Modular counterflow structure

CN224911818UActive Publication Date: 2026-10-30WUXI CUICHUN BIOMATERIALS TECH CO LTD
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Patent Information

Application Number
CN202522643667.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-12-12
Publication Date
2026-10-30
Estimated Expiration
2035-12-12

AI Technical Summary

Technical Problem

[0003]但是现有的大尺寸对流柱在放大时面临加工难度激增的瓶颈,且从小试到符合生产规模的尺寸,放大周期长、验证成本较高,另外单一柱体随着尺寸的增大会存在柱效下降的情况

Benefits of technology

本实用新型的模块化对流结构,采用进口组件和出口组件,使得多个对流柱实现并联,能够根据产能需求自由组合对流柱的数量与体积,实现冗余设计,而且可以方便从小试到生产规模的无缝放大,放大周期大幅缩短,验证成本较低。

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Abstract

The utility model discloses a modularization convection structure, including a plurality of convection column, import subassembly and export subassembly, and convection column is used for separating mixed component, the convection column includes the shell, and the shell both ends are linked with import end and export end respectively, and the shell middle part is equipped with the convection column polymer in, and the convection column polymer is equipped with filter core in, and the mixed component is from import end and is discharged from export end after filter core filtration separation, import subassembly is connected with import end, is used for with the mixed component input convection column, export subassembly is connected with export end, is used for discharging after the component of filter core separation, the utility model discloses modularization convection structure, adopts import subassembly and export subassembly, makes a plurality of convection column realize parallel connection, can according to the capacity demand free combination convection column's number and volume, realizes redundancy design, and can be convenient from small test to production scale's seamless amplification, and the amplification cycle is shortened greatly, and the verification cost is lower.
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Description

Technical Field

[0001] This utility model relates to chromatographic analysis technology, specifically a modular convection structure. Background Technology

[0002] Chromatography is a separation and analysis method, and separation is the core. Therefore, the convection column, which performs the separation function, is the heart of the chromatographic system.

[0003] However, existing large-size convection columns face a bottleneck of increased processing difficulty when scaled up. Furthermore, the scale-up process from small-scale testing to production-scale dimensions is lengthy and costly to verify. Additionally, the efficiency of a single column decreases as its size increases. Utility Model Content

[0004] To address the shortcomings of the existing technology, this utility model provides a modular convection structure that allows for free combination of the number and volume of columns according to production capacity requirements, achieving redundant design. It also facilitates seamless scaling up from small-scale trials to production scale, significantly shortening the scaling-up cycle and reducing verification costs.

[0005] To achieve the above technical objectives, this utility model adopts the following technical solution: a modular convection structure, comprising... Several convection columns are used to separate mixed components. Each convection column includes a shell with an inlet and an outlet connected to its two ends. A convection column polymer is disposed in the middle of the shell, and a filter element is disposed inside the convection column polymer. The mixed components enter from the inlet, are filtered and separated by the filter element, and are discharged from the outlet. The inlet component, connected to the inlet end, is used to input the mixed components into the convection column; The outlet component, connected to the outlet end, is used to discharge the components separated by the filter element.

[0006] Preferably, the diameter of the convection column facing the inlet end is greater than the diameter of the convection column away from the outlet end.

[0007] Preferably, the inlet assembly includes an inlet main pipe and several inlet branch pipes, each inlet branch pipe corresponding to a convection column. One end of each inlet branch pipe is connected to the inlet main pipe, and the other end of each inlet branch pipe is connected to the inlet end.

[0008] Preferably, the inlet branch pipe is equipped with a flow control valve, which controls the opening and closing of the inlet branch pipe.

[0009] Preferably, the outlet component includes an outlet main pipe and several outlet branch pipes, each outlet branch pipe corresponding to a convection column, with one end of each outlet branch pipe connected to the outlet main pipe and the other end of each outlet branch pipe connected to the outlet end.

[0010] Preferably, the outlet branch pipe is equipped with a flow detector, which is used to detect the flow rate of the outlet branch pipe.

[0011] In summary, this utility model achieves the following technical effects: The modular convection structure of this utility model adopts inlet and outlet components, enabling multiple convection columns to be connected in parallel. The number and volume of convection columns can be freely combined according to production capacity requirements to achieve redundant design. Moreover, it can be easily scaled up seamlessly from small-scale testing to production scale, significantly shortening the scale-up cycle and reducing verification costs. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the modular convection structure of this utility model; Figure 2 This is a schematic diagram of the modular convection structure of this utility model; Explanation of reference numerals in the accompanying drawings: 1. Inlet main pipe; 2. Inlet branch pipe; 3. Flow control valve; 4. Convection column; 41. Housing; 42. Convection column polymer; 43. Filter element; 44. Inlet end; 45. Outlet end; 5. Outlet branch pipe; 6. Flow detector; 7. Outlet main pipe. Detailed Implementation

[0013] The present invention will be further described in detail below with reference to the accompanying drawings.

