A solvent preparation device

Abstract

This invention discloses a solvent preparation device, belonging to the field of cell culture. The solvent preparation device includes a base, a mixing mechanism on the base for mixing solvents, a temperature control chamber mounted on the base, a control panel on the outside of the temperature control chamber, a shielding component on the outside of the temperature control chamber, and a fixing ring fixed inside the temperature control chamber. The fixing ring has a notch corresponding to the position of the shielding component, and a turntable is slidably connected to the fixing ring. This invention solves the problem of temperature fluctuations caused by frequent opening of the temperature control chamber when handling test tubes in existing solvent preparation devices. By incorporating an automatic tube-pushing structure inside the temperature control chamber, this invention effectively avoids temperature fluctuations inside the chamber caused by traditional handling methods. This design ensures that the internal environment remains at a constant temperature, keeping the solvent at optimal storage and reaction conditions, thereby guaranteeing the accuracy of experimental data and the stability of the process.

Description

Technical Field

[0001] This utility model relates to the field of cell culture, specifically a solvent preparation device. Background Technology

[0002] Chinese hamster ovary cells (CHO) are currently the most widely used mammalian cell culture system in the biopharmaceutical field. In the past few years, approved recombinant cell drugs have developed rapidly. Fed-batch culture is widely used to produce therapeutic proteins because of its simple operation and high product potency. During cell culture, a solvent preparation device is usually used to prepare the experimental solvent to facilitate the smooth progress of the experiment. Existing solvent preparation devices cannot automatically push solvent tubes during use. All tubes are stored inside a temperature-controlled chamber. When staff retrieve or place tubes, they need to frequently open the chamber door, resulting in the exchange of hot and cold air and significant internal temperature fluctuations. This makes it difficult to maintain the constant temperature range required for the experiment, which not only affects the stability of the solvent and the reaction effect but may also prolong the experiment time and increase the inconvenience of manual operation. In addition, repeatedly opening and closing the chamber door increases energy consumption, reduces the efficiency of the temperature control system, and is not conducive to the precise control of the experimental environment.

[0003] In summary, to ensure temperature stability and improve experimental efficiency during solvent preparation, it is necessary to address the issue of temperature fluctuations caused by frequent opening and closing of the temperature control chamber during test tube handling. The goal is to enable the device to automatically push test tubes while maintaining a constant temperature environment, thereby reducing manual intervention and preventing temperature imbalances. Utility Model Content

[0004] The purpose of this invention is to provide a solvent preparation device that, by setting an automatic push structure for test tubes inside the temperature control chamber, can avoid large fluctuations in the internal temperature of the temperature control chamber and solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a solvent mixing device, including a base, a mixing mechanism on the base for mixing solvents, a temperature control box mounted on the base, a control panel mounted on the outside of the temperature control box, a shielding component on the outside of the temperature control box, a fixing ring fixed inside the temperature control box, a notch on the fixing ring corresponding to the position of the shielding component, a turntable slidably connected to the fixing ring, a driving component inside the temperature control box for driving the turntable to rotate, multiple circumferentially distributed grooves on the turntable, slide blocks slidably connected inside the grooves, one side of the slide block being arc-shaped, an insertion hole on the slide block for inserting a test tube, one end of a spring mounted inside the groove, the other end of the spring being fixedly connected to the corresponding slide block, and a positioning mechanism on the outside of the slide block for limiting the sliding of the slide block.

[0006] Preferably, the shielding assembly includes a channel installed on the outside of the temperature control box, a hinge installed on the channel, and a baffle installed on the hinge, the baffle being rotatably connected to the channel via the hinge.

[0007] Preferably, the drive assembly includes a gear fixed to the bottom of the turntable, a drive motor installed on the bottom surface inside the temperature control box, and a gear installed at the output end of the drive motor. The gear meshes with the gear, and the drive motor is used to drive the gear to rotate.

