Magnetic protein concentrator

Abstract

The utility model relates to the technical field of concentrator, and disclose a kind of magnetic protein concentrator, including operating component, limiting component, stirring assembly, the operating component includes base, the front of base is respectively equipped with operating panel and adjusting button, the limiting component includes locating plate.The magnetic protein concentrator, operating component, stirring assembly, base, operating panel, adjusting button, electric telescopic rod, motor, main gear, auxiliary gear structure are set, so that the concentrator in the operation process, user can be through operating panel and adjusting button respectively operating electric telescopic rod and motor operation, so that the magnetic stirring rod on lifting plate is inserted into the protein solution containing magnetic bead in beaker, again through motor operation driving magnetic stirring rod rotation and adsorbing magnetic bead, using centrifugal force and the movement of magnetic bead makes that protein is adsorbed on magnetic bead and completes purification operation, and then improve the purification efficiency and purification effect of protein solution to user.

Description

Technical Field

[0001] This utility model relates to the field of concentration instruments, specifically a magnetic protein concentration instrument. Background Technology

[0002] Using biomimetic mineralization, magnetic iron oxide can be synthesized in the ferritin cavity to form magnetin, also known as superparamagnetic protein. Magnetin is a novel magnetic nanomaterial with good biocompatibility and flexibility in biomedical applications. However, in order to ensure product quality during the manufacturing process, the magnetic protein needs to be purified.

[0003] In biological experiments, protein concentration is a common operation. Traditional methods such as ultrafiltration and centrifugation have problems such as low efficiency and complicated operation. Although the magnetic bead method is highly efficient, manual operation is cumbersome and easy to cause sample loss. Therefore, there is an urgent need for an automated and efficient protein concentration instrument. Summary of the Invention

[0004] In view of the shortcomings of the prior art, this utility model provides a magnetic protein concentrator to solve the problems mentioned in the background.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a magnetic protein concentrator, comprising a control component, a limiting component, and a stirring component, wherein the control component includes a base, and the front of the base is provided with a control panel and adjustment buttons respectively; The limiting assembly includes a positioning plate, a support plate fixedly mounted on the outer wall of the positioning plate, a limiting plate one and a limiting plate two respectively provided on the top of the support plate, extension plates fixedly mounted on both sides of the support plate, a movable groove opened on the top of the extension plate, a crossbar fixedly mounted on the inner wall of the movable groove, a return spring sleeved on the outer wall of the crossbar, a slider abutting on the outer wall of the return spring, a connecting rod fixedly mounted on the outer wall of the slider, and an arc-shaped plate fixedly mounted on the end of the connecting rod away from the slider. The limiting plate one and the limiting plate two can be replaced by the limiting plate three and the limiting plate four respectively. The top of the limiting plate one, the limiting plate two, the limiting plate three, and the limiting plate four are respectively provided with a circular groove and a docking groove. The outer wall of the limiting plate three and the limiting plate four are provided with a force-bearing plate. The top of the limiting plate one and the limiting plate three are provided with a magnet two. The bottom of the limiting plate two and the limiting plate four are provided with an installation groove. The inner wall of the installation groove is fixedly mounted with a magnet one. The stirring assembly includes an electric telescopic rod, the output shaft of which is equipped with a motor, the output shaft of which is fixedly fitted with a main gear, the outer wall of which is meshed with a secondary gear, and the inner wall of which is fixedly fitted with a magnetic stirring rod.

[0006] Through the above technical solution, the setting of limiting components, positioning plates, trays, limiting plate one, limiting plate two, and extension plate structure allows the user to adjust the space between the tray and the arc plate by moving the slider during use. This facilitates the user placing beakers in the concentrator to concentrate the magnetic proteins inside. If a small beaker needs to be placed in the concentrator, the user can remove limiting plate one and limiting plate two by pulling the protrusions upwards. Then, limiting plate three and limiting plate four, which are equipped with force plates, are placed on top of the tray. This allows the concentrator to concentrate magnetic proteins in beakers of different sizes. At the same time, the clamping effect of the arc plate and the force plate ensures that the beaker will not shift position or even tip over due to the vibration generated during stirring or equipment operation, thereby improving the stability of the beaker during stirring and the application range of the concentrator.

[0007] Preferably, a magnetic strip is fixedly mounted on the top of the pallet, and magnets are provided at the bottom of the first limiting plate, the second limiting plate, the third limiting plate, and the magnetic strips are attracted to each other by opposite polarities.