[0014] This specific embodiment is merely an explanation of the present utility model and is not intended to limit the present utility model. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but as long as they are within the scope of the claims of the present utility model, they are protected by patent law.

[0015] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0016] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0017] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0018] In this utility model, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature is in indirect contact with the second feature through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0019] Example 1: like Figure 1 As shown, a modular convection structure includes four convection columns, an inlet assembly, and an outlet assembly. like Figure 2 As shown, the convection column 4 is used to separate mixed components. The convection column 4 includes a shell 41, with an inlet end 44 and an outlet end 45 connected to both ends of the shell 41. A convection column polymer 42 is disposed in the middle of the shell 41, and a filter element 43 is disposed inside the convection column polymer 42. The mixed components enter from the inlet end 44, are filtered and separated by the filter element 43, and are discharged from the outlet end 45. The inlet assembly is connected to the inlet end 44 and is used to input the mixed components into the convection column 4. The outlet assembly is connected to the outlet end 45 and is used to discharge the components separated by the filter element 43. The convection column polymer 42 is used to support the filter element 43.

[0020] The modular convection structure in this embodiment uses inlet and outlet components, enabling multiple convection columns 4 to be connected in parallel. The number and volume of convection columns 4 can be freely combined according to production capacity requirements, achieving redundant design. Moreover, it can be easily scaled up seamlessly from small-scale trials to production scale, significantly shortening the scale-up cycle and reducing verification costs.

[0021] The diameter of the convection column 4 at the inlet end 44 is larger than the diameter of the convection column 4 at the outlet end 45; this setting can remind the operator and prevent the operator from installing the convection column 4 against the flow.

[0022] The inlet assembly includes an inlet main pipe 1 and four inlet branch pipes 2. Each inlet branch pipe 2 corresponds to a convection column 4. One end of each inlet branch pipe 2 is connected to the inlet main pipe 1, and the other end of each inlet branch pipe 2 is connected to the inlet end 44.

[0023] The inlet branch pipe 2 is equipped with a flow control valve 3, which controls the opening and closing of the inlet branch pipe 2; the flow control valve 3 is selected from Beijing Jingliang Technology's ACU10FD-MC.

[0024] The outlet assembly includes an outlet main pipe 7 and four outlet branch pipes 5. Each outlet branch pipe 5 corresponds to a convection column 4. One end of each outlet branch pipe 5 is connected to the outlet main pipe 7, and the other end of each outlet branch pipe 5 is connected to the outlet end 45.

[0025] The outlet branch pipe 5 is equipped with a flow detector 6, which is used to detect the flow rate of the outlet branch pipe 5; the flow detector 6 is a Keyence FD-Q.

[0026] During operation, flow detector 6 detects the flow of the corresponding outlet branch pipe 5 and feeds it back to the software control center. The software control center uses a Siemens CNC system to adjust the flow control valve 3 to ensure consistent flow across all modules. Each convection column 4 module can independently maintain a high throughput flow rate. After parallel connection, the total processing capacity has a strictly linear relationship with the number of convection columns 4, thus overcoming the limitation that the efficiency of a single column decreases as its size increases. Moreover, the number and volume of convection columns 4 can be freely combined according to production capacity requirements to achieve redundant design and improve system fault tolerance. In addition, the combination of the number and volume of convection columns 4 can achieve seamless scaling up from pilot testing to production scale, shortening the scaling-up cycle.

[0027] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present utility model shall fall within the scope of the technical solution of the present utility model.

Claims

1. A modular convection structure, characterized in that, include Several convection columns are used to separate mixed components. Each convection column includes a shell with an inlet and an outlet connected to its two ends. A convection column polymer is disposed in the middle of the shell, and a filter element is disposed inside the convection column polymer. The mixed components enter from the inlet, are filtered and separated by the filter element, and are discharged from the outlet. The inlet component, connected to the inlet end, is used to input the mixed components into the convection column; The outlet component, connected to the outlet end, is used to discharge the components separated by the filter element.

2. The modular convection structure according to claim 1, characterized in that, The diameter of the convection column at the inlet end is larger than the diameter at the outlet end.

3. The modular convection structure according to claim 1, characterized in that, The inlet assembly includes an inlet main pipe and several inlet branch pipes. Each inlet branch pipe corresponds to a convection column. One end of each inlet branch pipe is connected to the inlet main pipe, and the other end of each inlet branch pipe is connected to the inlet end.

4. A modular convection structure according to claim 3, characterized in that, The inlet branch pipe is equipped with a flow control valve, which controls the opening and closing of the inlet branch pipe.

5. A modular convection structure according to claim 1, characterized in that, The outlet component includes an outlet main pipe and several outlet branch pipes. Each outlet branch pipe corresponds to a convection column. One end of each outlet branch pipe is connected to the outlet main pipe, and the other end of each outlet branch pipe is connected to the outlet end.

6. A modular convection structure according to claim 5, characterized in that, The outlet branch pipe is equipped with a flow detector, which is used to detect the flow rate of the outlet branch pipe.