A multi-station fully automatic HE dyeing machine

Abstract

This utility model discloses a multi-station fully automatic HE staining machine, including a machine base with a feeding and heating mechanism, a hopper channel, and a discharging mechanism. The feeding and heating mechanism is used to transport the hopper into the hopper channel. The machine base has multiple second processing stations, and the hopper channel has multiple hopper pushing mechanisms for pushing the hopper to slide along the hopper channel. The discharging mechanism includes a discharging pushing mechanism and a discharging channel, which pushes the hopper on the hopper channel to the discharge end of the discharging channel. The machine base also has a liquid injection mechanism and a waste liquid recovery mechanism. The liquid injection mechanism injects the drug solution into the hopper, and the waste liquid recovery mechanism removes the waste liquid from the hopper. This invention enables fully automated production line operation of tissue sections from heating and multi-station staining to discharging, significantly improving the equipment's throughput and staining efficiency, and is suitable for large-scale sample processing.

Description

Technical Field

[0001] This utility model relates to the field of medical auxiliary device technology, specifically to a multi-station fully automatic HE staining machine. Background Technology

[0002] Staining is of great significance in the diagnosis of pathological tissue morphology, scientific experimental research, and teaching. Without staining tissue sections, the internal structure of the tissue cannot be seen, and the cell nuclei cannot be identified. Therefore, researchers cannot provide a basis for judgment to determine whether the tissue is abnormal.

[0003] HE staining uses hematoxylin and eosin to stain the nucleus and cytoplasm, respectively, to distinguish the morphology of normal cells. In practical applications, it can identify abnormal pathological changes such as tissue cell necrosis, edema, degeneration, and inflammatory cell infiltration.

[0004] Currently, most tissue section staining methods still rely on manual operation, which is inefficient. Even with some HE staining equipment, the level of automation is low, and most only have one staining station, resulting in low efficiency. Therefore, it is necessary to design a multi-functional automated HE staining device. Utility Model Content

[0005] To address some or all of the problems existing in the prior art, this utility model provides a multi-station fully automatic HE staining machine, including a machine base. The machine base is equipped with a feeding and heating mechanism, a material hopper channel, and a discharging mechanism. One end of the material hopper channel is connected to the feeding and heating mechanism, and the other end is connected to the discharging mechanism. The feeding and heating mechanism heats the tissue sections in the material hopper and transports the heated material to the material hopper channel. Multiple second processing stations are located on the machine base corresponding to the material hopper channel. Multiple material hopper pushing mechanisms are provided on the material hopper channel to push the material hoppers in the material hopper channel. The material hopper slides along the flow channel, thereby moving the hopper to each of the second processing positions. The discharge mechanism includes a discharge pushing mechanism and a discharge flow channel mounted on the machine platform. One end of the discharge flow channel is the discharge end, and the other end is connected to the hopper flow channel. The discharge pushing mechanism is connected to both the hopper flow channel and the discharge channel, and can push the hopper in the hopper flow channel to the discharge end of the discharge flow channel. A liquid injection mechanism and a waste liquid recovery mechanism are respectively provided at the corresponding positions of each of the second processing positions on the machine platform. The liquid injection mechanism is used to inject liquid medicine into the hopper, and the waste liquid recovery mechanism is used to remove the waste liquid from the hopper.

[0006] As a further improvement of this utility model, the feeding and heating mechanism includes a feeding mechanism, a baking oven, and a feeding push mechanism respectively disposed on the machine base; the feeding mechanism includes a feeding lifting module, which is connected to the machine base, and a feeding tray is provided on the output end of the feeding lifting module. The feeding tray is used to place a hopper containing tissue sections. The feeding lifting module can drive the tray to move up and down, thereby causing the hopper to extend into or out of the baking oven. The baking oven is used to heat the tissue sections in the hopper. The feeding push mechanism is connected to the feeding mechanism and the hopper flow channel respectively, and is used to push the hopper on the feeding tray into the hopper flow channel.

