device for blood collection from mice, which is another angle of this utility model.

[0020] Figure 4 yes Figure 3 A magnified view of section B.

[0021] Figure 5 This is a three-dimensional cross-sectional view of the fixation device for blood collection from mice according to this utility model.

[0022] Figure 6 This is a three-dimensional structural diagram of the pressurization mechanism of this utility model.

[0023] Wherein, 1 is a support, 101 is a frame, 102 is a support leg, 103 is a mounting port, 2 is a flat plate, 201 is a rotating rod, 202 is a locking ring, 203 is a handle, 204 is a first slide groove, 3 is a limb fixation mechanism, 3a is a fixing channel, 301 is a fixing seat, 301a is a second slide groove, 301b is a vent, 302 is an arc-shaped plate, 303 is an inlet, 304 is an outlet, 305 is a through hole, 306 is a fixing plate, 306a is a fixing strap, 4 is a neck clamping mechanism, 4a is a locking space, 4b For the clamping space, 401 is the first clamping plate, 401a is the first clamping plate, 402 is the second clamping plate, 402a is the second clamping plate, 5 is the anti-bite mechanism, 501 is the sliding rod, 502 is the protective cover, 6 is the pressurizing mechanism, 601 is the connecting rod, 602 is the pressure plate, 603 is the pressure rod, 604 is the elastic component, 604a is the cylinder, 604a1 is the center hole, 604b is the compression spring, 604c is the annular baffle, 7 is the tail clamping mechanism, 701 is the clamping block, 701a is the arc-shaped groove, and 702 is the clamping opening. Detailed Implementation

[0024] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0025] Reference Figure 1 and Figure 3This paper illustrates an embodiment of a mouse blood collection and fixation device. The device mainly includes a support 1 and a plate 2 rotatably mounted on the support 1. The plate 2 is primarily equipped with a limb fixation mechanism 3, a neck clamping mechanism 4, and an anti-bite mechanism 5 to achieve basic mouse fixation. The device can be made of plastic. The limb fixation mechanism 3 is used to fix the mouse's body and limbs. The neck clamping mechanism 4 is used to hold the mouse's head to prevent displacement and can lift the neck skin to stabilize and protrude the eyeballs for easy blood collection. The anti-bite mechanism 5 can be fitted onto the mouse's head to prevent biting the user and can be adjusted back and forth on the plate 2 to accommodate mice of different lengths. These components work together to fix the mouse stably and comprehensively before blood collection. Blood is primarily collected from the eyeballs, submandibular vein, and tail. The device is adaptable to different body sizes, reduces mouse stress, and avoids hemolysis or affecting blood components.

[0026] Reference Figure 1 The support 1 is a rectangular frame 101. Support legs 102 are located at the four corners of the bottom of the frame 101, raising the support 1 a certain distance off the ground. A mounting opening 103 for accommodating the plate 2 is formed on the support 1. The mounting opening 103 is rectangular, and the shape of the plate 2 matches the shape of the mounting opening 103. Shaft holes are provided on two opposite inner sidewalls of the mounting opening 103. Rotating rods 201 are respectively provided on the middle of both sides of the plate 2. The outer diameter of the rotating rod 201 matches the inner diameter of the shaft hole, allowing the plate 2 to rotate within the mounting opening 103 via the rotating rod 201. One rotating rod 201 passes through the shaft hole and extends to the outside of the support 1. One end of the extended rod has a locking ring 202, used to fix the rotation angle of the plate 2 relative to the support 1. The locking ring 202 is a nut. One end of the rotating rod 201 has an external thread. By tightening the nut to make it fit tightly against the outer sidewall of the support 1, the plate 2 can be locked at a preset rotation angle. In addition, a handle 203 is provided at one end of the rotating rod 201 to facilitate the rotation of the plate 2. During the experiment, the operator can adjust the tilt angle of the plate 2 using the handle 203, with a rotation range of 0° to 180° to accommodate different operational needs such as blood collection from the eyeball, submandibular vein, or tail. For example, when collecting blood from the eye, flipping the plate 2 180 degrees inverts the mouse, allowing gravity to assist in blood flow and improving sample collection efficiency.

