A high-speed homogenizing dispersion mixer for veterinary medicine emulsion with variable rotating speed

Abstract

The utility model provides a kind of veterinary drug emulsion high-speed homogenization dispersion stirring mixer with variable rotating speed, belong to veterinary medicine technical field, by being provided with the flow guide convex rib of axial extension and cross section is triangle in mixing cylinder inner wall surface, make material produce downward axial flow component when high-speed rotation, while the spiral flow guide groove of being set up in the outer surface of stirring shaft produces upward conveying effect, establish the circulation flow path of material, avoid vortex stagnant zone and local excessive shearing phenomenon in mixing cylinder, and by controlling the radial clearance between the outer edge of homogenization blade and mixing cylinder inner wall surface and using tapered friction wheel group to realize stepless regulation of rotating speed, ensure that different viscosity and formula veterinary drug emulsion can obtain uniform and stable homogenization effect, solve the technical problem that uneven material flow distribution leads to unstable homogenization effect in the process of high-speed homogenization dispersion stirring of veterinary drug emulsion.

Description

Technical Field

[0001] This utility model belongs to the field of veterinary drug technology, specifically, it relates to a high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed. Background Technology

[0002] In the preparation of veterinary drug emulsions, high-speed homogenization and dispersion are required to uniformly disperse the active pharmaceutical ingredients in the emulsion matrix. Traditional homogenizers mainly rely on homogenizing blades mounted at the lower end of the mixing shaft to shear and disperse the materials. The shearing force generated by high-speed rotation reduces the drug particles to micron or even submicron sizes, thereby improving the stability and bioavailability of veterinary drug emulsions. In actual production, they are widely used in the preparation of various veterinary injections, oral emulsions, and topical creams. However, when existing homogenizers operate at high speeds, the materials often exhibit uneven flow within the mixing cylinder. Some materials concentrate in the upper region of the mixing cylinder, forming stagnant eddies, while the materials in the bottom region experience rapid temperature increases due to the strong shearing action of the homogenizing blades, leading to degradation of heat-sensitive drug components. Furthermore, due to the lack of an effective axial circulation mechanism, the shear intensity experienced by materials at different locations within the mixing cylinder varies significantly, resulting in uneven particle size distribution in the final product and affecting the quality stability of the veterinary drug emulsion. Furthermore, existing speed control devices mostly employ segmented gear transmission mechanisms, which cannot achieve continuous speed adjustment. This makes it difficult to precisely optimize process parameters for veterinary drug emulsions with different viscosities and formulations. When processing high-viscosity materials, insufficient mixing is prone to occur, while when processing low-viscosity materials, excessive speed may lead to material splashing and air bubble entrainment. In other words, existing technologies suffer from the technical problem of uneven material flow distribution during high-speed homogenization and dispersion of veterinary drug emulsions, resulting in unstable homogenization effects. Utility Model Content

[0003] In view of this, the present invention provides a high-speed homogenizing and dispersing mixer for veterinary drug emulsion with variable rotation speed, which can solve the technical problem in the prior art where the uneven material flow distribution during high-speed homogenizing and dispersing of veterinary drug emulsion leads to unstable homogenization effect.

[0004] This invention is implemented as follows: This invention provides a high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed, including a mixing cylinder and a power mechanism. A stirring shaft is installed inside the mixing cylinder, and a homogenizing cutter assembly is installed at the lower end of the stirring shaft. The homogenizing cutter assembly includes several radially arranged homogenizing blades. Several guide ribs are evenly distributed circumferentially on the inner wall of the mixing cylinder, extending axially along the mixing cylinder. The cross-section of the guide ribs is triangular, and the inclined surface of the guide ribs faces the rotation direction of the stirring shaft. The radial gap between the outer edge of the homogenizing blades and the inner wall of the mixing cylinder is 5% to 8% of the radius of the homogenizing blades. The upper end of the stirring shaft is connected to the output shaft of the power mechanism. By setting axially extending, triangular-shaped guide ribs on the inner wall of the mixing cylinder, with the inclined surface of the guide ribs facing the rotation direction of the stirring shaft, the material generates a downward axial flow component along the inclined surface of the guide ribs during the mixing process, preventing excessive accumulation of material in the upper part of the mixing cylinder. At the same time, by controlling the radial gap between the outer edge of the homogenizing blades and the inner wall of the mixing cylinder to 5% to 8% of the radius of the homogenizing blades, the material is ensured to be subjected to sufficient shearing action during high-speed rotation, achieving a homogenization effect. The conical friction wheel set enables stepless adjustment of the rotation speed to meet the processing requirements of veterinary drug emulsions of different viscosities.