[0008] Through the above technical solution, by setting up the magnet three and magnetic strip structure, after the limit plate one and limit plate two or limit plate three and limit plate four are installed, the opposite poles of magnet three and magnetic strip are used to fix the above four components, thereby ensuring that the vibration force generated by the operation of the equipment will not affect the stability of limit plate one, limit plate two, limit plate three and limit plate four, and thus ensure the normal operation of the equipment.

[0009] Preferably, a beaker is placed on top of the tray, and the outer wall of the beaker is in close contact with the outer wall of the arc plate. Both the arc plate and the load-bearing plate are provided with a rubber layer.

[0010] Through the above technical solution, the rubber material has good elasticity and wear resistance, which can effectively avoid the situation where excessive pressure is applied during the clamping process of the beaker, resulting in wear or even damage to the beaker. This ensures the clamping effect of the arc plate and the force plate on the beaker, and also ensures the service life of the beaker, thereby improving the practicality of the concentrator.

[0011] Preferably, the outer walls of the first and second limiting plates, as well as the third and fourth limiting plates, are all provided with arc-shaped grooves. The inner walls of the arc-shaped grooves on the third and fourth limiting plates are fixedly assembled with the outer walls of the force-bearing plate, and the outer walls of the force-bearing plate are tightly fitted with the outer walls of the beaker.

[0012] Through the above technical solution, by setting the force plate structure, during the use of the concentrator, after removing the first and second limiting plates and installing the third and fourth limiting plates, the force plate can fit against the outer wall of the small beaker. This makes it easier for the user to place the small beaker between the fourth limiting plate and the arc plate after pulling the slider to complete the clamping, thereby ensuring the range of use of the concentrator and making it easier for the user to operate.

[0013] Preferably, the outer wall of the limiting plate three is fixedly fitted with two protrusions, and the two protrusions are symmetrically distributed along the outer wall of the limiting plate three.

[0014] With the above technical solution, and through the three-structure of protrusions and limiting plates, when users disassemble or assemble limiting plates three and four or limiting plates one and two, they can also complete the disassembly and assembly of the above four components by lifting the protrusions with one hand. This makes it easier for users to replace components, thereby facilitating user operation and improving user efficiency.

[0015] Preferably, the output shaft of the electric telescopic rod is fixedly equipped with a lifting plate, and the number of magnetic stirring rods is several, with the several magnetic stirring rods evenly distributed along the bottom of the lifting plate.

[0016] Through the above technical solution, the lifting plate and magnetic stirring rod structure allow the user to extend the magnetic stirring rod into the beaker by raising and lowering the lifting plate during use. The operation of the electric telescopic rod drives the magnetic stirring rod to rotate, thereby causing the magnetic protein solution in the beaker to be purified by stirring and centrifugal force, thus ensuring the normal operation of the concentrator.

[0017] Preferably, the control panel and the adjustment button are electrically connected, and the adjustment button is electrically connected to the electric telescopic rod and the motor respectively.

[0018] Through the above technical solution, the base, electric telescopic rod, and motor structure enable the concentrator to raise and lower the lifting plate using the electric telescopic rod during use. This eliminates the need for manual adjustment by the user, allowing operators to complete the operation directly through the control panel and adjustment buttons. This simplifies the operation process of the concentrator and improves its automation.

[0019] Compared with the prior art, the present invention provides a magnetic protein concentrator with the following advantages: 1. This magnetic protein concentrator, through its control components, stirring components, base, control panel, adjustment buttons, electric telescopic rod, motor, main gear, and auxiliary gear structure, allows the user to operate the electric telescopic rod and motor via the control panel and adjustment buttons during operation. This causes the magnetic stirring rod on the lifting plate to extend into the protein solution containing magnetic beads in the beaker. The motor then drives the magnetic stirring rod to rotate and attract the magnetic beads. Centrifugal force and the movement of the magnetic beads cause the protein to adhere to the magnetic beads, completing the purification process. This improves the user's efficiency and purification effect on the protein solution.

[0020] 2. This magnetic protein concentrator, through its set of limiting components, positioning plates, support plates, limiting plate one, limiting plate two, limiting plate three, limiting plate four, force plate, and arc-shaped plate structure, allows the concentrator to limit large beakers during operation. Limiting plates one and two restrict the beakers, while the arc-shaped plate clamps them, ensuring stability during protein solution purification. Users can also remove limiting plates one and two and replace them with limiting plates three and four, ensuring the concentrator is also suitable for smaller beakers, thus expanding its application range. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a side sectional view of the present invention. Figure 3 This utility model Figure 2 Enlarged structural diagram at point A in the middle; Figure 4 This is a schematic diagram of the limiting plate structure of this utility model; Figure 5 This is a partial cross-sectional structural diagram of the present invention.

