Molecular diagnostic device

Abstract

The utility model discloses a molecular diagnostic equipment, including case, first transfer device and second transfer device, the inner chamber of case is divided into sample detection chamber and expendable material loading chamber, and the sample detection chamber is divided into sample processing area and sample detection area, and still be formed with first loading port and second loading port in the case, and first transfer device is located in expendable material loading chamber, and is used for with expendable material in expendable material loading chamber is transferred to sample processing area through first loading port, and second transfer device includes first transmission line body, first mechanical arm and second mechanical arm, and first transmission line body passes through second loading port setting, and first mechanical arm is located in sample processing area, and is used for with expendable material on sample processing assembly is transferred to first transmission line body, and second mechanical arm is located in sample detection area, and is used for with expendable material on first transmission line body is transferred to sample detection assembly, and the physical separation of the equipment each area effectively avoided cross -contamination, and the reliability of detection result is guaranteed.

Description

Technical Field

[0001] This utility model belongs to the field of molecular diagnostic technology, and specifically relates to a molecular diagnostic device. Background Technology

[0002] In the detection of respiratory diseases, rapid and accurate molecular diagnostics are crucial for the early detection and treatment of diseases. However, the complex molecular diagnostic experimental process, such as opening and dispensing sample tubes, nucleic acid extraction, system construction, PCR amplification and detection, often requires a large number of personnel with biotechnology experimental capabilities to perform the actual operation. This is inefficient, and the test results are easily affected by human error, environmental factors and other factors, making it difficult to meet the timeliness and standardization requirements of large-scale screening scenarios.

[0003] Although existing molecular detection equipment can perform automated nucleic acid detection, the unreasonable layout of each functional area can easily lead to sample or reagent contamination, affecting the reliability of the test results. Utility Model Content

[0004] In view of the above-mentioned defects or deficiencies, this utility model provides a molecular diagnostic device, which aims to solve the technical problem that the unreasonable partitioning of existing molecular detection devices can easily lead to contamination.

[0005] To achieve the above objectives, this utility model provides a molecular diagnostic device, comprising: The chassis has an internal cavity divided into a sample detection chamber and a consumable loading chamber along the height direction. The sample detection chamber is divided into a sample processing area and a sample detection area along the length direction. The sample processing area is equipped with a sample processing assembly, and the sample detection area is equipped with a sample detection assembly. The chassis also has a first loading port connecting the sample detection area and the consumable loading chamber, and a second loading port connecting the sample processing area and the sample detection area. The first transfer device is located in the consumables feeding chamber and is used to transfer the consumables in the consumables feeding chamber to the sample processing area through the first feeding port. The second transfer device includes a first conveyor line, a first robotic arm, and a second robotic arm. The first conveyor line passes through a second loading port. The first robotic arm is located in the sample processing area and is used to transfer consumables from the sample processing assembly to the first conveyor line. The second robotic arm is located in the sample detection area and is used to transfer consumables from the first conveyor line to the sample detection assembly.

[0006] In this embodiment of the invention, the feeding chamber is divided into a reagent tube feeding area and a pipette tip feeding area along its width. A first feeding port connects the sample processing area and the pipette tip feeding area. A first transfer device is located in the pipette tip feeding area and is used to move the pipette tip consumables to the sample processing area. A third feeding port is also formed inside the chassis, which connects the sample processing area and the reagent tube feeding area. The molecular diagnostic device also includes a third transfer device located in the reagent tube feeding area, which is used to transfer the reagent tube consumables to the sample processing area through the third feeding port.

[0007] In this embodiment of the invention, the chassis is provided with a first partition and a second partition. The first partition separates the reagent tube loading area and the pipette tip loading area, and the second partition separates the sample processing area and the sample detection area. The first partition and the second partition are spaced apart to form a pipette tip storage area. The pipette tip storage area is provided with a pipette tip storage rack. The molecular diagnostic equipment also includes a pipette tip conveyor line and a fourth transfer device. The pipette tip conveyor line is located on the side of the second partition facing the pipette tip loading area. The fourth transfer device is used to pick up pipette tip consumables from the pipette tip storage rack and transfer them to the pipette tip conveyor line. The first transfer device is used to transfer pipette tip consumables from the pipette tip conveyor line to the sample detection area.

