A sample injection mechanism of a liquid chromatograph-mass spectrometer

Abstract

The utility model relates to chemical analysis technical field, concretely is a kind of sample introduction mechanism of liquid chromatography mass spectrometer, including manual sample introduction mechanism, the end of manual sample introduction mechanism filling mouth is fixedly installed with sleeve, sleeve is concentric with manual sample introduction mechanism, and the end away from manual sample introduction mechanism of sleeve is hinged with multiple support assemblies for straightening needle cylinder, the outer surface of sleeve is equipped with the drive assembly for controlling multiple support assemblies synchronous outward turning or inward turning;By setting drive assembly and support assembly, utilize drive assembly control multiple support assemblies synchronous outward turning or inward turning, both can adapt to the injection needle cylinder of multiple diameters, can also ensure that the needle head of needle cylinder can keep concentric with manual sample introduction mechanism, ensure that the needle head of needle cylinder can keep concentric with manual sample introduction mechanism, avoid the bending problem caused by docking deflection when needle head inserts, and staff does not need to keep straightening action for a long time, reduce the operation difficulty and labor intensity.

Description

Technical Field

[0001] This utility model relates to the field of chemical analysis technology, and in particular to an injection mechanism for a liquid chromatography-mass spectrometry instrument. Background Technology

[0002] Liquid chromatography-mass spectrometry (LC-MS) is an analytical instrument that combines the high-efficiency separation capability of liquid chromatography with the high sensitivity and specificity of mass spectrometry. It is primarily used for the separation, qualitative and quantitative analysis of target compounds in complex mixtures.

[0003] Chinese Patent CN208476871U discloses an automatic sample introduction device for a liquid chromatography-mass spectrometry (LC-MS) instrument. Existing LC-MS instrument sample introduction mechanisms are divided into manual and automatic injection. In manual injection, the operator draws the sample using a syringe, then inserts the syringe needle into the manual injection mechanism, injecting the sample into the instrument through the syringe. During injection, the syringe and needle must be kept concentric with the manual injection mechanism at all times, and the syringe must remain stationary for a period after injection before being withdrawn. However, in manual injection, the concentricity of the syringe and injection mechanism is entirely controlled by the operator, making it highly susceptible to needle misalignment at the injection port, directly causing needle bending and damage. Furthermore, the syringe must be kept stationary throughout the entire injection process; even slight hand movement during this process can lead to needle bending or sample spillage, further increasing the operational difficulty and error rate. Therefore, the operator must constantly maintain hand tension to keep the syringe upright, which can easily lead to arm fatigue during prolonged operation. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the prior art, solve the problems mentioned in the background art, and provide an injection mechanism for a liquid chromatography-mass spectrometry instrument.

[0005] The purpose of this utility model is achieved through the following technical solution: a sample injection mechanism for a liquid chromatography-mass spectrometry instrument, including a manual sample injection mechanism, wherein a sleeve is fixedly installed at the end of the injection port of the manual sample injection mechanism, the sleeve is concentric with the manual sample injection mechanism, and a plurality of support components for straightening the syringe are hinged to the end of the sleeve away from the manual sample injection mechanism. The outer surface of the sleeve is provided with a drive component for controlling the plurality of support components to flip outward or inward synchronously.

[0006] Preferably, the support assembly includes a support arm hinged to the sleeve, and a roller is rotatably provided at the end of the support arm away from the sleeve.

[0007] Preferably, the drive assembly includes a knob and a movable cylinder fitted on the outer surface of the sleeve. The knob is threadedly connected to the sleeve, the movable cylinder is axially slidably connected to the sleeve, and the knob is rotatably connected to the movable cylinder. A gear is fixedly provided at one end of the support arm that is hinged to the sleeve, and a plurality of meshing grooves that cooperate with the gear are opened on the inner wall of the movable cylinder.

[0008] Preferably, the sleeve has a hinge groove corresponding to the position of the support arm, and the support arm is hinged to the sleeve by a pin.

[0009] Preferably, the outer surface of the sleeve is provided with a threaded groove, and the inner wall of the knob is provided with an internal thread that matches the threaded groove.

[0010] Preferably, a connecting ring is fixedly provided at one end of the knob facing the movable cylinder, and a rotating hole is provided on the movable cylinder corresponding to the position of the connecting ring. The connecting ring is connected to the rotating hole through a bearing.