[0022] The components include: 1. Control components; 101. Base; 102. Control panel; 103. Adjustment button; 2. Limiting components; 201. Positioning plate; 202. Support plate; 203. Limiting plate one; 204. Limiting plate two; 205. Extension plate; 206. Movable groove; 207. Crossbar; 208. Return spring; 209. Slider; 210. Connecting rod; 211. Arc plate; 212. Limiting plate three; 213. Limiting plate four; 214. Force plate; 215. Circular groove; 216. Docking groove; 217. Mounting groove; 218. Magnet one; 219. Magnet two; 3. Stirring components; 301. Electric telescopic rod; 302. Motor; 303. Main gear; 304. Secondary gear; 305. Magnetic stirring rod. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Example 1: like Figure 1-3 As shown, a magnetic protein concentrator includes a control component 1, a limiting component 2, and a stirring component 3. The control component 1 includes a base 101, and the front of the base 101 is provided with a control panel 102 and an adjustment button 103. The limiting component 2 includes a positioning plate 201. A support plate 202 is fixedly mounted on the outer wall of the positioning plate 201. A first limiting plate 203 and a second limiting plate 204 are respectively provided on the top of the support plate 202. An extension plate 205 is fixedly mounted on both sides of the support plate 202. A movable groove 206 is opened on the top of the extension plate 205. A crossbar 207 is fixedly mounted on the inner wall of the movable groove 206. A return spring 208 is sleeved on the outer wall of the crossbar 207. A slider 209 is abutted on the outer wall of the return spring 208. A connecting rod 210 is fixedly mounted on the outer wall of the slider 209. An arc is fixedly mounted on the end of the connecting rod 210 away from the slider 209. The shape plate 211, the limiting plate 1 203 and the limiting plate 204 can be replaced by the limiting plate 3 212 and the limiting plate 4 213 respectively. The top of the limiting plate 1 203, the limiting plate 204, the limiting plate 3 212 and the limiting plate 4 213 are respectively provided with a circular groove 215 and a docking groove 216. The outer wall of the limiting plate 3 212 and the limiting plate 4 213 are provided with a force plate 214. The top of the limiting plate 1 203 and the limiting plate 3 212 are provided with a magnet 219. The bottom of the limiting plate 204 and the limiting plate 4 213 are provided with an installation groove 217. The inner wall of the installation groove 217 is fixedly fitted with a magnet 218. The stirring assembly 3 includes an electric telescopic rod 301. The output shaft of the electric telescopic rod 301 is equipped with a motor 302. The output shaft of the motor 302 is fixedly mounted with a main gear 303. The outer wall of the main gear 303 is meshed with a secondary gear 304. The inner wall of the secondary gear 304 is fixedly sleeved with a magnetic stirring rod 305.

[0025] The advantage is that, through the structure of the limiting component 2, positioning plate 201, support plate 202, limiting plate one 203, limiting plate two 204, and extension plate 205, the user can adjust the space between the support plate 202 and the arc plate 211 by moving the slider 209 during use. This facilitates placing beakers in the concentrator to concentrate the magnetic proteins inside. If a small beaker needs to be placed in the concentrator, the user can lift the protrusions upwards by hand. Limiting plate 1 203 and limiting plate 204 are removed respectively. Then, limiting plate 3 212 and limiting plate 4 213, which are equipped with force plate 214, are placed on the top of support plate 202. This enables the concentrator to concentrate magnetic proteins in beakers of different sizes. At the same time, the clamping effect of arc plate 211 and force plate 214 ensures that the beaker will not shift position or even tip over due to the vibration force generated during stirring or equipment operation. This improves the stability of the beaker during stirring and the application range of the concentrator.

[0026] Specifically: The top of the tray 202 is fixedly equipped with a magnetic strip, and the bottom of the limiting plate 1 203, limiting plate 204, limiting plate 3 212 and limiting plate 4 213 are all equipped with magnet 3, and magnet 3 and magnetic strip are attracted to each other by opposite polarities.

