A cleaning device for capillary gas chromatography columns

Abstract

The utility model relates to chromatographic column cleaning technical field especially is related to a kind of cleaning device for capillary gas chromatographic column, it include: infusion pump, provide conveying power for cleaning solvent;Solvent bottle, mobile place in infusion pump;Hose, connect between infusion pump and solvent bottle;Connecting pipe, with the output end of infusion pump mobile sleeve joint;Transmission pipe, with the one end of connecting pipe away from infusion pump connection;Two-way connecting device, one end is connected with transmission pipe;Chromatographic column, it is located in two-way connecting device one side, and it is connected with two-way connecting device far from transmission pipe one end by column tube;Waste liquid bottle, with column tube export end is connected.The utility model provides the cleaning device by infusion pump provides stable power and by the sealing design of two-way connecting device two sides can guarantee the stable delivery of cleaning solvent, and there is no leakage in conveying process.

Description

Technical Field

[0001] This utility model relates to the field of chromatographic column cleaning technology, and in particular to a cleaning device for capillary gas chromatography columns. Background Technology

[0002] Gas chromatography (GC) is a commonly used separation and detection method, widely applied in fields such as petrochemicals, pharmaceuticals, environmental monitoring, biochemistry, and food testing. The most commonly used chromatographic column in GC is the capillary GC column, which offers advantages such as high separation efficiency, fast analysis speed, high sensitivity, low eddy diffusion, narrow peak detection, and good peak symmetry. However, capillary GC columns also have disadvantages such as susceptibility to contamination and difficulty in removing contaminants.

[0003] Existing cleaning methods are mainly divided into negative pressure method and gas source pressurization method for solvent bottle; negative pressure method uses negative pressure as pressure source, the negative pressure source is connected to capillary gas chromatography column, and under the action of negative pressure, the solvent is drawn into the capillary chromatography column to play a cleaning role. The gas-source pressurization method, also known as the gas-pressure-driven liquid method, involves connecting a capillary gas chromatography column to a solvent bottle, with the column submerged below the solvent surface. The solvent bottle is connected to a pressurized gas source (usually a nitrogen cylinder). The pressure from the gas source acts on the solvent surface, forcing the solvent to flow through the column to release the pressure. However, existing cleaning methods have several drawbacks: Negative pressure method: Negative pressure sources are inconvenient to use, and leaks at the device contacts are difficult to avoid under negative pressure. This limits the length of the capillary gas chromatography column (around 10 meters) suitable for this method, as insufficient pressure prevents the solvent from completely passing through the column. Gas-source pressurization method for solvent bottles: Requires high pressure resistance from the solvent bottle. High-pressure gas operation poses potential safety risks, and leaks at the device contacts are difficult to avoid. Utility Model Content

[0004] Therefore, it is necessary to provide a cleaning device for capillary gas chromatography columns that can conveniently clean longer chromatographic columns without causing leakage at the joints, in order to address the above-mentioned technical problems.

[0005] This utility model provides a cleaning device for capillary gas chromatography columns, comprising: Infusion pumps provide the power to deliver cleaning solvents; The solvent bottle is movably placed inside the infusion pump; A flexible tube connects the infusion pump to the solvent bottle; A connecting pipe is movably connected to the output end of the infusion pump; A transmission tube is connected to the end of the connecting tube furthest from the infusion pump; A two-way connecting device, one end of which is connected to the transmission pipe; A chromatographic column is located on one side of the two-way connection device and is connected to the end of the two-way connection device away from the transfer tube via a column tube. The waste liquid bottle is connected to the outlet end of the column tube.

[0006] In one embodiment, the liquid delivery flow rate of the infusion pump is adjustable from 0.01 ml / min to 10 ml / min, and the output pressure is not less than the minimum pressure required for the cleaning solvent to flow through the chromatographic column.

[0007] In one embodiment, the two-way connection device includes a main body shell, a flow channel disposed inside the main body shell, and a first connection end and a second connection end respectively disposed at both ends of the main body shell; the first connection end is used to connect the transmission tube, and the second connection end is used to connect the column tube.

[0008] In one embodiment, the first connecting end is provided with a threaded tightening structure and a conical sealing joint. The threaded tightening structure compresses the conical sealing joint to achieve a sealed connection with the transmission pipe.

