A magnetic separation cleaning device and a sample analyzer

Abstract

The application discloses a magnetic separation and cleaning device and a sample analyzer. The magnetic separation and cleaning device comprises a magnetic separation disc and a plurality of groups of magnets. The magnetic separation disc is provided with a plurality of groups of workstations and a first workstation. The first workstation and the plurality of groups of workstations are sequentially and spacedly arranged along the circumference of the magnetic separation disc. Each group of workstations comprises sequentially arranged liquid injection workstations, magnetic aggregation workstations and liquid suction workstations. Each group of magnets is correspondingly arranged with a group of workstations, and the group of magnets is correspondingly arranged with the magnetic aggregation workstations and the liquid suction workstations in the same workstation. According to the application, the group of magnets is only correspondingly arranged with the magnetic aggregation workstations and the liquid suction workstations, and no magnetic field exists in the liquid injection workstations. Therefore, in the process of injecting cleaning liquid, the magnetic beads in the reaction cup will not be gathered together due to the magnetic field, but will be fully contacted with the cleaning liquid. Moreover, the plurality of groups of workstations can clean the magnetic beads for multiple times, so that the cleaning efficiency of the magnetic beads is improved, and the practicability of the magnetic separation and cleaning device is improved.

Description

Technical Field

[0001] This application relates to the field of sample analysis technology, and in particular to a magnetic separation and cleaning device and a sample analyzer. Background Technology

[0002] Currently, in instruments using immunomagnetic beads for sample concentration detection, magnetic separation and cleaning is a crucial step. It removes unbound substances through magnetic field adsorption, retaining the immunomagnetic beads to achieve target analyte quantification. Existing technologies typically cover the entire rotating disk with a magnetic separation area, placing both the injection and aspiration stations under the same magnetic field. This design has significant drawbacks: because both injection and aspiration occur within the magnetic field, the magnetic beads are difficult to detach from the magnetic field during injection, remaining in an aggregated state and failing to fully mix and contact with the cleaning solution, resulting in a severe decrease in cleaning efficiency. Furthermore, if the reaction solution has a high viscosity, the aspiration resistance increases, leading to more residual liquid and further weakening the cleaning effect, ultimately affecting the accuracy and reliability of the detection. Utility Model Content

[0003] To address the aforementioned technical problems, this application provides a magnetic separation cleaning device, comprising a magnetic separation disk and multiple sets of magnets.

[0004] The magnetic separation disk is provided with multiple workstation groups and a first workstation, and the first workstation and the multiple workstation groups are arranged at intervals along the circumference of the magnetic separation disk; wherein, each workstation group includes a liquid injection workstation, a magnetic aggregation workstation and a liquid suction workstation arranged at intervals in sequence;

[0005] The multiple sets of magnets are spaced apart from the magnetic separation disk, and each set of magnets corresponds to the magnetic agglomeration station and the liquid suction station in the same work station group.

[0006] The magnetic separation disk rotates around a central axis to move the reaction cups placed on the magnetic separation disk between workstations; the first workstation is used to receive the reaction cups, and the multiple workstation groups are used to clean the magnetic beads in the reaction cups multiple times.

[0007] The magnet assembly includes an inner magnet and an outer magnet, with the outer magnet disposed around the inner magnet, and a channel for the reaction cup to pass through is formed between the outer magnet and the inner magnet;

[0008] The inner magnet and the outer magnet are arranged with opposite magnetic properties.

[0009] The multiple workstation groups include a first workstation group, a second workstation group, and a third workstation group arranged sequentially at intervals. The multiple magnet groups include a first magnet group, a second magnet group, and a third magnet group. The first magnet group is arranged corresponding to the first workstation group, the second magnet group is arranged corresponding to the second workstation group, and the third magnet group is arranged corresponding to the third workstation group.

[0010] The first magnet group and the third magnet group have the same magnetic poles, and the first magnet group and the second magnet group have opposite magnetic poles.

[0011] The magnetic separation cleaning device further includes a liquid injection component, which is spaced apart from the magnetic separation disk and is used to inject cleaning liquid into the reaction cup located at the liquid injection station.

