A high performance liquid chromatograph temperature control device

Abstract

The utility model provides a kind of high performance liquid chromatograph temperature control device, comprising: temperature control device and cleaning mechanism, cleaning mechanism is arranged on the outer wall of temperature control device, cleaning mechanism includes fixed plate, ultrasonic generator, connecting line, vibration head, threaded rod and blowdown piece, fixed plate is arranged on the bottom wall of temperature control device, ultrasonic generator is arranged on fixed plate, one end of connecting line is connected with the output end of ultrasonic generator, vibration head is connected with the other end of connecting line, hexagonal thread groove is set up on the outer wall of vibration head, threaded rod is arranged on the outer wall of temperature control device, and threaded rod and vibration head form threaded connection. The utility model discloses a kind of high performance liquid chromatograph temperature control device, by the setting of cleaning mechanism, can effectively clean scale and impurities adhered on the outer wall of helical annular tube using cavitation effect and mechanical vibration effect of ultrasonic in the case where helical annular tube is not disassembled, significantly improve the temperature control precision of temperature control device and prolong its service life.

Description

Technical Field

[0001] This utility model relates to the technical field of high performance liquid chromatographs, and in particular to a temperature control device for a high performance liquid chromatograph. Background Technology

[0002] High-performance liquid chromatography (HPLC) is an instrument that uses the principle of high-performance liquid chromatography to analyze organic compounds that have high boiling points, are not easily volatile, are unstable when heated, and have large molecular weights. The temperature control device is a key auxiliary component of HPLC, used to accurately control the column temperature and mobile phase temperature to ensure the repeatability and accuracy of the separation effect.

[0003] Currently, after prolonged use, traditional temperature control devices are prone to scale and impurities accumulating on the outer wall of the spiral annular tube. These deposits not only affect the temperature control accuracy but may also shorten the device's lifespan. Although the spiral annular tube can be disassembled for cleaning, this method is cumbersome and may damage the temperature control device during disassembly and reinstallation. Utility Model Content

[0004] This utility model aims to at least partially solve one of the technical problems in the above-mentioned technologies.

[0005] Therefore, the present invention provides a high-performance liquid chromatograph temperature control device. Through the setting of a cleaning mechanism, it can effectively clean the scale and impurities adhering to the outer wall of the spiral annular tube by utilizing the cavitation effect of ultrasound and mechanical vibration without disassembling the spiral annular tube. This significantly improves the temperature control accuracy of the temperature control device and extends its service life, while greatly reducing the labor intensity of the staff and improving the cleaning efficiency.

[0006] To achieve the above objectives, the first aspect of this utility model proposes a temperature control device for a high-performance liquid chromatograph, comprising: a temperature control device and a cleaning mechanism. The cleaning mechanism is disposed on the outer wall of the temperature control device and includes a fixed plate, an ultrasonic generator, a connecting wire, a vibrator head, a threaded rod, and a drain component. The fixed plate is disposed on the bottom wall of the temperature control device, the ultrasonic generator is disposed on the fixed plate, one end of the connecting wire is connected to the output end of the ultrasonic generator, the vibrator head is connected to the other end of the connecting wire, a hexagonal threaded groove is formed on the outer wall of the vibrator head, and the threaded rod is disposed on the outer wall of the temperature control device, and the threaded rod and the vibrator head form a threaded connection.

[0007] In addition, the high-performance liquid chromatograph temperature control device proposed above according to this utility model may also have the following additional technical features: Specifically, the sewage discharge device includes a sewage pipe and a valve. One end of the sewage pipe is connected to a temperature control device, and the valve is installed on the outer wall of the sewage pipe.

[0008] Specifically, the bottom wall of the temperature control device is provided with a stirring assembly, which includes a driving component, a rotating rod, a rotating disk and a stirring impeller. The driving component is located on the bottom wall of the temperature control device, one end of the rotating rod is connected to the output end of the driving component, the rotating disk is connected to the other end of the rotating rod, and the stirring impeller is located on the outer wall of the rotating disk.

