A glucose isomerase plate-and-frame filter-press fixed-bed reactor

Abstract

The utility model discloses a kind of glucose isomerase plate and frame filter pressing fixed bed reactor, including support and the tank body being fixedly installed on support and being connected with plate and frame filter outlet liquid port, further include: fixedly installed in tank body middle part for loading glucose granule's reaction bed, the top end cover of the reaction bed is annular and is provided with for permeating glucose feed liquid's seepage hole, the bottom end cover of the reaction bed is provided for guiding gas's guide element;Temperature control is used for temperature control and is arranged on tank body.This utility model is through the seepage hole of reaction bed top annular distribution, multistage gas dispersion's diffusion pipe-air inlet pipe-L shape pipe combination and gas outlet hole design, realize that feed liquid and reaction medium, gas and reaction medium are fully and evenly contacted, effectively reduce the situation of local reaction incomplete, while gas auxiliary mass transfer effect improves the overall efficiency of isomerization reaction, help to improve glucose to fructose conversion rate.

Description

Technical Field

[0001] This utility model relates to the field of biochemical reaction equipment technology, and more specifically, to a plate and frame filter press fixed bed reactor for glucose isomerase. Background Technology

[0002] Fixed-bed reactors for glucose isomerase are core equipment in the production of fructose syrup in the food industry. Their core function is to provide a stable environment for the reaction catalyzed by glucose isomerase to convert glucose into fructose, enabling enzyme reuse and continuous product separation. This directly determines the production efficiency, product yield, and production cost of fructose syrup. Due to their ease of operation and high enzyme utilization, these reactors have become the mainstream reaction equipment in large-scale fructose syrup production.

[0003] In industrial production, glucose feedstock solution needs to be pretreated by plate and frame filtration to remove impurities such as proteins, colloids, and suspended solids, preventing clogging of the reactor bed and affecting enzyme activity. In some processes, plate and frame filtration is also used for pre-compacting glucose isomerase immobilization carriers to improve the structural stability of the carriers. The material treated by plate and frame filtration (or the reaction system filled with pre-compacted carriers) is continuously fed into the fixed-bed reactor to complete the isomerization reaction under enzyme catalysis, forming a continuous production process.

[0004] However, existing reactors have certain problems in practical applications: First, the contact uniformity between the feed liquid and the reaction medium is poor, and the feed liquid after plate and frame filtration cannot fully penetrate into the reaction medium, resulting in incomplete local reactions and low overall reaction efficiency. Second, the gas interaction effect is poor, and the introduced gas cannot diffuse evenly throughout the reaction area, making it difficult to fully contact the reaction medium and limiting mass transfer efficiency. Third, the temperature control precision is insufficient, making it impossible to stably maintain the suitable temperature required for enzyme catalysis, and temperature fluctuations can easily reduce enzyme activity and affect product yield. Fourth, waste liquid treatment is inconvenient, and the waste liquid generated during the reaction process is easy to remain inside the equipment, which not only causes waste but may also affect the subsequent reaction effect. Fifth, the loading stability of the reaction medium is insufficient, and it is easily affected by fluid or gas impacts during long-term operation. At the same time, the product discharge process is not smooth, making it difficult to efficiently adapt to the continuous process of plate and frame filter press, resulting in a decrease in production continuity. Therefore, we urgently need a fixed-bed plate and frame filter press reactor for glucose isomerase to solve the above problems. Utility Model Content

[0005] One objective of this invention is to provide a new technical solution for a plate and frame filter press fixed bed reactor for glucose isomerase. Through the synergistic design of annular permeation holes, multi-stage gas dispersion components, a stable temperature control jacket, and dedicated conveying / discharging pipes, it achieves efficient contact between the feed liquid and the reaction medium, a stable reaction environment, and convenient medium replacement. It is suitable for continuous plate and frame filter press processes, thereby improving production efficiency and continuity.