[0012] In each of the aforementioned workstation groups, the amount of liquid injected into the reaction cup at the injection station is equal.

[0013] The magnetic separation cleaning device further includes a liquid suction component, which is spaced apart from the magnetic separation disk and is used to suck up the waste liquid in the reaction cup located at the liquid suction station.

[0014] Each set of workstations includes one injection workstation, two magnetic agglomeration workstations, and one liquid suction workstation. The injection workstation, the two magnetic agglomeration workstations, and the liquid suction workstation of each set of workstations are arranged sequentially along the rotation direction of the magnetic separation disk.

[0015] The magnetic separation disk is further provided with a second station, which is located between the first station and the third station group, for temporarily storing the reaction cup after the magnetic balls have been cleaned.

[0016] To address the aforementioned technical problems, this application also provides a sample analyzer, including the magnetic separation and cleaning device and the detection device as described above. The magnetic separation and cleaning device and the detection device are arranged at intervals. The detection device is used to detect the sample in the reaction cup, and the magnetic separation and cleaning device is used to receive the reaction cup after the detection device has finished detecting it, so as to clean the magnetic beads in the reaction cup.

[0017] The beneficial effects of this application are as follows: Unlike existing technologies, the magnetic separation cleaning device provided in this application includes a magnetic separation disk and multiple sets of magnets. The magnetic separation disk is provided with multiple workstations and a first workstation. The first workstation and the multiple workstations are arranged sequentially and at intervals along the circumference of the magnetic separation disk. Each workstation includes a liquid injection workstation, a magnetic aggregation workstation, and a liquid suction workstation arranged sequentially. Each magnet set corresponds to a workstation, and the magnet set corresponds to the magnetic aggregation workstation and the liquid suction workstation within the same workstation. This application ensures that the magnetic beads in the reaction cup do not clump together due to the magnetic field during the injection of cleaning liquid, but instead fully contact the cleaning liquid. Furthermore, the multiple workstations can perform multiple cleaning cycles on the magnetic beads, improving the cleaning efficiency and enhancing the practicality of the magnetic separation cleaning device. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] in:

[0020] Figure 1 This is a schematic diagram of an embodiment of the magnetic separation cleaning device of this application.

[0021] Reference numerals in the attached figures: 1. Magnetic separation cleaning device; 11. Magnetic separation disc; 111. First station; 112. Liquid injection station; 113. Magnetic aggregation station; 114. Liquid suction station; 115. First station group; 116. Second station group; 117. Third station group; 118. Second station; 12. Magnet group; 121. Inner magnet; 122. Outer magnet; 123. First magnet group; 124. Second magnet group; 125. Third magnet group. Detailed Implementation

[0022] The embodiments of this application will now be described in detail with reference to the accompanying drawings.

[0023] In the following description, specific details such as particular system architectures, interfaces, and technologies are presented for illustrative purposes rather than for limiting purposes, in order to provide a thorough understanding of this application.

[0024] In this application, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0025] In this application, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent three cases: A alone, A and B simultaneously, and B alone. Additionally, the character " / " generally indicates that the preceding and following related objects are in an "or" relationship. Furthermore, "many" in this application means two or more. Moreover, the term "at least one" in this application means any combination of at least two of any one or more of a plurality of objects. For example, including at least one of A, B, and C can mean including any one or more elements selected from the set consisting of A, B, and C. Furthermore, the terms "first," "second," and "third" in this application are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features.

[0026] Please see Figure 1 , Figure 1 This is a schematic diagram of the structure of an embodiment of the magnetic separation cleaning device of this application. The magnetic separation cleaning device 1 provided in this application includes a magnetic separation disk 11 and multiple sets of magnet groups 12.

[0027] The magnetic separation disk 11 is provided with multiple workstation groups and a first workstation 111. The first workstation 111 and the multiple workstation groups are arranged sequentially and at intervals along the circumference of the magnetic separation disk 11. Each workstation group includes a liquid injection workstation 112, a magnetic aggregation workstation 113, and a liquid suction workstation 114 arranged sequentially and at intervals. Multiple magnet groups 12 are arranged at intervals with the magnetic separation disk 11, and each magnet group 12 corresponds to the magnetic aggregation workstation 113 and the liquid suction workstation 114 in the same workstation group.

