A cell culture roller bottle holder facilitating cleaning

Abstract

The utility model discloses a cell culture rolling bottle fixing frame convenient to clean, the utility model relates to cell culture equipment technical field, including fixed platform, base and support, and the inside of fixed platform distribution has the rolling bottle limiting mechanism, the utility model's advantage lies in: through setting adjustable annular limiting plate at the both ends of rolling bottle cylinder, through the adjustment movement and make its located rolling bottle both ends, and then can to rolling bottle axial location, prevent the displacement that rolling bottle is in starting, braking or rolling process because of inertia produces, also alleviate the shake of bottle body simultaneously, provide more stable growth environment for cell, in addition set up liftable protective top plate above rolling bottle, can with annular limiting plate cooperation, make rolling bottle construct three -dimensional package formula fixed structure, and then protect experimental sample, and the connecting piece of rolling bottle cylinder is connected with installation groove through locking bolt, make rolling bottle cylinder detachable, and then convenient rolling bottle cylinder dismounting cleaning or replacement, effectively prevent the breeding and cross infection of microorganism.

Description

Technical Field

[0001] This utility model relates to the field of cell culture equipment technology, specifically to a cell culture roller bottle holder that is easy to clean. Background Technology

[0002] Roller flasks are important containers used in cell culture to expand the cell culture area, especially suitable for the industrial production of vaccines, monoclonal antibodies and biotherapeutic drugs. During the culture process, the roller flask is placed on a special fixing frame and slowly rolled to make the cells adhere evenly and grow. Most existing cell culture roller flask fixing frames are made of multi-layer frame welding, which makes it easy for culture medium or cleaning agent to remain in the narrow gaps, resulting in incomplete cleaning and corners.

[0003] The applicant found through a search that a Chinese patent discloses "A Roller Bottle for Mixing Multiple Gases", with publication number "CN218189243U". This patent mainly uses a rolling cylinder to roll the roller bottle, but it lacks a structure to assist in the protection of the roller bottle, which makes the roller bottle easy to deviate or fall during the rolling process, affecting the placement effect of the roller bottle. Therefore, we propose a cell culture roller bottle fixing frame that is easy to clean. Utility Model Content

[0004] The purpose of this invention is to provide a cell culture roller bottle holder that is easy to clean.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a cell culture roller bottle holder that is easy to clean, comprising a fixing platform, a base and a support, wherein a roller bottle limiting mechanism is distributed on the inner side of the fixing platform.

[0006] The bottle-rolling limiting mechanism includes a bottle-rolling cylinder. Both ends of the bottle-rolling cylinder are fitted with annular limiting plates. T-shaped blocks are symmetrically arranged on the inner sides of both sides of the annular limiting plates. A cylindrical groove is formed between the annular limiting plates and the T-shaped blocks. A locking rod is slidably connected in the cylindrical groove. An annular pressure plate is fixedly connected to the outer surface of the end of the locking rod near the T-shaped block. A spring is provided on the side of the annular pressure plate away from the T-shaped block. The spring is sleeved on the outside of the locking rod.

[0007] A protective top plate is slidably connected to the bracket. The protective top plate is located above the rolling bottle, and the bottom side of the protective top plate has fixing holes that are adapted to fit the rolling bottle.

[0008] As a further embodiment of this utility model: a cylinder mechanism is installed at the top of the bracket, and the output end of the cylinder mechanism is bolted to the top side of the protective top plate.

[0009] As a further embodiment of this utility model: the rolling bottle limiting mechanism further includes a rolling assembly, the rolling assembly includes rotating rods, the rotating rods are arranged at both ends of the fixed platform, a transmission belt is provided between the rotating rods at one end, and the input end of the transmission belt is connected to the output end of the motor inside the base.

[0010] As a further embodiment of this utility model: each of the two rotating rods at both ends is provided with an installation groove on one side facing each other, and both ends of the roller cylinder are fixedly connected with connecting parts, and locking bolts are provided between the connecting parts and the installation grooves.

[0011] As a further embodiment of this utility model: T-shaped guide grooves are symmetrically provided on the outer surfaces of both ends of the roller cylinder, and locking holes are arranged in the T-shaped guide grooves.

