Microsphere flexible filling system

Abstract

The utility model discloses a kind of microsphere flexible filling systems, comprising: displacement mechanism, the output end of displacement mechanism is used to clamp to be filled bottle, and control to be filled bottle moves between filling station and conveying station;Filling mechanism, filling mechanism includes filling machine, filling station, material box, filling pipeline and cut-off component;Material box and filling station are all arranged on filling machine, and material box has a gas inlet pipeline interface and a discharge port;Filling pipeline is arranged on the outer wall of filling machine, and input port is communicated with the discharge port of material box, output port is located directly above filling station;Cut-off component is set on filling machine, and contact with filling pipeline, for controlling the on-off of filling pipeline.The utility model is by above-mentioned setting, and flexible filling of microsphere solution is realized using gas pressure, to avoid the risk of microsphere damage and pollution caused by pump pressurization, effectively guarantee the structural integrity and safety of microsphere solution in filling process.

Description

Technical Field

[0001] This utility model relates to the fields of pharmaceuticals, cosmetics and food industry, and in particular to a microsphere flexible filling system. Background Technology

[0002] In existing technologies, the filling of aqueous suspension oil microsphere solutions generally relies on pump pressurization to achieve pipeline transmission, thereby completing the filling function. However, this method has certain drawbacks: during the filling process, the microspheres are repeatedly subjected to pump shear force (i.e., the mechanical force generated by the rotation of the impeller) as the solution is driven to flow through the pump impeller. This causes the continuous shearing during the pumping process to damage the surface modification layer of the microspheres, resulting in damage to the structural integrity of the microspheres. For functional microspheres (such as drug-loaded microspheres and active ingredient-encapsulated microspheres), this damage will directly affect their efficacy or functional characteristics.

[0003] Furthermore, due to the complex internal structure of the pump body, residual solution is easily left after long-term use, which can breed microorganisms or produce impurities, increasing the probability of contamination during the filling process.

[0004] Therefore, a microsphere flexible filling system is needed to solve the above problems. Utility Model Content

[0005] The purpose of this invention is to provide a flexible microsphere filling system that utilizes gas pressure to achieve flexible filling of microsphere solutions, thereby avoiding the risk of microsphere damage and contamination caused by pump pressurization, and effectively ensuring the structural integrity and safety of the microsphere solution during the filling process.

[0006] To solve the above-mentioned technical problems, this utility model provides a microsphere flexible filling system, comprising: A shifting mechanism, the output end of which is used to clamp the bottle to be filled and control the bottle to be filled to move between the filling station and the conveying station; A filling mechanism, comprising a filling machine with the filling station, a filling station, a material box, a filling pipeline, and a shut-off component; The material box and the filling station are both set on the filling machine platform, and the material box has an air inlet pipe interface and a material outlet. When gas is input into the material box through the air inlet interface, the microsphere solution in the material box flows out from the outlet under the action of gravity and micro-positive pressure. The filling pipeline is arranged on the outer wall of the filling machine, and its inlet is connected to the outlet of the material box, and its outlet is located directly above the filling station. The shut-off component is disposed on the filling machine platform and in contact with the filling pipeline, and is used to control the on / off state of the filling pipeline.

[0007] Furthermore, the filling pipeline includes an output pipeline and a negative pressure pipeline; The output pipeline is connected to the discharge port of the material box and is in contact with the cut-off component; One end of the negative pressure pipeline is connected to the outer wall of the output pipeline and is located below the shut-off component; When the cut-off component controls the output pipeline to be shut off, the negative pressure pipeline is used to draw in and contain a portion of the microsphere solution located below the cut-off component in the output pipeline.

[0008] Furthermore, the negative pressure pipeline is installed at an upward angle.

[0009] Furthermore, a positioning seat and a clamp are fixedly installed on the outer wall of the filling machine. The positioning seat is located below the clamp and is used to position the output pipeline so that the output pipeline is set vertically. The clamp and the outer wall of the filling machine form a limiting frame, and the lower end of the output pipe passes through the limiting frame. The cutoff assembly includes an electric push rod and a cutoff plate; The electric push rod is installed inside the filling machine and its output end is connected to the stop plate. It is used to control the stop plate to move back and forth to squeeze the output pipe located in the limiting frame or to separate it from the output pipe, so that the output pipe is blocked or flows.

[0010] Furthermore, the filling machine platform is equipped with a lifting seat, which is located directly below the filling pipeline, to form the filling station; The lifting platform has a built-in weighing sensor.

[0011] Furthermore, the filling machine is equipped with a lifting screw module inside; The lower surface of the lifting seat is fixedly connected to the output end of the lifting screw module.