[0009] Specifically, the temperature control device includes a heating chamber, an insulation layer, a bracket, a handle, a spiral annular tube, an inlet pipe, and an outlet pipe. The heating chamber is located inside the chromatograph, the insulation layer is located on the inner wall of the heating chamber, the bracket is located on the heating chamber, the handle is located on the bracket, the spiral annular tube is located inside the heating chamber, and one end of the inlet pipe is connected to one end of the spiral annular tube, and one end of the outlet pipe is connected to the other end of the spiral annular tube.

[0010] Specifically, a support plate is provided on the outer wall of the heating box, and a first fixing bolt is provided on the outer wall of the support plate. The first fixing bolt passes through the support plate and is threadedly connected to the heating box.

[0011] Specifically, a second fixing bolt is provided on the support plate, and the second fixing bolt passes through the support plate and is threadedly connected to the chromatograph.

[0012] Compared with the prior art, the present invention has the following beneficial effects: by setting up a cleaning mechanism, it is possible to effectively clean the scale and impurities attached to the outer wall of the spiral annular tube by utilizing the cavitation effect of ultrasonic waves and mechanical vibration without disassembling the spiral annular tube. This significantly improves the temperature control accuracy of the temperature control device and extends its service life, while greatly reducing the labor intensity of the staff and improving the cleaning efficiency.

[0013] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0014] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the following description of the embodiments taken in conjunction with the accompanying drawings, in which: Figure 1 This is a schematic diagram of a high-performance liquid chromatograph temperature control device according to an embodiment of the present invention; Figure 2 This is a schematic diagram of the cleaning mechanism of a high-performance liquid chromatograph temperature control device according to an embodiment of the present invention; Figure 3 This is a schematic diagram of the stirring assembly structure of a temperature control device for a high-performance liquid chromatograph according to an embodiment of the present invention. Figure 4This is a schematic diagram of the structure of a support plate for a temperature control device of a high-performance liquid chromatograph, according to an embodiment of the present invention, in conjunction with a second fixing bolt.

[0015] Reference numerals: 1. Temperature control device; 11. Heating box; 12. Insulation layer; 13. Bracket; 14. Handle; 15. Spiral annular tube; 16. Air inlet pipe; 17. Air outlet pipe; 2. Cleaning mechanism; 21. Fixing plate; 22. Ultrasonic generator; 23. Connecting wire; 24. Vibrator head; 25. Hexagonal threaded groove; 26. Threaded rod; 3. Drainage component; 31. Drainage pipe; 32. Valve; 4. Stirring assembly; 41. Drive component; 42. Rotating rod; 43. Rotating disk; 44. Stirring impeller; 5. Support plate; 6. First fixing bolt; 7. Second fixing bolt. Detailed Implementation

[0016] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this utility model, and should not be construed as limiting this utility model.

[0017] The following describes a high-performance liquid chromatograph temperature control device according to an embodiment of the present invention with reference to the accompanying drawings.

[0018] like Figures 1-4 As shown in the figure, a high-performance liquid chromatograph temperature control device according to an embodiment of the present invention includes: a temperature control device 1 and a cleaning mechanism 2.

[0019] The cleaning mechanism 2 is installed on the outer wall of the temperature control device 1. The cleaning mechanism 2 includes a fixing plate 21, an ultrasonic generator 22, a connecting wire 23, a vibrator head 24, a threaded rod 26, and a drain component 3.

[0020] The fixing plate 21 is set on the bottom wall of the temperature control device 1, the ultrasonic generator 22 is set on the fixing plate 21, one end of the connecting line 23 is connected to the output end of the ultrasonic generator 22, the vibrator head 24 is connected to the other end of the connecting line 23, a hexagonal threaded groove 25 is opened on the outer wall of the vibrator head 24, and the threaded rod 26 is set on the outer wall of the temperature control device 1, and the threaded rod 26 and the vibrator head 24 form a threaded connection.

