Powdered chemotherapy drug reconstitution device

Abstract

The utility model discloses a powder chemotherapy medicine redissolving equipment belongs to the technical field of preparation configuration equipment. Including: the turnover mechanism includes the base, and is installed in the base upside directly through a pair of side plate turnover board, the turnover board is driven through worm drive motor, the rotation shakes even -faced mechanism, including the rotation motor of installation on the turnover board, and the carousel of by rotation motor drive, the solvent injection mechanism, including injection needle, and install in the base one side and drive the up and down movement of injection needle's elevating system. Adopt carousel can fix a group by the powder chemotherapy medicine of penicillin bottle package once, then through solvent injection mechanism one by one and carry out solvent injection, can batch solid -liquid mixing, has shortened the time of the preparation of multiple penicillin bottles, solvent extraction, injection, relies on the turnover board and realizes the slow turnover of all penicillin bottles, utilizes carousel simultaneously and realizes the soft rolling of solvent in penicillin bottle, so that the powder chemotherapy medicine is fully dissolved in solvent.

Description

Technical Field

[0001] This utility model relates to a device for reconstituted powdered chemotherapy drugs, belonging to the technical field of pharmaceutical preparation equipment. Background Technology

[0002] Intravenous chemotherapy is a crucial treatment for cancer. Some chemotherapy drugs are packaged in vials as lyophilized powders. Before administration, medical personnel must reconstitute the powdered chemotherapy drug with a small amount of a prescribed solvent, transforming it into a liquid, and then further dilute it to the required concentration before injection into the patient.

[0003] The reconstitution process of powdered chemotherapy drugs requires strict adherence to drug preparation standards. The solvent must be injected into the vial to ensure uniform mixing and complete dissolution of the drug powder, guaranteeing accurate drug concentration and dosage. During mixing, vigorous or large-scale shaking should be avoided to prevent air bubbles or drug inactivation. Current mixing machines use rapid vibration. When the vibration amplitude is too small, some drug powder adheres to the upper part of the vial wall and cannot dissolve fully; when the vibration amplitude is too large, air bubbles are easily generated or the drug becomes ineffective. Furthermore, in clinical practice, a single patient often requires multiple vials of medication for combined or continuous use. For example, some patients may require up to 12 vials of chemotherapy powder for a single treatment session. Under current technology, personnel must perform puncture, solvent injection, and gentle mixing steps one by one, resulting in repetitive and time-consuming operations, inefficient drug preparation, increased clinical workload, and patient waiting time.

[0004] Therefore, a powder chemotherapy drug reconstitution device was designed, which automatically injects solvent and shakes the drug by a gentle rolling motion to improve the efficiency and consistency of drug reconstitution, reduce the burden on medical staff, and meet the clinical need for rapid and safe drug administration. Summary of the Invention

[0005] The technical problem to be solved by this utility model is to provide a device for reconstituted powdered chemotherapy drugs, which solves the problem of low efficiency in the current method of manually reconstituted powdered chemotherapy drugs.

[0006] The technical problem to be solved by this utility model is achieved by the following technical solution:

[0007] A device for reconstituted powdered chemotherapy drugs, comprising:

[0008] The flipping mechanism includes a base and a flipping plate mounted directly above the base via a pair of side plates, the flipping plate being driven by a worm gear motor;

[0009] The rotating and shaking mechanism includes a rotary motor mounted on the flip plate and a turntable driven by the rotary motor. The turntable has a plurality of fixing grooves evenly distributed along the same circumference for fixing vials.

[0010] The solvent injection mechanism includes an injection needle and a lifting mechanism mounted on one side of the base and driving the injection needle to move up and down.

[0011] Preferably, a cover plate is installed above the turntable to cover the fixing groove, and the cover plate has an injection window that holds the vial body in place and allows the vial cap to leak out.

