A three-phase reaction apparatus for non-naloxone synthesis

Abstract

The utility model relates to the technical field of reaction equipment, especially a kind of three-phase reaction equipment for non-naratriptan synthesis, it is swung to material by swinging device, by processing bin provides reaction place, by heating device, the material in processing bin is heated, by stirring device, the material in processing bin is stirred, by injection device carries out reaction gas injection;Including operation platform;Still include swinging device, processing bin, heating device, stirring device and injection device, swinging device is installed on operation platform, processing bin and injection device are all installed on swinging device, heating device and stirring device are all installed on processing bin;Swing, processing bin provides reaction place, heating device heats, stirring device stirs, and injection device carries out gas injection.

Description

Technical Field

[0001] This utility model relates to the technical field of reaction equipment, and in particular to a three-phase reaction apparatus for the synthesis of non-nelitonee. Background Technology

[0002] Fennellone is an important pharmaceutical ingredient. In the synthesis process of high-value-added drugs such as fenelone, a gas-liquid-solid three-phase reaction is often involved. At present, the industry generally uses mechanically stirred tanks or fixed-bed reactors to complete such processes. In order to achieve rapid and efficient reactions, a three-phase reaction device for the synthesis of fenelone has emerged.

[0003] For example, in a class of prior art represented by application number CN201720443171.0, the main structure includes a reaction chamber, a feed pipe, valves, a stirring device, a heating device, and a discharge device. A feed pipe with a valve is located on the upper right side of the reaction chamber; a stirring device is located at the center of the top of the reaction chamber; a heating device is located at the bottom of the reaction chamber; and a discharge device is located on the lower left side of the reaction chamber. This invention uses a stirring device to stir the raw materials, thereby promoting the reaction; a heating device to heat the raw materials, thereby accelerating the reaction rate; and finally, a discharge device.

[0004] During use, it was found that the synthesis of high-value-added drugs such as fenelone often involves a gas-liquid-solid three-phase reaction. Existing reaction equipment relies on the shear force generated by the rotation of internal impellers, which easily creates mixing dead zones within the reactor, resulting in insufficient contact between the gas, liquid, and solid phases. For processes like fenelone synthesis, which require extremely high reaction uniformity, this leads to decreased reaction selectivity, increased byproducts, and affects the optical purity of the final product. Therefore, there is an urgent need for a three-phase reaction device for fenelone synthesis. Utility Model Content

[0005] To solve the above-mentioned technical problems, this utility model provides a three-phase reaction device for the synthesis of non-nelitone ketone, which uses a swaying device to sway the material, a processing chamber to provide a reaction site, a heating device to heat the material in the processing chamber, a stirring device to stir the material in the processing chamber, and an injection device to inject reaction gas.

[0006] This invention discloses a three-phase reaction apparatus for the synthesis of phenelzine, comprising an operating table; and further comprising a swaying device, a processing chamber, a heating device, a stirring device, and an injection device. The swaying device is mounted on the operating table, the processing chamber and the injection device are both mounted on the swaying device, and the heating device and the stirring device are both mounted on the processing chamber. The swaying device sways the material, the processing chamber provides the reaction site, the heating device heats the material in the processing chamber, the stirring device stirs the material in the processing chamber, and the injection device injects the reaction gas.

[0007] Preferably, the operating table includes a base, a bracket, and a fixed seat. The base is installed in the working area, the bracket is installed at the top of the base, and the fixed seat is installed at the side of the bracket; the base, bracket, and fixed seat provide support.

[0008] Preferably, the swing device includes a motor and a rotating shaft. The motor is mounted on the side of the bracket, and the output end of the motor is rotatably connected to the input end of the rotating shaft. A retaining sleeve is provided on the rotating shaft. When the motor is started, the rotating shaft and the retaining sleeve are driven to rotate.

[0009] Preferably, the processing chamber includes a chamber body and a discharge pipe. The chamber body is mounted on a sleeve, and the discharge pipe is connected to the bottom end of the chamber body. A valve is provided on the discharge pipe. When the valve is opened, the reacted drug in the chamber body is discharged through the output end of the discharge pipe.

[0010] Preferably, the heating device includes an electric heater, which is mounted on the chamber and equipped with a controller; the controller controls the electric heater and heats the medicine in the chamber.

[0011] Preferably, the stirring device includes a sealing cover, a feed pipe, a second motor, and a motor shaft. The sealing cover is installed on the top of the chamber by screws, the feed pipe is connected to the top of the sealing cover, the second motor is installed on the top of the sealing cover, and the output end of the second motor is rotatably connected to the input end of the motor shaft. The motor shaft is equipped with multiple sets of stirring blades, and the side ends of the stirring blades are equipped with scrapers. Solid and liquid raw materials are poured into the chamber through the feed pipe. When the second motor is started, the motor shaft, stirring blades, and scrapers are driven to rotate. The stirring blades stir the raw materials, and the scrapers scrape off the residue on the inner wall of the chamber.

