A filtration device for the production of pharmaceutical intermediates

Abstract

The utility model relates to the technical field of pharmaceutical chemical industry equipment, especially relate to a kind of filter device of production pharmaceutical intermediates, the problem that filter barrel of existing device cannot be integrally disassembled to cause inner wall residue to be difficult to remove is solved.A kind of filter device of production pharmaceutical intermediates, including device body, top cover and the feed hopper connected in the top of top cover, the bottom of one side of device body is connected with discharge pipe;The inside of device body is provided with mounting bracket, and mounting bracket includes bottom ring plate and top ring plate, and the bottom of top ring plate is connected with the top of bottom ring plate by several support plates, and the outer ring of bottom ring plate is detachably connected with the lateral wall of device body by several connecting structures;Filter cartridge is arranged between top ring plate and bottom ring plate.The utility model is integrally disassembled by filter cartridge and supporting installation structure, realizes the thorough cleaning of the inner wall of filter cartridge, effectively avoids cross contamination.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical and chemical equipment technology, and in particular to a filtration device for producing pharmaceutical intermediates. Background Technology

[0002] Filtration devices for phosphorus-containing pharmaceutical intermediates are key equipment for solid-liquid separation in pharmaceutical and chemical production processes. They are primarily used in the synthesis or purification of phosphorus-containing compounds to effectively separate solid impurities, unreacted phosphorus-containing raw materials, or byproduct particles from the reaction solution, thereby obtaining high-purity phosphorus-containing liquid intermediates. Because phosphorus-containing pharmaceutical intermediates typically exhibit high reactivity or are more sensitive to impurities, their requirements for purity, cleanliness, and batch consistency are particularly stringent. The efficiency, sealing, and ease of cleaning of the filtration process directly affect product quality, yield, and the stability of subsequent processes. Therefore, the structural design and operational performance of the filtration device play a crucial role in the production of phosphorus-containing pharmaceutical intermediates.

[0003] Existing filtration devices for producing pharmaceutical intermediates, such as the structure disclosed in utility model patent CN 211158794 U, while incorporating an openable cover, processing tank, sliding rod, and fixedly connected filter barrel, and lining the bottom of the filter barrel with a square filter cloth for easy removal and reuse of large particles, thus alleviating filter cloth clogging to some extent, still have shortcomings in practical application: the fixed connection between the filter barrel and the sliding rod only allows for filter cloth replacement or removal, not complete disassembly of the entire filter barrel. During continuous or multi-batch production, reaction residues, fine particles, or crystals gradually adhere to the inner wall of the filter barrel, which are difficult to remove completely through conventional rinsing. Over time, the accumulation of dirt on the inner wall not only reduces the effective filtration volume but may also become a source of cross-contamination, affecting the purity of subsequent batches of product. Utility Model Content

[0004] The purpose of this invention is to provide a filtration device for producing pharmaceutical intermediates, which solves the problem in the prior art where the filter barrel and slide bar are fixedly connected, allowing only the filter cloth to be replaced or removed, but not the entire filter barrel to be disassembled.

[0005] To achieve the above objectives, this utility model provides a filtration device for producing pharmaceutical intermediates, including a device body, a top cover, and a feed hopper connected to the top of the top cover. A discharge pipe is connected to the bottom of one side of the device body. The device body has an internal mounting frame, which includes a bottom ring plate and a top ring plate. The bottom of the top ring plate is connected to the top of the bottom ring plate through several support plates. The outer ring of the bottom ring plate is detachably connected to the side wall of the device body through several connecting structures. A filter cylinder is provided between the top ring plate and the bottom ring plate. The bottom of the filter cylinder is connected to the top of the bottom ring plate through a docking structure. The top outer ring of the filter cylinder is detachably connected to the top of the top ring plate through a positioning structure. The bottom of the feed hopper extends to the inner top position of the filter cylinder. The top cover is detachably connected to the top of the device body.

[0006] The support plate is made of metal. One end of the support plate is fixedly connected to the bottom bolt of the top ring plate, and the other end is fixedly connected to the top bolt of the bottom ring plate.

