A liquid dispensing chromatography system architecture

Abstract

The utility model discloses a kind of liquid preparation chromatography system structure, to solve the problem of cross contamination in prior art, system cannot be effectively evacuated, pump speed is easily affected by column pressure. It includes cabinet, inlet valve, outlet valve, power mechanism, flowmeter, anti-mixing valve, bubble trap, bypass & evacuation valve, proportional control valve, column valve and detector etc.;Power mechanism includes 2~6 power pumps, anti-mixing valve after each pump is integrated in a valve island, pump after to evacuation port pipeline is horizontal flow direction, facilitate evacuation, proportional control valve simulates column pressure to prepare liquid;The utility model is applicable to liquid preparation chromatography work, ensure the working effect and practicality of device.

Description

Technical Field

[0001] This utility model belongs to the technical field of liquid preparation chromatography system structure, and specifically relates to a liquid preparation chromatography system structure. Background Technology

[0002] The solution preparation chromatography system integrates the online solution preparation system with the chromatography system, eliminating the intermediate solution storage step, saving operating space, and improving solution preparation chromatography efficiency.

[0003] Currently, in the liquid preparation chromatography systems used by domestic users, there are often parallel flow paths after the pumps of different power pumps, which can easily lead to cross-contamination. Flow meters are mostly installed vertically, which makes it easy for liquid to accumulate in the pipeline after the pump and cannot be effectively emptied. When switching from liquid preparation to column inlet, the pump speed is easily affected by the column pressure, which is not in line with practical applications and affects the practicality of the device. Utility Model Content

[0004] (1) Technical problems to be solved To address the shortcomings of existing technologies, the purpose of this utility model is to provide a liquid preparation chromatography system structure. This liquid preparation chromatography system structure aims to solve the technical problems in existing technologies, such as the parallel flow paths after pumps of different power pumps, which easily lead to cross-contamination; the vertical installation of flow meters, which easily causes liquid to accumulate in the pipeline after pumps and cannot be effectively emptied; and the fact that the pump speed is easily affected by column pressure when switching to column inlet during the liquid preparation process, which is not in line with practical applications and affects the practicality of the device.

[0005] (2) Technical solution To address the aforementioned technical problems, this utility model provides a liquid preparation chromatography system structure, including a cabinet, a power pump installed in the cabinet, and an anti-mixing valve connected to the power pump. The anti-mixing valve is connected to a bubble trap via a pipe, and a bypass vent valve is connected to the bottom of the anti-mixing valve. The anti-mixing valve is connected to a pre-column pH / conductivity detector via a pipe, and the pre-column pH / conductivity detector is connected to a pre-column pressure sensor via a pipe. A proportional control valve is installed on the pipe at the top of the pre-column pH / conductivity detector, a column position valve is installed on the pipe at the top of the proportional control valve, and a post-column pH / conductivity detector and an ultraviolet detector are installed on the pipe at the top of the column position valve. An outlet valve is fixedly installed on the pipe at one end of the ultraviolet detector.

[0006] Preferably, the flow meter is installed horizontally; the anti-mixing valve is in the form of a valve island and is located at the intersection of the flow paths of each pump; a static mixer is provided after the anti-mixing valve; the pipeline from the power pump to the vent is horizontal.

[0007] Furthermore, the proportional regulating valve is located at the bottom end of the column-front pressure sensor and is installed at the branch position.

[0008] Furthermore, the inlet valve and outlet valve are connected to a SIP valve; a three-inlet valve island is provided below the SIP valve.

[0009] Furthermore, one end of the cabinet is equipped with a computer, keyboard, air filter, emergency stop button, power indicator light, buzzer alarm, and power switch; and the other end of the cabinet is equipped with a three-way air supply unit, wherein the bottom of the cabinet is equipped with casters, fixed feet, vent, one-way valve, and vent pipe.

[0010] Furthermore, the power pump is a diaphragm pump, and the number is 2 to 6 units. A pressure sensor is installed after the power pump.

[0011] Furthermore, the bubble trap is equipped with a level gauge, and a first bubble sensor and a second bubble sensor are respectively installed before and after the bubble trap.

[0012] Furthermore, the number of column position valves is 1 to 2, and a column pressure sensor is provided after each column position valve.

[0013] Furthermore, the inlet valve, anti-mixing valve, bypass venting valve, proportional regulating valve, column position valve, outlet valve, SIP valve, and one-in-three-out valve island all adopt pneumatic diaphragm valves.

[0014] (3) Beneficial effects Compared with the prior art, the beneficial effects of this utility model are as follows: This utility model integrates the anti-mixing valves after each pump into a valve island, located at the intersection of each pump flow path, which can effectively avoid the problem of cross-contamination between the pump flow paths; The flow direction is horizontal throughout the pipeline from the pump to the drain port. The flow meter is installed horizontally, which can effectively avoid the problem of liquid accumulation in the pipeline after the pump and ineffective drainage. By using a proportional control valve to simulate column pressure for liquid preparation and then switching to column inlet mode, the problem of pump speed being affected by column pressure can be effectively avoided. Attached Figure Description

[0015] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a left view of the liquid preparation chromatography system.