[0012] Furthermore, the material box has a receiving cavity, the cross-section of which is set as a trapezoidal structure, and the discharge port is located at the bottom end of the receiving cavity; The cavity contains a liquid level sensor.

[0013] Furthermore, the top of the material box has a cover plate; The filling machine is equipped with a vacuum adsorption seat on its exterior, which controls the lifting and lowering of the cover plate in the height direction.

[0014] Furthermore, the displacement mechanism is a four-axis robot with a gripper assembly.

[0015] Furthermore, multiple sets of the filling pipeline, the shut-off component, and the filling station are provided, and they correspond one-to-one and are arranged in rows at equal intervals on the filling machine platform.

[0016] Compared with the prior art, the present invention has at least the following beneficial effects: By incorporating a shifting mechanism capable of holding the bottles to be filled between the filling station and the conveying station, a material box with an air inlet interface, and a filling pipeline, when the bottles need to be filled, gas is simply injected into the material box through the air inlet interface. This allows the microsphere solution to flow smoothly along the filling pipeline to the bottles at the filling station under the influence of gravity and slight positive pressure. This avoids the risk of microsphere damage and contamination caused by pump pressurization. Furthermore, by incorporating a shut-off component, the filling pipeline can be blocked when filling is complete, thus preventing drip contamination and ensuring the structural integrity and safety of the microsphere solution during the filling process.

[0017] Furthermore, by setting up a filling pipeline that includes an output pipeline and a negative pressure pipeline, and placing the negative pressure pipeline below the cut-off component, when filling is completed and the cut-off component blocks the output pipeline, the negative pressure pipeline can be connected to an external vacuum negative pressure device to absorb and contain the microsphere solution in the part of the output pipeline located below the cut-off component, thereby further improving the anti-drip contamination performance. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of a microsphere flexible filling system in one embodiment of the present invention; Figure 2 This is a partial structural diagram of the contact position between the cut-off component and the filling pipeline in a microsphere flexible filling system according to an embodiment of the present invention. Figure 3 This is a schematic diagram of the structure of the stop component and the clamp of the microsphere flexible filling system in one embodiment of the present invention; Figure 4 This is a schematic diagram of the material box of the microsphere flexible filling system in one embodiment of the present invention; Figure 5 This is a front view of the lifting screw module inside the filling machine in a microsphere flexible filling system according to an embodiment of the present invention, when exposed. Figure 6 This is a schematic diagram of the lifting screw module and lifting seat in a microsphere flexible filling system according to one embodiment of the present invention.

[0019] Reference numerals: 1. Shifting mechanism; 2. Filling machine platform; 21. Positioning seat; 22. Clamp; 23. Lifting seat; 24. Lifting screw module; 25. Vacuum adsorption seat; 3. Material box; 31. Air inlet pipe interface; 32. Receiving cavity; 33. Liquid level sensor; 4. Filling pipe; 41. Output pipe; 42. Negative pressure pipe; 5. Cut-off assembly; 51. Electric push rod; 52. Cut-off plate. Detailed Implementation

[0020] The microsphere flexible filling system of this utility model will now be described in more detail with reference to the schematic diagrams, which illustrate preferred embodiments of this utility model. It should be understood that those skilled in the art can modify the utility model described herein while still achieving its advantageous effects. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit the utility model.

[0021] Furthermore, based on the teachings of this specification, those skilled in the art can form new technical solutions through cross-combination of different implementation methods without creating technical contradictions. Such variations should all be considered to fall within the protection scope of this patent.

[0022] The present invention will be described in more detail below by way of example with reference to the accompanying drawings. The advantages and features of the present invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the present invention.

[0023] like Figures 1 to 6 As shown, this utility model embodiment proposes a microsphere flexible filling system, comprising: A shifting mechanism 1 is provided, the output end of which is used to clamp the bottle to be filled and control the movement of the bottle between the filling station and the conveying station. This mechanism controls the filling of the bottle and places the filled solution bottle on the conveying station for output to the next process. Preferably, the shifting mechanism 1 is a four-axis robot with a gripper assembly.

[0024] One side of the shifting mechanism 1 is equipped with a conveyor belt, which is used as a conveying station for conveying.

[0025] The filling mechanism includes a filling machine 2 with the filling station, a filling station, a material box 3, a filling pipeline 4, and a shut-off component 5.

[0026] The material box 3 and the filling station are both set on the filling machine 2, and the material box 3 has an air inlet pipe interface 31 and a discharge port for connecting the air inlet pipe, so that gas can be input into the material box 3 through the air inlet pipe interface 31.