[0007] The connecting structure includes a fixing plate, one end of which is fixedly connected to the side wall of the bottom ring plate, and the other end is fixedly connected to the side wall of the device body by bolts.

[0008] The positioning structure includes several positioning screws arranged in a ring along the circumference of the top ring plate. Several positioning plates are fixedly connected to the top of the outer ring of the filter cylinder. The top of the positioning plate is provided with positioning holes that are compatible with the positioning screws. One end of the positioning screw is threaded with a positioning nut.

[0009] The filter cylinder has an opening at the bottom, and a bottom filter plate is threadedly connected inside the opening. A bottom plate is connected to the outer ring of the bottom filter plate.

[0010] The docking structure includes a mounting ring connected to the bottom of the bottom plate and several docking posts connected to the bottom of the mounting ring. The top of the bottom ring plate has several docking holes that are adapted to the docking posts.

[0011] This utility model discloses a filtration device for producing pharmaceutical intermediates. By designing the filter cartridge as a completely detachable independent unit and combining it with the modular structure of the mounting bracket, the filter cartridge can be quickly removed and reset. Impurities adhering to the inner wall of the filter cartridge can be thoroughly cleaned or sterilized in an open external environment, avoiding the shortcomings of traditional fixed structures that are difficult to clean due to space constraints. At the same time, the detachable connection between the top cover and the device body and the reasonable arrangement of the feed hopper ensure the sealing of the filtration process and the convenience of operation. The discharge pipe is located at the bottom of the device body, which facilitates the complete discharge of filtrate and reduces residue. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below.

[0013] Figure 1 This is a schematic diagram of the overall structure of an embodiment of the present utility model.

[0014] Figure 2This is a structural schematic diagram of the filter cartridge and mounting bracket according to an embodiment of the present utility model.

[0015] Figure 3 This is a schematic diagram of the bottom ring plate and the fixing plate in an embodiment of the present invention.

[0016] Figure 4 This is a schematic diagram of the top ring plate and positioning screw in an embodiment of the present invention.

[0017] Figure 5 This is a schematic diagram of the mounting ring and docking post according to an embodiment of the present invention.

[0018] In the diagram: 1. Device body; 2. Feed hopper; 3. Top cover; 4. Discharge pipe; 5. Filter cylinder; 6. Mounting frame; 7. Fixing plate; 8. Bottom ring plate; 9. Top ring plate; 10. Positioning screw; 11. Docking hole; 12. Support plate; 13. Positioning plate; 14. Handle; 15. Bottom filter plate; 16. Bottom plate; 17. Docking column; 18. Mounting ring. Detailed Implementation

[0019] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0020] Example 1 Please see Figure 1-5 As shown, a filtration device for producing pharmaceutical intermediates according to this embodiment includes a device body 1, a top cover 3 and a feed hopper 2 connected to the top of the top cover 3, and a discharge pipe 4 connected to the bottom of one side of the device body 1. The device body 1 is provided with a mounting frame 6 inside. The mounting frame 6 includes a bottom ring plate 8 and a top ring plate 9. The bottom of the top ring plate 9 is connected to the top of the bottom ring plate 8 through several support plates 12. The outer ring of the bottom ring plate 8 is detachably connected to the side wall of the device body 1 through several connecting structures. A filter cylinder 5 is provided between the top ring plate 9 and the bottom ring plate 8. The bottom of the filter cylinder 5 is connected to the top of the bottom ring plate 8 through a docking structure. The top outer ring of the filter cylinder 5 is detachably connected to the top of the top ring plate 9 through a positioning structure. The bottom of the feed hopper 2 extends to the inner top position of the filter cylinder 5. The top cover 3 is detachably connected to the top of the device body 1.