[0021] The sewage discharge component 3 includes a sewage discharge pipe 31 and a valve 32.

[0022] One end of the drain pipe 31 is connected to the temperature control device 1, and the valve 32 is installed on the outer wall of the drain pipe 31.

[0023] It should be noted that the ultrasonic generator 22 described in this embodiment can generate ultrasonic waves of a specific frequency. These ultrasonic waves are transmitted to the transducer 24 through the connecting line 23. The transducer 24 further amplifies the ultrasonic energy and acts on the inner wall of the heating box 11. Through the conduction of water inside the heating box 11, the scale and other impurities attached to the outer wall of the spiral annular tube 15 are subjected to the cavitation effect and mechanical vibration of the ultrasonic waves, thereby gradually peeling off from the tube wall and the box wall.

[0024] Specifically, after prolonged use, scale or impurities will adhere to the outer wall of the internal spiral annular tube 15 of the temperature control device 1, increasing the surface thermal resistance of the spiral annular tube 15 and causing a decrease in temperature control accuracy.

[0025] When it is necessary to clean the outer wall of the spiral annular tube 15, the staff first activates the ultrasonic generator 22. The ultrasonic generator 22 transmits the ultrasonic signal to the transducer 24 through the connecting line 23. The transducer 24 generates high-frequency vibration. The high-frequency vibration is conducted through the water inside the heating box 11 and acts on the outer wall of the spiral annular tube 15, causing the scale and impurities attached to it to be gradually peeled off by the cavitation effect of the ultrasonic waves and the mechanical vibration.

[0026] Meanwhile, the vibrator head 24 and the threaded rod 26 are connected by threads. When the vibrator head 24 wears out after long-term operation or requires maintenance, the operator can use a suitable tool to insert into the hexagonal threaded groove 25 and rotate the tool to drive the vibrator head 24 to rotate, thus easily removing the vibrator head 24 from the threaded rod 26 for replacement or maintenance. This design greatly improves the convenience and maintainability of the device. Furthermore, when the vibrator head 24 is installed on the threaded rod 26, its tight fit ensures that ultrasonic energy is efficiently transferred to the interior of the heating chamber 11, reducing energy loss.

[0027] In addition, the staff can simultaneously start the drive unit 41. The output end of the drive unit 41 drives the rotating rod 42 to rotate, and the rotating rod 42 drives the rotating disk 43 to rotate. The stirring impeller 44 on the rotating disk 43 rotates accordingly, stirring the water in the heating box 11 and making the water flow. This can better carry the scale and impurities that have been peeled off to the drain pipe 31 through the water flow.

[0028] After a period of cleaning, the staff opens valve 32, and the sewage containing scale and impurities is discharged from the temperature control device 1 through drain pipe 31, thus completing the cleaning of the outer wall of the spiral annular tube 15. This effectively improves the temperature control accuracy of the temperature control device 1, extends its service life, and eliminates the need to disassemble the spiral annular tube 15 for manual cleaning, greatly reducing the labor intensity of the staff and improving the cleaning efficiency.

[0029] In one embodiment of this application, such as Figure 3As shown, a stirring assembly 4 is provided on the bottom wall of the temperature control device 1.

[0030] The stirring assembly 4 includes a drive unit 41, a rotating rod 42, a rotating disk 43, and a stirring impeller 44.

[0031] The driving component 41 is installed on the bottom wall of the temperature control device 1. One end of the rotating rod 42 is connected to the output end of the driving component 41, the rotating disk 43 is connected to the other end of the rotating rod 42, and the stirring impeller 44 is installed on the outer wall of the rotating disk 43.