[0008] Preferably, the positioning mechanism includes a guide component and a limiting component, both of which are disposed on the outside of the slide. The guide component is used to limit the sliding direction of the slide, and the limiting component is used to limit the sliding distance of the slide.

[0009] Preferably, the guide component includes a positioning groove formed inside the slide and a positioning strip installed on the side of the slide, the positioning strip being slidably connected to the positioning groove.

[0010] Preferably, the limiting component includes a limiting hole formed on the slide, a limiting rod fixed inside the slide groove, a limiting block fixed to the end of the limiting rod, and a limiting ring fixed outside the limiting hole. The limiting block is slidably connected to the limiting hole, and the inner diameter of the limiting ring is smaller than the diameter of the limiting block.

[0011] Preferably, the mixing mechanism includes a support component and a stirring component. The support component is disposed on a base, and the stirring component is mounted on the support component. The support component is used to position the stirring component, and the stirring component is used to stir the solvent.

[0012] Preferably, the support assembly includes a base mounted on the base, a column fixed on the base, an adjustment seat mounted on the outside of the column, and a fastening bolt connected to the adjustment seat, wherein the adjustment seat is slidably connected to the column.

[0013] Preferably, the stirring assembly includes a servo motor mounted on an adjusting base, a stirring rod mounted on the output end of the servo motor, and stirring blades fixed to the bottom end of the stirring rod. The servo motor is used to drive the stirring rod to rotate.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows: This invention, by incorporating an automatic tube-pushing structure within the temperature-controlled chamber, effectively avoids temperature fluctuations caused by traditional handling methods. This design ensures a consistently constant temperature within the chamber, keeping the solvent at its optimal storage and reaction conditions. This guarantees the accuracy of experimental data and the stability of the process. The automatic tube-pushing function enables precise positioning and efficient tube transfer, significantly improving the continuity and controllability of the solvent preparation process. Simultaneously, the closed-loop operation reduces external environmental interference, lowering the waiting time for temperature recovery and improving the energy efficiency of the equipment. This automated operation mode under constant temperature conditions not only optimizes the stability of the experimental process but also provides more reliable temperature protection for precision chemical reactions, contributing to more reproducible experimental results. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a three-dimensional structural diagram of the internal structure of the temperature control box of this utility model; Figure 3 This is a three-dimensional structural diagram of the drive component of this utility model; Figure 4 This is a three-dimensional structural diagram of the slide block of this utility model; Figure 5 This is a three-dimensional structural diagram of the fixing ring of this utility model; Figure 6 This is a three-dimensional structural diagram of the hybrid mechanism of this utility model.

[0016] In the diagram: 1. Base; 21. Base; 22. Column; 23. Adjustment seat; 24. Fastening bolt; 25. Servo motor; 26. Stirring rod; 27. Stirring blade; 3. Temperature control box; 4. Control panel; 51. Channel; 52. Hinge; 53. Baffle; 6. Fixing ring; 7. Notch; 8. Turntable; 91. Gear column; 92. Drive motor; 93. Gear; 10. Slide groove; 11. Slide seat; 12. Insertion hole; 13. Test tube; 14. Spring; 151. Positioning groove; 152. Positioning strip; 153. Limiting hole; 154. Limiting rod. Detailed Implementation

[0017] The present invention will be further described below with reference to specific embodiments.

[0018] Refer to the instruction manual appendix Figures 1 to 6A solvent mixing device includes a base 1, a mixing mechanism for mixing solvents on the base 1, a temperature control box 3 mounted on the base 1, a control panel 4 mounted on the outside of the temperature control box 3, a shielding component on the outside of the temperature control box 3, a fixing ring 6 fixed inside the temperature control box 3, a notch 7 on the fixing ring 6 corresponding to the position of the shielding component, a turntable 8 slidably connected to the fixing ring 6, a driving component inside the temperature control box 3 for driving the turntable 8 to rotate, a plurality of circumferentially distributed sliding grooves 10 on the turntable 8, a sliding seat 11 slidably connected inside the sliding grooves 10, one side of the sliding seat 11 being arc-shaped, an insertion hole 12 on the sliding seat 11, a test tube 13 inserted into the insertion hole 12, one end of a spring 14 mounted inside the sliding groove 10, the other end of the spring 14 being fixedly connected to the corresponding sliding seat 11, a positioning mechanism on the outside of the sliding seat 11 for limiting the sliding of the sliding seat 11.