[0011] The beneficial effects of the injection mechanism of this liquid chromatography-mass spectrometry system are as follows: by setting up a drive component and a support component, the drive component controls multiple support components to flip outward or inward synchronously. This not only adapts to injection syringes of various diameters, but also ensures that the syringe needle can remain concentric with the manual injection mechanism. This avoids the bending problem caused by misalignment of the needle during insertion, and eliminates the need for operators to maintain a straightening action for a long time. It reduces the difficulty and labor intensity of operation, allowing operators to complete manual injection operations more easily. Attached Figure Description

[0012] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0014] Figure 2 This is a schematic diagram of the structure of the support arm of this utility model after it has been flipped outwards from the first perspective.

[0015] Figure 3 This is a schematic diagram of the structure of the support arm of this utility model after it has been flipped outwards from a second perspective.

[0016] Figure 4 This is a schematic diagram of the structure of the support arm of this utility model after it is flipped inward from the first perspective.

[0017] Figure 5 This is a structural schematic diagram of the support arm of this utility model after it has been flipped inward from a second perspective.

[0018] Figure 6 This is a structural schematic diagram of the support arm of this utility model after it has been flipped inward from a third-view perspective.

[0019] Figure 7 This is a schematic diagram showing the disassembled structure of the sleeve and the manual sample feeding mechanism of this utility model;

[0020] Figure 8 This is a schematic diagram showing the disassembled structure of the drive assembly and sleeve of this utility model.

[0021] In the diagram: 1. Manual sample feeding mechanism; 2. Sleeve; 201. Hinge groove; 202. Threaded groove; 3. Support assembly; 301. Support arm; 302. Roller; 303. Gear; 4. Drive assembly; 401. Knob; 4011. Internal thread; 4012. Connecting ring; 402. Movable cylinder; 4021. Rotating hole; 403. Engaging groove. Detailed Implementation

[0022] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0023] Additional aspects and advantages of this invention will be further set forth in the description which follows in conjunction with the accompanying drawings, and in part will be obvious from the description or may be learned by practice of the invention.

[0024] like Figures 1 to 8 As shown, a sample introduction mechanism for a liquid chromatography-mass spectrometry (LC-MS) instrument includes a manual sample introduction mechanism 1. A sleeve 2 is fixedly installed at the end of the injection port of the manual sample introduction mechanism 1. The sleeve 2 is concentric with the manual sample introduction mechanism 1. Multiple support components 3 for straightening the syringe are hinged to the end of the sleeve 2 away from the manual sample introduction mechanism 1. The outer surface of the sleeve 2 is provided with a drive component 4 for controlling the multiple support components 3 to flip outward or inward synchronously. By controlling the multiple support components 3 to flip outward or inward synchronously through the drive component 4, it can be adapted to injection syringes of various diameters. This allows the sample introduction mechanism to be used with syringes of different specifications, enhancing the applicability and versatility of the equipment, and ensuring that the needle tip of the syringe remains concentric with the manual sample introduction mechanism.

[0025] The support assembly 3 includes a support arm 301 hinged to the sleeve 2. The sleeve 2 has a hinge groove 201 at the position corresponding to the support arm 301. The support arm 301 is hinged to the sleeve 2 by a pin. The pin ensures the stability of the support arm 301 when it is flipped. A roller 302 is rotatably provided at the end of the support arm 301 away from the sleeve 2. The function of the support assembly 3 and the roller 302 is to keep the syringe stable during the injection process, reducing the probability of needle bending and damage caused by improper operation or syringe instability. The multiple rollers 302 provide support for the syringe when the needle is inserted, so the operator does not need to keep the syringe in a tense state to support it, reducing the workload. After the injection is completed, the rollers 302 can still provide support for the syringe, so the operator does not need to keep it upright for a long time, reducing the difficulty of operation and labor intensity, and making it easier for the operator to complete the manual injection operation.

[0026] Drive assembly 4 includes a knob 401 and a movable cylinder 402 fitted onto the outer surface of sleeve 2. The knob 401 is threadedly connected to sleeve 2. The outer surface of sleeve 2 has a threaded groove 202. The inner wall of the knob 401 has an internal thread 4011 that matches the threaded groove 202. The engagement between the internal thread 4011 and the threaded groove 202 allows the knob 401 to slide axially on the outer surface of sleeve 2 during rotation. The movable cylinder 402 is axially slidably connected to sleeve 2, and the knob 401 is rotatably connected to the movable cylinder 402. A connecting ring 4012 is fixedly provided at one end of the knob 401 facing the movable cylinder 402. A rotating hole 4021 is provided at the position of the connecting ring 4012 on the cylinder 402. The connecting ring 4012 is connected to the rotating hole 4021 through a bearing. By using the bearing, the friction between the knob 401 and the movable cylinder 402 can be reduced and the movable cylinder 402 can be moved with the knob 401. When the knob 401 rotates, the movable cylinder 402 will not rotate with the knob 401, so that the movable cylinder 402 can be stably controlled to slide on the outer surface of the sleeve 2. A gear 303 is fixedly provided at one end of the support arm 301 that is hinged to the sleeve 2. Multiple meshing grooves 403 that cooperate with the gear 303 are provided on the inner wall of the movable cylinder 402.