[0005] The height of the guide ribs gradually decreases from top to bottom along the axial direction of the mixing cylinder. The distance between the top of the guide rib and the bottom of the mixing cylinder is greater than the distance between the starting end of the guide rib and the top of the mixing cylinder. By making the height of the guide ribs gradually decrease from top to bottom along the axial direction of the mixing cylinder, the material receives a strong guiding effect at the upper part of the mixing cylinder, and the guiding effect gradually weakens as the material flows downward. This avoids excessive axial flow of the material at the bottom, which would affect the shearing effect of the homogenizing blades on the material, thus achieving a reasonable flow distribution of the material within the mixing cylinder and improving the uniformity of homogeneous dispersion.

[0006] The homogenizing blade has an arc-shaped leading edge and a straight trailing edge, and a torsion angle along its radial direction, which gradually increases from the root to the tip. By making the leading edge of the homogenizing blade arc-shaped and the trailing edge straight, the fluid resistance of the homogenizing blade during high-speed rotation is reduced. Simultaneously, by having a gradually increasing torsion angle along the radial direction, the homogenizing blade generates shear forces in different directions on the material at different radial positions, enhancing the three-dimensional turbulence effect of the material, improving the dispersion uniformity of each component in the veterinary drug emulsion, and preventing stratification.

[0007] The outer surface of the stirring shaft is provided with several spiral guide grooves along the axial direction. The spiral helix angle of the spiral guide grooves is 15 to 25 degrees, and the depth of the spiral guide grooves gradually increases from top to bottom along the axial direction of the stirring shaft. By creating spiral guide grooves with a spiral helix angle of 15 to 25 degrees on the outer surface of the stirring shaft, and making the depth of the spiral guide grooves gradually increase from top to bottom along the axial direction, the material is axially conveyed upward along the spiral guide grooves when the stirring shaft rotates. This forms a circulating flow path with the downward flow generated by the guide ribs, enhancing the overall convective mixing effect of the material, avoiding dead zones at the bottom of the mixing cylinder, and ensuring the full dispersion of the effective components in the veterinary drug emulsion.

[0008] The mixing cylinder has a conical bottom with a cone angle of 60 to 90 degrees. The homogenizing blade assembly is located above the apex of the cone, and the axial distance between the homogenizing blade assembly and the apex is 10% to 15% of the inner diameter of the mixing cylinder. By making the bottom of the mixing cylinder a conical structure with a cone angle in the range of 60 to 90 degrees, and maintaining an axial distance of 10% to 15% of the inner diameter of the mixing cylinder between the homogenizing blade assembly and the apex, material accumulation at the bottom is avoided. Simultaneously, sufficient space is provided for the high-speed rotation of the homogenizing blades, allowing material to smoothly enter the homogenization area, improving the material processing efficiency of the homogenizing blade assembly, and ensuring the quality stability of the veterinary drug emulsion.

[0009] Optionally, the power mechanism includes a motor and a speed adjustment mechanism; the speed adjustment mechanism is connected to the upper end of the stirring shaft via a conical friction wheel assembly; the conical friction wheel assembly of the speed adjustment mechanism includes a driving conical wheel and a driven conical wheel, the conical surfaces of the driving conical wheel and the driven conical wheel are in contact with each other, and the driving conical wheel is provided with a position adjustment device along its axial direction to change the contact position between the driving conical wheel and the driven conical wheel; the driving conical wheel is connected to the output of the motor. By adopting a conical friction wheel assembly structure in which the driving and driven conical wheels are in contact with each other, and by providing a position adjustment device to change the contact position between the driving and driven conical wheels, continuous stepless adjustment of the stirring shaft speed is achieved, avoiding the discontinuous gear problem of traditional gear transmission mechanisms. This allows operators to precisely adjust the stirring speed according to the viscosity and formulation requirements of different veterinary drug emulsions, improving the adaptability and processing flexibility of the equipment.