[0027] Reference Figure 1 , 34. A limb fixation mechanism 3 is mounted on a flat plate 2. The limb fixation mechanism 3 includes a fixing base 301 and a pair of arc-shaped plates 302 mounted on the fixing base 301. The fixing base 301 is inverted U-shaped and includes a central horizontal plate and parallel vertical plates connected to both ends of the horizontal plate. The pair of arc-shaped plates 302 extend upwards from both sides of the horizontal plate and converge towards the central axis of the horizontal plate, thereby defining a fixing channel 3a for accommodating mouse limbs by the fixing base 301 and the pair of arc-shaped plates 302. An inlet 303 and an outlet 304 are formed at both ends of the fixing channel 3a, respectively. The inlet 303 allows the mouse body to enter, and the outlet 304 is used for positioning the mouse head to extend. Through holes 305 are formed on both sides of the fixing channel 3a to receive the mouse limbs. The through holes 305 correspond to the mouse limbs to facilitate the extension of the mouse limbs. The fixed channel 3a has multiple fixing plates 306 on both sides corresponding to the through holes 305. Fixing straps 306a are mounted across the fixing plates 306 for securing the mouse's limbs. By binding the mouse's wrist, which passes through the through holes 305, to the fixing plates 306, the mouse's limbs can be controlled, allowing for quick fixation and removal. The fixing straps 306a can be Velcro, elastic bandages, snap-on fixing straps, etc.

[0028] In an embodiment not shown, the fixing band 306a is an inverted U-shaped fixing ring. Both ends of the fixing ring are bolted to the fixing plate 306 to adjust its height. Specifically, symmetrical connecting portions are provided at both ends of the fixing ring, and multiple adjusting holes extending vertically are provided on the connecting portions. A threaded screw is vertically mounted on the upper surface of the fixing plate 306. During assembly, the adjusting holes of the fixing ring are aligned with the screw, allowing the screw to pass through the adjusting holes sequentially, and then the matching nut is screwed onto the screw from below the fixing plate. Depending on the thickness of the mouse's limbs, the experimenter can loosen the nut to release the lock, allowing the fixing ring to slide up and down along the screw within the range of the adjusting holes. After adjusting to the appropriate height, the nut is tightened again, ensuring a tight fit between the upper surface of the nut and the connecting portion of the fixing ring.

[0029] The fixing base 301 is provided with multiple ventilation holes 301b. That is to say, multiple ventilation holes 301b are distributed on the horizontal plate and / or vertical plate of the fixing base 301, which can ensure the effective circulation of air in the fixing channel 3a and avoid the mice from experiencing stress reactions such as stuffiness and irritability due to being in a relatively closed space for a long time.

[0030] Reference Figure 1 and Figure 2The neck clamping mechanism 4 includes a first clamping plate 401 and a second clamping plate 402 rotatably disposed on one side of the fixed base 301. When the first clamping plate 401 and the second clamping plate 402 rotate and approach each other, a clamping space 4a is formed between them to clamp the mouse's neck, effectively preventing the mouse's head from moving back and forth. The first clamping plate 401 and the second clamping plate 402 are L-shaped plates and symmetrically arranged, and are rotatably connected to the side wall of the fixed base 301 via a rotating shaft. The rotating shaft can be a positioning pin or a bearing structure. The first clamping plate 401 and the second clamping plate 402 can rotate towards each other within a range of 0-90° around the rotating shaft, thereby adjusting the size of the clamping space 4a.

[0031] A first clamping plate 401a and a second clamping plate 402a are vertically disposed at the free ends of the first clamping plate 401 and the second clamping plate 402, respectively. When the first clamping plate 401 and the second clamping plate 402 rotate and approach each other, a clamping space 4b is formed between the first clamping plate 401a and the second clamping plate 402a for clamping the skin of the mouse's neck. By moderately lifting the neck skin, the muscles of the mouse's face and shoulders can be controlled, making the mouse's eyeballs protrude stably and facilitating blood collection. The clamping space 4b and the clamping space 4a are vertically connected and arranged in a stepped manner.

[0032] The first clamping plate 401 and the second clamping plate 402 are detachable. For example, the end of the rotating shaft is provided with a threaded interface, and the clamping plate is fixed to the rotating shaft by a nut or quick-release buckle to achieve detachability. Different sizes of clamping plates can be replaced according to the size of the mouse to stably clamp the mouse's neck.

[0033] In an embodiment not shown, the inner surfaces of the first clamping plate 401a and the second clamping plate 402a may be provided with anti-slip pads to enhance the friction of clamping the mouse's neck skin and prevent the mouse's skin from slipping off.