[0021] In practical use, the filtration device for producing pharmaceutical intermediates first injects the reaction liquid to be filtered through the feed hopper 2. The bottom of the feed hopper 2 extends to the inner top of the filter cylinder 5, allowing the liquid to directly enter the interior of the filter cylinder 5. Under gravity or slight pressure, the reaction liquid passes through the filter media of the filter cylinder 5, such as filter cloth or filter screen. Solid impurities are trapped inside the filter cylinder 5, while the clarified liquid flows through the cylinder wall into the annular space between the device body 1 and the filter cylinder 5, and is finally discharged from the discharge pipe 4 at the bottom of one side of the device body 1, completing the solid-liquid separation. After filtration, if cleaning or replacement of the filter components is required, the top cover 3 can be removed from the top of the device body 1. Then, the positioning structure between the outer ring of the top of the filter cylinder 5 and the top ring plate 9 can be released, and the docking structure between the bottom of the filter cylinder 5 and the bottom ring plate 8 can be disconnected. At this time, the entire filter cylinder 5 can be cleaned and replaced. Remove the entire unit from the mounting frame 6. The mounting frame 6 consists of a top ring plate 9, a bottom ring plate 8, and several support plates 12. It is detachably connected to the side wall of the device body 1 via the connecting structure of the outer ring of the bottom ring plate 8. If necessary, the entire mounting frame 6 can also be removed together with the filter cartridge 5. Since the filter cartridge 5 is an independent and detachable structure, the operator can thoroughly rinse, wipe, or sterilize its inner wall, outer wall, and filter media from the outside to completely remove any adhering residues, fine particles, or crystals, thus preventing dirt accumulation. After cleaning, reconnect the filter cartridge 5 to the bottom ring plate 8 via the docking structure and lock it to the top ring plate 9 via the positioning structure. Then, reinstall the top cover 3, and the next batch of filtration can be carried out. The entire operation process does not require complex cleaning inside the confined space of the device, significantly improving maintenance efficiency and cleaning thoroughness.

[0022] Example 2 Please see Figure 1-5 As shown, in this embodiment, a filtration device for producing pharmaceutical intermediates has a support plate 12 made of metal. One end of the support plate 12 is fixedly connected to the bottom bolt of the top ring plate 9, and the other end is fixedly connected to the top bolt of the bottom ring plate 8. The top of the filter cylinder 5 is connected to several handles (14). Specifically, by using a metal support plate 12, with one end fixedly connected to the bottom bolt of the top ring plate 9 and the other end fixedly connected to the top bolt of the bottom ring plate 8, the metal support plate 12 provides high-strength support when the mounting frame 6 bears the weight of the filter cylinder 5 and the material. The bolt connection facilitates disassembly and maintenance, thereby enhancing the overall structural stability and load-bearing capacity of the mounting frame 6 while also ensuring detachability.

[0023] The positioning structure includes several positioning screws 10 arranged in a ring along the circumference of the top ring plate 9. Several positioning plates 13 are fixedly connected to the top of the outer ring of the filter cylinder 5. The top of the positioning plate 13 is provided with positioning holes that are adapted to the positioning screws 10. One end of the positioning screw 10 is threaded with a positioning nut. Specifically, by including the positioning screws 10 arranged in a ring along the circumference of the top ring plate 9, the positioning plate 13 with positioning holes fixedly connected to the top of the outer ring of the filter cylinder 5, and the positioning nut threaded to the end of the positioning screw 10, when installing the filter cylinder 5, the positioning plate 13 is put into the positioning screw 10 and the positioning nut is tightened, so that the top of the filter cylinder 5 can be firmly pressed onto the top ring plate 9. This achieves the effect of quick, reliable, and detachable positioning of the top of the filter cylinder 5, preventing the cylinder from loosening or leaking during the filtration process.

[0024] Example 3 Please see Figure 1-5 As shown, this embodiment of a filtration device for producing pharmaceutical intermediates includes a connecting structure comprising a fixing plate 7. One end of the fixing plate 7 is fixedly connected to the side wall of the bottom ring plate 8, and the other end is bolted to the side wall of the device body 1. Specifically, by including the fixing plate 7 in the connecting structure, with one end fixedly connected to the side wall of the bottom ring plate 8 and the other end bolted to the side wall of the device body 1, when installing or disassembling the mounting bracket 6, the bottom ring plate 8 and the device body 1 can be quickly connected or separated simply by tightening or loosening the bolts. This simplifies the overall assembly and disassembly process of the mounting bracket 6 and improves equipment maintenance efficiency.