[0006] According to a first aspect of the present invention, a fixed-bed reactor for glucose isomerase plate and frame filter press is provided, comprising a support and a tank fixedly mounted on the support and connected to the outlet of the plate and frame filter press, further comprising: a reaction bed fixedly mounted in the middle of the tank for loading glucose particles, wherein the top end cap of the reaction bed is provided with annular permeation holes for permeating glucose solution, and the bottom end cap of the reaction bed is provided with a guide for guiding gas; and a temperature control unit provided on the tank for temperature control.

[0007] Optionally, a mounting frame for supporting the reaction bed is fixedly installed inside the tank, and the mounting frame is fixedly installed with the reaction bed. A drain hole for discharging waste liquid is opened on the mounting frame located at the lower part.

[0008] Optionally, a collection tray for temporarily storing waste liquid is fixedly connected to the lower part of the tank, and the input end of the collection tray is connected to the bottom wall of the tank through a pipe.

[0009] Optionally, the guide includes a diffuser tube fixedly installed inside the tank and located below the reaction bed. The input end of the diffuser tube is connected to an external gas supply unit. An air inlet pipe is fixedly installed inside the tank, and the input end of the air inlet pipe corresponds to the output end of the diffuser tube.

[0010] Optionally, at least four sets of L-shaped pipes for guiding gas are installed at equal intervals around the end of the air inlet pipe, and several air outlet holes are opened on the L-shaped pipes along their path.

[0011] Optionally, the temperature control unit includes a jacket formed on the tank body, one side of the tank body is connected to an external heating device through a first connecting pipe, and the other side of the tank body is connected to an external circulation device through a second connecting pipe, and both the first connecting pipe and the second connecting pipe are connected to the jacket.

[0012] Optionally, the inner bottom wall of the reaction bed is conical, a conveying pipe connected to the upper end cover of the reaction bed is installed on the tank, and a discharge pipe connected to the lower end cover of the reaction bed is installed at the lower part of the tank.

[0013] 1. According to one embodiment of this disclosure, the glucose isomerase plate and frame filter press fixed bed reactor achieves full and uniform contact between the feed liquid and the reaction medium, and between the gas and the reaction medium, through the design of a ring-shaped distribution of permeation holes at the top of the reaction bed, a multi-stage gas dispersion diffuser-air inlet-L-shaped pipe combination, and an outlet hole. This effectively reduces the situation of incomplete local reaction, and at the same time, the gas-assisted mass transfer improves the overall efficiency of the isomerization reaction, which helps to improve the conversion rate of glucose to fructose.

[0014] 2. According to one embodiment of this disclosure, the glucose isomerase plate and frame filter press fixed bed reactor ensures stable and controllable reaction temperature through a jacket and heat-conducting medium circulation loop, adapting to the optimal catalytic requirements of glucose isomerase; the loading and unloading process of the reaction medium is simplified through the delivery pipe and discharge pipe, and the waste liquid centralized collection design of the collection tray reduces the difficulty of equipment maintenance and downtime. At the same time, the stable support of the bracket and mounting frame improves the stability of equipment operation. The whole system is adapted to the continuous plate and frame filter press process, which helps to improve production continuity and operation convenience.

[0015] Other features and advantages of the present invention will become clear from the following detailed description of exemplary embodiments of the present invention with reference to the accompanying drawings. Attached Figure Description

[0016] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments of the present invention and, together with their description, serve to explain the principles of the present invention.

[0017] Figure 1 This is a schematic diagram of the overall structure of a plate and frame filter press fixed bed reactor for glucose isomerase in one embodiment; Figure 2 This is a first-view cross-sectional structural schematic diagram of a plate and frame filter press fixed bed reactor for glucose isomerase in one embodiment; Figure 3 This is a second-view cross-sectional structural schematic diagram of a plate and frame filter press fixed bed reactor for glucose isomerase in one embodiment; Figure 4 One embodiment is a plate and frame filter press fixed bed reactor for glucose isomerase. Figure 3 Schematic diagram of the cross-section structure at the center; Figure 5 This is a schematic diagram of the L-shaped tube structure of a plate and frame filter press fixed bed reactor for glucose isomerase in one embodiment.