[0007] As a further improvement of this utility model, a blocking mechanism and a positioning mechanism are respectively provided on the material hopper flow channel at positions corresponding to each of the second processing positions. The blocking mechanism is used to prevent the material hopper from sliding in the material hopper flow channel, and the positioning mechanism is used to limit the material hopper to the position corresponding to the second processing position in the material hopper flow channel.

[0008] As a further improvement of this utility model, the hopper pushing mechanism includes a pushing fixed frame, which is connected to the machine base. The pushing fixed frame is equipped with a hopper pushing motor and a hopper pushing driven wheel. The output end of the hopper pushing motor is equipped with a hopper pushing driving wheel. A hopper pushing transmission belt is sleeved on the hopper pushing driving wheel and the hopper pushing driven wheel. A hopper pushing slider is equipped on the hopper pushing transmission belt. A hopper pushing block is equipped on the hopper pushing slider. The hopper pushing block can abut against the hopper in the hopper flow channel.

[0009] As a further improvement of this utility model, the machine base is provided with a dyeing mounting frame, and the liquid injection mechanism includes a liquid injection transverse movement module. The liquid injection transverse movement module is connected to the dyeing mounting frame. The output end of the liquid injection transverse movement module is provided with a liquid injection lifting mounting plate. The liquid injection lifting mounting plate is provided with a liquid injection lifting module and a needle cleaning assembly. The output end of the liquid injection lifting module is provided with a liquid injection needle. One end of the liquid injection needle is externally connected to a liquid injection pump. The liquid injection transverse movement module and the liquid injection lifting module can drive the liquid injection needle to extend into each material trough of the material bin. The liquid injection lifting module can also drive the liquid injection needle to connect with the needle cleaning assembly. The needle cleaning assembly is used to clean the liquid injection needle.

[0010] As a further improvement of this utility model, the lower end face of the injection needle is a sealed structure, and the liquid outlet of the injection needle is located on the side wall of the injection needle; the needle cleaning assembly includes a cleaning mounting frame, which is connected to the injection lifting mounting plate, and a cleaning tank is provided on the cleaning mounting frame. The cleaning tank has a needle hole that passes through the upper and lower end faces of the cleaning tank, and the injection needle can pass through the needle hole and is clearance-fitted with the needle hole; the side wall of the cleaning tank is provided with a water inlet connector and a water outlet connector, which are respectively connected to the needle hole. The water inlet connector is connected to the cleaning liquid, and the water outlet connector is connected to the negative pressure suction device.

[0011] As a further improvement of this utility model, the waste liquid recovery mechanism includes a recovery transverse module, which is connected to the dyeing mounting frame. The output end of the recovery transverse module is provided with a recovery lifting module, and the output end of the recovery lifting module is provided with a liquid extraction needle and an air blowing assembly. The liquid extraction needle is externally connected to a negative pressure suction device, and the air blowing assembly is externally connected to an air source. The recovery transverse module and the recovery lifting module can drive the liquid extraction needle to extend into each material trough of the hopper, and the air blowing assembly is used to blow air into the material trough.

[0012] As a further improvement of this utility model, the output end of the recovery lifting module is provided with a positioning rotary motor, and the output end of the positioning rotary motor is provided with a rotary mounting block. The positioning rotary motor can drive the rotary mounting block to rotate, and the liquid suction needle and the air blowing assembly are respectively connected to the rotary mounting block.

[0013] As a further improvement of this utility model, the air blowing assembly includes an air nozzle, which is connected to the output end of the recycling lifting module. One end of the air nozzle is connected to an external air source, and the other end is provided with a triangular air blowing part. Multiple air blowing holes are provided on the end face of the air blowing part. There are two liquid drawing needles, and the two liquid drawing needles are symmetrically distributed on both sides of the air nozzle. The distance between the two liquid drawing needles is less than the length of the material trough.