[0008] In this embodiment of the present invention, the sample processing assembly includes a sample transfer component, a sample purification component, and a capping component arranged sequentially along the length direction. The sample transfer component is used to transfer the sample in the sample tube to the reagent tube consumable. The sample purification component is used to purify the sample in the reagent tube consumable and transfer the purified sample to the detection container consumable. The capping component is used to cap the detection container consumable. The first robotic arm is used to transfer the capped detection container consumable to the first conveyor line.

[0009] In this embodiment of the present invention, the sample transfer assembly includes a sample tube carrier, a cap-opening robotic arm, and a first pipetting robotic arm. The sample tube carrier and the first loading port are spaced apart along the width direction. The cap-opening robotic arm is used to open the caps of the sample tubes on the sample tube carrier. The first pipetting robotic arm is used to replace pipette tip consumables and transfer the sample in the sample tube to reagent tube consumables.

[0010] In this embodiment of the utility model, the sample tube carrier includes a sample tube support frame and a first tube clamping mechanism. The bottom of the sample tube support frame is provided with a first slide rail, which extends along the width direction. The first tube clamping mechanism is used to clamp the tube body of the sample tube.

[0011] In this embodiment of the utility model, the sample tube carrier further includes an expedited shipment carrier, a sample tube detector, and a controller. The expedited shipment carrier is used to carry the sample tubes, the sample tube detector is used to detect the sample tubes on the expedited shipment carrier, and the controller is used to control the cap-opening robotic arm to transfer the sample tubes on the expedited shipment carrier to the first tube clamping mechanism when the sample tube detector detects the sample tubes.

[0012] In this embodiment of the invention, there are two sample tube support frames, and each sample tube support frame is provided with a first slide rail at its bottom.

[0013] In this embodiment of the present invention, the molecular diagnostic device further includes a second conveyor line for conveying reagent tube consumables. The second conveyor line is disposed between the sample transfer component and the first loading port and extends to the rear side of the sample purification component. The sample purification component includes a plurality of purification processing modules and a fifth transfer device. The fifth transfer device is used to pick up the reagent tube consumables on the second conveyor line and transfer them to one of the plurality of purification processing modules.

[0014] In this embodiment of the utility model, several purification processing modules include: The washing and dispensing module is used to clean and purify the samples inside the reagent tubes. The oscillation heating module is used to oscillate and / or heat the sample in the reagent tube consumable; The magnetic suction module is used to magnetically purify samples within reagent tubes.

[0015] In this embodiment of the utility model, the bottom of the fourth transfer device is provided with a second slide rail, which extends along the width direction, and a plurality of purification processing modules are disposed on both sides of the second slide rail.

[0016] In this embodiment of the utility model, the capping assembly includes a testing consumable container, a cover plate support frame, a third conveyor line, and a third robotic arm. The third conveyor line extends along its length and passes sequentially through the sample purification assembly, the testing consumable container, and the cover plate support frame. The third robotic arm is used to grip the testing container consumables in the testing consumable container and transfer them to the third conveyor line, and to grip the cover plate consumables on the cover plate support frame to cap the testing container consumables on the third conveyor line.

[0017] Through the above technical solutions, the molecular diagnostic device provided by this utility model embodiment has the following beneficial effects: When using the aforementioned molecular diagnostic equipment, the internal cavity of the chassis is physically divided into a sample processing area, a sample testing area, and a consumable loading chamber, respectively corresponding to the functional requirements of sample processing, sample testing, and consumable storage. The required consumables enter the sample processing area through the first loading port via a first transfer device. The sample processing assembly performs pre-testing treatment, and the processed samples are loaded into the consumables and sequentially transferred to the sample testing assembly via a first robotic arm, a first conveyor line, and a second robotic arm for testing. Throughout the process, the physical separation of each area effectively avoids cross-contamination, ensuring the reliability of the test results.

[0018] Other features and advantages of this invention will be described in detail in the following detailed description section. Attached Figure Description

[0019] The accompanying drawings are provided to illustrate the present invention and form part of the specification. They are used together with the following detailed description to explain the present invention, but do not constitute a limitation thereof. In the drawings: Figure 1 This is a front view diagram of a molecular diagnostic device according to one embodiment of the present invention; Figure 2 This is a rear view of a molecular diagnostic device according to an embodiment of the present invention; Figure 3 This is a structural diagram of the first cabin according to an embodiment of the present invention; Figure 4 This is a structural diagram of the second compartment according to one embodiment of the present invention; Figure 5 This is a structural diagram of the third compartment according to one embodiment of the present invention; Figure 6 This is a structural diagram of the fourth compartment according to one embodiment of the present invention.