[0010] The homogenizing blades consist of 3 to 6 blades, which are evenly distributed around the circumference of the stirring shaft. The included angle between any two adjacent blades is 60 to 120 degrees. The blades are fixed to the lower end of the stirring shaft via keyway connections. By setting the number of blades to 3 to 6 and maintaining the included angle between adjacent blades within the range of 60 to 120 degrees, the homogenizing blades ensure a balanced shearing action on the material during rotation. This avoids excessive power consumption due to too many blades or insufficient shearing due to too few blades. Furthermore, the keyway connection facilitates disassembly, replacement, and maintenance of the blades, extending the equipment's service life.

[0011] In this design, the base width of the triangle in the cross-section of the guide rib is greater than the height of the triangle. The number of guide ribs is 6 to 12, and the circumferential spacing between adjacent guide ribs along the inner wall of the mixing cylinder is equal. By making the base width of the triangle in the cross-section of the guide rib greater than the height of the triangle, the structural strength of the guide rib is enhanced, preventing deformation under the impact of high-speed material flow. Simultaneously, by setting the number of guide ribs to 6 to 12 and ensuring equal circumferential spacing between adjacent guide ribs, uniform flow guidance is ensured near the inner wall of the mixing cylinder, avoiding dead zones in local areas and improving overall mixing uniformity.

[0012] The stirring shaft is made of stainless steel, the homogenizing blades are made of titanium alloy, and the mixing cylinder is made of double-layered stainless steel, with an interlayer space between the inner and outer layers. Using stainless steel for the stirring shaft ensures good corrosion resistance and mechanical strength. Using titanium alloy for the homogenizing blades leverages the high strength and wear resistance of titanium alloy to extend their service life. The double-layered stainless steel structure of the mixing cylinder, with an interlayer space between the inner and outer layers, provides a structural foundation for subsequent temperature control functions, thus improving the reliability and durability of the equipment.

[0013] The mixing cylinder has a feed inlet at its upper end, with an inner diameter of 30% to 50% of the cylinder's inner diameter. A discharge outlet is located on the lower side wall of the mixing cylinder, connected to a conveying pipeline via a flange. The upper end of the stirring shaft is connected to the top cover of the mixing cylinder via a bearing housing. By setting the feed inlet's inner diameter to 30% to 50% of the cylinder's inner diameter, material can smoothly enter the mixing cylinder without clogging. The discharge outlet on the lower side wall of the mixing cylinder, connected to the conveying pipeline via a flange, facilitates continuous output of the finished emulsion and rapid assembly / disassembly of the pipeline system. The bearing housing connects the stirring shaft to the top cover of the mixing cylinder, ensuring stable rotation of the shaft, reducing vibration and noise during operation, and improving the overall stability of the equipment.

[0014] It should be noted that this utility model provides axially extending guide ribs with triangular cross-sections on the inner wall of the mixing cylinder, with the inclined surfaces of the guide ribs facing the rotation direction of the stirring shaft. By utilizing the guiding effect of the guide ribs on the material flow direction, the material generates a downward axial flow component along the inclined surfaces of the guide ribs when rotating at high speed. This avoids excessive accumulation of material in the upper part of the mixing cylinder, forming a vortex stagnation zone. At the same time, by gradually decreasing the height of the guide ribs from top to bottom along the axial direction, the axial flow velocity of the material at different height positions is reasonably controlled, ensuring that the material can be evenly distributed throughout the entire mixing cylinder. This invention utilizes a spiral guide groove on the outer surface of the mixing shaft. The upward conveying action of the spiral guide groove during rotation, combined with the downward flow generated by the guide ribs, forms a complete circulating flow path, enhancing the overall convective mixing effect of the material. This ensures that material at all locations within the mixing cylinder fully passes through the shearing zone of the homogenizing cutter, preventing excessive shearing and temperature rise caused by prolonged material retention in localized areas. Furthermore, by employing a conical friction wheel assembly as a speed adjustment mechanism, continuous stepless adjustment of the mixing shaft speed is achieved, allowing operators to precisely control the shearing intensity and mixing time according to the specific requirements of different veterinary drug emulsions. In summary, this invention solves the technical problem mentioned in the background art where uneven material flow distribution during high-speed homogenization and dispersion of veterinary drug emulsions leads to unstable homogenization effects. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0016] Figure 2 This is a schematic diagram of the homogenized cutter head assembly.