[0027] The advantage is that, through the structure of magnet three and magnetic strip, after the installation of limit plate one 203 and limit plate two 204 or limit plate three 212 and limit plate four 213, the opposite poles of magnet three and magnetic strip are attracted to fix the above four components, thereby ensuring that the vibration force generated by the operation of the equipment will not affect the stability of limit plate one 203, limit plate two 204, limit plate three 212 and limit plate four 213, and thus ensure the normal operation of the equipment.

[0028] Specifically: a beaker is placed on top of the tray 202, and the outer wall of the beaker is in close contact with the outer wall of the arc plate 211. Both the arc plate 211 and the load-bearing plate 214 are provided with a rubber layer.

[0029] The advantage is that the rubber material has good elasticity and wear resistance, which can effectively avoid excessive pressure during the clamping process of the beaker, which may lead to wear or even damage to the beaker. This ensures the clamping effect of the arc plate 211 and the force plate 214 on the beaker, and also ensures the service life of the beaker, thereby improving the practicality of the concentrator.

[0030] Example 2: like Figure 4-5 As shown, this is an improvement on the previous embodiment.

[0031] Specifically: the outer walls of the limiting plate 1 203, the limiting plate 204, the limiting plate 3 212, and the limiting plate 4 213 are all provided with arc-shaped grooves. The inner walls of the arc-shaped grooves on the limiting plate 3 212 and the limiting plate 4 213 are fixedly assembled with the outer wall of the force plate 214, and the outer wall of the force plate 214 is tightly fitted with the outer wall of the beaker.

[0032] The advantage is that, through the designed force plate 214 structure, during the use of the concentrator, after removing the first limiting plate 203 and the second limiting plate 204 and installing the third limiting plate 212 and the fourth limiting plate 213, the force plate 214 can be used to fit against the outer wall of the small beaker. This makes it easier for the user to place the small beaker between the fourth limiting plate 213 and the arc plate 211 after pulling the slider 209, thereby ensuring the usability of the concentrator and making it easier for the user to operate.

[0033] Specifically: The outer wall of the limiting plate 3 212 is fixedly equipped with two protrusions, and the two protrusions are symmetrically distributed along the outer wall of the limiting plate 3 212.

[0034] The advantage is that, through the structure of the protrusion and the limiting plate 3 212, when the user disassembles or assembles the limiting plate 3 212 and the limiting plate 4 213 or the limiting plate 1 203 and the limiting plate 2 204, the user can also complete the disassembly and assembly of the above four components by lifting the protrusion with one hand. This makes it easier for the user to replace the components, thereby facilitating the user's operation and improving the user's operating efficiency.

[0035] Specifically: the output shaft of the electric telescopic rod 301 is fixedly equipped with a lifting plate, and there are several magnetic stirring rods 305, which are evenly distributed along the bottom of the lifting plate.

[0036] The advantage is that, through the structure of the lifting plate and magnetic stirring rod 305, the user can extend the magnetic stirring rod 305 into the beaker by raising and lowering the lifting plate during the use of the concentrator. The operation of the electric telescopic rod 301 drives the magnetic stirring rod 305 to rotate, so that the magnetic protein solution in the beaker is purified by stirring and centrifugal force, thus ensuring the normal operation of the concentrator.

[0037] Specifically: the control panel 102 and the adjustment button 103 are electrically connected, and the adjustment button 103 is electrically connected to the electric telescopic rod 301 and the motor 302 respectively.

[0038] The advantage is that, through the structure of the base 101, electric telescopic rod 301, and motor 302, the concentrator can use the electric telescopic rod 301 to drive the lifting plate to rise and fall during use, without the need for manual adjustment by the user. The operator can directly complete the operation through the buttons on the control panel 102 and the adjustment button 103, thereby simplifying the operation process of the concentrator and improving its automation.

[0039] Working principle: First, the user can pull the slider 209 to move the corresponding arc plate 211 away from the electric telescopic rod 301. Then, the user can place the beaker in the arc groove opened on the limiting plate 1 203 or the limiting plate 204. Then, release the slider 209 so that the rubber layer on the arc plate 211 fits tightly against the outer wall of the beaker, thus ensuring the stability of the beaker during the stirring process. If it is necessary to place beakers of different sizes in the concentrator, the user can lift one protrusion with each hand to disassemble the limiting plate 1 203 and the limiting plate 204. At this time, the magnet 3 separates from the magnetic strip. The user can then reinstall the limiting plate 3 212 and the limiting plate 4 213 on the support plate 202, and then repeat the same steps to place the small beakers in the concentrator. The beaker is placed in the arc-shaped groove on the limiting plate 212 or the limiting plate 213. Then, the slider 209 is pulled to move, so that the rubber layer on the force plate 214 and the arc plate 211 are tightly attached to the outer wall of the small beaker, thereby improving the application range of the concentrator and ensuring the stability of the small beaker during the stirring process. During stirring, the user can adjust the height of the lifting plate by adjusting the adjustment button 103, and then operate the motor 302 through the control panel 102 to make the magnetic stirring rod 305 extend into the beaker to stir the protein solution containing magnetic beads in the beaker, recover the magnetic beads, and then complete the purification operation. This makes it easier for the user to operate, thereby improving the automation of the concentrator, the user's work efficiency, and the purification effect of the protein solution.