[0012] Preferably, the turntable has a D-shaped threaded shaft in the middle, and the cover plate has a D-shaped hole in the middle that mates with the D-shaped threaded shaft. The cover plate is locked and fixed by a hand-tightening nut that mates with the D-shaped threaded shaft.

[0013] Preferably, a return spring is sleeved on the D-shaped threaded shaft, the return spring is located between the turntable and the cover plate, and one end of the return spring is fixed to the turntable.

[0014] Preferably, a rubber adapter is provided in the fixing groove, the outer side of the rubber adapter is interference-fitted with the fixing groove, and the inner diameter of the rubber adapter adopts various specifications that are interference-fitted with the outer diameter of the vial body of different specifications.

[0015] Preferably, the injection needle is connected to the solvent via an infusion tube and a metering infusion pump.

[0016] Preferably, the lifting mechanism includes a housing, a lifting motor, a drive gear, a slide rod, a screw, a clamping slider, and a driven gear. The housing is fixed to the base via an L-shaped plate. The lifting motor is installed inside the housing, and the shaft of the lifting motor extends from the top of the housing. The drive gear is fixed to the shaft of the lifting motor. The slide rod is vertically installed in front of the housing. The screw is vertically and rotatably installed in front of the housing. The driven gear is fixed to the top of the screw and meshes with the drive gear. The clamping slider is sleeved on the slide rod, and the middle part of the clamping slider engages with the screw through a threaded hole. The injection needle is fixed on the clamping slider, and the tip of the injection needle is aligned with the center of the vial.

[0017] Preferably, the clamping slider includes a slider portion and a clamping portion, both having mating semicircular holes. The clamping portion is fixed to the slider portion by screws, and the injection needle is fixed in a pair of the semicircular holes.

[0018] Preferably, one end of the flip plate is hinged to the side plate on the corresponding side, and the other end of the flip plate is connected to the shaft of the worm gear drive motor fixed on the side plate on the other side.

[0019] Preferably, the injection needle has replaceable needles of different specifications.

[0020] The beneficial effects of this utility model are:

[0021] 1. A turntable can hold a group of powdered chemotherapy drugs packaged in vials at a time, and then the solvent injection mechanism can inject the solvent one by one, which can batch solid-liquid mixing and shorten the time for preparing multiple vials, extracting solvent and injecting.

[0022] 2. The solvent is gently shaken using a rotating shaking mechanism. After the solvent is injected into the vial, all vials are slowly rotated using a flipping plate. At the same time, the solvent is gently rolled within the vial using a turntable, so that the powdered chemotherapy drug is fully dissolved in the solvent, thereby achieving reconstitution. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the structure during solvent injection in this utility model;

[0024] Figure 2 This is a schematic diagram of the flipping mechanism and the rotating and shaking mechanism.

[0025] Figure 3 This is a schematic diagram of the solvent injection mechanism;

[0026] Figure 4 This is a schematic diagram of the structure of this utility model during shaking.

[0027] In the picture:

[0028] 1. Vial;

[0029] 2. Tilting mechanism; 201. Base; 202. Side plate; 203. Tilting plate; 204. Worm gear drive motor; 205. Cover plate; 206. Injection window; 207. D-shaped hole;

[0030] 3. Rotary shaking mechanism; 301. Rotary motor; 302. Turntable; 303. Fixing groove; 304. Rubber adapter; 305. D-shaped threaded shaft; 306. Hand-tightening nut; 307. Return spring;

[0031] 4. Solvent injection mechanism; 401. Injection needle; 402. Housing; 403. Lifting motor; 404. Drive gear; 405. Slide rod; 406. Screw; 407. Clamping slider; 408. Driven gear; 409. L-shaped plate; 410. Slider part; 411. Clamping part; 412. Semicircular hole; 413. Replaceable needle. Detailed Implementation

[0032] In order to make the technical means, creative features, objectives and effects of this utility model easier to understand, the following description, in conjunction with specific illustrations, further elaborates on this utility model.