[0009] In one embodiment, the second connecting end is provided with a tightening screw and a sealing gasket. The sealing gasket is located in the hollow part of the main body shell. The sealing gasket is deformed by the tightening screw, thereby achieving a sealed connection with the column tube.

[0010] In one embodiment, the flow channel has a preset volume for achieving a smooth transition and delivery of the cleaning solvent.

[0011] In one embodiment, the waste liquid bottle is provided with an inlet connector and a outlet connector. The inlet connector is connected to the column tube, and the outlet connector is connected to the external environment to balance the pressure inside the bottle.

[0012] In one embodiment, an inlet connector is provided on one side of the column tube, which is connected to the transmission tube, and an outlet connector is provided on the other side of the column tube, which is connected to the inlet connector of the waste liquid bottle.

[0013] In one embodiment, the main body shell is made of a corrosion-resistant material.

[0014] In one embodiment, the cleaning solvent includes one or more combinations of methanol, ethanol, dichloromethane, and n-hexane.

[0015] The aforementioned cleaning device for capillary gas chromatography columns provides stable power through a pump and ensures smooth delivery of the cleaning solvent through a sealed design on both sides of the double-port connection device, preventing leakage during delivery. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the structure of the double-pass connecting device in this utility model; Figure 3 This is a schematic diagram of the chromatographic column in this invention; Figure 4 This is a schematic diagram of the waste liquid bottle in this utility model.

[0018] Figure label: 1. Infusion pump; 2. Solvent bottle; 3. Tube; 4. Connecting tube; 5. Transfer tube; 6. Two-way connector; 61. Main body shell; 62. Flow channel; 63. First connecting end; 64. Second connecting end; 65. Threaded tightening structure; 66. Conical sealing joint; 67. Tightening screw; 68. Sealing gasket; 7. Chromatographic column; 8. Column tube; 9. Waste liquid bottle; 10. Inlet connector; 11. Discharge connector; 12. Inlet connector; 13. Outlet connector. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0020] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on the other component or there may be an intermediate component. When a component is considered to be "connected to" another component, it can be directly connected to the other component or there may be an intermediate component present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this specification are for illustrative purposes only and do not represent the only possible implementation.

[0021] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0022] In this utility model, unless otherwise explicitly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature and the second feature are in indirect contact through an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0023] Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by one of ordinary skill in the art to which this specification belongs. The terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used in this specification includes any and all combinations of one or more of the associated listed items.

[0024] The following is combined Figures 1-4 This invention describes a cleaning device for a capillary gas chromatography column.

[0025] like Figures 1-4 As shown, in one embodiment, a cleaning device for a capillary gas chromatography column 7 includes: a pump 1 for providing power to deliver cleaning solvent; Solvent bottle 2 is movably placed inside infusion pump 1; Tube 3 connects the infusion pump 1 and the solvent bottle 2; Connecting pipe 4 is movably connected to the output end of infusion pump 1; The transmission tube 5 is connected to the end of the connecting tube 4 away from the infusion pump 1; A two-way connecting device 6, one end of which is connected to the transmission pipe 5; The chromatographic column 7 is located on one side of the two-way connecting device 6 and is connected to the end of the two-way connecting device 6 away from the transfer tube 5 via the column tube 8. Waste liquid bottle 9 is connected to the outlet end of column tube 8.

[0026] Specifically, a solvent bottle 2 containing cleaning solvent is placed into an infusion pump 1. The solvent bottle 2 is connected to the input end of the infusion pump 1 via a hose 3. The output pipe of the infusion pump 1 is connected to a connecting pipe 4. The end of the connecting pipe 4 away from the infusion pump 1 is connected to a transmission pipe 5, and the other end of the output pipe is connected to a two-way connector 6. One side of the chromatographic column 7 is connected to the output pipe via a column tube 8, and the other end of the chromatographic column 7 is connected to a waste bottle 9 via the outlet end of the column tube 8. During cleaning, the motor of the infusion pump 1 is started, and the infusion pump 1 draws cleaning solvent from the solvent bottle 2. The cleaning solvent is introduced into the infusion pump 1 through the hose 3, and then introduced into the interior of the chromatographic column 7 through the connecting pipe 4, transmission pipe 5, two-way connector 6, and column tube 8 to clean the interior. The wastewater after cleaning is discharged from the column tube 8 at the other end of the chromatographic column 7 into the waste bottle 9 for centralized treatment. The infusion pump 1 provides stable power, and with the dedicated two-way connector 6 and wastewater treatment structure, the problems of unstable power, high safety risks, and poor adaptability of existing cleaning methods are solved.