[0040] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A magnetic protein concentrator, comprising a control component (1), a limiting component (2), and a stirring component (3), characterized in that: The control component (1) includes a base (101), and the front of the base (101) is provided with a control panel (102) and an adjustment button (103). The limiting component (2) includes a positioning plate (201). A support plate (202) is fixedly mounted on the outer wall of the positioning plate (201). A limiting plate one (203) and a limiting plate two (204) are respectively provided on the top of the support plate (202). An extension plate (205) is fixedly mounted on both sides of the support plate (202). A movable groove (206) is opened on the top of the extension plate (205). A crossbar (207) is fixedly mounted on the inner wall of the movable groove (206). A return spring (208) is sleeved on the outer wall of the crossbar (207). A slider (209) abuts against the outer wall of the return spring (208). A connecting rod (210) is fixedly mounted on the outer wall of the slider (209). The end of the connecting rod (210) away from the slider (209) is fixedly mounted with... Equipped with an arc plate (211), the first limiting plate (203) and the second limiting plate (204) can be replaced by the third limiting plate (212) and the fourth limiting plate (213) respectively. The top of the first limiting plate (203), the second limiting plate (204), the third limiting plate (212) and the fourth limiting plate (213) are respectively provided with a circular groove (215) and a docking groove (216). The outer walls of the third limiting plate (212) and the fourth limiting plate (213) are provided with a force plate (214). The top of the first limiting plate (203) and the third limiting plate (212) are provided with a magnet (219). The bottom of the second limiting plate (204) and the fourth limiting plate (213) are provided with an installation groove (217). The inner wall of the installation groove (217) is fixedly fitted with a magnet (218). The stirring assembly (3) includes an electric telescopic rod (301), the output shaft of which is equipped with a motor (302), the output shaft of which is fixedly fitted with a main gear (303), the outer wall of which is meshed with a secondary gear (304), and the inner wall of which is fixedly fitted with a magnetic stirring rod (305).

2. The magnetic protein concentrator according to claim 1, characterized in that: The top of the tray (202) is fixedly equipped with a magnetic strip, and the bottom of the limiting plate one (203), limiting plate two (204), limiting plate three (212) and limiting plate four (213) are all provided with magnet three, and magnet three and magnetic strip are attracted to each other.

3. A magnetic protein concentrator according to claim 1, characterized in that: A beaker is placed on top of the tray (202), and the outer wall of the beaker is in close contact with the outer wall of the arc plate (211). Both the arc plate (211) and the force plate (214) are provided with a rubber layer.

4. A magnetic protein concentrator according to claim 3, characterized in that: The outer walls of the limiting plate one (203), limiting plate two (204), limiting plate three (212), and limiting plate four (213) are all provided with arc-shaped grooves. The inner walls of the arc-shaped grooves on the limiting plate three (212) and limiting plate four (213) are fixedly assembled with the outer wall of the force plate (214), and the outer wall of the force plate (214) is tightly fitted with the outer wall of the beaker.

5. A magnetic protein concentrator according to claim 1, characterized in that: The outer wall of the limiting plate three (212) is fixedly fitted with two protrusions, and both protrusions are symmetrically distributed along the outer wall of the limiting plate three (212).

6. A magnetic protein concentrator according to claim 1, characterized in that: The output shaft of the electric telescopic rod (301) is fixedly equipped with a lifting plate, and there are several magnetic stirring rods (305), and the several magnetic stirring rods (305) are evenly distributed along the bottom of the lifting plate.

7. A magnetic protein concentrator according to claim 1, characterized in that: The control panel (102) and the adjustment button (103) are electrically connected, and the adjustment button (103) is electrically connected to the electric telescopic rod (301) and the motor (302) respectively.

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