[0014] As a further improvement of this utility model, the discharge pushing mechanism includes a discharge pushing frame, which is connected to the machine base. The discharge pushing frame is equipped with a discharge motor, and the output end of the discharge motor is equipped with a discharge driving wheel. Discharge driven wheels are respectively provided at both ends of the discharge pushing frame. A discharge transmission belt is sleeved on the discharge driving wheel and the discharge driven wheel. A discharge pushing block is provided on the discharge transmission belt. A pusher block is provided on the discharge pushing block. The pusher block can pass through the hopper channel and the discharge channel respectively. The pusher block is hinged to the discharge pushing block, and the pusher block can swing about the hinge point as the axis. A pusher limiting post is provided on the discharge pushing block, and the pusher block can abut against the pusher limiting post.

[0015] Compared with the prior art, the beneficial effects of this utility model are: This invention achieves a fully automated production line operation for tissue sectioning, from heating and multi-station staining to unloading, through the coordinated operation of the feeding and heating mechanism, the material hopper channel, multiple processing stations, and the unloading mechanism. Multiple processing stations can perform staining operations simultaneously, significantly improving the equipment's throughput and staining efficiency, making it suitable for processing large batches of samples. Attached Figure Description

[0016] To more clearly illustrate the solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the structure of the silo in an embodiment of this utility model; Figure 2 This is a schematic diagram of the hopper from another perspective in an embodiment of this utility model; Figure 3 This is a schematic diagram of the overall structure of an embodiment of this utility model; Figure 4 This is a structural schematic diagram from another perspective of an embodiment of the present utility model; Figure 5 This is a schematic diagram of the feeding mechanism in an embodiment of this utility model; Figure 6 This is a schematic diagram of the feeding and pushing machine in an embodiment of this utility model; Figure 7 This is a partial structural schematic diagram of an embodiment of the present utility model; Figure 8 This is a schematic diagram of the structure of the hopper pushing mechanism in this embodiment of the utility model; Figure 9 This is a schematic diagram of the hopper pushing mechanism from another perspective in an embodiment of this utility model; Figure 10 This is a partial structural schematic diagram of an embodiment of the present utility model; Figure 11 This is a schematic diagram of the structure of the liquid injection transverse movement module in an embodiment of this utility model; Figure 12 This is a schematic diagram of the structure of the liquid injection lifting module in an embodiment of this utility model; Figure 13 This is a schematic diagram of the liquid injection lifting module from another perspective in an embodiment of this utility model; Figure 14 This is a schematic diagram of the structure of the syringe cleaning assembly in an embodiment of this utility model; Figure 15 This is a schematic diagram of the structure of the recovery lifting module in an embodiment of this utility model; Figure 16 This is a schematic diagram of the recovery lifting module from another perspective in an embodiment of this utility model; Figure 17 This is a schematic diagram of the air blowing assembly in an embodiment of the present invention; Figure 18 This is a schematic diagram of the material discharge pushing mechanism in an embodiment of this utility model; Figure 19 yes Figure 18 A magnified structural diagram of part A in the middle; Figure 20 This is a schematic diagram of the processing blocking mechanism in an embodiment of this utility model. Detailed Implementation

[0018] Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains; the terminology used in the specification is for the purpose of describing particular embodiments only and is not intended to limit the invention; the terms "comprising" and "having," and any variations thereof, in the specification, claims, and accompanying drawings of this invention are intended to cover non-exclusive inclusion. The terms "first," "second," etc., in the specification, claims, or accompanying drawings of this invention are used to distinguish different objects, not to describe a particular order.

[0019] In this invention, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this invention. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor is it a mutually exclusive, independent, or alternative embodiment to other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described in this invention can be combined with other embodiments.

[0020] To enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0021] like Figure 1-20As shown, a multi-station automatic hematoxylin and eosin (HE) staining machine includes a machine base 100. A feeding and heating mechanism 300, a material hopper channel 200, and a discharging mechanism 400 are fixedly installed on the machine base 100. One end of the material hopper channel 200 is connected to the feeding and heating mechanism 300, and the other end is connected to the discharging mechanism 400. The feeding and heating mechanism 300 is used to heat the tissue sections in the material hopper, making them easier to stain. Simultaneously, the feeding and heating mechanism 300 can also sequentially push the heated tissue sections from the hopper into the material hopper channel 200.