[0027] See Figure 1 As shown, in this embodiment, the liquid delivery flow rate of the infusion pump 1 is adjustable from 0.01 ml / min to 10 ml / min, and the output pressure is not less than the minimum pressure required for the cleaning solvent to flow through the chromatographic column 7.

[0028] Specifically, the output pressure of the infusion pump 1 is stable, which can continuously clean the chromatographic column 7. The infusion pump 1 itself can adjust the delivery flow rate of the cleaning solvent. The benefits of a stable flow rate are: avoiding uneven contact between the solvent and impurities caused by "sudden changes in speed" - if the flow rate suddenly increases, it may impact the stationary phase inside the column; if it suddenly decreases, impurities are prone to local accumulation inside the column, forming "secondary pollution".

[0029] See Figure 1 and Figure 2 As shown, in this embodiment, the two-way connecting device 6 includes a main body shell 61, a flow channel 62 disposed inside the main body shell 61, and a first connecting end 63 and a second connecting end 64 respectively disposed at both ends of the main body shell 61; the first connecting end 63 is used to connect the transmission pipe 5, and the second connecting end 64 is used to connect the column pipe 8.

[0030] Specifically, the cleaning solvent coming out of the transfer tube 5 enters the column tube 8 and the chromatographic column 7 through the flow channel 62 opened inside the main body shell 61. The first connecting tube 4 and the second connecting end 64 provided on both sides of the main body shell 61 are used to connect the transfer tube 5 and the column tube 8, respectively.

[0031] See Figure 2 As shown, in this embodiment, the first connecting end 63 is provided with a threaded tightening structure 65 and a conical sealing joint 66. The threaded tightening structure 65 compresses the conical sealing joint 66 to achieve a sealed connection with the transmission pipe 5.

[0032] Specifically, one end of the transmission pipe 5 is connected to the threaded tightening structure 65. The threaded tightening structure 65 squeezes the conical sealing joint 66 into the main body shell 61, so that the transmission pipe 5 and the flow channel 62 are interconnected, realizing the flow of cleaning solvent. Secondly, the design of the conical sealing joint 66 can enhance the sealing of the connection between the transmission pipe 5 and the inlet end of the double-pass connection device, so that there will be no air leakage and the stability of the transmission process is guaranteed.

[0033] See Figure 2 As shown, in this embodiment, the second connecting end 64 is provided with a tightening screw 67 and a sealing gasket 68. The sealing gasket 68 is located in the hollow part of the main body shell 61. The sealing gasket 68 is deformed by the tightening screw 67, thereby achieving a sealed connection with the column tube 8.

[0034] Specifically, the sealing performance on the other side of the double-pass connection device can also be enhanced by designing a tightening screw 67 and a sealing gasket 68. By tightening the screw 67 to compress the sealing gasket 68 and cause it to deform, a sealed connection between the double-pass connection device and the column tube 8 can be achieved, preventing air leakage on the other side.

[0035] See Figure 2 As shown, in this embodiment, the flow channel 62 has a preset volume to achieve a smooth transition and delivery of the cleaning solvent.

[0036] Specifically, after the dual-channel connection device is installed between the infusion pump 1 and the chromatographic column 7, the internal flow channel 62 can realize the stable delivery of the cleaning solvent.

[0037] See Figures 2-4 As shown, in this embodiment, the waste liquid bottle 9 is provided with an inlet connector 10 and a discharge connector 11. The inlet connector 10 is connected to the column tube 8, and the discharge connector 11 is connected to the external environment to balance the pressure inside the bottle.

[0038] Specifically, the waste liquid bottle 9 is equipped with an inlet connector 10 and a discharge connector 11 at the top. The inlet connector 10 is connected to the column tube 8, and the discharge connector 11 is connected to the external environment to balance the pressure inside the bottle.

[0039] See Figures 2-4 As shown, in this embodiment, an inlet connector 12 is provided on one side of the column tube 8, which is connected to the transmission tube 5, and an outlet connector 13 is provided on the other side of the column tube 8, which is connected to the inlet connector 10 of the waste liquid bottle 9.