[0025] The bottom of the filter cartridge 5 has an opening, and the bottom filter plate 15 is threadedly connected to the inside of the opening. The bottom plate 16 is connected to the outer ring of the bottom filter plate 15. Specifically, by providing an opening at the bottom of the filter cartridge 5, threadedly connecting the bottom filter plate 15 inside the opening, and connecting the bottom plate 16 to the outer ring of the bottom filter plate 15, the filter media at the bottom of the filter cartridge 5 can be replaced or cleaned independently. The threaded connection ensures a tight seal, achieving the effect of facilitating the replacement or cleaning of the bottom filter components, improving filtration efficiency and cleaning flexibility.

[0026] The docking structure includes a mounting ring 18 connected to the bottom of the bottom plate 16 and several docking posts 17 connected to the bottom of the mounting ring 18. The top of the bottom ring plate 8 has several docking holes 11 that are adapted to the docking posts 17. Specifically, by including the mounting ring 18 connected to the bottom of the bottom plate 16 and several docking posts 17 connected to the bottom of the mounting ring 18, and the docking holes 11 that are adapted to the docking posts 17 on the top of the bottom ring plate 8, when installing the filter cartridge 5, inserting the docking posts 17 into the docking holes 11 can achieve precise bottom alignment and initial support. Combined with the top positioning structure, double fixing is completed, which achieves the effect of ensuring accurate installation position of the filter cartridge 5, stable connection, and preventing displacement or overturning.

[0027] In practical use, the filtration device for producing pharmaceutical intermediates first introduces the reaction liquid to be filtered through the feed hopper 2. The feed hopper 2 is connected to the top of the detachable top cover 3, and its bottom extends to the inner top of the filter cylinder 5, allowing the liquid to directly enter the interior of the filter cylinder 5. Under gravity or slight pressure, the reaction liquid passes through the filter media on the side walls and bottom of the filter cylinder 5. Solid impurities are trapped inside the filter cylinder 5, while the clarified liquid passes through the filter media into the annular space between the device body 1 and the filter cylinder 5, and is finally discharged from the discharge pipe 4 at the bottom of one side of the device body 1, completing the solid-liquid separation. The bottom of the filter cylinder 5 is equipped with an opening... The filter cartridge 5 has an opening with an internal threaded connection to a bottom filter plate 15. A bottom plate 16 is connected to the outer ring of the bottom filter plate 15. A mounting ring 18 is fixed to the bottom of the bottom plate 16, and several mating posts 17 are connected to the bottom of the mounting ring 18. These mating posts 17 can be inserted into mating holes 11 at the top of the bottom ring plate 8, achieving precise alignment and initial support of the bottom of the filter cartridge 5. Simultaneously, several positioning plates 13 are fixedly connected to the top of the outer ring of the filter cartridge 5. Positioning holes are provided at the top of the positioning plates 13, allowing the insertion of positioning screws 10 arranged in a circular array along the circumference of the top ring plate 9. Tightening the positioning nuts securely presses the top of the filter cartridge 5 firmly into place. On the top ring plate 9, a double reliable fixation is formed at the top and bottom; the top ring plate 9 and the bottom ring plate 8 are connected by several support plates 12 made of metal material. The two ends of the support plates 12 are fixed to the bottom of the top ring plate 9 and the top of the bottom ring plate 8 by bolts, forming a high-strength and detachable mounting frame 6; the outer ring of the bottom ring plate 8 is bolted to the side wall of the device body 1 by fixing plates 7, so that the entire mounting frame 6 is stably installed inside the device body 1; after filtration, the operator can first remove the top cover 3, loosen the positioning nut to release the constraint of the positioning screw 10 on the positioning plate 13, and then connect the docking column. 17. Pull out from the docking hole 11 to remove the entire filter cartridge 5 from the mounting bracket 6. If necessary, loosen the bolts on the fixing plate 7 and remove the entire mounting bracket 6 along with the filter cartridge 5. In an open environment, thoroughly rinse, wipe or sterilize the inner wall, outer wall, bottom filter plate 15 and filter media of the filter cartridge 5 to completely remove any adhering residues, fine particles or crystals. After cleaning or replacement, reassemble in the reverse order: first insert the docking post 17 into the docking hole 11, then put on the positioning plate 13 and tighten the positioning nut, and put the top cover 3 back on to proceed with the next batch of operations.