[0034] In an embodiment not shown, a hook 51 is provided on the first clamping plate 401a, and a corresponding slot is provided on the second clamping plate 402a to cooperate with the hook. When the first clamping plate 401 and the second clamping plate 402 rotate toward each other, so that the first clamping plate 401a and the second clamping plate 402a are close to and fit against the skin of the mouse's neck, the hook is inserted into the slot to form a buckle to lock the relative position of the two clamping plates.

[0035] Reference Figure 1 and Figure 5The anti-bite mechanism 5 is slidably arranged along the length of the plate 2, corresponding to the neck clamping mechanism 4, and is used to fit over the mouse's head during experimental operations to prevent the mouse from biting the experimenter. The anti-bite mechanism 5 includes a slide rod 501 and a protective cover 502 disposed on the upper end of the slide rod 501. A first groove 204 is provided on the plate 2 along its length, and the slide rod 501 is slidably connected to the first groove 204. The slide rod 501 has an annular protrusion on its circumferential wall that abuts against the upper surface of the plate 2 to fix the height position of the slide rod 501. The lower outer wall of the slide rod 501 is threaded. When the slide rod 501 is inserted into the first groove 204, a nut is threaded into the slide rod 501 and tightened until it abuts against the bottom of the plate 2, thereby locking the front and rear positions of the slide rod 501 within the first groove 204. The protective cover 502 is funnel-shaped and perforated to facilitate the mouse's breathing. Its outer wall has two symmetrically arranged strip-shaped holes, which correspond to the mouse's eyes. The anti-bite mechanism 5 can be flexibly adjusted to the front and back positions according to the different body lengths of mice.

[0036] Reference Figure 1 and Figure 6 A pressure mechanism 6 is provided between a pair of arc-shaped plates 302. The function of the pressure mechanism 6 is to apply appropriate pressure to the limbs of the mouse, making it easier for the limbs to extend out of the through hole 305, so that the experimenter can fix them. The pressure mechanism 6 includes a connecting rod 601 horizontally disposed between the pair of arc-shaped plates 302 and a pressure plate 602 slidably disposed below the connecting rod 601, the pressure plate 602 being located within the fixed channel 3a. The upper part of the arc-shaped plates 302 has a slot, the connecting rod 601 is inserted into the slot of the two arc-shaped plates 302, and the pressure plate 602 can move up and down in the vertical direction.

[0037] A pressure rod 603 is vertically mounted at the top center of the pressure plate 602. The upper end of the pressure rod 603 passes through the connecting rod 601 and extends upward to a certain height. An elastic component 604 is provided on the portion of the pressure rod 603 above the connecting rod 601. The elastic component 604 includes a cylindrical body 604a disposed on the upper surface of the connecting rod 601. The cylindrical body 604a has a central hole 604a1 through which the pressure rod 603 passes. A compression spring 604b is disposed inside the cylindrical body 604a and sleeved on the outside of the pressure rod 603. An annular baffle 604c is provided on the circumferential wall of the pressure rod 603, and the annular baffle 604c abuts against the upper end face of the compression spring 604b. In use, the experimenter presses down the pressure rod 603, causing the pressure plate 602 to move downward within the fixed channel 3a, applying moderate pressure to the mouse limbs, prompting the mouse to naturally extend its limbs to the outside of the through hole 305, thus improving the convenience of limb fixation operations. After the pressure is applied, the pressure rod 603 is released, and the rebound force of the compressed spring 604b lifts the annular baffle 604c, which in turn pushes the pressure rod 603 to move upward, causing the pressure plate 602 to automatically reset.

[0038] refer to Figure 3 and Figure 4 On the other side of the fixed base 301, a tail clamping mechanism 7 is also provided. The tail clamping mechanism 7 includes a pair of symmetrically arranged clamping blocks 701. On the other side of the fixed base 301, a second sliding groove 301a is provided along its horizontal direction. The clamping blocks 701 are slidably connected in the second sliding groove 301a, so that the two clamping blocks 701 can move towards each other or away from each other along the second sliding groove 301a. The inner side of the clamping blocks 701 has an arc-shaped groove 701a. When the two clamping blocks 701 slide towards each other to the closed position, the two arc-shaped grooves 701a form a clamping opening 702 for clamping the tail.

[0039] In an embodiment not shown, one of the clamping blocks 701 has a protrusion on one side, and the other clamping block 701 has a slot that engages with the protrusion on one side. When it is necessary to clamp the mouse tail, the two clamping blocks 701 slide and move closer together. Through the engagement of the protrusion and the slot, the two clamping blocks 701 can clamp the mouse tail.