[0032] It should be noted that the driving component 41 described in this embodiment is a motor. When the operator starts the driving component 41, the output end of the driving component 41 drives the rotating rod 42 to rotate. The rotating rod 42 further drives the rotating disk 43 to rotate, and the stirring impeller 44 set on the outer wall of the rotating disk 43 also rotates accordingly, thereby realizing the stirring of the liquid inside the temperature control device 1 and ensuring that the liquid temperature is uniform.

[0033] Specifically, during the heating process, the operator can activate the drive unit 41. The output end of the drive unit 41 drives the rotating rod 42 to rotate, which in turn drives the rotating disk 43 to rotate. The rotating disk 43 then drives the stirring impeller 44 to rotate as well. The stirring impeller 44 rotates in the liquid within the heating chamber 11, creating a stirring effect. This stirring action breaks down the temperature gradient in the liquid, allowing heat to be distributed more evenly and preventing localized overheating or overcooling. As a result, the temperature control device 1 can more precisely control the liquid temperature, improving the accuracy and stability of temperature control.

[0034] In one embodiment of this application, such as Figure 1 As shown, the temperature control device 1 includes a heating box 11, an insulation layer 12, a bracket 13, a handle 14, a spiral annular tube 15, an air inlet pipe 16, and an air outlet pipe 17.

[0035] The heating chamber 11 is located inside the chromatograph, the heat insulation layer 12 is located on the inner wall of the heating chamber 11, the bracket 13 is located on the heating chamber 11, the handle 14 is located on the bracket 13, the spiral annular tube 15 is located inside the heating chamber 11, and one end of the inlet pipe 16 is connected to one end of the spiral annular tube 15, and one end of the outlet pipe 17 is connected to the other end of the spiral annular tube 15.

[0036] It should be noted that the temperature control device 1 described in this embodiment adopts a water bath heating method.

[0037] Specifically, when temperature control of the sample is required, the operator first places the sample on the tray 13, and then introduces hot air into the spiral annular tube 15 through the air inlet pipe 16. The hot air flows within the spiral annular tube 15, transferring heat to the water in the heating chamber 11, thus raising the water temperature. The insulation layer 12 effectively reduces heat loss and improves heating efficiency. The water in the heating chamber 11 transfers heat to the sample placed on the tray 13 through heat conduction, thereby achieving temperature control of the sample.

[0038] When the water temperature is too high, the operator introduces cold air into the spiral annular tube 15 through the air inlet pipe 16. The cold air flows within the spiral annular tube 15, absorbing heat from the water in the heating chamber 11 and lowering the water temperature. By controlling the timing and flow rate of the hot or cold air, the operator can precisely adjust the water temperature in the heating chamber 11, thereby achieving precise control over the temperature of the sample placed on the tray 13.

[0039] At the same time, whether hot or cold air is introduced, the gas will eventually be discharged through the exhaust pipe 17, ensuring smooth gas circulation inside the temperature control device 1 and maintaining a stable temperature control environment.

[0040] After the temperature control treatment of the sample is completed, the staff must first shut off the gas supply to the inlet pipe 16 and the outlet pipe 17 to ensure that there is no more gas flow in the spiral annular tube 15. Then, the staff can carefully remove the tray 13 from the heating chamber 11 using the handle 14 and take the temperature-controlled sample away from the tray 13.

[0041] In one embodiment of this application, such as Figure 4 As shown, a support plate 5 is provided on the outer wall of the heating box 11, and a first fixing bolt 6 is provided on the outer wall of the support plate 5. The first fixing bolt 6 passes through the support plate 5 and is threadedly connected to the heating box 11.