[0017] Figure 3 This is a schematic diagram of the arrangement of the guide ribs on the inner wall of the mixing cylinder.

[0018] Figure 4 This is a schematic diagram of the speed regulation mechanism.

[0019] In the attached drawings, the reference numerals are explained as follows: 01 Mixing cylinder, 02 Stirring shaft, 03 Homogenizing cutter head assembly, 031 Homogenizing blade, 04 Guide rib, 05 Speed ​​adjustment mechanism, 051 Driving cone wheel, 052 Driven cone wheel, 06 Feed inlet, 07 Discharge outlet, 08 Spiral guide groove, 09 Bearing seat, 10 Conical structure. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below.

[0021] This utility model provides a high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed, comprising:

[0022] like Figures 1-4As shown, this utility model includes a mixing cylinder 01 and a speed regulating mechanism 05. The mixing cylinder 01 is welded from double-layer stainless steel plates, with the inner layer made of 304 stainless steel and the outer layer made of 316 stainless steel. A sandwich space with a thickness of 15mm to 25mm is formed between the inner and outer layers. This sandwich space is used for subsequent installation of a temperature control system. The inner diameter of the mixing cylinder 01 is 200mm to 400mm, the height is 300mm to 600mm, and the wall thickness is 3mm to 6mm. A stirring shaft 02 is installed inside the mixing cylinder 01. The stirring shaft 02 is machined from a stainless steel round bar with a diameter of 40mm to 80mm, and the surface is polished to achieve a surface roughness of Ra0.8. The lower end of the stirring shaft 02 is fixed with a homogenizing cutter head assembly 03 via a keyway connection. The homogenizing cutter head assembly 03 includes several radially arranged homogenizing blades 031. The homogenizing blades 031 are milled from titanium alloy material, with a thickness of 2mm to 4mm and a length of 50mm to 100mm. The leading edge of the homogenizing blades 031 is machined into an arc shape with a radius of 5mm to 10mm, while the trailing edge remains straight. The homogenizing blades 031 have a torsion angle along their radial direction. This torsion angle gradually increases from 15 degrees at the root of the homogenizing blades 031 to 45 degrees at the tip. The change in the torsion angle adopts a linear transition method. A number of flow-guiding ribs 04 are evenly distributed circumferentially on the inner wall surface of the mixing cylinder 01. The flow-guiding ribs 04 are fixed to the inner wall surface by argon arc welding using the same 304 stainless steel plate as the inner layer of the mixing cylinder 01. The flow-guiding ribs 04 extend axially along the mixing cylinder 01, with an extension length of 60% to 80% of the height of the mixing cylinder 01. The cross-section of the flow-guiding ribs 04 is triangular, with a base width of 10mm to 20mm and a height of 5mm to 12mm. The inclined surface of the flow-guiding ribs 04 forms an angle of 30 degrees to 45 degrees with the radial direction of the mixing cylinder 01. The inclined surface faces the rotation direction of the stirring shaft 02. When the stirring shaft 02 rotates clockwise, the inclined surface of the flow-guiding ribs 04 faces the clockwise direction. The radial gap between the outer edge of the homogeneous blade 031 and the inner wall of the mixing cylinder 01 is 5% to 8% of the radius of the homogeneous blade 031. When the radius of the homogeneous blade 031 is 80 mm, the radial gap is 4 mm to 6.4 mm.The speed adjustment mechanism 05 is connected to the upper end of the stirring shaft 02 via a conical friction wheel assembly. The conical friction wheel assembly includes a driving conical wheel 051 and a driven conical wheel 052. The driving conical wheel 051 is driven by a motor, and the driven conical wheel 052 is fixed to the upper end of the stirring shaft 02 via a key connection. The conical surfaces of the driving conical wheel 051 and the driven conical wheel 052 are in contact with each other, and the half-cone angle of the conical surfaces is 15 degrees to 30 degrees. The driving conical wheel 051 is provided with a position adjustment device along