[0028] Specifically, such as Figure 1As shown, the first station 111 serves as a station for receiving the reaction cup, while the liquid injection station 112 serves as a station for injecting cleaning fluid into the reaction cup. The magnetic aggregation station 113 applies a magnetic field to the magnetic balls in the reaction cup, causing them to adhere to the reaction cup wall. The liquid suction station 114 serves as a station for removing the cleaning waste liquid from the reaction cup. In other words, the reaction cup can be placed in the first station 111, then moved to the liquid injection station 112 to inject cleaning fluid, then moved to the magnetic aggregation station 113 to apply a magnetic field to the magnetic balls, causing them to adhere to the reaction cup wall, and finally moved to the liquid suction station 114 to remove the cleaning waste liquid from the reaction cup, completing one cleaning cycle of the magnetic balls.

[0029] In this embodiment, the magnetic separation disk 11 is provided with multiple workstations, and each workstation includes a liquid injection station 112, a magnetic aggregation station 113 and a liquid suction station 114. That is, the magnetic balls can be cleaned multiple times, further improving the cleaning efficiency of the magnetic balls.

[0030] Furthermore, since each magnet group 12 is only set at the magnetic aggregation station 113 and the liquid absorption station 114 within the same workstation group, that is, on the magnetic separation disk 11, only the magnetic aggregation station 113 and the liquid absorption station 114 have a magnetic field, while there is no magnetic field at the liquid injection station 112. Consequently, during the process of moving the reaction cup to the liquid injection station 112 to inject the cleaning fluid, since there is no magnetic field at the liquid injection station 112, that is, the magnetic balls will not be adsorbed onto the reaction cup wall under the action of the magnetic field. The magnetic balls can fully contact the cleaning fluid, improving the cleaning uniformity and avoiding the aggregation phenomenon caused by magnetic field adsorption.

[0031] Furthermore, the magnet assembly 12 only covers the magnetic aggregation station 113 and the liquid absorption station 114, which reduces the amount of magnets used and ensures that the magnetic beads are effectively captured at the required adsorption stations. Next, the magnetic balls, which are thoroughly mixed with the cleaning liquid, enter the magnetic aggregation station 113 and are adsorbed onto the reaction vessel wall under the action of the magnetic field. Then, they enter the liquid absorption station 114. Since there is also a magnetic field at the liquid absorption station 114, the magnetic balls maintain their aggregated state and are adsorbed onto the reaction vessel wall. At this time, the cleaning waste liquid is sucked away, which reduces the probability of the magnetic balls being sucked away and improves the safety of the magnetic balls being cleaned in the magnetic separation cleaning device 1.

[0032] In the magnetic separation cleaning device 1 provided in this embodiment, by setting the liquid injection station 112 in a non-magnetic field area, the magnetic beads can be fully mixed with the cleaning liquid during the liquid injection process, improving the cleaning uniformity and avoiding aggregation caused by magnetic field adsorption. The magnet group 12 only covers the magnetic aggregation and liquid absorption stations 114, which reduces the amount of magnets used and ensures that the magnetic beads are effectively captured at the stations where adsorption is required.

[0033] Optionally, the magnetic separation disk 11 rotates around its central axis to move the reaction cups placed on the magnetic separation disk 11 between workstations. As mentioned above, the first workstation 111 is used to receive the reaction cups, and multiple workstations are used to clean the magnetic beads in the reaction cups multiple times.

[0034] Specifically, after receiving the reaction cup at the first station 111, the magnetic separation disk 11 rotates to move the reaction cup to the liquid injection station 112 in the station group adjacent to the first station 111, so as to inject cleaning fluid into the reaction cup. Then, the magnetic separation disk 11 continues to rotate, moving the reaction cup to the magnetic aggregation station 113, so that the magnetic balls in the reaction cup are adsorbed onto the wall of the reaction cup under the action of the magnetic field. Then, the magnetic separation disk 11 rotates to move the reaction cup to the liquid suction station 114, so as to suck away the cleaning waste liquid in the reaction cup, completing one cleaning of the magnetic balls.