[0019] It should be noted that this structure realizes the automatic pushing function of test tube 13. The slide 11 can move to the position of the shielding component when the drive component drives the turntable 8 to rotate, and the test tube 13 can be controlled to enter and exit inside and outside the temperature control chamber 3 through the cooperation of spring 14 and positioning mechanism. The entire process does not require opening the temperature control chamber 3, effectively maintaining a constant temperature environment inside the chamber.

[0020] Refer to the instruction manual appendix Figure 2 and Figure 4 The shielding assembly includes a channel 51 installed on the outside of the temperature control box 3, a hinge 52 installed on the channel 51, and a baffle 53 installed on the hinge 52. The baffle 53 is rotatably connected to the channel 51 via the hinge 52.

[0021] It should be noted that when the slide 11 is pushed out and contacts the baffle 53 under the action of the spring 14, it can lift the baffle 53 and open it only briefly when the test tube 13 is pushed past, so as to minimize the heat exchange between the outside air and the inside of the temperature control box 3, thereby avoiding temperature fluctuations and maintaining the stability of the internal constant temperature environment.

[0022] Refer to the instruction manual appendix Figure 2 and Figure 3 The drive assembly includes a gear 91 fixed to the bottom of the turntable 8, a drive motor 92 installed on the bottom surface inside the temperature control box 3, and a gear 93 installed at the output end of the drive motor 92. The gear 93 meshes with the gear 91, and the drive motor 92 is used to drive the gear 93 to rotate.

[0023] It should be noted that the drive motor 92 drives the gear 93 to rotate, which in turn drives the gear post 91 that meshes with the gear 93 to rotate, ultimately precisely controlling the rotation of the turntable 8 on the fixed ring 6. This is the key power source for realizing the on-demand switching of multiple test tubes 13 on the turntable 8 and automatically pushing the target test tube 13 to the channel 51 position.

[0024] Refer to the instruction manual appendix Figure 2 and Figure 4 The positioning mechanism includes a guide component and a limiting component. Both the guide component and the limiting component are located on the outside of the slide 11. The guide component is used to limit the sliding direction of the slide 11, and the limiting component is used to limit the sliding distance of the slide 11.

[0025] It should be noted that the guide component ensures that the slide 11 slides along the predetermined path in the slide groove 10, and the limiting component precisely controls the sliding stroke of the slide 11. The two work together to ensure the directional accuracy and positional stability of the test tube 13 during the pushing process, so that it can pass through the channel 51 smoothly and will not deviate from the predetermined trajectory.

[0026] Refer to the instruction manual appendix Figures 2 to 4 The guide assembly includes a positioning groove 151 formed inside the slide 10 and a positioning strip 152 installed on the side of the slide block 11, with the positioning strip 152 slidably connected to the positioning groove 151.

[0027] It should be noted that by utilizing the sliding engagement between the positioning strip 152 and the positioning groove 151, the movement direction of the slide block 11 within the slide groove 10 is strictly limited, ensuring that it can only slide in a straight line along the length of the slide groove 10, thereby ensuring the accuracy and consistency of the path of the slide block 11 and the test tube 13 during pushing.

[0028] Refer to the instruction manual appendix Figures 2 to 4 The limiting component includes a limiting hole 153 opened on the slide 11, a limiting rod 154 fixed inside the slide groove 10, a limiting block fixed at the end of the limiting rod 154, and a limiting ring fixed outside the limiting hole 153. The limiting block is slidably connected to the limiting hole 153, and the inner diameter of the limiting ring is smaller than the diameter of the limiting block.