[0040] Specifically, an inlet connector 12 is provided on one side of the column tube 8 for connecting to the transmission tube 5, and an outlet connector 13 is provided on the other side for connecting to the inlet connector 10 of the waste liquid bottle 9, which can ensure that no leakage occurs during the transportation of cleaning solvent.

[0041] In this embodiment, the main body shell 61 is made of a corrosion-resistant material.

[0042] Specifically, the core objective of cleaning the capillary gas chromatography column 7 is to remove contaminants from the column. If the material of the outer shell 61 is not corrosion-resistant, impurities will precipitate under the action of solvents, causing "secondary contamination" of the chromatographic column 7, which violates the original purpose of cleaning.

[0043] In this embodiment, the cleaning solvent includes one or more combinations of methanol, ethanol, dichloromethane, and n-hexane.

[0044] Specifically, by using the "single selection or combination" of four solvents, precise matching can be achieved for different types of contamination: for example, hexane is used to clean column 7 (non-polar hydrocarbon contamination) after detecting petroleum samples; methanol is used to clean column 7 (polar contamination) after detecting organic acids in food; and methanol + dichloromethane (1:1) can be used to clean column 7 (polar-non-polar mixed contamination) after detecting mixed samples, achieving blind-zone-free cleaning.

[0045] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0046] The above-described embodiments are merely illustrative of several implementations of this utility model, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of this utility model. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the appended claims.

Claims

1. A cleaning device for a capillary gas chromatography column, characterized in that, include: Infusion pumps provide the power to deliver cleaning solvents; The solvent bottle is movably placed inside the infusion pump; A flexible tube connects the infusion pump to the solvent bottle; A connecting pipe is movably connected to the output end of the infusion pump; A transmission tube is connected to the end of the connecting tube furthest from the infusion pump; A two-way connecting device, one end of which is connected to the transmission pipe; A chromatographic column is located on one side of the two-way connection device and is connected to the end of the two-way connection device away from the transfer tube via a column tube. The waste liquid bottle is connected to the outlet end of the column tube.

2. The cleaning device for a capillary gas chromatography column according to claim 1, characterized in that, The liquid delivery flow rate of the infusion pump is adjustable from 0.01 ml / min to 10 ml / min, and the output pressure is not less than the minimum pressure required for the cleaning solvent to flow through the chromatographic column.

3. The cleaning device for a capillary gas chromatography column according to claim 1, characterized in that, The two-way connection device includes a main body shell, a flow channel disposed inside the main body shell, and a first connection end and a second connection end disposed at both ends of the main body shell; the first connection end is used to connect to the transmission tube, and the second connection end is used to connect to the column tube.

4. A cleaning device for a capillary gas chromatography column according to claim 3, characterized in that, The first connecting end is provided with a threaded tightening structure and a conical sealing joint. The threaded tightening structure compresses the conical sealing joint to achieve a sealed connection with the transmission pipe.

5. A cleaning device for a capillary gas chromatography column according to claim 3, characterized in that, The second connection end is provided with a tightening screw and a sealing gasket. The sealing gasket is located in the hollow part of the main body shell. The sealing gasket is deformed by the tightening screw, thereby achieving a sealed connection with the column tube.

6. A cleaning device for a capillary gas chromatography column according to claim 3, characterized in that, The flow channel has a preset volume to achieve a smooth transition and delivery of the cleaning solvent.

7. A cleaning device for a capillary gas chromatography column according to claim 1, characterized in that, The waste liquid bottle is equipped with an inlet connector and a outlet connector. The inlet connector is connected to the column tube, and the outlet connector is connected to the external environment to balance the pressure inside the bottle.

8. A cleaning device for a capillary gas chromatography column according to claim 7, characterized in that, An inlet connector is provided on one side of the column tube, which is connected to the transmission tube. An outlet connector is provided on the other side of the column tube, which is connected to the inlet connector of the waste liquid bottle.

9. A cleaning device for a capillary gas chromatography column according to claim 3, characterized in that, The main outer shell is made of corrosion-resistant material.

10. A cleaning device for a capillary gas chromatography column according to claim 1, characterized in that, The cleaning solvents include one or more combinations of methanol, ethanol, dichloromethane, and n-hexane.

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