[0018] The following are marked in the diagram: 1. Support; 2. Tank; 3. Reaction bed; 4. Leakage hole; 5. Mounting frame; 6. Drain hole; 7. Collection tray; 8. Diffuser; 9. Air inlet pipe; 10. L-shaped pipe; 11. Gas outlet; 12. Jacket; 13. First connecting pipe; 14. Second connecting pipe; 15. Conveying pipe; 16. Discharge pipe. Detailed Implementation

[0019] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that, unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps set forth in these embodiments do not limit the scope of the present invention.

[0020] The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the invention or its application or use.

[0021] Techniques, methods, and equipment known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and equipment should be considered part of the specification.

[0022] In all the examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values.

[0023] like Figure 1-5 As shown, a plate and frame filter press fixed bed reactor for glucose isomerase includes a support 1 and a tank 2 fixedly installed on the support 1 and connected to the outlet of the plate and frame filter press.

[0024] Here, a support structure constructed with high-strength materials provides a stable installation foundation for the entire reaction equipment, effectively mitigating the vibration effects caused by fluid flow and gas introduction during operation, and preventing equipment displacement or loosening of interfaces. The sealed shell design of the main body of the equipment not only adapts to the discharge requirements of the front-end pretreatment process, achieving smooth material flow, but also reduces the contact between the internal material and the external environment, lowering the risk of contamination. At the same time, the smooth inner wall design reduces material residue, facilitating subsequent cleaning and maintenance.

[0025] It also includes a reaction bed 3 fixedly installed in the middle of the tank 2 for loading glucose granules. The top end cap of the reaction bed 3 has an annular permeation hole 4 for permeating glucose solution. A mounting frame 5 for supporting the reaction bed 3 is fixedly installed inside the tank 2, and the mounting frame 5 is fixedly installed with the reaction bed 3.

[0026] Here, the permeation hole 4 is used for the permeation and distribution of the liquid. Through a reasonable distribution design, the liquid can enter the reaction area simultaneously from multiple points, avoiding the concentrated impact of the liquid on the local medium, expanding the contact coverage of the liquid and the medium, improving the contact uniformity, and ensuring the sufficiency of the reaction.

[0027] Furthermore, the mounting frame 5 serves as the load-bearing and fixing component of the reaction bed 3. Its structural strength can effectively support the weight of the reaction bed 3 and the internal medium. The firm connection prevents the reaction bed 3 from shaking or shifting during operation. At the same time, it reserves a reasonable channel for the flow of waste liquid below, taking into account both stability and functionality.

[0028] The mounting bracket 5 at the bottom is provided with a drain hole 6 for draining waste liquid. The bottom of the tank body 2 is fixedly connected with a collection tray 7 for temporarily storing waste liquid. The input end of the collection tray 7 is connected to the bottom wall of the tank body 2 through a pipe.

[0029] Here, the drain hole 6 is responsible for guiding the waste liquid out. Its hole size and distribution design can quickly export the waste liquid generated in the reaction area, avoid the waste liquid from accumulating at the bottom of the reaction bed 3, prevent the waste liquid from interfering with the reaction environment, and ensure the stability of the reaction conditions.

[0030] Furthermore, the collection tray 7, as a centralized collection component for waste liquid, can collect the dispersed waste liquid in a unified manner, avoiding equipment pollution or resource waste caused by the random flow of waste liquid. At the same time, it provides convenience for the subsequent centralized treatment of waste liquid, simplifies the operation process, and improves the efficiency of waste liquid treatment.

[0031] The bottom end cap of the reaction bed 3 is provided with a guide for guiding gas. The guide includes a diffuser 8 fixedly installed inside the tank 2 and located below the reaction bed 3. The input end of the diffuser 8 is connected to an external gas supply unit. An air inlet pipe 9 is fixedly installed inside the tank 2. The input end of the air inlet pipe 9 corresponds to the output end of the diffuser 8. At least four sets of L-shaped pipes 10 for guiding gas are installed circumferentially and equidistantly at the end of the air inlet pipe 9. Several air outlet holes 11 are opened on the L-shaped pipes 10 along their path.