[0020] Explanation of reference numerals in the attached figures Detailed Implementation

[0021] The specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are for illustration and explanation only and are not intended to limit the scope of this utility model.

[0022] The following is for reference. Figures 1 to 6 This invention describes the molecular diagnostic device.

[0023] This invention provides a molecular diagnostic device, comprising: The chassis 100 has an inner cavity divided into a sample detection chamber and a consumable loading chamber along the height direction. The sample detection chamber is divided into a sample processing area 101 and a sample detection area 102 along the length direction. A sample processing assembly is provided in the sample processing area 101, and a sample detection assembly 502 is provided in the sample detection area 102. The chassis 100 also has a first loading port 103 connecting the sample detection area 102 and the consumable loading chamber, and a second loading port connecting the sample processing area 101 and the sample detection area 102. The first transfer device is located in the consumables feeding chamber and is used to transfer the consumables in the consumables feeding chamber to the sample processing area 101 through the first feeding port 103. The second transfer device includes a first conveyor line 409, a first robotic arm 412, and a second robotic arm 501. The first conveyor line 409 is disposed through a second loading port. The first robotic arm 412 is disposed in the sample processing area 101 and is used to transfer consumables on the sample processing assembly to the first conveyor line 409. The second robotic arm 501 is disposed in the sample detection area 102 and is used to transfer consumables on the first conveyor line 409 to the sample detection assembly 502.

[0024] When using the aforementioned molecular diagnostic equipment, the internal cavity of the chassis 100 is physically divided into a sample processing area 101, a sample testing area 102, and a consumable loading chamber, respectively corresponding to the functional requirements of sample processing, sample testing, and consumable storage. The required consumables enter the sample processing area 101 through the first loading port 103 via a first transfer device. The sample processing assembly performs pre-testing processing, and the processed samples are loaded into the consumables and sequentially transferred to the sample testing assembly 502 for testing via the first robotic arm 412, the first conveyor line 409, and the second robotic arm 501. Throughout the process, the physical separation of each area effectively avoids cross-contamination and ensures the reliability of the test results.

[0025] Specifically, the main frame of the chassis 100 can be sequentially divided along its length into a first compartment 200, a second compartment 300, a third compartment 400, and a fourth compartment 500. Each compartment is equipped with a partition to divide its internal space into an upper space and a lower space. The upper spaces of the first compartment 200, the second compartment 300, and the third compartment 400 are connected to form a sample processing area 101, and the lower spaces of the first compartment 200, the second compartment 300, and the third compartment 400 are connected to form a consumables loading chamber. The upper space of the fourth compartment 500 forms a sample detection area 102, and the lower space of the fourth compartment 500 is used as a waste collection area.

[0026] Further, see Figure 3The first chamber 200 is equipped with a cap-opening robotic arm 201, a quality control agent carrier 202, a first reagent mixing device 203, a sample tube carrier 204, an express delivery carrier 205, a third transfer device 206, a pipette tip conveyor line 207, a second conveyor line 208, a first tube clamping mechanism 209, a pipette tip box fixing device 210, and a first pipetting robotic arm 211.

[0027] Further, see Figure 4 The second chamber 300 is equipped with a second pipetting robot arm 301, a washing and injection module 302, an oscillation and heating module 303, a second reagent mixing device 304, a settling module 305, a fifth transfer device 306, a magnetic suction module 307, a washing liquid tank placement rack 308, and a waste bin 309.

[0028] Further, see Figure 5 The third compartment 400 is equipped with a third robotic arm 401, a second tube clamping mechanism 402, a third conveyor line 403, a suction head waste rack 404, a fourth transfer device 405, a suction head storage rack 406, a testing consumables container 407, a cover plate support frame 408, a first conveyor line 409, a reagent support frame 410, and a base plate 411.

[0029] Further, see Figure 6 The fourth compartment 500 is equipped with a second robotic arm 501, a sample testing assembly 502, and a waste disposal port 503.

