A sampling connector for pharmaceutical production

Abstract

The utility model provides a kind of sampling connector for pharmaceutical production, it is related to pharmaceutical production sampling equipment field, it includes sampling valve, still includes the connector main body that upper and lower through, the upper end and the lower end of the connector main body are equipped with flange connecting part, the flange connecting part can be connected with the vertical section of filter aid feeding system pipeline by flange;The side wall of connector main body is equipped with the communicating port that is connected to outside, and the sampling valve is installed at communicating port;The inside of connector main body is fixed with intercepting plate, the side of intercepting plate is arc edge and is attached to the inner wall of connector main body, intercepting plate is inclined from the side close to the radial center of connector main body to the side of communicating port;The communicating port is located above the bottom edge of intercepting plate, the utility model solves the technical problem of liquid splashing in the sampling process in prior art, is easy to high temperature scald.

Description

Technical Field

[0001] This utility model relates to the field of sampling equipment for pharmaceutical production, and in particular to a sampling connector for pharmaceutical production. Background Technology

[0002] In the pharmaceutical manufacturing process, in accordance with the requirements of Good Manufacturing Practice (GMP), it is necessary to clean and sample the production pipelines to verify the cleaning effect and avoid residual media from affecting the quality of subsequent drugs.

[0003] Currently, there are two main sampling methods for filter aid feeding systems. One method uses a sampling spoon: the end pipe of the feeding system is directly connected to the reaction vessel, and the sampling personnel hold the sampling spoon and insert it from the reaction vessel opening to the outlet of the pipe to collect the sample. Because the sample water flows rapidly and has a strong impact force, liquid splashing is easily caused, making it difficult to obtain a sufficient sample in a single sampling. This process requires multiple samplings, increasing the risk of sample contamination. Therefore, existing technologies also connect a tank to the end of the feeding system, and sampling is performed at the outlet of the mobile tank. The structure can be referenced in Chinese Utility Model Patent Publication No. CN104275117A, which includes a tank connected to a water valve. Sampling is achieved by opening the water valve to allow the liquid to be discharged.

[0004] However, the existing method of sampling through tanks still has certain drawbacks: In pharmaceutical production, after the tank is connected to the end of the feeding system, the impact force of the medium in the pipeline will create a large pressure inside the tank, and the liquid is prone to splashing due to pressure during the sampling process; moreover, the liquid involved in the sampling is often high-temperature clean water, and the splashed liquid directly comes into contact with the sampling personnel, which can easily cause burns and other injuries. Utility Model Content

[0005] This application provides a sampling connector for pharmaceutical production, which solves the technical problems of liquid splashing and easy high-temperature burns during the sampling process in the prior art.

[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a sampling connector for pharmaceutical production, including a sampling valve and a connector body that extends vertically. The connector body has flange connections at both its upper and lower ends, which can be connected to the vertical section of a filter aid feeding system pipeline via flanges. The side wall of the connector body has a connecting port to the outside, and the sampling valve is installed at the connecting port. An inclined baffle plate is fixed inside the connector body, with one side of the baffle plate having an arc-shaped edge that fits against the inner wall of the connector body. The baffle plate slopes downwards from the side closest to the radial center of the connector body to the side of the connecting port. The connecting port is located above the bottom edge of the baffle plate.

[0007] When using this connector, first connect the flanges at the top and bottom of the connector body to the vertical section of the filter aid feeding system pipeline using flange connections. The medium in the pipeline flows into the connector body from top to bottom. Because there is a flow-stopping plate fixed at an angle inside the connector body, the flow-stopping plate can directly receive part of the flowing medium and guide the medium to flow smoothly along the inclined flow-stopping plate to the connection port and out through the sampling valve. Therefore, the flow-stopping plate can guide the medium and avoid generating large pressure at the sampling valve, thereby effectively avoiding the phenomenon of liquid splashing caused by a sudden increase in pressure at the sampling valve, and thus preventing the splashed high-temperature cleaning water from directly contacting the sampling personnel and causing burns.

[0008] As a further improvement to the above scheme, the intercepting plate is a planar plate structure.

