A new type of efficient stirring paddle for microbial fermentation polypeptide production
Patent Information
- Application Number
- CN202522625806.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-11
- Publication Date
- 2026-10-30
- Estimated Expiration
- 2035-12-11
AI Technical Summary
传统的固定角度桨叶，无论是径向流还是轴向流设计，其产生的流场特性和剪切力水平是固定的，无法同时兼顾不同发酵阶段的矛盾需求，从而导致前期混合不匀或后期细胞损伤，进而降低了多肽产量与质量；
[0010]综上所述，本实用新型的技术效果和优点：该用于微生物发酵多肽生产的新型高效搅拌桨叶，通过在固定环内部设置的调节组件对伸缩组件进行调节，可以使固定环四周设置的桨叶进行同步转动，从而可以调节桨叶的倾斜角度，可以优化微生物发酵时的流场与混合效率，适应不同发酵阶段，进而提升微生物发酵时多肽的生产效率。
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Figure CN224912167U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the technical field of microbial fermentation equipment, specifically, it relates to a novel high-efficiency stirring blade for the production of polypeptides through microbial fermentation. Background Technology
[0002] In the process of producing high-value peptides by microbial fermentation, the stirring paddle is the core component of the fermenter. Its core function is to achieve uniform mixing and efficient mass transfer of the gas, liquid and solid phases, especially to ensure the timely supply of dissolved oxygen to meet the needs of microbial cell growth and product synthesis. Traditional fixed-angle blades, whether designed for radial or axial flow, produce fixed flow field characteristics and shear force levels, which cannot simultaneously meet the conflicting needs of different fermentation stages. This leads to uneven mixing in the early stage or cell damage in the later stage, thereby reducing peptide yield and quality. To address the aforementioned issues, this application proposes a novel, highly efficient stirring impeller for the production of polypeptides through microbial fermentation. Utility Model Content
[0003] In view of the problems in related technologies, this utility model proposes a novel high-efficiency stirring blade for the production of peptides by microbial fermentation, so as to overcome the above-mentioned technical problems existing in the existing related technologies.
[0004] To achieve the above objectives, the present invention adopts the following technical solution: A novel high-efficiency stirring impeller for the production of peptides by microbial fermentation includes a fixed ring, an adjustment component inside the fixed ring, the adjustment component including a first rotating groove formed inside the fixed ring, a rotating shaft rotatably connected inside the first rotating groove, a telescopic component provided on the side of the rotating shaft away from the fixed ring, a second rotating groove formed inside the fixed ring, and a rotating ring rotatably connected inside the fixed ring.
[0005] Preferably, the outer side wall of the rotating shaft is provided with a toothed groove, and the rotating ring is provided with a first tooth on the side near the rotating shaft, wherein the outer side wall of the first tooth is adapted to the inner side wall of the toothed groove.
[0006] Preferably, the outer wall of the rotating ring is rotatably connected to the inner wall of the second rotating groove, and the outer wall of the rotating shaft is rotatably connected to the inner wall of the first rotating groove.
[0007] Preferably, the bottom of the rotating ring is provided with a third rotating groove, the inside of the rotating ring is provided with a second tooth, the outer side wall of the second tooth is engaged with a gear, a rotating column is fixedly connected to the bottom center of the gear, and a limit groove is provided at the bottom of the fixed ring.
[0008] Preferably, the telescopic assembly includes a fixed column fixed to the side of the rotating shaft away from the fixed ring, a limiting shaft fixedly connected to the side of the fixed column away from the rotating shaft, a blade body sleeved on the outer side wall of the limiting shaft, and a sliding groove formed on the outer side wall of the limiting shaft.
[0009] Preferably, a limiting ring is fixedly connected to the end of the limiting shaft away from the fixed column, a contraction spring is fixedly connected to the side of the limiting ring near the limiting shaft, the end of the contraction spring away from the limiting ring is fixedly connected to the blade body, and a telescopic groove is provided at the center of the blade body.
[0010] In summary, the technical effects and advantages of this utility model are as follows: This novel high-efficiency stirring blade for microbial fermentation of peptides can adjust the telescopic component by setting the adjustment component inside the fixed ring, so that the blades set around the fixed ring can rotate synchronously, thereby adjusting the tilt angle of the blades, optimizing the flow field and mixing efficiency during microbial fermentation, adapting to different fermentation stages, and thus improving the peptide production efficiency during microbial fermentation. Attached Figure Description
[0011] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram of the first tooth and its related structures of the present invention; Figure 3 This is a schematic diagram of the gear and related structures of this utility model; Figure 4 This is a schematic diagram of the first rotating groove and its related structures of the present invention; Figure 5 This is a schematic diagram of the telescopic component and related structures of this utility model.