[0033] like Figure 1 As shown, this powdered chemotherapy drug reconstitution equipment is mainly used for reconstitution of powdered chemotherapy drugs, providing a hardware foundation for automated solvent injection and thorough shaking and dissolution of powdered chemotherapy drugs during the reconstitution process. The main structure includes a flipping mechanism 2 for batch flipping of vials 1, a rotating and shaking mechanism 3 for batch rotating of vials 1, and a solvent injection mechanism 4 for batch injection of solvent into vials 1.

[0034] like Figure 1 , Figure 2 As shown, the flipping mechanism 2 includes a base 201 made of medical-grade stainless steel, with suction cups around its bottom for attaching to and fixing to the biosafety countertop to prevent tipping. A flipping plate 203 is mounted directly above the base 201 via a pair of side plates 202. Connecting shafts are located at both ends of the flipping plate 203. One end of each connecting shaft is rotatably mounted on the corresponding side plate 202 via bearings, while the other connecting shaft is connected to the shaft of a worm gear drive motor 204, which drives the flipping action.

[0035] The rotating and mixing mechanism 3 includes a rotary motor 301 mounted on a tilting plate 203. The rotary motor 301 is a stepper motor, capable of accurately rotating each fixing slot 303 directly below the injection needle 401. It also includes a turntable 302 driven by the rotary motor 301, on which multiple fixing slots 303 for fixing vials 1 are evenly distributed along the same circumference. Rubber adapters 304 are installed within the fixing slots 303, with their outer sides interfering with the fixing slots. The inner diameter of the rubber adapters 304 varies to fit the outer diameter of vials 1 of different sizes. The use of rubber adapters 304 allows for the fixing of vials 1 of various sizes, expanding the applicability of this equipment.

[0036] like Figure 2 As shown, in some embodiments, a cover plate 205 for covering the fixing groove 303 is installed above the turntable 302. The cover plate 205 is a plastic circular plate. The cover plate 205 is provided with an injection window 206 that holds the body of the vial 1 and allows the top cover of the vial 1 to leak out. The injection window 206 is a circular hole.

[0037] like Figures 1-4 As shown, this equipment performs the following steps for batch reconstitution of powdered chemotherapy drugs:

[0038] (1) After sterilization, the vial 1 with the top cover opened is installed in the fixing groove 303 of the turntable 302, and the cover plate 205 is fixed by hand screwing.

[0039] (2) The rotary motor 301 (stepper motor) controls the turntable 302 to rotate a specific angle each time (for example, when 12 fixed slots 303 are set on the turntable 302, each rotation is 360° / 12=30°, and the needle tip of the injection needle 401 is aligned with the center of one of the fixed slots 303 at the initial position). At the same time, the injection needle 401 of the solvent injection mechanism 4 is driven by the lifting mechanism to insert into the rubber stopper of the vial 1 and inject the solvent into the vial 1 in a quantitative manner. According to the above steps, the operator controls the rotating shaking mechanism 3 and the solvent injection mechanism 4 to inject the solvent into the vial 1 one by one, and performs solid-liquid mixing in batches, which shortens the preparation, solvent extraction and injection time of multiple vials 1.

[0040] (3) After the solvent injection of all vials 1 is completed, the solvent injection mechanism 4 is controlled to retract the injection needle 401 upward to prevent it from affecting the flipping plate 203. The flipping plate 203 is driven from the initial fixed surface of vial 1 facing upward (0°) to the downward position (180°) and then back to the initial position. This is repeated 3-5 times. During this flipping process, the rotary motor 301 is started to drive the turntable 302 to maintain a low speed (3-6 r / min) to achieve a gentle and mild shaking effect. The turntable 302 is used to make the solvent roll gently in vial 1 so that the powdered chemotherapy drug can be fully dissolved in the solvent, thereby achieving reconstitution.