[0009] As a further improvement to the above solution, the intercepting plate is a non-planar plate structure with a downward bulge in the middle. This forms a slope that is low in the middle and high on both sides, which allows the medium to flow more smoothly to the connection port and avoids turbulence or rebound of the medium on the plate surface.

[0010] As a further improvement to the above solution, the arc-shaped edge of the intercepting plate is welded and fixed to the inner wall of the connector body, and the intercepting plate is provided with a vertically penetrating guide hole on the edge of the side near the communication port on the connector body, and the guide hole is located below the communication port. The width of the guide hole is less than one-third of the diameter of the communication port. The guide hole can prevent residual media from staying on the intercepting plate for a long time and deteriorating, avoid contaminating the purity of the samples taken later, and ensure the accuracy of sample testing results in drug production.

[0011] As a further improvement to the above solution, the flow cut-off plate is detachably installed inside the connector body; thus, if the flow cut-off plate deforms after long-term use, resulting in a decrease in buffering or flow guiding effect, or if surface damage occurs due to medium corrosion, a new flow cut-off plate can be directly removed and replaced without replacing the entire sampling connector, thereby reducing equipment maintenance costs.

[0012] As a further improvement to the above solution, the inner wall of the connector body is provided with a groove, and the arc-shaped edge of the intercepting plate is engaged in the groove.

[0013] As a further improvement to the above solution, the inner wall of the connector body is fixed with an arc-shaped upper base plate and an arc-shaped lower base plate. The arc-shaped upper base plate and the arc-shaped lower base plate are both curved strip structures and are fitted and fixed to the inner wall of the connector body. The arc-shaped edge of the intercepting plate is engaged between the arc-shaped upper base plate and the arc-shaped lower base plate.

[0014] As a further improvement to the above solution, the inner wall of the connector body is provided with a vertical guide groove. The guide groove is located below the communication port of the connector body. The upper end of the guide groove is higher than the inclined bottom edge of the arc-shaped upper base plate, and the lower end of the guide groove is lower than the inclined bottom edge of the arc-shaped lower base plate. The width of the guide groove is less than one-third of the diameter of the communication port. The guide groove can prevent residual media from staying on the intercepting plate for a long time and deteriorating, avoid contaminating the purity of the samples taken later, and ensure the accuracy of sample testing results in drug production.

[0015] As can be seen from the above technical solutions, this utility model has at least the following technical effects or advantages: When using this connector, first connect the flanges at the top and bottom of the connector body to the vertical section of the filter aid feeding system pipeline using flange connections. The medium in the pipeline flows into the connector body from top to bottom. Because there is a flow-stopping plate fixed at an angle inside the connector body, the flow-stopping plate can directly receive part of the flowing medium and guide the medium to flow smoothly along the inclined flow-stopping plate to the connection port and out through the sampling valve. Therefore, the flow-stopping plate can guide the medium and avoid generating large pressure at the sampling valve, thereby effectively avoiding the phenomenon of liquid splashing caused by a sudden increase in pressure at the sampling valve, and thus preventing the splashed high-temperature cleaning water from directly contacting the sampling personnel and causing burns. Attached Figure Description

[0016] To more clearly illustrate the technical solution of this utility model, the accompanying drawings used in the description will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 for Figure 1 Top view; Figure 3 This is a schematic diagram of the installation structure of the interceptor plate in Example 1; Figure 4 for Figure 3 A magnified view of a portion of point A in the middle; Figure 5 This is a schematic diagram of the installation structure of the interceptor plate in Example 2; Figure 6 for Figure 5 A magnified view of a portion of point B in the middle.

[0017] Explanation of reference numerals in the attached drawings: 1. Sampling valve, 2. Connector body, 3. Flange connection, 4. Connecting port, 5. Cut-off plate, 6. Guide hole, 7. Arc-shaped upper base plate, 8. Arc-shaped lower base plate, 9. Guide groove. Detailed Implementation

[0018] To enable those skilled in the art to better understand the technical solutions of this utility model, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this patent, other embodiments obtained by those skilled in the art without creative effort are all within the scope of protection of this patent.