[0035] Next, the magnetic separation disk 11 continues to rotate, rotating the reaction cup to the liquid injection station 112 on the adjacent work station group, and injecting cleaning fluid into the reaction cup again. As the magnetic separation disk 11 rotates, the magnetic balls in the reaction cup are magnetically agglomerated again, and the cleaning waste fluid in the reaction cup is sucked away again, completing the cleaning of the magnetic balls once more.

[0036] By setting up multiple workstations and rotating the magnetic separation disk 11, the magnetic balls in the reaction cup can be cleaned multiple times, enabling continuous operation of the cleaning process and improving overall processing efficiency.

[0037] Understandably, after receiving the reaction cup at the first station 111, the reaction cup is first moved to the liquid injection station 112 to receive the cleaning liquid. That is, at this time, the liquid in the reaction cup is a mixture of reaction waste liquid and cleaning liquid. The addition of cleaning liquid dilutes the high-viscosity reaction waste liquid, which solves the problem in the prior art that directly sucking up the reaction waste liquid leads to increased liquid suction resistance, more residual liquid, and weakened cleaning effect. This application reduces liquid suction resistance and reduces residual liquid by injecting cleaning liquid, thereby improving the thoroughness of cleaning.

[0038] Optionally, the magnet assembly 12 includes an inner magnet 121 and an outer magnet 122, with the outer magnet 122 disposed around the inner magnet 121. A channel for the reaction cup to pass through is formed between the outer magnet 122 and the inner magnet 121, wherein the inner magnet 121 and the outer magnet 122 are magnetically opposite.

[0039] Specifically, such as Figure 1As shown, the magnetic agglomeration station 113 and the liquid suction station 114 are located in the channel formed by the inner magnet 121 and the outer magnet 122. The channel formed by the inner magnet 121 and the outer magnet 122 allows the reaction cup to pass through. Therefore, the reaction cup can pass through the channel formed by the inner magnet 121 and the outer magnet 122 as the magnetic separation disk 11 rotates. The magnetic field formed by the inner magnet 121 and the outer magnet 122 will act on the magnetic ball in the reaction cup, so that the magnetic ball is attracted to the wall of the reaction cup.

[0040] In this configuration, the inner magnet 121 and the outer magnet 122 have opposite magnetic poles. Figure 1 This is a top view of the magnetic separation cleaning device 1. If the inner magnet 121 is a magnet with the S pole facing up and the N pole facing down, then the outer magnet 122 is a magnet with the N pole facing up and the S pole facing down, so as to form a stable magnetic field in the channel.

[0041] In one embodiment, the dimensions and spacing of the inner magnet 121 and the outer magnet 122 can be adjusted according to the diameter of the reaction cup to form a stable magnetic field and a channel that allows the reaction cup to pass through.

[0042] In this embodiment, a stronger magnetic field gradient is formed by combining inner and outer magnets with opposite magnetic properties, resulting in more uniform force on the magnetic beads during adsorption and improving magnetic separation efficiency. The annular channel design keeps the reaction vessel in a stable position during cleaning, preventing the magnetic beads from spreading.

[0043] Optionally, the multiple workstations include a first workstation group 115, a second workstation group 116, and a third workstation group 117 arranged sequentially at intervals, and the multiple magnet groups 12 include a first magnet group 123, a second magnet group 124, and a third magnet group 125. The first magnet group 123 is arranged corresponding to the first workstation group 115, the second magnet group 124 is arranged corresponding to the second workstation group 116, and the third magnet group 125 is arranged corresponding to the third workstation group 117.

[0044] The first magnet group 123 and the third magnet group 125 have the same magnetic poles, and the first magnet group 123 has opposite magnetic poles to the second magnet group 124.