[0032] Here, the diffuser 8 serves as a preliminary gas dispersion component, which can divert the gas introduced from the outside for the first time, avoiding the gas from concentrating and impacting a single area, laying the foundation for the uniform diffusion of the gas in the future, and ensuring that the gas can cover a wider reaction area.

[0033] Furthermore, the air inlet duct 9 receives the diffused gas and directs it to the area below the reaction zone. Its duct path design reduces gas flow resistance, ensuring smooth gas transmission and guiding the gas to flow in a designated direction to prevent gas leakage or ineffective loss. The L-shaped pipe 10 serves as a secondary dispersion and guiding component for the gas. Its special shape design allows the gas to be ejected from multiple directions at the bottom of the reaction zone, expanding the gas coverage area and ensuring that the gas can uniformly contact the reaction medium, thereby improving mass transfer efficiency.

[0034] Furthermore, the number and diameter of the gas outlet 11, as the final gas release port, can control the gas ejection rate and distribution density, avoiding excessively fast gas flow that impacts the medium or insufficient gas flow that fails to fully contact the medium, thus achieving a stable and uniform gas release.

[0035] It should be noted that the top of tank 2 is equipped with a pipe for discharging exhaust gas. This is a direct reference to conventional technical solutions and will not be elaborated on here.

[0036] A temperature control unit is installed on the tank body 2 for temperature control. The temperature control unit includes a jacket 12 opened on the tank body 2. One side of the tank body 2 is connected to an external heating device through a first connecting pipe 13, and the other side of the tank body 2 is connected to an external circulation device through a second connecting pipe 14. Both the first connecting pipe 13 and the second connecting pipe 14 are connected to the jacket 12. The inner bottom wall of the reaction bed 3 is conical. A conveying pipe 15 connected to the upper end cover of the reaction bed 3 is installed on the tank body 2, and a discharge pipe 16 connected to the lower end cover of the reaction bed 3 is installed at the lower part of the tank body 2.

[0037] Here, the interlayer 12 serves as the core space for temperature regulation. Its surrounding design allows the heat-conducting medium to uniformly envelop the reaction area, ensuring consistent temperature across all parts of the reaction area, reducing temperature gradients, and providing a stable temperature environment for enzyme catalytic reactions.

[0038] Furthermore, the first connecting pipe 13 serves as the input channel for the heat transfer medium. Its connection design enables precise docking with external heating equipment, ensuring smooth flow of the heat transfer medium into the jacket 12. At the same time, its sealing performance can prevent leakage of the heat transfer medium and ensure the stability of temperature regulation. The second connecting pipe 14 serves as the circulation output channel for the heat transfer medium, which can export the heat transfer medium in the jacket 12 to the external circulation equipment, forming a complete heat transfer medium circulation loop, ensuring the continuity and accuracy of temperature regulation, and avoiding temperature fluctuations.

[0039] Furthermore, the conveying pipe 15 is used for the input loading of particles (reaction medium) inside the reaction bed 3. Its diameter and connection position are designed to match the particle size, allowing the particles to enter the reaction bed 3 smoothly, avoiding blockage or spillage during loading, improving the convenience and uniformity of medium loading, and laying the foundation for the uniformity of subsequent reactions. The discharge pipe 16 is used for the output unloading of deactivated particles (waste medium) inside the reaction bed 3. Its connection position is designed to fit the bottom of the reaction bed 3, which can guide the waste particles to be discharged quickly and smoothly, reducing the residue of particles inside the reaction bed 3, simplifying the medium replacement process, shortening equipment downtime for maintenance, and improving production continuity.