[0027] The work process is as follows:

[0028] S1: When in use, by utilizing the fit between the internal thread 4011 and the thread groove 202, the knob 401 can slide axially on the outer surface of the sleeve 2 when it is rotated. Then, when the knob 401 is rotated, the movable cylinder 402 will not rotate with the knob 401, thereby stably controlling the sliding of the movable cylinder 402 on the outer surface of the sleeve 2.

[0029] S2: When the movable cylinder 402 slides on the outer surface of the sleeve 2, multiple gears 303 mesh with the meshing grooves 403 of the movable cylinder 402, so that the sliding of the movable cylinder 402 can cause multiple support arms 301 to flip outward or inward synchronously. This allows the user to adjust the spacing of multiple rollers 302 according to the diameter of the syringe, ensuring that the syringe needle can remain concentric with the manual sample injection mechanism 1. This avoids the bending problem caused by misalignment when the needle is inserted, thus ensuring that the sample can be accurately injected into the device, improving the accuracy and reliability of the injection, and reducing the risk of injection error and experimental failure caused by needle bending.

[0030] S3: During sample injection, the sample is drawn using a syringe, and then the syringe is controlled to pass between multiple rollers 302. The multiple rollers 302 provide support for the syringe when the needle is inserted, and the syringe can remain stable during the injection process, reducing the chance of needle bending and damage due to improper human operation or syringe instability. At this time, the staff does not need to keep a tight grip on the syringe at all times, reducing the workload.

[0031] S4: After injection, the roller 302 can still provide support for the syringe, eliminating the need for staff to maintain an upright position for a long time, reducing the difficulty and labor intensity of operation, and making it easier for staff to complete manual injection operations.

[0032] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model.

Claims

1. An injection mechanism for a liquid chromatography-mass spectrometry (LC-MS) instrument, characterized in that: The device includes a manual injection mechanism (1), and a sleeve (2) is fixedly installed at the end of the injection port of the manual injection mechanism (1). The sleeve (2) is concentric with the manual injection mechanism (1). A plurality of support components (3) for straightening the syringe are hinged to the end of the sleeve (2) away from the manual injection mechanism (1). The outer surface of the sleeve (2) is provided with a drive component (4) for controlling the plurality of support components (3) to flip outward or inward synchronously.

2. The sample introduction mechanism of a liquid chromatography-mass spectrometry system according to claim 1, characterized in that: The support assembly (3) includes a support arm (301) hinged to the sleeve (2), and a roller (302) is rotatably provided at one end of the support arm (301) away from the sleeve (2).

3. The sample introduction mechanism of a liquid chromatography-mass spectrometry instrument according to claim 2, characterized in that: The drive assembly (4) includes a knob (401) and a movable cylinder (402) fitted on the outer surface of the sleeve (2). The knob (401) is threadedly connected to the sleeve (2), and the movable cylinder (402) is axially slidably connected to the sleeve (2). The knob (401) is rotatably connected to the movable cylinder (402). A gear (303) is fixedly provided at one end of the support arm (301) that is hinged to the sleeve (2). The inner wall of the movable cylinder (402) is provided with a plurality of meshing grooves (403) that cooperate with the gear (303).

4. The sample introduction mechanism of a liquid chromatography-mass spectrometry instrument according to claim 2, characterized in that: The sleeve (2) has a hinge groove (201) at the position corresponding to the support arm (301), and the support arm (301) is hinged to the sleeve (2) by a pin.

5. The sample introduction mechanism of a liquid chromatography-mass spectrometry instrument according to claim 3, characterized in that: The outer surface of the sleeve (2) is provided with a threaded groove (202), and the inner wall of the knob (401) is provided with an internal thread (4011) that is compatible with the threaded groove (202).

6. The sample introduction mechanism of a liquid chromatography-mass spectrometry instrument according to claim 3, characterized in that: The knob (401) is fixedly provided with a connecting ring (4012) at one end facing the movable cylinder (402). The movable cylinder (402) is provided with a rotating hole (4021) corresponding to the position of the connecting ring (4012). The connecting ring (4012) is connected to the rotating hole (4021) through a bearing.

Images