[0017] Figure 2 This is a top view of the liquid preparation chromatography system.

[0018] Figure 3This is a rear view of the liquid preparation chromatography system.

[0019] Figure 4 This is a three-dimensional diagram of the liquid preparation chromatography system.

[0020] The labels in the attached diagram are as follows: 1. Cabinet; 2. Air filter; 3. Computer; 4. Emergency stop button; 5. Power indicator light; 6. Bubble alarm; 7. Keyboard; 8. Power switch; 9. Casters; 10. Fixed support feet; 11. Anti-mixing valve; 12. Static mixer; 13. First bubble sensor; 14. Bypass vent valve; 15. Second bubble sensor; 16. Vent port; 17. Check valve; 18. Pre-column pH / conductivity detector; 19. Vent pipe; 20. One-in-three-out valve island; 21. Proportional regulating valve; 22. Pre-column pressure sensor; 23. Gas source triplet; 24. Column position valve; 25. SIP valve; 26. Outlet valve; 27. Ultraviolet detector; 28. Post-column pH / conductivity detector; 29. ​​Post-column pressure sensor; 30. Bubble trap; 31. Post-pump pressure sensor; 32. Power pump; 33. Inlet valve; 34. Flow meter. Detailed Implementation

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] This specific embodiment describes a liquid preparation chromatography system structure, the schematic diagram of which is shown below. Figures 1 to 4As shown, the system includes a cabinet 1, a power pump 32 housed within the cabinet 1, and an anti-mixing valve 11 connected to the power pump 32. An inlet valve 33 is installed on one side of the power pump 32, and a flow meter 34 is fixed to the top of the power pump 32's pipe. The anti-mixing valve 11 is connected to a bubble trap 30 via a pipe, and a bypass vent valve 14 is connected to the bottom of the anti-mixing valve 11. The anti-mixing valve 11 is connected to a pre-column pH / conductivity detector 18 via a pipe, and the pre-column pH / conductivity detector 18 is connected to a pre-column pressure sensor 22 via a pipe. A proportional control valve 21 is installed on the pipe at the top of the pH / conductivity detector 18. A column position valve 24 is installed on the pipe at the top of the proportional control valve 21. A post-column pH / conductivity detector 28 and an ultraviolet detector 27 are installed on the pipe at the top of the column position valve 24. An outlet valve 26 is fixedly installed on the pipe at one end of the ultraviolet detector 27. The flow meter 34 is installed horizontally. The anti-mixing valve 11 adopts a valve island form and is located at the intersection of the flow paths of each pump. A static mixer 12 is provided after the anti-mixing valve 11. The pipeline from the power pump 32 to the vent 16 is horizontal. The proportional regulating valve 21 is located in front of or behind the column pressure sensor 22, and is installed in the branch position; the inlet valve 33 and outlet valve 26 are connected to the SIP valve 25; a three-inlet valve island 20 is provided below the SIP valve 25; the cabinet 1 is equipped with a computer 3, keyboard 7, air filter 2, emergency stop button 4, power indicator light 5, buzzer alarm 6, and power switch 8; the bottom of the cabinet is equipped with casters 9, fixed support feet 10, vent 16, check valve 17, and vent pipe 19; a three-unit air source assembly 23 is provided at the rear of the cabinet; the power pump 32 adopts... Diaphragm pumps, numbered 2 to 6, with a pump pressure sensor 31 after the power pump 32; bubble trap 30 is equipped with a level gauge, and bubble sensors 13 and 15 are installed before and after the bubble trap (30); column position valves 24, numbered 1 to 2, with a column pressure sensor 29 after the column position valve 24; inlet valve 33, anti-mixing valve 11, bypass vent valve 14, proportional regulating valve 21, column position valve 24, outlet valve 26, SIP valve 25, and one-in-three-out valve island 20 all adopt pneumatic diaphragm valves; the front of the cabinet 1 faces forward, left, or right.

[0023] Example 1: Liquid Preparation Chromatography Mode When operating in liquid preparation chromatography mode, the liquid enters the power pump 32 through inlet valve 33, then passes through pump post-pressure sensor 31 and flow meter 34. The liquids in each pump flow path converge at anti-mixing valve 11 and then enter static mixer 12. After passing through first bubble sensor 13, it enters or bypasses bubble trap 30 through bypass vent valve 14, passes through second bubble sensor 15, pre-column pH / conductivity detector 18, and pre-column pressure sensor 22, and then passes through proportional control valve 21 on the branch for liquid preparation and waste discharge. When the parameters of pre-column pH / conductivity detector 18 meet the process requirements, the branch of proportional control valve 21 is closed, and the system switches to column inlet mode. The liquid passes through column position valve 24, post-column pressure sensor 29, post-column pH / conductivity detector 28, and UV detector 27, and flows out through outlet valve 26. When the target substance is detected by post-column pH / conductivity detector 28 and UV detector 27, the outlet valve 26 is switched for collection.