[0045] For details, please continue reading. Figure 1 If the inner magnet 121 of the first magnet group 123 is defined as having its N pole facing upward, then the outer magnet 122 of the first magnet group 123 is defined as having its S pole facing upward. The inner magnet 121 of the second magnet group 124 is defined as having its S pole facing upward, and the outer magnet 122 of the second magnet group 124 is defined as having its N pole facing upward. The inner magnet 121 of the third magnet group 125 is defined as having its N pole facing upward, and the outer magnet 122 of the third magnet group 125 is defined as having its S pole facing upward.

[0046] Since the first magnet group 123 and the third magnet group 125 are far apart, they can be set with the same magnetic poles. However, since the second magnet group 124 and the first magnet group 123 are close together, the first magnet group 123 and the second magnet group 124 need to be set with opposite magnetic poles to avoid the difficulty of setting the magnet group 12 due to the repulsive force between the magnets.

[0047] Furthermore, by setting the magnetic poles of the second magnetic pole group opposite to those of the first and third magnetic pole groups, a magnetic field gradient variation region can be formed. This causes a dynamic migration effect when the magnetic ball moves to the next station group, enhancing the contact efficiency between the magnetic ball and the cleaning fluid. This magnetic pole arrangement optimizes the control of the magnetic field on the magnetic ball without increasing the number of magnets, allowing the magnetic ball to adhere more fully to the cup wall at the liquid suction station 114, reducing residual liquid. Simultaneously, the magnetic field gradient variation helps to evenly disperse the magnetic ball during liquid injection, improving the cleaning effect of the cleaning fluid on the magnetic ball.

[0048] Next, as the magnetic separation disk 11 rotates, the magnetic beads in the reaction cup can complete the first cleaning at the first station group 115, the second cleaning at the second station group 116, and the third cleaning at the third station group 117, thus realizing multiple cleaning of the magnetic beads in the reaction cup, improving the cleaning efficiency of the magnetic beads, and enhancing the practicality of the magnetic separation cleaning device 1.

[0049] Optionally, the magnetic separation cleaning device 1 also includes a liquid injection assembly (not shown), which is spaced apart from the magnetic separation disk 11 to inject cleaning liquid into the reaction cup located at the liquid injection station 112.

[0050] The magnetic separation cleaning device 1 may include multiple liquid injection components, which are set up in correspondence with multiple workstations. Each liquid injection component is set close to the liquid injection station 112 of the corresponding workstation group. When the magnetic separation disk 11 rotates the reaction cup to the liquid injection station 112, the liquid injection component can inject cleaning liquid into the reaction cup so that the cleaning liquid contacts and cleans the magnetic ball.

[0051] In one embodiment, the amount of liquid injected into the reaction cup at the injection station 112 in each group of workstations is equal.

[0052] In this embodiment, the structural design that maintains an equal injection volume can improve the uniformity of magnetic ball cleaning and avoid the problem of uneven magnetic ball distribution caused by differences in liquid volume.

[0053] It is understandable that, as mentioned above, the reaction cup received at the first station 111 contains reaction waste liquid. Therefore, when injecting cleaning liquid into the reaction cup of the liquid injection assembly at the first station group 115, the amount of cleaning liquid needs to be controlled in order to dilute the reaction waste liquid and prevent the reaction cup from overflowing.

[0054] Therefore, the amount of cleaning solution injected at the first station group 115 plus the amount of reagent in the reaction waste liquid must be equal to the amount of cleaning solution injected at the second station group 116 and equal to the amount of cleaning solution injected at the third station group 117. The amount of cleaning solution injected at the first station group 115 can be determined based on the amount of reagent in the reaction waste liquid in the reaction vessel.

[0055] Optionally, the magnetic separation cleaning device 1 also includes a liquid suction component (not shown), which is spaced apart from the magnetic separation disk 11 and is used to suction the waste liquid in the reaction cup located at the liquid suction station 114.

[0056] Specifically, when the magnetic separation disk 11 rotates the reaction cup to the liquid suction station 114, the liquid injection component can suck away the cleaning waste liquid in the reaction cup located at the liquid suction station 114, thus completing the first cleaning of the magnetic beads in the reaction cup.