[0019] Example 1 This utility model discloses a sampling connector for pharmaceutical production, such as... Figures 1 to 4 As shown, it includes a sampling valve 1 and a connector body 2 that runs vertically through the connector body 2. The upper and lower ends of the connector body 2 are provided with flange connection parts 3, which can be connected to the vertical section of the filter aid feeding system pipeline through the flange. The side wall of the connector body 2 is provided with a connecting port 4 that connects to the outside, and the sampling valve 1 is installed at the connecting port 4. A flow-blocking plate 5 is fixedly inclined inside the connector body 2. One side of the flow-blocking plate 5 is an arc edge that fits against the inner wall of the connector body 2. The flow-blocking plate 5 is inclined downward from the side near the radial center of the connector body 2 to the side of the connecting port 4. The connecting port 4 is located above the bottom edge of the flow-blocking plate 5.

[0020] In this embodiment, the intercepting plate 5 is a planar plate structure. After being installed at an angle, its arc-shaped edge fits against the inner wall of the connector body 2. Specifically, the tilt angle of the intercepting plate 5 is set between 40° and 50°. This angle allows the medium to flow smoothly along the plate surface to the connecting port 4 after impact, while also preventing the medium from rebounding and splashing due to an excessively large angle.

[0021] Furthermore, the arc-shaped edge of the intercepting plate 5 is welded and fixed to the inner wall of the connector body 2. A through-hole 6 is provided on the edge of the intercepting plate 5 near the connecting port 4, located directly below the connecting port 4, and the width of a single through-hole 6 is 1 / 3 of the diameter of the connecting port 4. The through-hole 6 can guide a small amount of residual medium on the intercepting plate 5 that is not promptly discharged from the connecting port 4 to the pipeline below the connector body 2, preventing the medium from accumulating and deteriorating on the intercepting plate 5.

[0022] In actual use, first connect the flange connection parts 3 at the upper and lower ends of the connector body 2 with the vertical flange section of the filter aid feeding system pipeline using bolts. Install sealing gaskets on the mating surfaces to ensure no media leakage. When sampling is required, slowly open the sampling valve 1 at the connection port 4; the medium in the pipeline flows from top to bottom, first impacting the inclined baffle plate 5. The buffered medium flows along the inclined surface of the baffle plate 5 to the connection port 4, and is discharged into the sampling container through the sampling valve 1, completing the sampling. After sampling, close the sampling valve 1. The small amount of medium remaining on the baffle plate 5 flows into the lower pipeline through the guide hole 6, eliminating the need for manual cleaning of the baffle plate 5.

[0023] In the above structure, the inclined baffle plate 5 can effectively buffer the impact force of the medium, solving the problem of the medium splashing easily due to high pressure in the prior art, and avoiding the high temperature medium from burning the sampling personnel; the guide hole 6 can avoid medium residue, further improving the cleanliness and practicality of the equipment.

[0024] Example 2 The difference between Embodiment 2 and Embodiment 1 lies in the installation structure of the baffle plate 5. The structures of the other components, such as the flange connection 3, the connecting port 4, and the sampling valve 1, are completely the same as those in Embodiment 1, and will not be described again here.

[0025] In this embodiment, as Figure 5 , Figure 6 As shown, the flow-blocking plate 5 is detachably installed inside the connector body 2. Specifically, an arc-shaped upper base plate 7 and an arc-shaped lower base plate 8 are welded and fixed to the inner wall of the connector body 2. Both are curved strip structures and are completely fitted to the inner wall of the connector body 2. The arc-shaped upper base plate 7 and the arc-shaped lower base plate 8 are arranged in parallel, and the gap width between them is adapted to the thickness of the flow-blocking plate 5. The arc-shaped edge of the flow-blocking plate 5 can be directly engaged in this gap to achieve a detachable connection. During installation, the arc-shaped edge of the flow-blocking plate 5 is inserted into the flange of the connector body 2, aligned with the gap, and then pushed in. During disassembly, the flow-blocking plate 5 is pulled out from the flange in the opposite direction, which facilitates subsequent cleaning or replacement of the flow-blocking plate 5.

[0026] Furthermore, the inner wall of the connector body 2 is provided with a vertical guide groove 9, which is located directly below the connecting port 4. Its upper end is higher than the inclined bottom edge of the arc-shaped upper base plate 7, and its lower end is lower than the inclined bottom edge of the arc-shaped lower base plate 8. The width of the guide groove 9 is 1 / 3 of the diameter of the connecting port 4, which can accommodate the medium remaining on the intercepting plate 5. When the intercepting plate 5 is engaged between the arc-shaped upper and lower base plates, the medium that has not been discharged from the intercepting plate 5 can flow into the guide groove 9 and flow along the guide groove 9 to the lower pipeline, replacing the function of the guide hole 6 in Embodiment 1.