[0012] As a further embodiment of this utility model: when the lock hole is aligned with the cylindrical groove, the lock rod is inserted into the lock hole.

[0013] As a further embodiment of this utility model: an annular embedding groove is provided on the inner wall of the cylindrical groove near the T-shaped block, and an annular magnetic absorbing piece is embedded in the annular embedding groove. A metal ring is provided on the outer surface of the annular pressure plate near the annular magnetic absorbing piece, and the metal ring is magnetically attracted to the annular magnetic absorbing piece.

[0014] Compared with the prior art, the beneficial effects of this utility model by adopting the above technical solution are as follows:

[0015] 1. This utility model sets adjustable annular limiting plates at both ends of the rolling bottle barrel. By adjusting and moving these plates, they are positioned at both ends of the rolling bottle, thereby limiting the axial movement of the rolling bottle and preventing displacement caused by inertia during startup, braking, or rolling. This also reduces the shaking of the bottle body and provides a more stable growth environment for cells. In addition, a liftable protective top plate is set above the rolling bottle, which can cooperate with the annular limiting plates to form a three-dimensional enveloping and fixing structure for the rolling bottle, eliminating the risk of displacement or detachment of the rolling bottle and thus protecting the experimental samples.

[0016] 2. The connecting parts at both ends of the roller cylinder of this utility model are connected to the mounting groove by locking bolts, so that the roller cylinder can be disassembled, which facilitates the disassembly, cleaning or replacement of the roller cylinder and effectively prevents the growth of microorganisms and cross-infection.

[0017] Other advantages, objectives and features of this invention will be set forth in part in the description which follows, and in part will be apparent to those skilled in the art from the following examination or study, or may be taught from the practice of this invention. Attached Figure Description

[0018] Figure 1This is a schematic diagram of the overall structure in an embodiment of this utility model;

[0019] Figure 2 This is a schematic diagram of the bottle-rolling limiting mechanism in an embodiment of the present invention;

[0020] Figure 3 This is a partial cross-sectional view of the roller cylinder in an embodiment of this utility model;

[0021] Figure 4 This is a partial cross-sectional view of the annular limiting plate in an embodiment of the present utility model;

[0022] Figure 5 This is a schematic diagram of the bottle roller in an embodiment of the present invention;

[0023] Figure 6 This is an enlarged view of Figure A in the embodiment of this utility model;

[0024] Figure 7 This is an enlarged view of Figure B in the embodiment of this utility model.

[0025] In the diagram: 1. Fixed platform; 2. Base; 3. Bracket; 4. Cylinder mechanism; 5. Protective top plate; 6. Bottle rolling limiting mechanism; 61. Rolling assembly; 611. Rotating rod; 612. Transmission belt; 613. Mounting groove; 62. Bottle rolling cylinder; 621. Connecting piece; 63. Locking bolt; 64. T-shaped guide groove; 65. Locking hole; 66. Annular limiting plate; 67. T-shaped block; 68. Cylindrical groove; 681. Locking rod; 682. Spring; 683. Annular pressure plate; 684. Annular embedding groove; 685. Annular magnetic suction piece. Detailed Implementation

[0026] The specific embodiments of this utility model will be further described below with reference to the accompanying drawings. It should be noted that the description of these embodiments is for the purpose of helping to understand this utility model, but does not constitute a limitation on this utility model.

[0027] Furthermore, the technical features involved in the various embodiments of this utility model described below can be combined with each other as long as they do not conflict with each other.

[0028] Please see the appendix Figure 1 - Appendix Figure 7 This utility model provides a cell culture roller bottle holder that is easy to clean, including a fixing platform 1, a base 2 and a support 3, with a roller bottle limiting mechanism 6 distributed on the inner side of the fixing platform 1.