[0057] Optionally, each set of workstations includes one injection workstation 112, two magnetic agglomeration workstations 113 and one suction workstation 114. The injection workstation 112, the two magnetic agglomeration workstations 113 and the suction workstation 114 of each set of workstations are arranged sequentially along the rotation direction of the magnetic separation disk.

[0058] Each workstation group comprises a combination of an injection station 112, two magnetic aggregation stations 113, and a suction station 114. The injection station 112, the two magnetic aggregation stations 113, and the suction station 114 in each workstation group are arranged sequentially along the rotation direction of the magnetic separation disk 11. After the reaction cup is injected with cleaning fluid at the injection station 112, it can be rotated to the two magnetic aggregation stations 113. Under the influence of the magnetic field at the magnetic aggregation station 113, the magnetic beads in the reaction cup are fully aggregated. The reaction cup is then rotated to the suction station 114, where the cleaning waste fluid in the reaction cup is suctioned out. Because the magnetic beads are adsorbed onto the reaction cup wall under the influence of the magnetic field, the safety of the magnetic beads during the cleaning process is improved.

[0059] In this embodiment, by increasing the number of magnetic aggregation stations 113, the aggregation time of magnetic beads is extended, thereby improving the adsorption efficiency of magnetic beads on the cup wall. The setting of two magnetic aggregation stations 113 allows the magnetic beads to aggregate more fully under the action of multiple magnetic fields, reducing the probability that the liquid suction component will suck up the magnetic beads, improving the safety of the magnetic beads during the cleaning process, and improving the practicality of the magnetic separation cleaning device 1.

[0060] Optionally, a second station 118 is also provided on the magnetic separation disk 11. The second station 118 is located between the first station 111 and the third station group 117, and is used to temporarily store the cleaned reaction cup.

[0061] The second station 118 on the magnetic separation disk 11 is located between the first station 111 and the third station group 117, and is used to temporarily store the cleaned reaction cups. This station achieves seamless process flow through a rational layout and can be automated with the help of a conveyor mechanism. This design optimizes the station sequence, making the cleaning process more consistent with fluid dynamics characteristics, for example, by providing transition spaces between cleaning steps to avoid mutual interference between the functions of different stations.

[0062] In one embodiment, the second station 118 may be configured as a magnetic field-free region to ensure that the reaction vessel is not subject to magnetic interference when it remains there.

[0063] In another embodiment, the first station 111 can also be used as a station for taking out reaction cups. That is, the magnetic separation disk 11 can rotate to move the reaction cup located on the second station 118 to the first station 111, and then the moving component can take away the cleaned reaction cup on the first station 111 and place another reaction cup that needs to be cleaned.

[0064] In other embodiments, the second station 118 can also be used as a station for taking out reaction cups. That is, when the magnetic separation disk 11 rotates the reaction cup from the third station group 117 to the second station 118, the moving component can take away the cleaned reaction cup from the second station 118. As the magnetic separation disk 11 rotates, the empty placement position on the second station 118 will move to the first station 111. The moving component can place the reaction cup to be cleaned on the first station 111, thereby improving the efficiency of taking out and placing reaction cups in the magnetic separation cleaning device 1.

[0065] In summary, the magnetic separation cleaning device 1 provided in this application, by placing the liquid injection station 112 in a non-magnetic field area, allows the magnetic beads to be fully mixed with the cleaning solution during the injection process, improving cleaning uniformity and avoiding aggregation caused by magnetic field adsorption. The magnet assembly 12 only covers the magnetic aggregation and liquid absorption stations 114, reducing the amount of magnets used while ensuring effective capture of the magnetic beads at the required adsorption stations. Adding a liquid injection step before the first liquid absorption can dilute the high-viscosity reaction solution, reduce liquid absorption resistance, and reduce residual liquid, thereby improving cleaning thoroughness. Simultaneously, by optimizing the station layout and magnet coverage, the device can adapt to the cleaning needs of samples with different viscosities, improving the accuracy and stability of the detection results.