[0030] In this embodiment of the invention, the feeding chamber is divided along its width into a reagent tube feeding area 104 and a pipette tip feeding area 105. A first feeding port 103 connects the sample processing area 101 and the pipette tip feeding area 105. A first transfer device is located in the pipette tip feeding area 105 and is used to transfer pipette tip consumables to the sample processing area 101. A third feeding port is also formed inside the chassis, connecting the sample processing area 101 and the reagent tube feeding area 104. A third transfer device 206 is located in the reagent tube feeding area 104 and is used to transfer reagent tube consumables to the sample processing area 101 through the third feeding port. Thus, the feeding process of pipette tip consumables and reagent tube consumables can be orderly separated through the partitioned design of the feeding chamber, avoiding contamination or interference between different types of consumables during the transfer process.

[0031] Specifically, the first transfer device is configured as a robotic arm with multi-degree-of-freedom motion capability, which can flexibly grasp the suction head consumables and deliver the suction head consumables to the first feeding channel through a preset motion trajectory.

[0032] Specifically, the suction head consumables include suction heads and suction head boxes, with multiple suction heads placed in each suction head box. A first transfer device is used to clamp the suction head box, and a suction head box fixing device 210 is provided at the first feeding channel. The suction head box fixing device 210 fixes the suction head box through a snap-fit ​​structure.

[0033] Specifically, the reagent tube consumables are set as an eight-tube array (i.e., eight reagent tubes connected in sequence). The third transfer device 206 has a horizontal transfer track and a lifting transfer track. Each track is equipped with a corresponding drive unit. The horizontal transfer track can be used to store the eight-tube array and to transfer the eight-tube array to the lifting transfer track, and then lift it to the sample processing area 101 by the lifting transfer track.

[0034] In this embodiment of the present invention, a first partition 107 and a second partition 108 are provided inside the chassis 100. The first partition 107 separates the reagent tube loading area 104 and the pipette tip loading area 105, and the second partition 108 separates the sample processing area 101 and the sample detection area 102. The first partition 107 and the second partition 108 are spaced apart to form a pipette tip storage area 106. The pipette tip storage area 106 is provided with a pipette tip storage rack 406. The molecular diagnostic equipment also includes a pipette tip conveyor line 207 and a fourth transfer device 405. The pipette tip conveyor line 207 is located on the side of the second partition 108 facing the pipette tip loading area 105. The fourth transfer device 405 is used to pick up the pipette tip consumables on the pipette tip storage rack 406 and transfer them to the pipette tip conveyor line 207. The first transfer device is used to transfer the pipette tip consumables on the pipette tip conveyor line 207 to the sample detection area 102. The pipette tip storage area 106 and the reagent tube loading area 104 are located on the same side, allowing operators to replenish pipette tip consumables and reagent tube consumables from the same side of the chassis 100, effectively shortening the operation path and improving loading efficiency.

[0035] Specifically, the fourth transfer device 405 is configured as a robotic arm with multi-degree-of-freedom motion capabilities, capable of flexibly grasping the suction head consumables and delivering them to the suction head conveyor line 207 via a preset motion trajectory. Furthermore, the suction head conveyor line 207 is equipped with a snap-fit ​​structure to secure the suction head consumables.

[0036] Specifically, the suction head storage area 106 is also equipped with a suction head waste rack 404, which is used to store used suction head consumables, or to store unused suction head consumables.

[0037] In this embodiment of the invention, the sample processing assembly includes a sample transfer component, a sample purification component, and a capping component arranged sequentially along its length. These components correspond to the first chamber 200, the second chamber 300, and the third chamber 400, respectively, with each chamber having a distinct function. Specifically, the sample transfer component transfers the sample from the sample tube to a reagent tube consumable; the sample purification component purifies the sample in the reagent tube consumable and transfers the purified sample to a detection container consumable; the capping component caps the detection container consumable; and the first robotic arm 412 transfers the capped detection container consumable to the first conveyor line 409.

[0038] Specifically, the sample transfer assembly includes a sample tube carrier, a cap-opening robotic arm 201, and a first pipetting robotic arm 211. The sample tube carrier and the first loading port 103 are spaced apart along the width direction. The cap-opening robotic arm 201 is used to open the caps of the sample tubes on the sample tube carrier. The first pipetting robotic arm 211 is configured to automatically pick up new pipette tips from the tip box according to a preset program, then transfer the sample in the sample tube to the reagent tube consumable. After completing one sample transfer operation, the used pipette tip is accurately placed into a preset waste collection area, and then the next pipette tip is replaced. By setting up the cap-opening robotic arm 201 and the first pipetting robotic arm 211, the risk of manual contact with samples can be reduced, and the level of automation of the operation can be improved.