[0027] Specifically, when gas is input into the material box 3 through the air inlet pipe interface 31, the microsphere solution in the material box 3 flows out from the outlet under the action of gravity and slight positive pressure. That is, the output operation is completed by the gas pressure and the gravity of the microsphere solution itself. Therefore, compared with the method of adding a pump body in the prior art, the risk of microsphere damage and contamination caused by pump pressurization can be effectively avoided.

[0028] In this embodiment, the filling pipeline 4 is arranged on the outer wall of the filling machine 2, and its inlet is connected to the outlet of the material box 3, and its outlet is located directly above the filling station.

[0029] The shut-off component 5 is disposed on the filling machine 2 and is in contact with the filling pipeline 4. It is used to control the opening and closing of the filling pipeline 4, so that after filling is completed, the filling pipeline 4 can be blocked by the shut-off component 5 to avoid drip contamination.

[0030] This device, by incorporating a shifting mechanism 1 capable of clamping and moving the bottles to be filled between the filling station and the conveying station, a material box 3 with an air inlet interface 31, and a filling pipeline 4, allows the microsphere solution to flow smoothly out along the filling pipeline 4 into the bottles at the filling station under the influence of gravity and slight positive pressure when the bottles need to be filled. This avoids the risk of microsphere damage and contamination caused by pump pressurization. Furthermore, by incorporating a shut-off component 5, the filling pipeline 4 can be blocked when filling is complete, thereby preventing drip contamination and ensuring the structural integrity and safety of the microsphere solution during the filling process.

[0031] In this embodiment, a specific filling pipeline 4 is also proposed so that when filling is completed and the filling is blocked by the cut-off component 5, the residual microsphere solution in the filling pipeline 4 will not drip out, so as to avoid drip contamination or affecting the filling accuracy.

[0032] Specifically, the filling pipeline 4 includes an output pipeline 41 and a negative pressure pipeline 42.

[0033] The output pipe 41 is connected to the outlet of the material box 3 and is in contact with the cut-off component 5. That is, the output pipe 41 serves as the main pipe for the output of the microsphere solution, while the cut-off component 5 is used to control the opening and closing of the output pipe 41.

[0034] One end of the negative pressure pipeline 42 is connected to the outer wall of the output pipeline 41 and is located below the cut-off component 5. This allows the negative pressure pipeline 42 to draw in and contain a portion of the microsphere solution located below the cut-off component 5 within the output pipeline 41 when the cut-off component 5 controls the output pipeline 41 to be shut off. This prevents residual microsphere solution in the output pipeline 41 from dripping out, thus avoiding dripping contamination or affecting filling accuracy, and further improving anti-drip contamination performance.

[0035] In other embodiments, a gas injection line can be connected to the middle of the negative pressure line 42 via a one-way valve, so that when filling is performed next time, the negative pressure device connected to the negative pressure line 42 remains closed, and the blowing device connected to the gas injection line is turned on to output the residual microsphere solution inside along the output line 41 to the bottle to be filled, thus completing the filling operation. This ensures that the microsphere solution will not form drip contamination, and also avoids the waste of microsphere solution.

[0036] In this embodiment, to prevent the negative pressure device connected to the negative pressure pipeline 42 from affecting the discharge of the microsphere solution in the output pipeline 41 when it is in the closed state, the negative pressure pipeline 42 is inclined upward, that is, the inclination direction of the negative pressure pipeline 42 is opposite to the direction of gravity, so that when the microsphere solution flows out under the action of micro-positive pressure and gravity, it will not enter the negative pressure pipeline 42, thereby ensuring that the setting of the negative pressure pipeline 42 will not interfere with the discharge of the microsphere solution in the output pipeline 41.

[0037] like Figure 1 and Figure 2 As shown, in order to enable the output pipe 41 to be set vertically so that the microsphere solution in the output pipe 41 can be better discharged, the filling machine 2 is further limited here.

[0038] Specifically, a positioning seat 21 and a clamp 22 are fixedly installed on the outer wall of the filling machine platform 2. The positioning seat 21 is located below the clamp 22 and is used to position the output pipeline 41 so that the output pipeline 41 is set vertically.

[0039] It should be noted that a limiting frame is formed between the clamp 22 and the outer wall of the filling machine platform 2, and the lower end of the output pipe 41 passes through the limiting frame so as to cooperate with the cut-off component 5 to complete the opening and closing of the output pipe 41.

[0040] Among them, such as Figure 3As shown, the cut-off assembly 5 includes an electric push rod 51 and a cut-off plate 52. The electric push rod 51 is disposed inside the filling machine 2 and its output end is connected to the cut-off plate 52. It is used to control the cut-off plate 52 to move back and forth within the limiting frame to squeeze the output pipe 41 located within the limiting frame or to separate it from the output pipe 41, so that the output pipe 41 is blocked or flows.