[0029] It should be noted that when the slide 11 moves, the limiting block on the limiting rod 154 passively slides within the limiting hole 153 of the slide 11, and the limiting ring acts as a stop for the limiting block, together limiting the sliding distance of the slide 11 within the slide groove 10, preventing it from slipping off, and ensuring that the test tube 13 can reach the precise predetermined position when it is pushed out.

[0030] Refer to the instruction manual appendix Figure 1 and Figure 6 The mixing mechanism includes a support assembly and a stirring assembly. The support assembly is disposed on the base 1, and the stirring assembly is mounted on the support assembly. The support assembly is used to position the stirring assembly, and the stirring assembly is used to stir the solvent.

[0031] It should be noted that fixing the position of the stirring component by the support component and having the stirring component perform the stirring operation on the solvent is the core functional unit for achieving uniform mixing of the solvent.

[0032] Refer to the instruction manual appendix Figure 1 and Figure 6 The support assembly includes a base 21 mounted on the base 1, a column 22 fixed on the base 21, an adjustment seat 23 mounted on the outside of the column 22, and a fastening bolt 24 connected to the adjustment seat 23. The adjustment seat 23 is slidably connected to the column 22.

[0033] It should be noted that the height can be adjusted by sliding the adjusting seat 23 on the column 22, and the position can be fixed by using the fastening bolt 24. This allows the mixing assembly to adapt to containers of different heights or sizes, providing flexible operating space and stable support positioning.

[0034] Refer to the instruction manual appendix Figure 6 The stirring assembly includes a servo motor 25 mounted on the adjusting base 23, a stirring rod 26 mounted on the output end of the servo motor 25, and a stirring blade 27 fixed to the bottom end of the stirring rod 26. The servo motor 25 is used to drive the stirring rod 26 to rotate.

[0035] It should be noted that the servo motor 25 provides power to drive the stirring rod 26 and stirring blade 27 to rotate, thereby efficiently and uniformly mixing the solvent in the container and ensuring the quality and efficiency of solvent preparation.

[0036] Working principle: When test tube 13 needs to be retrieved, the drive motor 92 is started via the control panel 4, which drives the gear 93 at its output end to rotate. The gear 93 meshes with the toothed column 91 fixed at the bottom of the turntable 8, driving the turntable 8 to rotate on the fixed ring 6 inside the temperature control box 3. The slide block 11 can slide outward from the temperature control box 3 under the action of the spring 14 in the sliding groove 10 distributed on the circumference of the turntable 8 until the target slide block 11 is aligned with the position of the outer channel 51 of the temperature control box 3. At this time, the slide block 11 moves outward along the sliding groove 10 under the action of the spring 14. When the slide block 11 moves, the positioning strip 152 on its side slides in the positioning groove 151 inside the sliding groove 10 to ensure the linear movement direction. At the same time, the limiting block on the limiting rod 154 fixed inside the sliding groove 10 slides in the limiting hole 153 of the slide block 11. When the limiting block contacts the limiting hole 153 fixed outside the limiting hole 153, the slide block moves outward. During the cycle, the movement of the slide 11 is restricted, and the test tube 13 precisely reaches the predetermined push position. The outward-moving slide 11 pushes open the baffle 53 installed on the channel 51 through the hinge 52, briefly forming an outlet. The test tube 13 moves out of the temperature control box 3 with the slide 11 and is exposed in the channel 51 for use or solvent transfer. After use, the drive motor 92 continues to run, and the arc surface of the slide 11 is squeezed, pushing the slide 11 to overcome the force of the spring 14 and move along the slide groove 10 to the inside of the temperature control box 3 to reset. The baffle 53 automatically falls back and closes the channel 51 under the action of gravity. The whole process does not require opening the main body of the temperature control box 3, and maintains the constant temperature environment inside the box to the maximum extent. When it is necessary to mix solvents, the adjusting seat 23 on the column 22 can be adjusted to a suitable height and fixed with the fastening bolt 24. The servo motor 25 on the adjusting seat 23 is started, which drives the stirring rod 26 and the stirring blade 27 to rotate to complete the stirring.