[0028] This complete technical solution, through the coordinated operation of the device body 1, top cover 3, feed hopper 2, discharge pipe 4, filter cylinder 5, mounting frame 6, fixing plate 7, bottom ring plate 8, top ring plate 9, positioning screw 10, docking hole 11, support plate 12, positioning plate 13, bottom filter plate 15, bottom plate 16, docking column 17, and mounting ring 18, comprehensively solves the problem in existing technologies where the filter cylinder cannot be completely disassembled, leading to difficulty in removing inner wall dirt and easy cross-contamination. The filter cylinder 5, as an independent, fully detachable unit, achieves rapid disassembly through the insertion of the bottom docking column 17 into the docking hole 11 and the locking of the top positioning screw 10 into the positioning plate 13. Quick, stable, and repeatable installation and disassembly; the bottom filter plate 15 is threaded to the bottom of the filter cylinder 5, facilitating individual replacement or cleaning and improving filtration flexibility; the metal support plate 12 is bolted to the top ring plate 9 and the bottom ring plate 8, ensuring the high strength load-bearing capacity of the mounting frame 6 while facilitating maintenance and disassembly; the fixing plate 7 bolts the bottom ring plate 8 to the side wall of the device body 1, allowing the entire mounting frame 6 to be removed as a whole, greatly expanding the cleaning operation space; the top cover 3 is detachably connected to the device body 1, and with the reasonable arrangement of the feed hopper 2, ensures filtration sealing and ease of operation; the discharge pipe 4 is located at the bottom, facilitating complete discharge of filtrate.

[0029] The above-disclosed embodiments are merely one or more preferred embodiments of this application and should not be construed as limiting the scope of this application. Those skilled in the art can understand that all or part of the processes for implementing the above embodiments and equivalent changes made in accordance with the claims of this application still fall within the scope of this application.

Claims

1. A filtration device for producing pharmaceutical intermediates, characterized in that, include: The device body, top cover, and feed hopper connected to the top of the top cover; a discharge pipe is connected to the bottom of one side of the device body. The device body has an internal mounting frame, which includes a bottom ring plate and a top ring plate. The bottom of the top ring plate is connected to the top of the bottom ring plate through several support plates. The outer ring of the bottom ring plate is detachably connected to the side wall of the device body through several connecting structures. A filter cylinder is provided between the top ring plate and the bottom ring plate. The bottom of the filter cylinder is connected to the top of the bottom ring plate through a docking structure. The top outer ring of the filter cylinder is detachably connected to the top of the top ring plate through a positioning structure. The bottom of the feed hopper extends to the inner top position of the filter cylinder. The top cover is detachably connected to the top of the device body.

2. The filtration device for producing pharmaceutical intermediates according to claim 1, characterized in that, The support plate is made of metal. One end of the support plate is fixedly connected to the bottom bolt of the top ring plate, and the other end is fixedly connected to the top bolt of the bottom ring plate.

3. The filtration device for producing pharmaceutical intermediates according to claim 1, characterized in that, The connecting structure includes a fixing plate, one end of which is fixedly connected to the side wall of the bottom ring plate, and the other end is fixedly connected to the side wall of the device body by bolts.

4. A filtration device for producing pharmaceutical intermediates according to claim 2, characterized in that, The positioning structure includes several positioning screws arranged in a ring along the circumference of the top ring plate. Several positioning plates are fixedly connected to the top of the outer ring of the filter cylinder. The top of the positioning plate is provided with positioning holes that are compatible with the positioning screws. One end of the positioning screw is threaded with a positioning nut.

5. A filtration device for producing pharmaceutical intermediates according to claim 3, characterized in that, The bottom of the filter cylinder has an opening, and a bottom filter plate is threadedly connected to the inside of the opening. A bottom plate is connected to the outer ring of the bottom filter plate.

6. A filtration device for producing pharmaceutical intermediates according to claim 5, characterized in that, The docking structure includes a mounting ring connected to the bottom of the bottom plate and several docking posts connected to the bottom of the mounting ring. The top of the bottom ring plate has several docking holes that are adapted to the docking posts.

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