[0012] Preferably, the injection device includes a power pump, a first air pipe, a hose, and a second pipe. The power pump is installed at the top of the fixed base. The input end of the power pump is connected to the output end of the first air pipe, the output end of the power pump is connected to the input end of the hose, the output end of the hose is connected to the input end of the second pipe, the second pipe passes through a sealing cover, and multiple sets of nozzles are connected to the output end of the second pipe. When the power pump is started, the gas in the raw material enters through the input end of the first air pipe, the gas flows along the hose and the second pipe, and the nozzles discharge the gas into the chamber.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows: the material is swung by a swaying device, a reaction site is provided by a processing chamber, the material in the processing chamber is heated by a heating device, the material in the processing chamber is stirred by a stirring device, and the reaction gas is injected by an injection device. Attached Figure Description

[0014] Figure 1 This is an isometric drawing of the structure of this utility model; Figure 2 yes Figure 1 Structural isometric drawing of the operating table and swing device in this utility model; Figure 3 yes Figure 1 Exploded view of the structure of the operating table and swing device in this utility model; Figure 4 This is an isometric drawing of the structure of this utility model; Figure 5 yes Figure 1 Enlarged isometric view of the stirring device and injection device structure in this utility model.

[0015] The attached diagram is labeled as follows: 01, operating table; 11, base; 12, bracket; 13, fixed seat; 02, swing device; 21, motor one; 22, rotating shaft; 23, ferrule; 03, processing chamber; 31, chamber body; 32, discharge pipe; 33, valve; 04, heating device; 41, electric heater; 42, controller; 05, stirring device; 51, sealing cover; 52, feed pipe; 53, motor two; 54, motor shaft; 55, stirring blade; 56, scraper; 06, injection device; 61, power pump; 62, first air pipe; 63, hose; 64, second pipe; 65, nozzle. Detailed Implementation

[0016] To facilitate understanding of this utility model, a more complete description will be given below with reference to the accompanying drawings. This utility model can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to make the disclosure of this utility model more thorough and complete.

[0017] Example 1 A three-phase reaction apparatus for the synthesis of phenelzine includes an operating table 01; characterized in that it further includes a rocking device 02, a processing chamber 03, a heating device 04, a stirring device 05, and an injection device 06, wherein the rocking device 02 is mounted on the operating table 01, the processing chamber 03 and the injection device 06 are both mounted on the rocking device 02, and the heating device 04 and the stirring device 05 are both mounted on the processing chamber 03. The swaying device 02 sways, the processing chamber 03 provides a reaction site, the heating device 04 heats, the stirring device 05 stirs, and the injection device 06 injects gas. The operating table 01 includes a base 11, a bracket 12 and a fixed seat 13. The base 11 is installed in the working area, the bracket 12 is installed on the top of the base 11, and the fixed seat 13 is installed on the side of the bracket 12. The swing device 02 includes a motor 21 and a rotating shaft 22. The motor 21 is mounted on the side of the bracket 12. The output end of the motor 21 is rotatably connected to the input end of the rotating shaft 22. A retainer 23 is provided on the rotating shaft 22. The processing chamber 03 includes a chamber body 31 and a discharge pipe 32. The chamber body 31 is mounted on the sleeve 23, and the discharge pipe 32 is connected to the bottom end of the chamber body 31. A valve 33 is provided on the discharge pipe 32. The stirring device 05 includes a sealing cover 51, a feed pipe 52, a second motor 53, and a motor shaft 54. The sealing cover 51 is installed on the top of the chamber 31 by screws. The feed pipe 52 is connected to the top of the sealing cover 51. The second motor 53 is installed on the top of the sealing cover 51. The output end of the second motor 53 is rotatably connected to the input end of the motor shaft 54. Multiple sets of stirring blades 55 are provided on the motor shaft 54. The side end of the stirring blades 55 is provided with a scraper 56. The injection device 06 includes a power pump 61, a first air pipe 62, a hose 63, and a second pipe 64. The power pump 61 is installed at the top of the fixed base 13. The input end of the power pump 61 is connected to the output end of the first air pipe 62. The output end of the power pump 61 is connected to the input end of the hose 63. The output end of the hose 63 is connected to the input end of the second pipe 64. The second pipe 64 passes through the sealing cover 51. Multiple sets of nozzles 65 are connected to the output end of the second pipe 64. The swaying device 02 sways, the processing chamber 03 provides a reaction site, the stirring device 05 stirs, and the injection device 06 injects gas. Solid and liquid raw materials are poured into the chamber 31 through the feed pipe 52. After the addition is complete, the feed pipe 52 is sealed. Then, the gas in the raw materials is introduced into the chamber 31 through the input end of the first gas pipe 62 by starting the power pump 61. The gas flows along the hose 63 and the second pipe 64. The nozzle 65 discharges the gas into the chamber 31. Then, the motor 53 is started, which drives the motor shaft 54, the stirring blade 55 and the scraper 56 to rotate. The stirring blade 55 stirs the raw materials and the scraper 56 scrapes off the residue on the inner wall of the chamber 31. Then, the motor 21 is started, which drives the rotating shaft 22 and the clamp 23 to rotate, causing the chamber 31 to swing left and right to mix the materials evenly. When the specified reaction time is reached, the motor 21, the electric heater 41 and the motor 53 are stopped. Then, the valve 33 is opened, and the reacted drug in the chamber 31 is discharged through the output end of the discharge pipe 32.