[0039] Specifically, the structure of the cap-opening robotic arm 201 is selected according to the structure of the sample tube. For example, if the tube body and cap of the sample tube are connected by threads, the cap-opening robotic arm 201 can be configured to have a rotating clamping mechanism, which clamps the cap and applies a rotational torque to unscrew the cap. If the sample tube has a press-type cap design, the cap-opening robotic arm 201 can be equipped with a gripper with an elastic pressing component, which first applies a downward pressing unlocking force to the cap, and then clamps the cap to complete the vertical removal action.

[0040] In this embodiment of the invention, the sample tube carrier includes a sample tube support frame 204 and a first tube clamping mechanism 209. The sample tube support frame 204 has a first slide rail at its bottom, extending along its width. The first tube clamping mechanism 209 is used to clamp the body of the sample tube. By providing the first tube clamping mechanism 209, the body of the sample tube can be fixed, ensuring that the tube remains stationary during the opening process and guaranteeing a high success rate for opening the cap.

[0041] Specifically, the first tube clamping mechanism 209 includes a housing with several through holes, each through hole corresponding to a sample tube, and a clamping claw inside the housing to fix or release the tube.

[0042] In this embodiment of the invention, the sample tube carrier further includes an expedited shipment carrier 205, a sample tube detector, and a controller. The expedited shipment carrier 205 carries sample tubes, the sample tube detector detects the sample tubes on the expedited shipment carrier 205, and the controller controls the cap-opening robotic arm 201 to transfer the sample tubes from the expedited shipment carrier 205 to the first tube clamping mechanism 209 when the sample tube detector detects a sample tube. The expedited shipment carrier 205 enables priority processing of sample tubes. When the sample tube detector detects a sample tube to be processed on the expedited shipment carrier 205, the controller immediately responds and adjusts the working sequence of the cap-opening robotic arm 201, prioritizing the transfer of expedited sample tubes to the first tube clamping mechanism 209 for cap opening. This effectively shortens the processing time for expedited samples, meets the needs of emergency testing scenarios, and improves the overall emergency response capability and work efficiency of the equipment. Of course, the expedited shipment carrier 205 can also be used to hold abnormal sample tubes, allowing the data from the abnormal sample tubes to be extracted separately from the test results.

[0043] In this embodiment of the invention, there are two sample tube support frames 204, and each sample tube support frame 204 has a first slide rail at its lower end. The two sample tube support frames 204 are used for sample tube injection and retrieval, respectively, and the injection and retrieval are staggered to avoid interference.

[0044] In this embodiment of the invention, the sample tube carrier further includes a quality control agent carrier 202, which is arranged in parallel with the sample tube carrier 204. The quality control agent carrier 202 is used to carry the sample tube containing the quality control agent. By comparing the actual detection results of the quality control agent with known standard data, possible errors in the detection system can be detected in a timely manner, providing an important guarantee for the quality control of molecular diagnostic results.

[0045] Specifically, a first reagent mixing device 203 is provided between the quality control reagent carrier 202 and the sample tube carrier 204, which can perform a mixing operation on the sample according to the testing needs.

[0046] In this embodiment of the present invention, the molecular diagnostic device further includes a second conveyor line 208 for conveying reagent tube consumables. The second conveyor line 208 is disposed between the sample transfer component and the first loading port 103 and extends to the rear side of the sample purification component. The sample purification component includes several purification processing modules and a fifth transfer device 306. According to the processing needs of different samples, the fifth transfer device 306 picks up the reagent tube consumables on the second conveyor line 208 and transfers them to one of the several purification processing modules according to a set program.

[0047] Specifically, the purification processing modules include: a washing and dispensing module 302, which is used to wash and purify the sample in the reagent tube consumable; an oscillation and heating module 303, which is used to oscillate or heat the sample in the reagent tube consumable individually, or to oscillate and heat simultaneously; and a magnetic adsorption module 307, which is used to magnetically adsorb and purify the sample in the reagent tube consumable.

[0048] Specifically, the fifth transfer device 306 is provided with a second slide rail at the bottom. The second slide rail extends along the width direction. Several purification processing modules are respectively arranged on both sides of the second slide rail. The fifth transfer device 306 moves to the position of the corresponding purification processing module through the second slide rail and pushes the reagent tube consumables horizontally into the corresponding purification processing module.