its axial direction. This position adjustment device adopts a screw and nut mechanism. By rotating the adjustment handwheel, the position of the driving conical wheel 051 along the axial direction is changed, thereby changing the contact position between the driving conical wheel 051 and the driven conical wheel 052, realizing continuous adjustment of the speed of the driven conical wheel 052. The speed adjustment range is 500 r / min to 5000 r / min. The height of the guide rib 04 gradually decreases from top to bottom along the axial direction of the mixing cylinder 01. Near the top of the mixing cylinder 01, the height of the guide rib 04 is 12mm, and near the bottom, the height decreases to 5mm. The height change adopts a linear decreasing method. The distance between the top of the guide rib 04 and the bottom of the mixing cylinder 01 is 20% to 30% of the height of the mixing cylinder 01. Several spiral guide grooves 08 are formed along the axial direction on the outer surface of the stirring shaft 02. The spiral guide grooves 08 are formed by milling. The spiral helix angle of the spiral guide grooves 08 is 15 degrees to 25 degrees. The depth of the spiral guide grooves 08 gradually increases from top to bottom along the axial direction of the stirring shaft 02. Near the upper end of the stirring shaft 02, the depth of the spiral guide grooves 08 is 2mm, and near the lower end, the depth increases to 6mm. The width of the spiral guide grooves 08 is 5mm to 10mm, and the circumferential spacing between two adjacent spiral guide grooves 08 is equal. The bottom of the mixing cylinder 01 is a conical structure 10 with a cone angle of 60 to 90 degrees, preferably 75 degrees. The height of the conical structure 10 is 50 mm to 100 mm. The homogenizing cutter head assembly 03 is located above the cone apex of the conical structure 10. The axial distance between the homogenizing cutter head assembly 03 and the cone apex of the conical structure 10 is 10% to 15% of the inner diameter of the mixing cylinder 01. When the inner diameter of the mixing cylinder 01 is 300 mm, the axial distance is 30 mm to 45 mm. The number of homogenizing blades 031 is 3 to 6, preferably 4. The homogenizing blades 031 are distributed at equal angles along the circumference of the stirring shaft 02. The included angle between two adjacent homogenizing blades 031 is 60 degrees to 120 degrees. When there are 4 homogenizing blades 031, the included angle between two adjacent homogenizing blades 031 is 90 degrees. The homogenizing blades 031 are fixed to the lower end of the stirring shaft 02 by a T-shaped keyway connection. The depth of the keyway is 5 mm to 10 mm. The number of guide ribs 04 is 6 to 12, preferably 8. The circumferential spacing between two adjacent guide ribs 04 along the inner wall of the mixing cylinder 01 is equal. When there are 8 guide ribs 04, the circumferential included angle between two adjacent guide ribs 04 is 45 degrees.A feed inlet 06 is provided at the upper end of the mixing cylinder 01. The inner diameter of the feed inlet 06 is 30% to 50% of the inner diameter of the mixing cylinder 01. When the inner diameter of the mixing cylinder 01 is 300mm, the inner diameter of the feed inlet 06 is 90mm to 150mm. A removable feeding cover is provided above the feed inlet 06, and the feeding cover is connected to the feed inlet 06 by a quick-release clamp. A discharge outlet 07 is provided at the lower part of the side wall of the mixing cylinder 01. The discharge outlet 07 is located at a height of 10% to 20% above the bottom of the mixing cylinder 01. The discharge outlet 07 is connected to the conveying pipeline by a flange connection. The flange adopts the PN16 standard, and the inner diameter of the discharge outlet 07 is 25mm to 50mm. The upper end of the stirring shaft 02 is connected to the top cover of the mixing cylinder 01 through the bearing housing 09. Two deep groove ball bearings are installed in the bearing housing 09. The bearing model is 6208 or 6210. The bearings are installed back to back. The bearing housing 09 and the top cover are connected by bolts. There are 6 to 8 bolts with bolt specifications of M10 to M12.

