A mouse intravenous injection experiment fixation device

Abstract

This utility model relates to the field of mouse intravenous injection technology and discloses a mouse intravenous injection experiment fixation device, including a base, an mounting platform fixedly connected to the upper end of the base, a conical restraint cylinder fixedly connected to the upper end of the mounting platform, a prostrate platform fixedly connected inside the conical restraint cylinder, a cover plate slidably connected to one side of the conical restraint cylinder, and locking compartments fixedly connected to both sides of the conical restraint cylinder. The two sides of the cover plate are slidably connected to the interiors of the two locking compartments respectively. This utility model can effectively simulate a cave-like state, reducing the anxiety of mice entering the restraint cylinder, soothing the mice's emotions, and reducing the occurrence of stress from struggling inside the restraint cylinder. Simultaneously, the fixation frame can fix the mouse's tail, avoiding direct binding of the mouse's body and affecting its breathing, thus ensuring effective fixation without adversely affecting the mouse's condition.

Description

Technical Field

[0001] This utility model relates to the field of mouse intravenous injection technology, and in particular to a fixation device for mouse intravenous injection experiments. Background Technology

[0002] Tail vein injection in mice is commonly used for drug efficacy evaluation and pharmacokinetic experiments. During tail vein injection, the mouse needs to be restrained in a restraint tube to restrict its movement, and the injection is performed through an opening at one end of the restraint tube that exposes the mouse's tail.

[0003] A search revealed that Chinese Patent Publication No. CN217960401U discloses a fixation device for mouse tail vein injection. This device includes a cylindrical structure positioned on a test bench. The cylindrical structure comprises an intravenous injection area, a pick-up and drop area, and an anesthesia area, arranged sequentially from back to front and interconnected. A movable piston, which is slidably positioned within the cylindrical structure and cooperates with the mouse's head positioning, forms an intravenous injection chamber when the movable piston is positioned in the intravenous injection area and an anesthesia chamber when the movable piston is positioned in the anesthesia area. This device can reliably position the mouse, increasing the comfort of intravenous injection, preventing the mouse from running around, and improving the success rate and efficiency of intravenous injection.

[0004] However, in existing technologies, when fixing mice before injection, the mice are usually directly inserted into a restraint tube that restricts their movement. However, most existing restraint tubes are cylindrical and lack mechanisms to soothe the mice, causing them to struggle and become stressed after entering the restraint tube, which affects the smooth progress of the experiment. At the same time, when fixing the mice, a restraint plate is usually used to compress the mice's range of motion, making them unable to move. The restraint plate also compresses the mice's breathing, causing adverse effects. A solution is proposed to solve the problems mentioned in the background technology. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides a mouse intravenous injection experiment fixation device, which aims to improve the situation where mice are usually directly inserted into a restraint tube to restrict their movement before injection. However, existing restraint tubes are mostly cylindrical and lack mechanisms to soothe the mice, causing them to struggle and become stressed after entering the restraint tube, which affects the smooth progress of the experiment. At the same time, when fixing mice, a fixation plate is usually used to compress the mouse's range of motion, making it unable to move. The fixation plate can also compress the mouse's breathing, causing adverse effects.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: It includes a base, an mounting platform fixedly connected to the upper end of the base, a conical restraint cylinder fixedly connected to the upper end of the mounting platform, a prone platform fixedly connected inside the conical restraint cylinder, a cover plate slidably connected to one side of the conical restraint cylinder, and buckle compartments fixedly connected to both sides of the conical restraint cylinder. The two sides of the cover plate are slidably connected to the interiors of the two buckle compartments respectively. A pull rod is fixedly connected to one side of the cover plate. A sliding groove is provided at the upper end of the conical restraint cylinder, and a fixing mechanism is provided at the upper end of the base.

[0007] Preferably, the fixing mechanism includes a fixing frame, the lower end of the fixing frame is fixedly connected to the upper end of the base, a fixing rod is slidably connected to one side of the fixing frame, and a lead screw is rotatably connected to one side of the fixing frame, with the outer surface of the lead screw being threadedly connected to the inner surface of the fixing rod.

[0008] Preferably, a first bevel gear is fixedly connected to one end of the lead screw, and a second bevel gear is rotatably connected to the lower side of one side of the fixing frame. The outer surface of the first bevel gear meshes with the outer surface of the second bevel gear, and a knob is fixedly connected to one side of the second bevel gear.

[0009] Preferably, a support rod is fixedly connected to the upper end of the base, and reinforcing ribs are fixedly connected to both sides of the support rod.

[0010] Preferably, a magnifying glass is rotatably connected to one end of the support rod, and a second knob is fixedly connected to one side of the magnifying glass.

[0011] Preferably, the upper end of the fixing frame is provided with a positioning groove, and a cold light lamp is fixedly connected to the middle of the upper end of the fixing frame.