[0049] Furthermore, the washing and dispensing module 302 is located close to the second conveyor line 208, and can directly clean and purify the reagent tube consumables on the second conveyor line 208. One side of the second slide rail is provided with an oscillation heating module 303 and a stationary module 305, and the other side is provided with a magnetic suction module 307 and an oscillation heating module 303.

[0050] Furthermore, a second reagent mixing device 304 is provided on the side of the stationary module 305 facing away from the second slide rail, which can mix and load amplification reagents as needed.

[0051] In this embodiment of the invention, the capping assembly includes a test consumable container 407, a cover plate support frame 408, a third conveyor line 403, and a third robotic arm 401. The third conveyor line 403 extends along its length and sequentially passes through the sample purification assembly, the test consumable container 407, and the cover plate support frame 408. The third robotic arm 401 is used to pick up the test container consumables in the test consumable container 407 and transfer them to the third conveyor line 403, and to pick up the cover plate consumables on the cover plate support frame 408 to cap the test container consumables on the third conveyor line 403. By capping the test container consumables, the evaporation of reagents and external contamination during the testing process can be effectively prevented, ensuring that the subsequent amplification reaction proceeds stably in a closed environment. After the third conveyor line 403 completes the capping operation, it will sequentially transport the sealed test container consumables to the subsequent sample testing area 102. The entire process does not require manual intervention, realizing fully automated flow from the use of test container consumables, reagent loading to capping, which greatly improves the efficiency and accuracy of molecular diagnostics.

[0052] Specifically, the third robotic arm 401 has multiple functional modules that can be used to grasp sample tubes for automatic opening, reagent dispensing, and sealing.

[0053] Specifically, the testing consumables container 407 is mounted on a sliding base plate 411, which is also equipped with a refrigeration device. The refrigeration device is equipped with a reagent support rack 410. The refrigeration device can stably control the temperature of the reagent support rack 410 area at a set low temperature to meet the low temperature storage requirements of the reagents.

[0054] It should be noted that in this embodiment of the utility model, the material transfer between multiple conveying mechanisms is involved, and the transfer process can be realized by corresponding robotic arms or gripper structures.

[0055] In the description of this utility model, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0056] In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0057] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0058] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A molecular diagnostic device, characterized in that, The molecular diagnostic device includes: The chassis (100) has an inner cavity divided into a sample detection chamber and a consumable loading chamber along the height direction. The sample detection chamber is divided into a sample processing area (101) and a sample detection area (102) along the length direction. A sample processing assembly is provided in the sample processing area (101), and a sample detection assembly (502) is provided in the sample detection area (102). The chassis (100) also has a first loading port (103) connecting the sample detection area (102) and the consumable loading chamber, and a second loading port connecting the sample processing area (101) and the sample detection area (102). The first transfer device is located in the consumable feeding chamber and is used to transfer the consumables in the consumable feeding chamber to the sample processing area (101) through the first feeding port (103). The second transfer device includes a first conveyor line (409), a first robotic arm (412), and a second robotic arm (501). The first conveyor line (409) is disposed through the second loading port. The first robotic arm (412) is disposed in the sample processing area (101) and is used to transfer consumables on the sample processing assembly to the first conveyor line (409). The second robotic arm (501) is disposed in the sample detection area (102) and is used to transfer consumables on the first conveyor line (409) to the sample detection assembly (502).

2. The molecular diagnostic device according to claim 1, characterized in that, The loading chamber is divided into a reagent tube loading area (104) and a pipette tip loading area (105) along its width. The first loading port (103) connects the sample processing area (101) and the pipette tip loading area (105). The first transfer device is located in the pipette tip loading area (105) and is used to transfer pipette tip consumables to the sample processing area (101). A third loading port is formed in the chassis (100). The third loading port connects the sample processing area (101) and the reagent tube loading area (104). The molecular diagnostic device also includes a third transfer device (206) located in the reagent tube loading area (104). The third transfer device is used to transfer reagent tube consumables to the sample processing area (101) through the third loading port.