[0041] The worm gear drive motor 204 can also be controlled to drive the tilting plate 203 to stop at multiple specific angles. In the event of a power outage, the worm gear drive motor 204 can maintain the rotation angle of the tilting plate 203 (e.g., stopping at 45°, 90°, and 135°), ensuring the solvent flows fully across and covers the inner wall of the vial 1, resulting in more thorough mixing. The worm gear drive motor 204 provides stable stopping, ensuring a stable and precise injection process when rotating to the initial position. The motor portion of the worm gear drive motor 204 uses a stepper motor. The stepper motor drives the worm to rotate, causing the worm wheel that meshes with the worm to rotate as well. The shaft fixed in the center of the worm wheel drives the tilting plate 203 to rotate.

[0042] like Figure 2 As shown, in some embodiments, to facilitate the quick assembly and disassembly of the cover plate 205, the turntable 302 has a D-shaped threaded shaft 305 in the middle, and the cover plate 205 has a D-shaped hole 207 in the middle that mates with the D-shaped threaded shaft 305. The cover plate 205 is locked in place by a hand-tightening nut 306 that mates with the D-shaped threaded shaft 305. The D-shaped threaded shaft 305 mates with the D-shaped hole 207, allowing for quick alignment of the injection window 206 with the fixing groove 303 below. The D-shaped threaded shaft 305 mates with the hand-tightening nut 306, facilitating the operator to lock the cover plate 205 to the neck of the vial 1.

[0043] like Figure 2 As shown, in some embodiments, after locking the cover plate 205, the injection window 206 of the cover plate 205 may be tightly fixed to the neck of the vial 1. Manually removing them one by one is time-consuming and laborious. To facilitate the removal of the cover plate 205 and allow it to quickly detach from the neck of the vial 1, a return spring 307 is fitted on the D-shaped threaded shaft 305. The return spring 307 is located between the turntable 302 and the cover plate 205, with one end fixed to the turntable 302 by adhesive or snap-fit. After removing the hand-tightening screw, the cover plate 205 springs up under the action of the return spring 307, making it easy for the operator to remove it from the vial 1. To ensure more even force distribution on the cover plate 205 when it springs up, a larger diameter return spring 307 can be selected. When disassembling the hand-tightening nut 306, the return spring 307 simultaneously lifts the cover plate 205 from all sides.

[0044] like Figure 1 , Figure 3 As shown, the solvent injection mechanism 4 includes an injection needle 401, which is connected to the solvent via an infusion tube and a metering pump. The metering pump allows for the injection of a predetermined amount of solvent after the injection needle 401 is inserted into the corresponding vial 1. A lifting mechanism is also included, mounted on one side of the base 201 and driving the injection needle 401 to move up and down. The lifting mechanism can be implemented using a pneumatic cylinder, linear motor, or other similar methods.

[0045] like Figure 3 As shown, in some embodiments, to ensure that the injection needle 401 inserts more stably into the stopper of the vial 1, the lifting mechanism includes a housing 402, a lifting motor 403, a drive gear 404, a slide bar 405, a screw 406, a clamping slider 407, and a driven gear 408. The housing 402 is fixed to the base 201 by an L-shaped plate 409. The lifting motor 403 is installed inside the housing 402, and the shaft of the lifting motor 403 extends from the top of the housing 402. The drive gear 404 is fixed... The slide bar 405 is vertically mounted on the front of the housing 402, and the screw 406 is vertically mounted and rotatably mounted on the front of the housing 402. The driven gear 408 is fixed on the top of the screw 406 and meshes with the drive gear 404. The clamping slider 407 is sleeved on the slide bar 405. The middle part of the clamping slider 407 is engaged with the screw 406 through a threaded hole. The injection needle 401 is fixed on the clamping slider 407. The needle tip of the injection needle 401 is directly facing the center of the vial 1.

[0046] Using a larger diameter driven gear 408 to mesh with the drive gear 404 amplifies the torque, providing greater insertion and withdrawal force for the injection needle 401. A screw 406, in conjunction with a clamping slider 407, maintains the position of the injection needle 401. The lifting motor 403 can be a stepper motor, allowing precise control of the insertion distance by setting the motor's rotation angle (number of revolutions).