[0012] Preferably, ventilation holes are provided on both sides of the conical binding cylinder.

[0013] Preferably, an anti-slip pad is fixedly connected to the lower end of the base.

[0014] Compared with the prior art, the advantages and positive effects of this utility model are as follows: This invention effectively simulates the state of a cave, reducing the anxiety of mice when they enter the restraint tube, soothing their emotions, and reducing the stress caused by their struggles inside the restraint tube. At the same time, the fixing frame can fix the tail part of the mouse, avoiding direct binding of the mouse's body and affecting its breathing, thus ensuring the fixation effect without adversely affecting the mouse's condition. Attached Figure Description

[0015] Figure 1 This is a perspective view of a mouse intravenous injection fixation device proposed in this utility model; Figure 2 This is a three-dimensional structural diagram of the other side of a mouse intravenous injection experiment fixation device proposed in this utility model; Figure 3 This invention provides a mouse intravenous injection experiment fixation device. Figure 1 Enlarged 3D structural diagram at point A; Figure 4 This is a three-dimensional structural diagram of the conical sampling cylinder portion in a mouse intravenous injection experimental fixation device proposed in this utility model; Figure 5 This is a three-dimensional structural diagram of the fixation frame in a mouse intravenous injection experiment fixation device proposed in this utility model.

[0016] Legend: 1. Base; 2. Mounting platform; 3. Conical restraint cylinder; 4. Vent hole; 5. Buckle compartment; 6. Slide groove; 7. Magnifying glass; 8. No. 2 knob; 9. Support rod; 10. Reinforcing rib; 11. Anti-slip pad; 12. Cold light lamp; 13. Fixing bracket; 14. Positioning groove; 15. Cover plate; 16. Pull rod; 17. Fixing rod; 18. Horizontal platform; 19. Lead screw; 20. No. 1 bevel gear; 21. No. 2 bevel gear; 22. No. 1 knob. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Reference Figures 1 to 5As shown, one embodiment of this utility model includes a base 1, characterized in that: a mounting platform 2 is fixedly connected to the upper end of the base 1, a conical restraint cylinder 3 is fixedly connected to the upper end of the mounting platform 2, a tilting platform 18 is fixedly connected inside the conical restraint cylinder 3, a cover plate 15 is slidably connected to one side inside the conical restraint cylinder 3, and buckle compartments 5 are fixedly connected to both sides of the conical restraint cylinder 3. The two sides of the cover plate 15 are slidably connected to the interiors of the two buckle compartments 5 respectively. A pull rod 16 is fixedly connected to one side of the cover plate 15. A groove 6 is provided at the upper end of the conical restraint cylinder 3, and the upper end of the base 1 is provided with... A fixing mechanism is provided, which includes a fixing frame 13. The lower end of the fixing frame 13 is fixedly connected to the upper end of the base 1. A fixing rod 7 is slidably connected to one side of the fixing frame 13. A lead screw 19 is rotatably connected to one side of the fixing frame 13. The outer surface of the lead screw 19 is threadedly connected to the inner surface of the fixing rod 17. A first bevel gear 20 is fixedly connected to one end of the lead screw 19. A second bevel gear 21 is rotatably connected to the lower side of one side of the fixing frame 13. The outer surface of the first bevel gear 20 meshes with the outer surface of the second bevel gear 21. A knob 22 is fixedly connected to one side of the second bevel gear 21.

[0019] In this embodiment, a conical restraint cylinder 3 is designed with a wide opening that gradually narrows towards the tail. When restraining a mouse, the mouse's tail can be pulled to pass through the groove 6, and then the mouse can be pulled backward to enter the conical restraint cylinder 3. The mouse's tail is then fixed above the restraint frame 13, and the cover plate 15 is inserted into the conical restraint cylinder 3, creating a dark space with a wide opening and a narrowing tail. Simultaneously, when restraining the mouse's tail, the first knob 22 can be rotated to rotate the second bevel gear 21, thereby engaging the meshing gear. When the first bevel gear 20 rotates, the lead screw 19 fixedly connected to it will also rotate, thereby driving the fixing rod 17 to move downward. The fixing rod 17 and the fixing frame 13 clamp and fix the mouse tail. This method can effectively simulate the state of a cave, reduce the anxiety of the mouse when entering the restraint tube, soothe the mouse's emotions, and reduce the occurrence of stress from struggling in the restraint tube. At the same time, the fixing frame 17 can fix the mouse tail, avoiding direct binding of the mouse's body and affecting the mouse's breathing. This ensures the fixation effect without adversely affecting the mouse's condition.