[0040] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention should be considered equivalent substitutions and are included within the protection scope of the present invention. The embodiments described in this disclosure are intended as non-limiting examples, and other embodiments may take various and alternative forms. Furthermore, the drawings are not necessarily to scale and may present simplified expressions of various features of the present disclosure, including, for example, specific dimensions, orientations, positions, and shapes. Details associated with such features will be determined in part by the intended application and usage environment of the described embodiments.

[0041] The detailed description and accompanying drawings are supporting and descriptive of this teaching, but the scope of this teaching is defined only by the claims. While the best mode and some other embodiments for carrying out this teaching have been described in detail, various alternative designs and embodiments exist for practicing the teaching as defined in the appended claims. Furthermore, this disclosure expressly includes combinations and sub-combinations of the elements and features set forth above and below.

Claims

1. A fixation device for blood collection from mice, characterized in that, include: Support; A flat plate rotatably mounted on the support; The limb fixation mechanism is provided on the plate. The limb fixation mechanism includes a fixing base and a pair of arc-shaped plates disposed on the fixing base. The fixing base and the pair of arc-shaped plates define a fixing channel for accommodating mouse limbs. The two ends of the fixing channel are respectively formed with an entrance for receiving the mouse and an exit for the mouse's head to protrude. The two sides of the fixing channel are formed with through holes for receiving the mouse's limbs. The neck clamping mechanism includes a first clamping plate and a second clamping plate rotatably disposed on one side of the fixing base. When the first clamping plate and the second clamping plate rotate close together, a locking space is formed between them for clamping the mouse's neck. A bite-proof mechanism slidably mounted on the plate, corresponding to the neck clamping mechanism, is used to fit over the mouse's head to prevent it from biting the user.

2. The fixing device according to claim 1, characterized in that, The support has an installation opening for accommodating the plate. Rotating rods are respectively provided on both sides of the plate. The rotating rods are rotatably connected to the inner sidewall of the installation opening. One end of the rotating rod has a locking ring for fixing the rotation angle of the plate relative to the support.

3. The fixing device according to claim 1, characterized in that, One end of the first card plate is provided with a first clamping plate, and one end of the second card plate is provided with a second clamping plate that cooperates with the first card plate. A clamping space for clamping the skin of the mouse neck is formed between the first clamping plate and the second clamping plate.

4. The fixing device according to claim 1, characterized in that, The fixed channel is provided with multiple fixing plates on both sides corresponding to the through holes, and the fixing plates are provided with fixing straps for binding the limbs of mice.

5. The fixing device according to claim 1, characterized in that, The anti-bite mechanism includes a slide rod and a protective cover disposed on the upper end of the slide rod. A first slide groove is provided on the plate along its length direction, and the slide rod is slidably connected to the first slide groove.

6. The fixing device according to claim 1, characterized in that, A pressurizing mechanism is provided between the pair of arc-shaped plates. The pressurizing mechanism includes a connecting rod horizontally disposed between the pair of arc-shaped plates and a pressure plate slidably disposed below the connecting rod. The pressure plate is located within the fixed channel.

7. The fixing device according to claim 6, characterized in that, A pressure rod is vertically installed on the top of the pressure plate. The upper end of the pressure rod passes through the connecting rod and extends upward to a certain height. An elastic component is provided on the part of the pressure rod above the connecting rod. The elastic component includes a cylinder disposed on the upper surface of the connecting rod. The cylinder has a central hole through which the pressure rod passes. A compression spring is disposed inside the cylinder and sleeved on the outside of the pressure rod. An annular baffle is provided on the circumferential wall of the pressure rod. The annular baffle abuts against the upper end face of the compression spring.

8. The fixing device according to claim 1, characterized in that, A tail clamping mechanism is also provided on the other side of the fixing base. The tail clamping mechanism includes a pair of clamping blocks arranged symmetrically. A second sliding groove is provided on the other side of the fixing base. The clamping blocks are slidably connected in the second sliding groove. One side of the clamping block has an arc-shaped groove. When the two clamping blocks are close together, the two arc-shaped grooves form a clamping opening for clamping the tail.

9. The fixing device according to claim 1, characterized in that, The mounting base is provided with multiple ventilation holes.

10. The fixing device according to claim 1, characterized in that, The base of the support has four supporting legs, which raise the support a certain distance off the ground.