[0012] In the diagram: 1. Fixed ring; 2. Adjustment assembly; 201. First rotating groove; 202. Rotating shaft; 203. Gear groove; 204. Second rotating groove; 205. Rotating ring; 206. First tooth; 207. Third rotating groove; 208. Second tooth; 209. Gear; 210. Rotating column; 211. Limiting groove; 3. Telescopic assembly; 301. Fixed column; 302. Limiting shaft; 303. Limiting ring; 304. Retraction spring; 305. Blade body; 306. Telescopic groove. Detailed Implementation
[0013] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.
[0014] Reference Figure 1-5A novel high-efficiency stirring impeller for microbial fermentation of peptides includes a fixed ring 1. An adjustment component 2 is disposed inside the fixed ring 1. The adjustment component 2 includes a first rotating groove 201 formed inside the fixed ring 1, a rotating shaft 202 rotatably connected inside the first rotating groove 201, and a telescopic component 3 disposed on the side of the rotating shaft 202 away from the fixed ring 1. A second rotating groove 204 is formed inside the fixed ring 1, and a rotating ring 205 is rotatably connected inside the fixed ring 1. By rotating the rotating shaft 202 inside the first rotating groove 201, and driven by the rotating ring 205, multiple rotating shafts 202 installed inside the fixed ring 1 rotate synchronously. This allows for synchronous angle adjustment of multiple telescopic components 3, thereby adjusting the turbulence caused by the telescopic components 3 to adapt to different fermentation stages of microorganisms.
[0015] Reference Figure 2 The outer wall of the rotating shaft 202 is provided with a toothed groove 203, and the rotating ring 205 is provided with a first tooth 206 on the side near the rotating shaft 202. The outer wall of the first tooth 206 is adapted to the inner wall of the toothed groove 203. The outer wall of the rotating shaft 202 is provided with a toothed groove 203, which is adapted to the first tooth 206 installed on the side of the rotating ring 205 near the rotating shaft 202. This allows the rotating ring 205 to rotate and drive the rotating shaft 202 to rotate. Thus, the rotating shaft 202 can drive the telescopic component 3, thereby allowing the telescopic component 3 to be adjusted in angle.
[0016] Reference Figure 2-4 The outer wall of the rotating ring 205 is rotatably connected to the inner wall of the second rotating groove 204, and the outer wall of the rotating shaft 202 is rotatably connected to the inner wall of the first rotating groove 201. By limiting the rotation of the rotating shaft 202 inside the first rotating groove 201, and rotating the rotating ring 205 inside the second rotating groove 204, the rotating shaft 202 and the rotating ring 205 are engaged by the first tooth 206, thereby causing the rotating ring 205 to drive the rotating shaft 202 to rotate.
[0017] Reference Figure 3 The bottom of the rotating ring 205 is provided with a third rotating groove 207. The inside of the rotating ring 205 is provided with a second tooth 208. A gear 209 is meshed with the outer wall of the second tooth 208. A rotating column 210 is fixedly connected to the bottom center of the gear 209. A limiting groove 211 is provided at the bottom of the fixed ring 1. The third rotating groove 207 at the bottom of the rotating ring 205 is adapted to the gear 209, and the gear 209 meshes with the rotating ring 205 through the second tooth 208. Thus, the rotating ring 205 can be rotated by the gear 209. The outer wall of the rotating column 210 is adapted to the inner wall of the limiting groove 211, so that the rotating column 210 drives the gear 209 to rotate the rotating ring 205, thereby adjusting the angle of the telescopic component 3.
[0018] Reference Figure 5 The telescopic component 3 includes a fixed post 301 fixed to the side of the rotating shaft 202 away from the fixed ring 1. A limiting shaft 302 is fixedly connected to the side of the fixed post 301 away from the rotating shaft 202. A blade body 305 is sleeved on the outer wall of the limiting shaft 302. A sliding groove is provided on the outer wall of the limiting shaft 302. The rotating shaft 202 and the limiting shaft 302 are connected and fixed by the fixed post 301, so that the blade body 305 is sleeved on the outer wall of the limiting shaft 302, and the blade body 305 can slide on the outer wall of the limiting shaft 302. This allows the blade body 305 to extend on the outer wall of the limiting shaft 302, and the sliding groove on the outer wall of the limiting shaft 302 limits the blade body 305.