[0066] This application also provides a sample analyzer (not shown), including the magnetic separation and cleaning device 1 and the detection device as described above. The detection device can be used to detect the sample in the reaction cup, and the magnetic separation and cleaning device 1 is used to receive the reaction cup after the detection device has finished detecting it, so as to clean the magnetic beads in the reaction cup.

[0067] Specifically, the magnetic separation and cleaning device 1 achieves three cleaning processes of "injection-absorption-injection-absorption-injection-absorption" for the reaction cup by adding a working station group, thereby improving the cleaning efficiency of the magnetic beads in the reaction cup, effectively removing unreacted substances, ensuring the accuracy of the detection results of the detection device, and improving the practicality of the sample analyzer.

[0068] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A magnetic separation cleaning device, characterized in that, Includes a magnetic separation disk and multiple sets of magnets. The magnetic separation disk is provided with multiple workstation groups and a first workstation, and the first workstation and the multiple workstation groups are arranged at intervals along the circumference of the magnetic separation disk; wherein, each workstation group includes a liquid injection workstation, a magnetic aggregation workstation and a liquid suction workstation arranged at intervals in sequence; The multiple sets of magnets are spaced apart from the magnetic separation disk, and each set of magnets corresponds to the magnetic agglomeration station and the liquid suction station in the same work station group.

2. The magnetic separation cleaning device according to claim 1, characterized in that, The magnetic separation disk rotates around its central axis to move the reaction cups placed on the magnetic separation disk between workstations; the first workstation is used to receive the reaction cups, and the multiple workstation groups are used to clean the magnetic beads in the reaction cups multiple times.

3. The magnetic separation cleaning device according to claim 1, characterized in that, The magnet assembly includes an inner magnet and an outer magnet, with the outer magnet disposed around the inner magnet, and a channel for the reaction cup to pass through is formed between the outer magnet and the inner magnet; The inner magnet and the outer magnet are arranged with opposite magnetic properties.

4. The magnetic separation cleaning device according to claim 3, characterized in that, The multiple workstation groups include a first workstation group, a second workstation group, and a third workstation group arranged at intervals in sequence. The multiple magnet groups include a first magnet group, a second magnet group, and a third magnet group. The first magnet group is arranged corresponding to the first workstation group, the second magnet group is arranged corresponding to the second workstation group, and the third magnet group is arranged corresponding to the third workstation group. The first magnet group and the third magnet group have the same magnetic poles, and the first magnet group and the second magnet group have opposite magnetic poles.

5. The magnetic separation cleaning device according to claim 1, characterized in that, The magnetic separation cleaning device also includes a liquid injection component, which is spaced apart from the magnetic separation disk and is used to inject cleaning liquid into the reaction cup located at the liquid injection station.

6. The magnetic separation cleaning device according to claim 5, characterized in that, The amount of liquid injected into the reaction cup at each injection station in each group of workstations is equal.

7. The magnetic separation cleaning device according to claim 1, characterized in that, The magnetic separation cleaning device also includes a liquid suction component, which is spaced apart from the magnetic separation disk and is used to suck up the waste liquid in the reaction cup located at the liquid suction station.

8. The magnetic separation cleaning device according to claim 1, characterized in that, Each set of workstations includes one injection workstation, two magnetic agglomeration workstations, and one suction workstation. The injection workstation, the two magnetic agglomeration workstations, and the suction workstation in each set of workstations are arranged sequentially along the rotation direction of the magnetic separation disk.

9. The magnetic separation cleaning device according to claim 4, characterized in that, The magnetic separation disk is also provided with a second station, which is located between the first station and the third station group, for temporarily storing the reaction cup after the magnetic balls have been cleaned.

10. A sample analyzer, characterized in that, The device includes a magnetic separation and cleaning apparatus and a detection apparatus as described in any one of claims 1-9, wherein the magnetic separation and cleaning apparatus and the detection apparatus are arranged at intervals, the detection apparatus is used to detect the sample in the reaction cup, and the magnetic separation and cleaning apparatus is used to receive the reaction cup after the detection apparatus has finished detecting it, so as to clean the magnetic beads in the reaction cup.

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