[0027] In this embodiment, the detachable structure of the baffle plate 5 allows it to be periodically removed for cleaning or replacement, better meeting the frequent cleaning needs in pharmaceutical production. The interlocking mechanism of the arc-shaped upper and lower base plates ensures the stability of the baffle plate 5 during operation, simplifies disassembly and assembly, and reduces maintenance difficulty. The guide channel 9 effectively solves the problem of media residue on the detachable baffle plate, ensuring the overall cleanliness and safety of the equipment.

[0028] In the description of this utility model, the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "vertical," and "horizontal," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for describing this utility model and do not require that this utility model be constructed or operated in a specific orientation, and therefore should not be construed as limiting this utility model. The terms "connected" and "linked" in this utility model should be interpreted broadly. For example, they can refer to a connection or a detachable connection; they can refer to a direct connection or an indirect connection through intermediate components. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0029] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in its embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novelty disclosed herein.

Claims

1. A sampling connector for pharmaceutical manufacturing, comprising a sampling valve (1), characterized in that, It also includes a connector body (2) that runs vertically through the connector body (2), and both the upper and lower ends of the connector body (2) are provided with flange connection parts (3). The flange connection parts (3) can be connected to the vertical section of the filter aid feeding system pipeline through the flange. The side wall of the connector body (2) is provided with a connecting port (4) that connects to the outside, and the sampling valve (1) is installed at the connecting port (4). The inside of the connector body (2) is fixed with a flow cut-off plate (5). One side of the flow cut-off plate (5) is an arc edge and fits against the inner wall of the connector body (2). The flow cut-off plate (5) is inclined downward from the side near the radial center of the connector body (2) to the side of the connecting port (4). The connecting port (4) is located above the bottom edge of the flow cut-off plate (5).

2. The sampling connector for pharmaceutical production according to claim 1, characterized in that, The cut-off plate (5) is a planar plate structure.

3. A sampling connector for pharmaceutical production according to claim 1, characterized in that, The cutoff plate (5) is a non-planar plate structure with the middle part of the cutoff plate (5) bulging downwards.

4. A sampling connector for pharmaceutical production according to claim 1, characterized in that, The arc-shaped edge of the interceptor plate (5) is welded and fixed to the inner wall of the connector body (2), and the interceptor plate (5) is provided with a guide hole (6) that runs vertically through the connector body (2) near the edge of the connector body (2) on the side of the communication port (4). The guide hole (6) is located below the communication port (4), and the width of the guide hole (6) is less than one-third of the diameter of the communication port (4).

5. A sampling connector for pharmaceutical production according to claim 1, characterized in that, The cut-off plate (5) is detachably installed inside the connector body (2).

6. A sampling connector for pharmaceutical production according to claim 5, characterized in that, The inner wall of the connector body (2) is provided with a groove, and the arc-shaped edge of the intercepting plate (5) is engaged in the groove.

7. A sampling connector for pharmaceutical production according to claim 5, characterized in that, The inner wall of the connector body (2) is fixed with an arc-shaped upper base plate (7) and an arc-shaped lower base plate (8). The arc-shaped upper base plate (7) and the arc-shaped lower base plate (8) are both curved strip structures and are attached and fixed to the inner wall of the connector body (2). The arc-shaped edge of the intercepting plate (5) is engaged between the arc-shaped upper base plate (7) and the arc-shaped lower base plate (8).

8. A sampling connector for pharmaceutical production according to claim 7, characterized in that, The inner wall of the connector body (2) is provided with a vertical guide groove (9). The guide groove (9) is located below the communication port (4) of the connector body. The upper end of the guide groove (9) is higher than the inclined bottom edge of the arc-shaped upper base plate (7), and the lower end of the guide groove (9) is lower than the inclined bottom edge of the arc-shaped lower base plate (8). The width of the guide groove (9) is less than one-third of the diameter of the communication port (4).

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