3. The molecular diagnostic device according to claim 2, characterized in that, The chassis (100) is provided with a first partition (107) and a second partition (108). The first partition (107) separates the reagent tube loading area (104) and the pipette tip loading area (105). The second partition (108) separates the sample processing area (101) and the sample detection area (102). The first partition (107) and the second partition (108) are spaced apart to form a pipette tip storage area (106). The pipette tip storage area (106) is provided with a pipette tip storage rack (406). The molecular diagnostic device further includes a pipette tip delivery line (207) and a fourth transfer device (405). The pipette tip delivery line (207) is located on the side of the second partition (108) facing the pipette tip loading area (105). The fourth transfer device (405) is used to pick up the pipette tip consumables on the pipette tip storage rack (406) and transfer them to the pipette tip delivery line (207). The first transfer device is used to transfer the pipette tip consumables on the pipette tip delivery line (207) to the sample detection area (102).

4. The molecular diagnostic device according to any one of claims 1 to 3, characterized in that, The sample processing assembly includes a sample transfer component, a sample purification component, and a capping component arranged sequentially along the length direction. The sample transfer component is used to transfer the sample in the sample tube to the reagent tube consumable. The sample purification component is used to purify the sample in the reagent tube consumable and transfer the purified sample to the detection container consumable. The capping component is used to cap the detection container consumable. The first robotic arm (412) is used to transfer the capped detection container consumable to the first conveyor line (409).

5. The molecular diagnostic device according to claim 4, characterized in that, The sample transfer assembly includes a sample tube carrier, a cap-opening robotic arm (201), and a first pipetting robotic arm (211). The sample tube carrier and the first loading port (103) are spaced apart along the width direction. The cap-opening robotic arm (201) is used to open the sample tube on the sample tube carrier. The first pipetting robotic arm (211) is used to replace pipette tip consumables and transfer the sample in the sample tube to the reagent tube consumables.

6. The molecular diagnostic device according to claim 5, characterized in that, The sample tube carrier includes a sample tube support frame (204) and a first tube clamping mechanism (209). The bottom of the sample tube support frame (204) is provided with a first slide rail, which extends along the width direction. The first tube clamping mechanism (209) is used to clamp the tube body of the sample tube.

7. The molecular diagnostic device according to claim 6, characterized in that, The sample tube carrier also includes an expedited shipment carrier (205), a sample tube detector, and a controller. The expedited shipment carrier (205) is used to carry sample tubes. The sample tube detector is used to detect the sample tubes on the expedited shipment carrier (205). The controller is used to control the cap-opening robotic arm (201) to transfer the sample tubes on the expedited shipment carrier (205) to the first tube clamping mechanism (209) when the sample tube detector detects a sample tube. And / or, the number of sample tube support frames (204) is two, and the bottom of each of the two sample tube support frames (204) is provided with the first slide rail.

8. The molecular diagnostic device according to claim 4, characterized in that, The molecular diagnostic device further includes a second conveyor line (208) for conveying reagent tube consumables. The second conveyor line (208) is located between the sample transfer assembly and the first loading port (103) and extends to the rear side of the sample purification assembly. The sample purification assembly includes a plurality of purification processing modules and a fifth transfer device (306). The fifth transfer device (306) is used to pick up the reagent tube consumables on the second conveyor line (208) and transfer them to one of the plurality of purification processing modules.

9. The molecular diagnostic device according to claim 8, characterized in that, Several of the purification processing modules include a washing and dispensing module (302), which is used to wash and purify the sample in the reagent tube consumable; And / or, some of the purification processing modules include an oscillation heating module (303) for oscillating and / or heating the sample in the reagent tube consumable; And / or, some of the purification processing modules include a magnetic suction module (307) for magnetically purifying samples within reagent tube consumables; And / or, the bottom of the fifth transfer device (306) is provided with a second slide rail, the second slide rail extends along the width direction, and a plurality of the purification processing modules are respectively disposed on both sides of the second slide rail.

10. The molecular diagnostic device according to claim 4, characterized in that, The sealing assembly includes a testing consumable container (407), a cover plate support frame (408), a third conveyor line (403), and a third robotic arm (401). The third conveyor line (403) extends along its length and passes sequentially through the sample purification assembly, the testing consumable container (407), and the cover plate support frame (408). The third robotic arm (401) is used to pick up the testing container consumables in the testing consumable container (407) and transfer them to the third conveyor line (403), and to pick up the cover plate consumables on the cover plate support frame (408) to seal the testing container consumables on the third conveyor line (403).

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