[0023] Specifically, the principle of this invention is as follows: This invention solves the technical problem of unstable homogenization effect caused by uneven material flow distribution during high-speed homogenization and dispersion of veterinary drug emulsions. Its fundamental principle lies in establishing an orderly circulating flow pattern of materials within the mixing cylinder by rationally designing the guide rib structure on the inner wall of the mixing cylinder and the spiral guide groove structure on the surface of the stirring shaft. The triangular cross-section design of the guide ribs allows the material to slide downwards along the inclined surface under the centrifugal force of high-speed rotation, transforming the original single circumferential rotational flow into a spiral flow containing an axial component. This flow pattern effectively breaks the eddy current stagnation zone at the top of the mixing cylinder, allowing the upper material to be continuously conveyed downwards to the shearing area of ​​the homogenizing cutter head. Meanwhile, the spiral guide groove on the surface of the stirring shaft exerts an upward conveying effect on the material near the shaft during rotation, transporting the material after shearing by the homogenizing cutter head back to the top of the mixing cylinder, forming a complete circulation path from top to bottom and then from bottom to top. The design of gradually decreasing height of the guide ribs along the axial direction ensures the flow balance of the material circulation, avoiding flow bottlenecks or excessive accumulation at a certain position. The radial gap between the outer edge of the homogenizing blades and the inner wall of the mixing cylinder is maintained at 5% to 8% of the radius of the homogenizing blades, so that the material is subjected to strong shearing action when passing through the gap, further refining the drug particles. The stepless speed change function of the conical friction wheel group provides a precise means of speed control for different process requirements, so that the entire homogenization and dispersion mixing process can be carried out under optimal process parameters. Therefore, the technical solution of this utility model is logically in complete compliance with the principles of fluid mechanics, and can effectively solve the problem of uneven material flow distribution and achieve a stable homogenization effect.

[0024] The operation method of this utility model is as follows: First, check whether the inside of the mixing cylinder 01 is clean, confirm that the stirring shaft 02 can rotate freely without abnormal noise, check the lubrication of the bearing seat 09, and add an appropriate amount of grease if necessary. Weigh and prepare the raw materials of the veterinary drug emulsion to be processed according to the formula requirements, including the active ingredient powder, emulsifier, oil phase matrix and aqueous phase matrix. First, add the oil phase matrix through the feed port 06. The temperature of the oil phase matrix is ​​controlled between 40℃ and 60℃. The amount added is 30% to 40% of the effective volume of the mixing cylinder 01. Then, start the speed adjustment mechanism 05 and adjust the axial position of the active cone wheel 051 so that the initial speed of the stirring shaft 02 is 1000 r / min to 1500 r / min. Run for 3 to 5 minutes to allow the oil phase matrix to form a uniform flow state in the mixing cylinder 01. With the stirring shaft 02 continuously running, the emulsifier is slowly added through the feed inlet 06 over a period of 2 to 3 minutes. During the addition process, the flow of the material inside the mixing cylinder 01 is observed to ensure that the emulsifier is evenly dispersed in the oil phase matrix. After the emulsifier is added, the rotation speed is adjusted to 2000 to 2500 r / min, and stirring is continued for 5 to 8 minutes to allow the emulsifier to fully dissolve. At this time, the guide ribs 04 guide the material to flow downward along the inner wall of the mixing cylinder 01, while the spiral guide grooves 08 transport the material near the stirring shaft 02 upward, forming a circulating flow. The homogenizing blades 031 shear and disperse the material passing through. Next, the aqueous phase matrix is ​​slowly added through inlet 06. The temperature of the aqueous phase matrix is ​​controlled between 40℃ and 60℃, and the temperature difference between it and the oil phase matrix is ​​controlled within 5℃. The addition rate is 10% to 15% of the total amount per minute. During the addition process, the rotation speed is maintained at 2000 r / min to 2500 r / min. After the aqueous phase matrix is ​​added, the active pharmaceutical ingredient powder is added in batches, with each batch accounting for 20% to 25% of the total amount. After each batch is added, the mixture is stirred for 2 to 3 minutes before adding the next batch. After all the drug powder has been added, the rotation speed is adjusted to 3500 r / min to 4500 r / min to enter the high-speed homogenization stage. The high-speed homogenization time is 15 to 25 minutes. During this process, the material forms an orderly circulating flow under the combined action of the guide ribs 04 and the spiral guide grooves 08. Each part of the material can pass through the shearing area of ​​the homogenizing blades 031 multiple times and be subjected to uniform shearing action. The drug particles are refined to a particle size range of 1μm to 5μm, and the emulsion exhibits a uniform milky white appearance without obvious particle texture. After homogenization, gradually reduce the speed to 1000 r / min and maintain low-speed stirring for 3 to 5 minutes to allow the air bubbles entrained in the material to be fully expelled. Then stop the rotation of the stirring shaft 02, open the valve of the discharge port 07, and let the finished emulsion flow out from the discharge port 07 into the conveying pipeline by gravity, thus completing the entire processing process.In this embodiment, since the height of the guide rib 04 gradually decreases from top to bottom, the material is subjected to a strong downward guiding effect at the upper part of the mixing cylinder 01, avoiding the formation of a vortex stagnation zone at the upper part. At the lower part of the mixing cylinder 01, the height of the guide rib 04 is small, so it will not excessively interfere with the shearing effect of the homogenizing blade 031. The upward conveying effect generated by the spiral guide groove 08 on the surface of the stirring shaft 02 during high-speed rotation and the downward guiding effect of the guide rib 04 form a complete circulation path, so that the material at all positions in the mixing cylinder 01 can be fully homogenized. The 5% to 8% radial gap between the outer edge of the homogenizing blade 031 and the inner wall of the mixing cylinder 01 ensures that the material is subjected to strong shearing force when passing through the gap. The stepless speed regulation function realized by the conical friction wheel group allows the operator to adjust the speed in real time according to the material state. The material flow distribution is uniform throughout the entire processing process, the homogenization effect is stable, and the particle size distribution of the finished emulsion is uniform without stratification.