[0037] It should be noted that the control method of this utility model is controlled by a controller. The control circuit of the controller can be implemented by simple programming by those skilled in the art. The power supply is also common knowledge in the art. Therefore, this utility model will not explain the control method and circuit connection in detail. In this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus.

[0038] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention.

Claims

1. A solvent dispensing device comprising a base (1), characterized in that, A mixing mechanism is provided on the base (1) for mixing solvents. A temperature control box (3) is installed on the base (1). A control panel (4) is installed on the outside of the temperature control box (3). A shielding component is provided on the outside of the temperature control box (3). A fixing ring (6) is fixed inside the temperature control box (3). A notch (7) is opened on the fixing ring (6) corresponding to the position of the shielding component. A turntable (8) is slidably connected to the fixing ring (6). A driving component is provided inside the temperature control box (3) for driving the turntable (8) to rotate. 8) Multiple circularly distributed grooves (10) are provided on the upper part. A slide seat (11) is slidably connected inside the groove (10). One side of the slide seat (11) is arc-shaped. An insertion hole (12) is provided on the slide seat (11). A test tube (13) is inserted into the insertion hole (12). One end of a spring (14) is installed inside the groove (10). The other end of the spring (14) is fixedly connected to the corresponding slide seat (11). A positioning mechanism is provided on the outside of the slide seat (11). The positioning mechanism is used to limit the sliding of the slide seat (11).

2. The solvent formulation device of claim 1, wherein The shielding assembly includes a channel (51) installed on the outside of the temperature control box (3), a hinge (52) installed on the channel (51), and a baffle (53) installed on the hinge (52). The baffle (53) is rotatably connected to the channel (51) via the hinge (52).

3. The solvent conditioning apparatus of claim 1, wherein, The drive assembly includes a gear (91) fixed to the bottom of the turntable (8), a drive motor (92) installed on the bottom surface inside the temperature control box (3), and a gear (93) installed at the output end of the drive motor (92). The gear (93) meshes with the gear (91), and the drive motor (92) is used to drive the gear (93) to rotate.

4. The solvent conditioning apparatus of claim 1, wherein, The positioning mechanism includes a guide component and a limiting component. Both the guide component and the limiting component are located on the outside of the slide (11). The guide component is used to limit the sliding direction of the slide (11), and the limiting component is used to limit the sliding distance of the slide (11).

5. The solvent conditioning apparatus of claim 4, wherein, The guide assembly includes a positioning groove (151) formed inside the slide (10) and a positioning strip (152) installed on the side of the slide (11), the positioning strip (152) being slidably connected to the positioning groove (151).

6. The solvent conditioning apparatus of claim 4, wherein, The limiting assembly includes a limiting hole (153) opened on the slide (11), a limiting rod (154) fixed inside the slide groove (10), a limiting block fixed at the end of the limiting rod (154), and a limiting ring fixed outside the limiting hole (153). The limiting block is slidably connected to the limiting hole (153), and the inner diameter of the limiting ring is smaller than the diameter of the limiting block.

7. The solvent conditioning apparatus of claim 1, wherein, The mixing mechanism includes a support component and a stirring component. The support component is set on the base (1), and the stirring component is installed on the support component. The support component is used to position the stirring component, and the stirring component is used to stir the solvent.

8. The solvent conditioning apparatus of claim 7, wherein, The support assembly includes a base (21) mounted on the base (1), a column (22) fixed on the base (21), an adjustment seat (23) mounted on the outside of the column (22), and a fastening bolt (24) connected to the adjustment seat (23). The adjustment seat (23) is slidably connected to the column (22).

9. The solvent formulation device of claim 8, wherein, The stirring assembly includes a servo motor (25) mounted on the adjusting seat (23), a stirring rod (26) mounted on the output end of the servo motor (25), and a stirring blade (27) fixed to the bottom end of the stirring rod (26). The servo motor (25) is used to drive the stirring rod (26) to rotate.

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