[0029] In embodiment 1, the bottle rolling limiting mechanism 6 includes a bottle rolling cylinder 62. Both ends of the bottle rolling cylinder 62 are fitted with annular limiting plates 66. T-shaped blocks 67 are symmetrically arranged on the inner sides of both sides of the annular limiting plates 66. A cylindrical groove 68 is opened through between the annular limiting plates 66 and the T-shaped blocks 67. A locking rod 681 is slidably connected in the cylindrical groove 68. An annular pressure plate 683 is fixedly connected to the outer surface of the end of the locking rod 681 near the T-shaped block 67. A spring 682 is provided on the side of the annular pressure plate 683 away from the T-shaped block 67. The spring 682 is fitted on the outside of the locking rod 681.

[0030] Specifically, the rolling bottle limiting mechanism 6 includes a rolling assembly 61, which includes a rotating rod 611. The rotating rods 611 are arranged at both ends of the fixed platform 1. A transmission belt 612 is provided between the rotating rods 611 at one end. The input end of the transmission belt 612 is connected to the output end of the motor inside the base 2.

[0031] In this embodiment, the motor causes the distributed rotating rods 611 to rotate via the transmission belt 612, thereby causing the rollers placed between the two roller cylinders 62 to roll. The slow rotation allows the culture medium to evenly cover the cell layer, improving culture efficiency.

[0032] Specifically, each of the two rotating rods 611 has an installation groove 613 on one side facing each other, and both ends of the roller cylinder 62 are fixedly connected to a connector 621, with a locking bolt 63 between the connector 621 and the installation groove 613.

[0033] In this embodiment, the connectors 621 at both ends of the roller cylinder 62 are connected to the mounting groove 613 by locking bolts 63, making the roller cylinder 62 detachable, which facilitates the disassembly, cleaning or replacement of the roller cylinder 62 and effectively prevents the growth of microorganisms and cross-infection.

[0034] Specifically, T-shaped guide grooves 64 are symmetrically provided on the outer surfaces of both ends of the roller cylinder 62. Locking holes 65 are arranged in the T-shaped guide grooves 64. When the locking holes 65 are aligned with the cylindrical grooves 68, the locking rod 681 is inserted into the locking holes 65.

[0035] In this embodiment, the user can simultaneously pull the pull rings on both sides of the locking rod 681, causing the annular pressure plate 683 to slide in the cylindrical groove 68, thereby squeezing the spring 682, so that the locking rod 681 moves away from the lock hole 65. By moving the annular limiting plate 66, the user can adjust it to the position at both ends of the rolling bottle. By releasing both hands, the spring 682 can be elastically reset, allowing the locking rod 681 to pass through the T-shaped block 67 and lock in the nearby lock hole 65.

[0036] Specifically, an annular embedding groove 684 is provided on the inner wall of the cylindrical groove 68 near the T-shaped block 67. An annular magnetic absorbing piece 685 is embedded in the annular embedding groove 684. A metal ring is provided on the outer surface of the annular pressure plate 683 near the annular magnetic absorbing piece 685. The metal ring is magnetically attracted to the annular magnetic absorbing piece 685.

[0037] Specifically, after the locking rod 681 is locked, the metal ring and the annular magnetic plate 685 are magnetically attracted, which can fix the locking rod 681, prevent the vibration caused by rolling from causing the spring 682 to vibrate and affecting the locking effect of the locking rod 681, and improve stability.

[0038] In embodiment 2, a protective top plate 5 is slidably connected to the bracket 3. The protective top plate 5 is located above the rolling bottle, and the bottom side of the protective top plate 5 is provided with fixing holes to match the rolling bottle.

[0039] Specifically, a cylinder mechanism 4 is installed at the top of the bracket 3, and the output end of the cylinder mechanism 4 is bolted to the top side of the protective top plate 5;

[0040] In this embodiment, a liftable protective top plate 5 is provided above the rolling bottle, which can cooperate with the annular limiting plate 66 to form a three-dimensional wrapping and fixing structure for the rolling bottle, eliminating the risk of displacement or falling off the rolling bottle, thereby protecting the experimental sample.