[0020] Example 2, as Figure 1 , Figure 2 , Figure 4 and Figure 5As shown, a support rod 9 is fixedly connected to the upper end of the base 1, and reinforcing ribs 10 are fixedly connected to both sides of the support rod 9. A magnifying glass 7 is rotatably connected to one end of the support rod 9, and a second knob 8 is fixedly connected to one side of the magnifying glass 7. A positioning groove 14 is opened at the upper end of the fixing frame 13, and a cold light lamp 12 is fixedly connected to the middle of the upper end of the fixing frame 13. Ventilation holes 4 are opened on both sides of the conical restraint cylinder 3, and an anti-slip pad 11 is fixedly connected to the lower end of the base 1.

[0021] In this embodiment, when puncturing the tail of a mouse with a syringe, the cold light lamp 12 above the fixture 13 can illuminate the puncture site of the mouse tail, making the blood vessels in the mouse tail clearly visible. At the same time, the magnifying glass 7 provided allows the experimenter to more easily identify the location of the blood vessels during the injection operation, making the device more convenient to use and improving the success rate of intravenous injection in mice.

[0022] Working principle: By setting a conical restraint cylinder 3 with a wide opening that gradually narrows towards the tail, when fixing a mouse, the mouse's tail can be pulled to pass through the groove 6, and then the mouse can be pulled backward to enter the conical restraint cylinder 3. The mouse's tail is then fixed above the fixing frame 13. The cover plate 15 is then inserted into the conical restraint cylinder 3, creating a dark space with a wide opening and a narrowing tail. To fix the mouse's tail, the first knob 22 can be turned to rotate the second bevel gear 21, which in turn rotates the meshing first bevel gear 20. At this time, the screw 19 fixedly connected to it will rotate, thereby driving the fixing rod 17 to move down. The fixing rod 17 and the fixing frame 13 clamp and fix the mouse's tail. This method effectively simulates the state of a cave, reducing the anxiety of mice when entering the restraint tube, soothing their emotions, and reducing the stress caused by struggling within the restraint tube. Simultaneously, the fixation frame 17 secures the mouse's tail, preventing direct binding of the body from affecting breathing, thus ensuring effective fixation without adversely affecting the mouse's condition. When puncturing the mouse's tail with a syringe, the cold light lamp 12 above the fixation frame 13 illuminates the puncture site, clearly displaying the blood vessels. Furthermore, the included magnifying glass 7 makes it easier for researchers to identify the location of blood vessels during injection, making the device more convenient to use and increasing the success rate of intravenous injection in mice.

[0023] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A mouse intravenous injection experiment fixing device, comprising a base (1), characterized in that: The upper end of the base (1) is fixedly connected to the mounting platform (2), the upper end of the mounting platform (2) is fixedly connected to the conical restraint cylinder (3), the inside of the conical restraint cylinder (3) is fixedly connected to the protractor (18), one side of the inside of the conical restraint cylinder (3) is slidably connected to the cover plate (15), both sides of the conical restraint cylinder (3) are fixedly connected to the buckle compartment (5), both sides of the cover plate (15) are slidably connected to the inside of the two buckle compartments (5), one side of the cover plate (15) is fixedly connected to the pull rod (16), the upper end of the conical restraint cylinder (3) is provided with a sliding groove (6), and the upper end of the base (1) is provided with a fixing mechanism.

2. The mouse intravenous experiment fixation device according to claim 1, characterized in that: The fixing mechanism includes a fixing frame (13), the lower end of the fixing frame (13) is fixedly connected to the upper end of the base (1), a fixing rod (17) is slidably connected to one side of the fixing frame (13), and a lead screw (19) is rotatably connected to one side of the fixing frame (13). The outer surface of the lead screw (19) is threadedly connected to the inner surface of the fixing rod (17).

3. The mouse intravenous injection experiment fixing device according to claim 2, characterized in that: One end of the lead screw (19) is fixedly connected to a first bevel gear (20), and a second bevel gear (21) is rotatably connected to the lower side of one side of the fixed frame (13). The outer surface of the first bevel gear (20) meshes with the outer surface of the second bevel gear (21), and a first knob (22) is fixedly connected to one side of the second bevel gear (21).

4. The mouse intravenous experiment fixation device according to claim 1, characterized in that: The upper end of the base (1) is fixedly connected to a support rod (9), and both sides of the support rod (9) are fixedly connected to reinforcing ribs (10).

5. The mouse intravenous injection experiment fixing device according to claim 4, characterized in that: One end of the support rod (9) is rotatably connected to a magnifying glass (7), and a second knob (8) is fixedly connected to one side of the magnifying glass (7).

6. The mouse intravenous experiment fixation device according to claim 2, characterized in that: The upper end of the fixed frame (13) is provided with a positioning groove (14), and a cold light lamp (12) is fixedly connected to the middle of the upper end of the fixed frame (13).

7. The mouse intravenous experiment fixation device according to claim 1, characterized in that: Both sides of the conical binding tube (3) are provided with ventilation holes (4).

8. The mouse intravenous injection experiment fixing device according to claim 7, characterized in that: An anti-slip pad (11) is fixedly connected to the lower end of the base (1).

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