[0042] Understandably, the support plate 5 is designed to provide sufficient space between the bottom of the temperature control device 1 and the chromatograph, allowing the drive component 41 to be installed in a suitable position. Simultaneously, the support plate 5 is securely connected to the heating chamber 11 via the first fixing bolt 6, ensuring the overall stability of the temperature control device 1 within the chromatograph and preventing positional shifts due to vibration or movement. This guarantees the normal operation and temperature control accuracy of the temperature control device 1. Furthermore, this design facilitates subsequent maintenance and repair. Operators can easily remove the support plate 5 and the entire temperature control device 1 from the chromatograph by disassembling the first fixing bolt 6 for necessary inspection, repair, or component replacement. After maintenance, the support plate 5 can be reinstalled back onto the chromatograph using the first fixing bolt 6, restoring the temperature control device 1 to normal operation.

[0043] In one embodiment of this application, such as Figure 4 As shown, a second fixing bolt 7 is provided on the support plate 5, and the second fixing bolt 7 passes through the support plate 5 and is threadedly connected to the chromatograph.

[0044] Understandably, the second fixing bolt 7 further enhances the connection stability between the temperature control device 1 and the chromatograph. During the operation of the temperature control device 1, minor vibrations or displacements may occur due to various factors. The second fixing bolt 7, together with the first fixing bolt 6, forms a double fixing mechanism, effectively preventing the temperature control device 1 from loosening or falling off inside the chromatograph.

[0045] Working principle: After the temperature control device 1 has been used for a long time, some scale or impurities will be attached to the outer wall of its internal spiral annular tube 15, which will increase the surface thermal resistance of the spiral annular tube 15 and reduce the temperature control accuracy.

[0046] When it is necessary to clean the outer wall of the spiral annular tube 15, the staff first activates the ultrasonic generator 22. The ultrasonic generator 22 transmits the ultrasonic signal to the transducer 24 through the connecting line 23. The transducer 24 generates high-frequency vibration. The high-frequency vibration is conducted through the water inside the heating box 11 and acts on the outer wall of the spiral annular tube 15, causing the scale and impurities attached to it to be gradually peeled off by the cavitation effect of the ultrasonic waves and the mechanical vibration.

[0047] Meanwhile, the vibrator head 24 and the threaded rod 26 are connected by threads. When the vibrator head 24 wears out after long-term operation or requires maintenance, the operator can use a suitable tool to insert into the hexagonal threaded groove 25 and rotate the tool to drive the vibrator head 24 to rotate, thus easily removing the vibrator head 24 from the threaded rod 26 for replacement or maintenance. This design greatly improves the convenience and maintainability of the device. Furthermore, when the vibrator head 24 is installed on the threaded rod 26, its tight fit ensures that ultrasonic energy is efficiently transferred to the interior of the heating chamber 11, reducing energy loss.

[0048] In addition, the staff can simultaneously start the drive unit 41. The output end of the drive unit 41 drives the rotating rod 42 to rotate, and the rotating rod 42 drives the rotating disk 43 to rotate. The stirring impeller 44 on the rotating disk 43 rotates accordingly, stirring the water in the heating box 11 and making the water flow. This can better carry the scale and impurities that have been peeled off to the drain pipe 31 through the water flow.

[0049] After a period of cleaning, the staff opens valve 32, and the sewage containing scale and impurities is discharged from the temperature control device 1 through drain pipe 31, thus completing the cleaning of the outer wall of the spiral annular tube 15. This effectively improves the temperature control accuracy of the temperature control device 1, extends its service life, and eliminates the need to disassemble the spiral annular tube 15 for manual cleaning, greatly reducing the labor intensity of the staff and improving the cleaning efficiency.

[0050] Furthermore, with the addition of the stirring assembly 4, during the heating process of the temperature control device 1, the operator can activate the drive unit 41. The output end of the drive unit 41 drives the rotating rod 42 to rotate, which in turn drives the rotating disk 43 to rotate. The rotation of the rotating disk 43 drives the stirring impeller 44 to rotate as well. The stirring impeller 44 rotates in the liquid within the heating chamber 11, producing a stirring effect. This stirring action breaks down the temperature gradient in the liquid, allowing heat to be distributed more evenly throughout the liquid and preventing localized overheating or overcooling. In this way, the temperature control device 1 can more precisely control the liquid temperature, improving the accuracy and stability of temperature control.