[0025] The following is a specific embodiment 1 of this utility model: This embodiment is an improvement on the specific implementation method. To meet the processing requirements of high-viscosity veterinary drug emulsions, the number of guiding ribs 04 is increased to 10, and the circumferential angle between two adjacent guiding ribs 04 is reduced to 36 degrees. Increasing the number of guiding ribs 04 forms a denser flow channel on the inner wall of the mixing cylinder 01, making it easier for high-viscosity materials to slide downwards along the inclined surface of the guiding ribs 04 under centrifugal force, thus preventing excessive accumulation of high-viscosity materials at the top of the mixing cylinder 01. Simultaneously, the number of homogenizing blades 031 is increased to 6, and the angle between two adjacent homogenizing blades 031 is 60 degrees. Increasing the number of homogenizing blades 031 increases the number of shearing operations on the material per unit time, making it easier to achieve sufficient dispersion for high-viscosity materials. During processing, the initial rotation speed was set to 800 r / min to 1200 r / min, lower than that in Example 1, to avoid excessive stirring resistance in high-viscosity materials at low speeds. As the viscosity of the material gradually decreased during processing, the rotation speed was gradually increased to 3000 r / min to 4000 r / min for high-speed homogenization, with the high-speed homogenization time extended to 20 to 30 minutes to ensure that the drug particles in the high-viscosity material were sufficiently refined. This embodiment enhanced the guiding and shearing effects on high-viscosity materials by increasing the number of guide ribs 04 and homogenizing blades 031. Combined with the adjusted rotation speed control strategy, it effectively solved the problem of uneven mixing that easily occurs during the processing of high-viscosity veterinary drug emulsions, and significantly improved the viscosity uniformity and stability of the finished emulsion.

[0026] The following is a specific embodiment 2 of this utility model: This embodiment is an improvement on the specific implementation method. For the processing requirements of veterinary drug emulsions containing heat-sensitive drug components, a cooling water circulation system is installed in the interlayer space of the mixing cylinder 01. The cooling water temperature is controlled between 15°C and 25°C. The interlayer space cools the mixing cylinder 01, preventing the material from overheating due to frictional heat generation during high-speed homogenization. Simultaneously, the torsion angle of the homogenizing blades 031 is optimized and adjusted, reducing the torsion angle at the root of the blades 031 to 10 degrees and the torsion angle at the tip to 35 degrees. Reducing the torsion angle lowers the shear strength of the homogenizing blades 031 on the material, reducing frictional heat generation. The reduction in shear strength is compensated by extending the homogenization time. The rotation speed during the high-speed homogenization stage is controlled between 3000 r / min and 3800 r / min, and the time is extended to 25 min to 35 min. During processing, the temperature of the material inside the mixing cylinder 01 is monitored in real time by a temperature sensor. When the material temperature approaches the lower limit of the degradation temperature of the heat-sensitive drug component, the stirring speed is appropriately reduced or stirring is paused. Processing continues only after the material temperature drops, ensuring that the material temperature is always controlled within a safe range throughout the entire processing. In this embodiment, by installing a cooling system in the interlayer space of the mixing cylinder 01 and optimizing the torsion angle of the homogenizing blades 031, the material temperature during processing is effectively controlled, avoiding the degradation and inactivation of the heat-sensitive drug component. At the same time, the circulating flow path established by the guide ribs 04 and the spiral guide grooves 08 ensures a uniform distribution of material temperature, preventing local overheating. The retention rate of the effective drug components in the finished emulsion is significantly improved, and the product quality is stable and reliable.