[0041] The system employs a cutoff assembly 5, which includes an electric push rod 51 and a cutoff plate 52. The electric push rod 51 precisely controls the movement of the cutoff plate 52 within the chamber. When it is necessary to block the output pipe 41, the electric push rod 51 pushes the cutoff plate 52 to squeeze the output pipe 41, using mechanical pressure to close the pipe and prevent the microsphere solution from dripping. When it is necessary for the pipe to flow, the electric push rod 51 drives the cutoff plate 52 to separate from the output pipe 41, allowing the solution to flow smoothly.

[0042] like Figure 5 and Figure 6 As shown, in a further embodiment, the filling machine 2 is further defined to form a filling station for performing the filling operation of bottles to be filled.

[0043] The filling machine platform 2 is equipped with a lifting seat 23, which is located directly below the filling pipeline 4, and is used to form the filling station.

[0044] The lifting seat 23 is equipped with a built-in weighing sensor to detect the weight of the bottle before, during, and after filling, and to provide real-time feedback to the control terminal so that the control terminal can coordinate the operation of each component and ensure the accuracy of filling.

[0045] Furthermore, the filling machine 2 is equipped with a lifting screw module 24, and the lower surface of the lifting seat 23 is fixedly connected to the output end of the lifting screw module 24. By setting up the lifting screw module 24 to drive the lifting seat 23 to move up and down, the output pipeline 41 and the liquid surface of the microsphere solution in the bottle to be filled can remain relatively stationary during the filling process. This reduces the error caused by the impact of the filling solution on the data obtained by the weighing sensor, further ensuring filling accuracy.

[0046] like Figure 1 and Figure 4 As shown, in a further embodiment, the structure of the material box 3 is further defined to better allow the microsphere solution to be discharged from the output pipe 41 under the action of gravity and micro-positive pressure.

[0047] Specifically, the material box 3 has a receiving cavity 32, the cross-section of the receiving cavity 32 is set as a trapezoidal structure, and the discharge port is located at the bottom end of the receiving cavity 32.

[0048] The containment cavity 32 is equipped with a liquid level sensor 33, which is used to detect the liquid level information of the microsphere solution in the containment cavity 32 and to feed the data back to the control terminal in real time, thereby reminding the operator to replenish the microsphere solution.

[0049] In this embodiment, the top of the material box 3 has a cover plate (not labeled in the figure) to open or close the receiving cavity 32, which facilitates the replenishment of microsphere solution.

[0050] The filling machine platform 2 is equipped with a vacuum adsorption seat 25 on its exterior, which controls the lifting and lowering of the cover plate in the height direction.

[0051] Furthermore, in one example, a robotic arm can be added to pour the storage cylinder containing the microsphere solution into the receiving cavity 32. This works in conjunction with the lifting vacuum adsorption seat 25 to achieve automated replenishment of the microsphere solution. The liquid level sensor 33 monitors the liquid level. When the liquid level sensor 33 detects that the liquid level of the microsphere solution has reached the preset level, it can send feedback to the control terminal, so that the robotic arm stops pouring the microsphere solution and simultaneously controls the lifting vacuum adsorption seat 25 to close the cover plate, thereby closing the receiving cavity 32 without manual operation, thus achieving the goal of improving the degree of automation.

[0052] In a further embodiment, the filling pipeline 4, the shut-off component 5, and the filling station are provided in multiple sets, corresponding one to one, and arranged in rows at equal intervals on the filling machine 2, so as to facilitate filling multiple bottles to be filled and meet the application requirements of batch filling.

[0053] In this embodiment, to facilitate understanding of the operation of the device, a method for filling microsphere solutions using the microsphere flexible filling system is also proposed, specifically including the following steps: The shifting mechanism 1 places the bottles to be filled on the filling station. The bottles to be filled can be conveyed by the conveying station, or an additional carrying station can be added to place the bottles to be filled. Gas (inert gas) is injected into the inlet pipe interface 31, and the flow of the outlet pipe 41 is controlled by the cut-off component 5. Under the action of gravity and slight positive pressure, the microsphere solution can be smoothly discharged from the outlet pipe 41 into the bottle to be filled for filling operation. During the filling process, the lifting screw module 24 is driven to move, so that the lifting seat 23 moves the bottle to be filled (i.e. moves downward) so that the lower end face of the output pipe 41 is at a predetermined height with the liquid level in the bottle to be filled, thereby improving the stability of filling. After filling is completed, the control cut-off component 5 is activated to block the output pipe 41 and activate the negative pressure device connected to the negative pressure pipe 42 so that the microsphere solution remaining in the output pipe 41 below the cut-off component 5 is drawn in and contained in the negative pressure pipe 42, preventing drip contamination. Finally, the control transfer mechanism 1 places the filled solution bottle on the conveying station for input to the next process.