[0040] In this invention, glucose isomerase immobilized particles are first smoothly fed into the reaction bed 3 through the delivery pipe 15, ensuring uniform filling and distribution under the stable support of the mounting frame 5. Then, the external heating and circulation equipment is activated, and the heat transfer medium flows into the jacket 12 of the tank 2 through the first connecting pipe 13, and then forms a closed-loop circulation through the second connecting pipe 14, stabilizing the temperature inside the tank 2 at the optimal catalytic temperature for glucose isomerase. The glucose solution pretreated by plate and frame filter press is guided to the top of the reaction bed 3 through the appropriate channel, and simultaneously permeates into the reaction medium from multiple points through the annularly distributed permeation holes 4. In the reaction medium, the isomerization reaction is initiated upon contact with the enzyme. Simultaneously, the gas output from the external gas supply unit is initially diverted through the diffuser 8 and directionally transported through the air inlet pipe 9. It is then further dispersed into a uniform airflow through the air outlet 11 of the L-shaped pipe 10 and smoothly sprayed onto the reaction medium to promote mass transfer. The fructose syrup generated by the reaction is guided to the bottom by the conical inner bottom wall of the reaction bed 3 and discharged to the subsequent equipment. The waste liquid generated is discharged through the drain hole 6 of the mounting frame 5 and flows into the collection tray 7 for centralized collection. When the enzyme activity of the reaction medium decreases, the inactivated particles are quickly unloaded through the discharge pipe 16, and then new medium is added through the delivery pipe 15 to restart the equipment.

[0041] Although specific embodiments of the present invention have been described in detail by way of examples, those skilled in the art should understand that the above examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Those skilled in the art should understand that modifications can be made to the above embodiments without departing from the scope and spirit of the present invention. The scope of the present invention is defined by the appended claims.

Claims

1. A plate and frame filter press fixed bed reactor for glucose isomerase, comprising a support (1) and a tank (2) fixedly mounted on the support (1) and connected to the outlet of the plate and frame filter press, characterized in that: Also includes: A reaction bed (3) for loading glucose granules is fixedly installed in the middle of the tank (2). The top end cover of the reaction bed (3) is provided with a permeation hole (4) for permeating glucose solution. The bottom end cover of the reaction bed (3) is provided with a guide for guiding gas. A temperature control unit is installed on the tank body (2) for temperature control.

2. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 1, characterized in that: The tank (2) is fixedly installed with a mounting frame (5) for supporting the reaction bed (3), and the mounting frame (5) is fixedly installed with the reaction bed (3). The mounting frame (5) located at the bottom is provided with a drain hole (6) for draining waste liquid.

3. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 1, characterized in that: The lower part of the tank (2) is fixedly connected to a collection tray (7) for temporarily storing waste liquid, and the input end of the collection tray (7) is connected to the bottom wall of the tank (2) through a pipe.

4. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 1, characterized in that: The guide includes a diffuser (8) fixedly installed inside the tank (2) and located below the reaction bed (3). The input end of the diffuser (8) is connected to an external gas supply unit. An air inlet pipe (9) is fixedly installed inside the tank (2). The input end of the air inlet pipe (9) corresponds to the output end of the diffuser (8).

5. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 4, characterized in that: At least four sets of L-shaped pipes (10) for guiding gas are installed at equal intervals around the end of the air inlet pipe (9), and several air outlet holes (11) are opened on the L-shaped pipes (10) along their path.

6. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 1, characterized in that: The temperature control unit includes a jacket (12) formed on the tank (2). One side of the tank (2) is connected to an external heating device through a first connecting pipe (13), and the other side of the tank (2) is connected to an external circulation device through a second connecting pipe (14). Both the first connecting pipe (13) and the second connecting pipe (14) are connected to the jacket (12).

7. The glucose isomerase plate and frame filter press fixed bed reactor according to claim 1, characterized in that: The inner bottom wall of the reaction bed (3) is conical. A conveying pipe (15) connected to the upper end cover of the reaction bed (3) is installed on the tank (2). A discharge pipe (16) connected to the lower end cover of the reaction bed (3) is installed at the lower part of the tank (2).

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