[0051] In summary, the high-performance liquid chromatograph temperature control device of this invention, through the cleaning mechanism 2, can effectively remove scale and impurities adhering to the outer wall of the spiral annular tube 15 without disassembling it, utilizing the cavitation effect of ultrasound and mechanical vibration. This significantly improves the temperature control accuracy of the temperature control device 1 and extends its service life, while greatly reducing the labor intensity of the staff and improving cleaning efficiency. Furthermore, by cooperating with the stirring component 4, during the cleaning process, the stirring component 4 can drive the water flow within the heating chamber 11, better carrying the detached scale and impurities to the drain pipe 31 for discharge, further enhancing the cleaning effect.

[0052] In the description of this specification, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this utility model, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0053] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0054] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A temperature control device for a high-performance liquid chromatograph, characterized in that, include: A temperature control device (1) and a cleaning mechanism (2) are provided. The cleaning mechanism (2) is located on the outer wall of the temperature control device (1). The cleaning mechanism (2) includes a fixed plate (21), an ultrasonic generator (22), a connecting line (23), a vibrating head (24), a threaded rod (26), and a drain component (3). The fixed plate (21) is located on the bottom wall of the temperature control device (1). The ultrasonic generator (22) is located on the fixed plate (21). One end of the connecting line (23) is connected to the output end of the ultrasonic generator (22). The vibrating head (24) is connected to the other end of the connecting line (23). A hexagonal threaded groove (25) is provided on the outer wall of the vibrating head (24). The threaded rod (26) is located on the outer wall of the temperature control device (1), and the threaded rod (26) and the vibrating head (24) form a threaded connection.

2. The temperature control device for a high-performance liquid chromatograph according to claim 1, characterized in that, The drain component (3) includes a drain pipe (31) and a valve (32). One end of the drain pipe (31) is connected to the temperature control device (1), and the valve (32) is disposed on the outer wall of the drain pipe (31).

3. The temperature control device for a high-performance liquid chromatograph according to claim 1, characterized in that, The bottom wall of the temperature control device (1) is provided with a stirring assembly (4). The stirring assembly (4) includes a driving component (41), a rotating rod (42), a rotating disk (43), and a stirring impeller (44). The driving component (41) is provided on the bottom wall of the temperature control device (1). One end of the rotating rod (42) is connected to the output end of the driving component (41). The rotating disk (43) is connected to the other end of the rotating rod (42). The stirring impeller (44) is provided on the outer wall of the rotating disk (43).

4. The temperature control device for a high-performance liquid chromatograph according to claim 1, characterized in that, The temperature control device (1) includes a heating box (11), an insulation layer (12), a bracket (13), a handle (14), a spiral annular tube (15), an air inlet pipe (16), and an air outlet pipe (17). The heating box (11) is located inside the chromatograph. The insulation layer (12) is located on the inner wall of the heating box (11). The bracket (13) is located on the heating box (11). The handle (14) is located on the bracket (13). The spiral annular tube (15) is located inside the heating box (11). One end of the air inlet pipe (16) is connected to one end of the spiral annular tube (15). One end of the air outlet pipe (17) is connected to the other end of the spiral annular tube (15).

5. The temperature control device for a high-performance liquid chromatograph according to claim 4, characterized in that, A support plate (5) is provided on the outer wall of the heating box (11), and a first fixing bolt (6) is provided on the outer wall of the support plate (5). The first fixing bolt (6) passes through the support plate (5) and is threadedly connected to the heating box (11).

6. The temperature control device for a high-performance liquid chromatograph according to claim 5, characterized in that, The support plate (5) is provided with a second fixing bolt (7), and the second fixing bolt (7) passes through the support plate (5) and is threadedly connected to the chromatograph.

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