[0054] In the above filling steps, this device uses the gravity of the microsphere solution and the micro-positive pressure to achieve the filling function. Therefore, compared with the pump pressurization method in the prior art, it can effectively avoid the risk of microsphere damage and contamination caused during operation, thereby achieving the purpose of ensuring the structural integrity and safety of the microsphere solution during the filling process.

[0055] Obviously, those skilled in the art can make various modifications and variations to this utility model without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this utility model and their equivalents, this utility model also intends to include these modifications and variations.

Claims

1. A microsphere flexible filling system, characterized in that, include: The shifting mechanism (1) is used to clamp the bottle to be filled and control the bottle to be filled to move between the filling station and the conveying station; The filling mechanism includes a filling machine (2), a filling station, a material box (3), a filling pipeline (4), and a shut-off component (5). The material box (3) and the filling station are both set on the filling machine (2), and the material box (3) has an air inlet pipe interface (31) and a material outlet. When gas is input into the material box (3) through the air inlet pipe interface (31), the microsphere solution in the material box (3) flows out from the outlet under the action of gravity and micro positive pressure; The filling pipeline (4) is arranged on the outer wall of the filling machine (2), and its inlet is connected to the outlet of the material box (3), and its outlet is located directly above the filling station. The cut-off component (5) is disposed on the filling machine (2) and in contact with the filling pipeline (4) for controlling the opening and closing of the filling pipeline (4).

2. The microsphere flexible filling system as described in claim 1, characterized in that, The filling pipeline (4) includes an output pipeline (41) and a negative pressure pipeline (42). The output pipe (41) is connected to the discharge port of the material box (3) and is in contact with the cut-off component (5); One end of the negative pressure pipeline (42) is connected to the outer wall of the output pipeline (41) and is located below the cut-off component (5); When the cut-off component (5) controls the output pipeline (41) to be cut off, the negative pressure pipeline (42) is used to draw in and contain a portion of the microsphere solution in the output pipeline (41) located below the cut-off component (5).

3. The microsphere flexible filling system as described in claim 2, characterized in that, The negative pressure pipeline (42) is installed at an upward angle.

4. The microsphere flexible filling system as described in claim 2, characterized in that, The outer wall of the filling machine (2) is fixedly installed with a positioning seat (21) and a clamp (22). The positioning seat (21) is located below the clamp (22) and is used to position the output pipeline (41) so that the output pipeline (41) is set vertically. Wherein, the clamp (22) and the outer wall of the filling machine (2) form a limiting frame, and the lower end of the output pipe (41) passes through the limiting frame; The cut-off assembly (5) includes an electric push rod (51) and a cut-off plate (52); The electric push rod (51) is located inside the filling machine (2) and its output end is connected to the stop plate (52). It is used to control the stop plate (52) to move back and forth to squeeze the output pipe (41) located in the limiting frame or to separate it from the output pipe (41), so that the output pipe (41) is blocked or flows.

5. The microsphere flexible filling system as described in claim 1, characterized in that, The filling machine (2) is provided with a lifting seat (23) and is located directly below the filling pipeline (4) to form the filling station; The lifting platform (23) has a built-in weighing sensor.

6. The microsphere flexible filling system as described in claim 5, characterized in that, The filling machine (2) is equipped with a lifting screw module (24). The lower surface of the lifting seat (23) is fixedly connected to the output end of the lifting screw module (24).

7. The microsphere flexible filling system as described in claim 1, characterized in that, The material box (3) has a receiving cavity (32), the cross section of the receiving cavity (32) is set as a trapezoidal structure, and the discharge port is located at the bottom end of the receiving cavity (32); The cavity (32) contains a liquid level sensor (33).

8. The microsphere flexible filling system as described in claim 1, characterized in that, The top of the material box (3) has a cover plate; The filling machine (2) is provided with a vacuum adsorption seat (25) on its exterior to control the lifting and lowering of the cover plate in the height direction.

9. The microsphere flexible filling system as described in claim 1, characterized in that, The shifting mechanism (1) is a four-axis robot with a gripper assembly.

10. The microsphere flexible filling system as described in claim 1, characterized in that, The filling pipeline (4), the shut-off component (5) and the filling station are all provided in multiple sets, and are arranged in rows at equal intervals on the filling machine (2).

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