[0027] The above description is only a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model.

Claims

1. A high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed, characterized in that, The device includes a mixing cylinder and a power mechanism. A stirring shaft is installed inside the mixing cylinder, and a homogenizing cutter assembly is installed at the lower end of the stirring shaft. The homogenizing cutter assembly includes several radially arranged homogenizing blades. Several guide ribs are evenly distributed circumferentially on the inner wall of the mixing cylinder, extending axially along the mixing cylinder. The cross-section of each guide rib is triangular, with its inclined surface facing the rotation direction of the stirring shaft. The radial gap between the outer edge of the homogenizing blades and the inner wall of the mixing cylinder is 5% to 8% of the radius of the homogenizing blades. The upper end of the stirring shaft is connected to the output shaft of the power mechanism.

2. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 1, characterized in that, The height of the guide rib gradually decreases from top to bottom along the axial direction of the mixing cylinder, and the distance between the top end of the guide rib and the bottom of the mixing cylinder is greater than the distance between the starting end of the guide rib and the top of the mixing cylinder.

3. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 2, characterized in that, The leading edge of the homogeneous blade is arc-shaped, the trailing edge of the homogeneous blade is straight, and the homogeneous blade has a torsion angle along its radial direction, which gradually increases from the root to the tip of the homogeneous blade.

4. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 3, characterized in that, The outer surface of the stirring shaft is provided with several spiral guide grooves along the axial direction. The spiral guide grooves have a spiral helix angle of 15 degrees to 25 degrees, and the depth of the spiral guide grooves gradually increases from top to bottom along the axial direction of the stirring shaft.

5. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 4, characterized in that, The bottom of the mixing cylinder is a conical structure with a cone angle of 60 to 90 degrees. The homogenizing cutter head assembly is located above the cone apex of the conical structure, and the axial distance between the homogenizing cutter head assembly and the cone apex of the conical structure is 10% to 15% of the inner diameter of the mixing cylinder.

6. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 5, characterized in that, The power mechanism includes a motor and a speed adjustment mechanism; the speed adjustment mechanism is connected to the upper end of the stirring shaft via a conical friction wheel assembly; the conical friction wheel assembly of the speed adjustment mechanism includes a driving conical wheel and a driven conical wheel, the conical surface of the driving conical wheel and the conical surface of the driven conical wheel are in contact with each other, the driving conical wheel is provided with a position adjustment device along its axial direction to change the contact position between the driving conical wheel and the driven conical wheel, and the driving conical wheel is connected to the output of the motor.

7. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 6, characterized in that, The number of homogenizing blades is 3 to 6. The homogenizing blades are distributed at equal angles on the circumference of the stirring shaft. The included angle between two adjacent homogenizing blades is 60 degrees to 120 degrees. The homogenizing blades are fixed to the lower end of the stirring shaft by keyway connection.

8. The high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 7, characterized in that, The width of the base of the triangle in the cross-section of the guide rib is greater than the height of the triangle. The number of guide ribs is 6 to 12, and the circumferential spacing between two adjacent guide ribs along the inner wall of the mixing cylinder is equal.

9. A high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 8, characterized in that, The stirring shaft is made of stainless steel, the homogenizing blades are made of titanium alloy, and the mixing cylinder is made of double-layered stainless steel, with an interlayer space formed between the inner and outer layers of the mixing cylinder.

10. A high-speed homogenizing and dispersing mixer for veterinary drug emulsions with variable rotation speed according to claim 9, characterized in that, The upper end of the mixing cylinder is provided with a feed inlet, the inner diameter of which is 30% to 50% of the inner diameter of the mixing cylinder. The lower part of the side wall of the mixing cylinder is provided with a discharge outlet, which is connected to the conveying pipeline through a flange connection. The upper end of the stirring shaft is connected to the top cover of the mixing cylinder through a bearing seat.

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