[0041] Working principle: The cell culture roller flask is placed between two roller flask cylinders 62. Then, the cylinder mechanism 4 is driven to lower the protective top plate 5 above the roller flask. Next, the user can simultaneously pull the pull rings on both locking rods 681, causing the annular pressure plate 683 to slide in the cylindrical groove 68, thereby squeezing the spring 682. This causes the locking rod 681 to move away from the locking hole 65. By moving the annular limiting plate 66, it is adjusted to the position at both ends of the roller flask. Releasing both hands allows the spring 682 to elastically return to its original position, allowing the locking rod 681 to pass through the T-shaped block 67 and lock in the nearby locking hole 65. Then, the motor is started, causing the transmission belt 612 to drive the rotating rod 611 to rotate, thereby causing the roller flask placed between the two roller flask cylinders 62 to roll. Through slow rotation, the culture medium is evenly covered with the cell layer. At this point, the entire workflow is complete.

[0042] The terms "front," "back," "left," "right," "top," and "bottom" all refer to the figures in the accompanying drawings. Figure 1 Based on.

[0043] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting the scope of protection of this utility model.

[0044] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments.

[0045] For those skilled in the art, various changes, modifications, substitutions, and alterations to these embodiments without departing from the principles and spirit of this utility model will still fall within the protection scope of this utility model.

Claims

1. A cell culture roller bottle holder that is easy to clean, comprising a fixing platform (1), a base (2), and a support (3), characterized in that: The inner side of the fixed platform (1) is provided with a rolling bottle limiting mechanism (6). The bottle-rolling limiting mechanism (6) includes a bottle-rolling cylinder (62). Both ends of the bottle-rolling cylinder (62) are fitted with annular limiting plates (66). T-shaped blocks (67) are symmetrically arranged on the inner sides of both sides of the annular limiting plates (66). A cylindrical groove (68) is opened through between the annular limiting plates (66) and the T-shaped blocks (67). A locking rod (681) is slidably connected in the cylindrical groove (68). An annular pressure plate (683) is fixedly connected to the outer surface of the locking rod (681) near the T-shaped block (67). A spring (682) is provided on the side of the annular pressure plate (683) away from the T-shaped block (67). The spring (682) is fitted on the outside of the locking rod (681). A protective top plate (5) is slidably connected to the bracket (3). The protective top plate (5) is located above the rolling bottle. Fixing holes are arranged on the bottom side of the protective top plate (5) to match the rolling bottle.

2. The cell culture roller bottle holder for easy cleaning according to claim 1, characterized in that: The top of the bracket (3) is equipped with a cylinder mechanism (4), and the output end of the cylinder mechanism (4) is bolted to the top side of the protective top plate (5).

3. The cell culture roller bottle holder for easy cleaning according to claim 1, characterized in that: The bottle-limiting mechanism (6) further includes a rolling assembly (61), which includes a rotating rod (611). The rotating rods (611) are arranged at both ends of the fixed platform (1). A transmission belt (612) is provided between the rotating rods (611) at one end. The input end of the transmission belt (612) is connected to the output end of the motor inside the base (2).

4. The cell culture roller bottle holder for easy cleaning according to claim 3, characterized in that: The rotating rods (611) at both ends are provided with mounting grooves (613) on opposite sides. The roller cylinder (62) is fixedly connected to both ends with connectors (621). Locking bolts (63) are provided between the connectors (621) and the mounting grooves (613).

5. The cell culture roller bottle holder for easy cleaning according to claim 1, characterized in that: T-shaped guide grooves (64) are symmetrically provided on the outer surfaces of both ends of the roller cylinder (62), and locking holes (65) are arranged in the T-shaped guide grooves (64).

6. The cell culture roller bottle holder for easy cleaning according to claim 5, characterized in that: When the lock hole (65) is aligned with the cylindrical groove (68), the lock rod (681) is inserted into the lock hole (65).

7. The cell culture roller bottle holder for easy cleaning according to claim 1, characterized in that: The cylindrical groove (68) has an annular embedding groove (684) on the inner wall of the side near the T-shaped block (67). An annular magnetic piece (685) is embedded in the annular embedding groove (684). The outer surface of the annular pressure plate (683) near the annular magnetic piece (685) is provided with a metal ring. The metal ring and the annular magnetic piece (685) are magnetically attracted to each other.

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