[0018] Example 2 like Figures 1 to 5 As shown, in addition to Embodiment 1, a heating device 04 is also included; The heating device 04 includes an electric heater 41, which is mounted on the chamber 31 and has a controller 42. Heating device 04 performs heating; The controller 42 controls the electric heater 41, and heats the medicine in the chamber 31.

[0019] This invention discloses a three-phase reaction apparatus for the synthesis of phenelzine. During operation, solid and liquid raw materials are first poured into the chamber 31 through the feed pipe 52. After addition, the feed pipe 52 is sealed. Then, by starting the power pump 61, gas from the raw materials enters through the input end of the first gas pipe 62. The gas flows along the hose 63 and the second pipe 64, and the nozzle 65 discharges the gas into the chamber 31. Next, by starting the second motor 53, the motor shaft 54, stirring blade 55, and scraper 56 rotate. The stirring blade 55 agitates the raw materials. The mixture is stirred, and the scraper 56 scrapes off the residue on the inner wall of the chamber 31. Then, the controller 42 controls the electric heater 41 to heat the medicine in the chamber 31. At the same time, the motor 21 is started, which drives the rotating shaft 22 and the clamp 23 to rotate, causing the chamber 31 to swing left and right to mix the materials evenly. When the specified reaction time is reached, the motor 21, the electric heater 41 and the motor 53 are stopped. Then, the valve 33 is opened to discharge the reacted medicine in the chamber 31 through the output end of the discharge pipe 32.

[0020] The motor 21, electric heater 41, motor 53, and power pump 61 of this utility model are commercially available. Technical personnel in this industry only need to install and operate them according to the accompanying instruction manual, without requiring any creative work from those skilled in the art.

[0021] The main function achieved by this invention is to achieve uniform mixing of solid, liquid and gaseous raw materials through swaying.

[0022] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A three-phase reaction apparatus for the synthesis of phenelzine, comprising an operating table (01); characterized in that, It also includes a swing device (02), a processing chamber (03), a heating device (04), a stirring device (05), and an injection device (06). The swing device (02) is installed on the operating table (01), the processing chamber (03) and the injection device (06) are both installed on the swing device (02), and the heating device (04) and the stirring device (05) are both installed on the processing chamber (03). The swaying device (02) sways, the processing chamber (03) provides a reaction site, the heating device (04) heats, the stirring device (05) stirs, and the injection device (06) injects gas.

2. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 1, characterized in that, The operating table (01) includes a base (11), a bracket (12) and a fixed seat (13). The base (11) is installed in the working area, the bracket (12) is installed on the top of the base (11), and the fixed seat (13) is installed on the side of the bracket (12).

3. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 2, characterized in that, The swing device (02) includes a motor (21) and a rotating shaft (22). The motor (21) is mounted on the side of the bracket (12). The output end of the motor (21) is rotatably connected to the input end of the rotating shaft (22). A retainer (23) is provided on the rotating shaft (22).

4. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 3, characterized in that, The processing chamber (03) includes a chamber body (31) and a discharge pipe (32). The chamber body (31) is installed on a sleeve (23), and the discharge pipe (32) is connected to the bottom end of the chamber body (31). A valve (33) is provided on the discharge pipe (32).

5. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 4, characterized in that, The heating device (04) includes an electric heater (41), which is mounted on the chamber (31) and a controller (42) is provided on the electric heater (41).

6. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 4, characterized in that, The stirring device (05) includes a sealing cover (51), a feed pipe (52), a second motor (53), and a motor shaft (54). The sealing cover (51) is installed on the top of the chamber (31) by screws. The feed pipe (52) is connected to the top of the sealing cover (51). The second motor (53) is installed on the top of the sealing cover (51). The output end of the second motor (53) is rotatably connected to the input end of the motor shaft (54). Multiple sets of stirring blades (55) are provided on the motor shaft (54). A scraper (56) is provided on the side end of the stirring blade (55).

7. The three-phase reaction apparatus for the synthesis of phenelzine as described in claim 6, characterized in that, The injection device (06) includes a power pump (61), a first air pipe (62), a hose (63), and a second pipe (64). The power pump (61) is installed at the top of the fixed base (13). The input end of the power pump (61) is connected to the output end of the first air pipe (62). The output end of the power pump (61) is connected to the input end of the hose (63). The output end of the hose (63) is connected to the input end of the second pipe (64). The second pipe (64) passes through the sealing cover (51). Multiple sets of nozzles (65) are connected to the output end of the second pipe (64).

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