[0047] like Figure 3 As shown, in some embodiments, the clamping slider 407 includes a slider portion 410 and a clamping portion 411, both having mating semi-circular holes 412. The clamping portion 411 is fixed to the slider portion 410 by screws. The injection needle 401 is fixed in a pair of semi-circular holes 412, facilitating the replacement of the injection needle 401. When injecting vials 1 of different sizes, or in case of damage, the injection needle 401 has replaceable needle tips 413 of different sizes, allowing for quick replacement of the needle tip.

[0048] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of protection claimed by this utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A device for reconstituted powdered chemotherapy drugs, characterized in that, include: The flipping mechanism includes a base and a flipping plate mounted directly above the base via a pair of side plates, the flipping plate being driven by a worm gear motor; The rotating and shaking mechanism includes a rotary motor mounted on the flip plate and a turntable driven by the rotary motor. The turntable has a plurality of fixing grooves evenly distributed along the same circumference for fixing vials. The solvent injection mechanism includes an injection needle and a lifting mechanism mounted on one side of the base and driving the injection needle to move up and down.

2. The powder chemotherapy drug reconstitution device according to claim 1, characterized in that, A cover plate is installed above the turntable to cover the fixing groove. The cover plate has an injection window that holds the vial body in place and allows the vial cap to leak out.

3. The powder chemotherapy drug reconstitution device according to claim 2, characterized in that, The turntable has a D-shaped threaded shaft in the middle, and the cover plate has a D-shaped hole in the middle that mates with the D-shaped threaded shaft. The cover plate is locked and fixed by a hand-tightening nut that mates with the D-shaped threaded shaft.

4. The powdered chemotherapy drug reconstitution device according to claim 3, characterized in that, A return spring is fitted on the D-shaped threaded shaft. The return spring is located between the turntable and the cover plate, and one end of the return spring is fixed to the turntable.

5. The reconstitution device for powdered chemotherapy drugs according to claim 1, characterized in that, A rubber adapter is provided in the fixing groove. The outer side of the rubber adapter is interference-fitted with the fixing groove. The inner diameter of the rubber adapter adopts various specifications that are interference-fitted with the outer diameter of different sizes of vials.

6. The powdered chemotherapy drug reconstitution device according to claim 1, characterized in that, The injection needle is connected to the solvent via an infusion tube and a metering infusion pump.

7. The powdered chemotherapy drug reconstitution device according to claim 1, characterized in that, The lifting mechanism includes a housing, a lifting motor, a drive gear, a slide rod, a screw, a clamping slider, and a driven gear. The housing is fixed to the base via an L-shaped plate. The lifting motor is installed inside the housing, and its shaft extends from the top of the housing. The drive gear is fixed to the shaft of the lifting motor. The slide rod is vertically installed in front of the housing. The screw is vertically and rotatably installed in front of the housing. The driven gear is fixed to the top of the screw and meshes with the drive gear. The clamping slider is sleeved on the slide rod, and its center engages with the screw via a threaded hole. The injection needle is fixed on the clamping slider, with the needle tip aligned with the center of the vial.

8. The powder chemotherapy drug reconstitution device according to claim 7, characterized in that, The clamping slider includes a slider part and a clamping part, both of which are provided with matching semi-circular holes. The clamping part is fixed to the slider part by screws, and the injection needle is fixed in a pair of semi-circular holes.

9. The reconstitution device for powdered chemotherapy drugs according to claim 1, characterized in that, One end of the flip plate is hinged to the side plate on the corresponding side, and the other end of the flip plate is connected to the shaft of the worm gear drive motor fixed on the side plate on the other side.

10. The powder chemotherapy drug reconstitution device according to claim 1, characterized in that, The injection needle has interchangeable needles of different sizes.

Images