[0024] Example 2: System Cleaning (CIP) Mode When operating the system in Clean In-Place (CIP) mode, all inlets and outlets of inlet valve 33 and outlet valve 26 are opened, and all power pumps 32 are started simultaneously. Liquid enters the power pump 32 through inlet valve 33, then passes through pump post-pressure sensor 31 and flow meter 34. Liquid in each pump flow path converges at anti-mixing valve 11 and then enters static mixer 12. After passing through first bubble sensor 13, it enters through bypass vent valve 14 or bypass bubble trap 30, passes through second bubble sensor 15, pre-column pH / conductivity detector 18, and pre-column pressure sensor 22, and flows out through proportional regulating valve 21 on the branch. Alternatively, the branch of proportional regulating valve 21 can be closed to the column inlet state. Liquid passes through column position valve 24, post-column pressure sensor 29, post-column pH / conductivity detector 28, and UV detector 27, and flows out through outlet valve 26. According to the CIP process, by switching the state of bypass vent valve 14, the state of proportional regulating valve 21 branch, and the state of column position valve 24, it is ensured that each flow path is cleaned in place.

[0025] Example 3: Steam In-Place (SIP) Mode When operating in steam inlet (SIP) mode, only the flow paths of inlet valve 33 and outlet valve 26 connected to the storage tank pipeline are activated, without the need to start the power pump 32. According to the SIP process, one or more inlets and outlets of inlet valve 33 and outlet valve 26 are opened, and at the same time, SIP valve 25 is switched to be connected to the one-inlet-three-outlet valve island 20 and isolated from the main pipeline of the chromatography system. The one-inlet-three-outlet valve island 20 can be switched to be connected to the SIP reflux, waste discharge pipeline or condensate pipeline according to the process.

[0026] Example 4: Emptying Mode When running in venting mode, inlet 1 of each inlet valve 33 is open, all ports of anti-mixing valve 11 are open, all ports of bypass venting valve 14 are open, proportional regulating valve 21 is 100% open, branch and column inlet are open, column position valve 24 is in bypass state, and outlet 1 of outlet valve 26 is open, thus achieving automatic venting.

[0027] All technical features in this embodiment can be freely combined according to actual needs.

[0028] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A liquid preparation chromatography system structure, characterized in that, The system includes a cabinet (1) and a power pump (32) installed in the cabinet (1), and an anti-mixing valve (11) connected to the power pump (32). An inlet valve (33) is installed on one side of the power pump (32), and a flow meter (34) is fixed at the top of the pipe of the power pump (32). The anti-mixing valve (11) is connected to a bubble trap (30) through a pipe, and a bypass vent valve (14) is connected to the bottom of the anti-mixing valve (11). The anti-mixing valve (11) is connected to a pre-column pH / conductivity detector (18) through a pipe. The pre-column pH / conductivity detector (18) is connected to a pre-column pressure sensor (22) via a pipe, and a proportional control valve (21) is installed on the pipe at the top of the pre-column pH / conductivity detector (18). A column position valve (24) is installed on the pipe at the top of the proportional control valve (21). A post-column pH / conductivity detector (28) and an ultraviolet detector (27) are installed on the pipe at the top of the column position valve (24). An outlet valve (26) is fixedly installed on the pipe at one end of the ultraviolet detector (27).

2. The structure of the liquid preparation chromatography system according to claim 1, characterized in that, The flow meter (34) is installed horizontally; the anti-mixing valve (11) is in the form of a valve island and is located at the intersection of the flow paths of each pump. A static mixer (12) is provided after the anti-mixing valve (11); the pipeline from the power pump (32) to the drain port (16) is horizontal.

3. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, The proportional control valve (21) is located at the bottom end of the column front pressure sensor (22) and is installed at the branch position.

4. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, The inlet valve (33) and outlet valve (26) are connected to a SIP valve (25); a three-inlet valve island (20) is provided below the SIP valve (25).

5. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, One end of the cabinet (1) is equipped with a computer (3), keyboard (7), air filter (2), emergency stop button (4), power indicator light (5), buzzer alarm (6), and power switch (8); and the other end of the cabinet is equipped with a gas source triple unit (23), wherein the bottom of the cabinet is equipped with casters (9), fixed support feet (10), vent (16), one-way valve (17), and vent pipe (19).

6. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, The power pump (32) is a diaphragm pump, and there are 2 to 6 units. A pump pressure sensor (31) is installed after the power pump (32).

7. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, The bubble trap (30) is equipped with a level gauge, and a first bubble sensor (13) and a second bubble sensor (15) are respectively provided in front of and behind the bubble trap (30).

8. The structure of a liquid preparation chromatography system according to claim 1, characterized in that, The number of column position valves (24) is 1 to 2, and a column pressure sensor (29) is provided after the column position valve (24).

9. The structure of a liquid preparation chromatography system according to claim 4, characterized in that, The inlet valve (33), anti-mixing valve (11), bypass vent valve (14), proportional regulating valve (21), column position valve (24), outlet valve (26), SIP valve (25), and one-in-three-out valve island (20) are all pneumatic diaphragm valves.

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