[0019] Reference Figure 5 A limiting ring 303 is fixedly connected to the end of the limiting shaft 302 away from the fixed column 301. A contraction spring 304 is fixedly connected to the side of the limiting ring 303 near the limiting shaft 302. The end of the contraction spring 304 away from the limiting ring 303 is fixedly connected to the blade body 305. A telescopic groove 306 is provided at the center of the blade body 305. The limiting ring 303 and the blade body 305 are connected by the contraction spring 304, so that when the fixed ring 1 stops rotating, the blade body 305 returns to its original position under the compression of the contraction spring 304. When the fixed ring 1 rotates, under the centrifugal force, the blade body 305 moves on the outer wall of the limiting shaft 302, so that the blade body 305 fits against the inner wall of the plate container.
[0020] Working principle: By fixing the fixed ring 1 to the drive shaft, rotating the rotating column 210 causes the gear 209 to drive the rotating ring 205 to rotate inside the second rotating groove 204. Under the connection of the first tooth 206, the rotating shaft 202 rotates synchronously, thereby driving the telescopic component 3 to rotate, thus adjusting the tilt angle of the blade body 305. When the fixed ring 1 rotates, under the centrifugal force, the blade body 305 slides on the outer wall of the limiting shaft 302. The blade body 305 remains stable under the limiting of the sliding groove, so that the side of the blade body 305 away from the fixed ring 1 is in contact with the inner wall of the container. When the fixed ring 1 stops rotating, under the compression of the contraction spring 304, the blade body 305 returns to its original position, thereby reducing the volume of the blade.
[0021] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A novel high-efficiency stirring impeller for microbial fermentation of polypeptides, comprising a fixing ring (1), characterized in that, An adjustment component (2) is provided inside the fixed ring (1). The adjustment component (2) includes a first rotating groove (201) opened inside the fixed ring (1). A rotating shaft (202) is rotatably connected inside the first rotating groove (201). A telescopic component (3) is provided on the side of the rotating shaft (202) away from the fixed ring (1). A second rotating groove (204) is opened inside the fixed ring (1). A rotating ring (205) is rotatably connected inside the fixed ring (1).
2. The novel high-efficiency stirring blade for microbial fermentation of polypeptides according to claim 1, characterized in that, The outer side wall of the rotating shaft (202) is provided with a tooth groove (203), and the rotating ring (205) is provided with a first tooth (206) on the side near the rotating shaft (202). The outer side wall of the first tooth (206) is adapted to the inner side wall of the tooth groove (203).
3. The novel high-efficiency stirring blade for microbial fermentation of polypeptides according to claim 1, characterized in that, The outer wall of the rotating ring (205) is rotatably connected to the inner wall of the second rotating groove (204), and the outer wall of the rotating shaft (202) is rotatably connected to the inner wall of the first rotating groove (201).
4. The novel high-efficiency stirring blade for microbial fermentation of polypeptides according to claim 1, characterized in that, The bottom of the rotating ring (205) is provided with a third rotating groove (207), the inside of the rotating ring (205) is provided with a second tooth (208), the outer side wall of the second tooth (208) is meshed with a gear (209), the bottom center of the gear (209) is fixedly connected with a rotating column (210), and the bottom of the fixed ring (1) is provided with a limiting groove (211).
5. A novel high-efficiency stirring blade for microbial fermentation of polypeptides according to claim 1, characterized in that, The telescopic assembly (3) includes a fixed column (301) fixed on the side of the rotating shaft (202) away from the fixed ring (1). A limiting shaft (302) is fixedly connected to the side of the fixed column (301) away from the rotating shaft (202). A blade body (305) is sleeved on the outer wall of the limiting shaft (302). A sliding groove is opened on the outer wall of the limiting shaft (302).
6. A novel high-efficiency stirring blade for microbial fermentation of polypeptides according to claim 5, characterized in that, The end of the limiting shaft (302) away from the fixed column (301) is fixedly connected to a limiting ring (303). A contraction spring (304) is fixedly connected to the side of the limiting ring (303) near the limiting shaft (302). The end of the contraction spring (304) away from the limiting ring (303) is fixedly connected to the blade body (305). A telescopic groove (306) is provided at the center of the blade body (305).