[0022] The machine tool 100 has five second processing stations 500 arranged along the material hopper channel 200. In other embodiments, the number of second processing stations 500 can be any other number. Each second processing station 500 has the same function, which is to stain the tissue sections in the material hopper 600. Multiple material hopper pushing mechanisms 210 are installed on the material hopper channel 200. The material hopper pushing mechanisms 210 are used to push the material hopper 600 containing the tissue sections to slide within the material hopper channel 200, thereby realizing the function of transferring the material hopper to each of the second processing stations 500 for staining.

[0023] The discharge mechanism 400 includes a discharge pushing mechanism 410 and a discharge channel 420 mounted on the machine base 100. One end of the discharge channel 420 is the discharge end 421, and the other end is connected to the hopper channel 200. A first processing station 700 is provided in the middle of the discharge channel 420. The first processing station 700 and the second processing station 500 have the same function, both used for staining tissue sections in the hopper. The discharge pushing mechanism 410 is connected to both the hopper channel 200 and the discharge channel 420. The discharge pushing mechanism 410 can push the hopper in the hopper channel 200 to the first processing station 700, and can also push the hopper on the first processing station 700 to the discharge end 421. The stained hopper can be pushed out by the discharge pushing mechanism 410, and then the hopper at the discharge end 421 can be removed manually or by downstream equipment.

[0024] The machine tool 100 is equipped with a liquid injection mechanism 800 and a waste liquid recovery mechanism 900 at corresponding positions to the first processing station 700 and the second processing station 500, respectively. The liquid injection mechanism 800 is used to inject the drug solution into the hopper, and the waste liquid recovery mechanism 900 is used to remove the waste liquid from the hopper. When the hopper pushing mechanism 210 or the discharge pushing mechanism 410 pushes the hopper to the processing station, the corresponding liquid injection mechanism 800 starts working, injecting the drug solution into the hopper, so that the drug solution contacts the tissue section and achieves staining. After staining, the waste liquid recovery mechanism 900 removes the remaining waste liquid in the hopper. Then, the liquid injection mechanism 800 can be used to inject new drug solution into the hopper, and the waste liquid recovery mechanism 900 can be used to remove the remaining waste liquid in the hopper. The above process is repeated. After the hopper is stained, the liquid injection mechanism 800 and the waste liquid recovery mechanism 900 are used to stain the tissue section in the next hopper, until all the tissue sections in the hopper are stained.

[0025] like Figure 1 As shown, it should be noted that the upper end of the material hopper 600 has multiple material troughs 601 distributed at equal intervals. The material troughs 601 are used to place glass slides 602 containing tissue sections.

[0026] In the actual processing, the operator places the hopper containing the tissue sections onto the feeding and heating mechanism 300. After heating by the feeding and heating mechanism 300, the first hopper is conveyed into the hopper flow channel 200. Then, the hopper pushing mechanisms 210 are sequentially controlled to push the hoppers to the junction of the hopper flow channel 200 and the discharge flow channel 420. The discharge pushing mechanism 410 then pushes the first hopper to the first processing position 700. Next, the liquid injection mechanism 800 and waste liquid recovery mechanism 900 corresponding to the first processing position 700 are controlled to perform staining on the tissue sections in the hopper at the first processing position 700. After staining, the stained hopper is pushed to the unloading end 421 by the unloading mechanism 410 to complete the unloading process.

[0027] During the above processing, after the material is pushed to the hopper at the first processing station 700, the feeding and heating mechanism 300 and the hopper pushing mechanism 210 continue to work, pushing the second hopper to the second processing station 500 closest to the discharge mechanism 400. Then, the liquid injection mechanism 800 and the waste liquid recovery mechanism 900 corresponding to the second processing station 500 work to perform staining operations on the tissue sections in the hopper at the processing station. Similarly, staining operations are performed simultaneously at all second processing stations 500, thereby improving processing efficiency.

[0028] In actual processing, because the first processing station 700 completes its feeding first, it will begin the dyeing process. Therefore, after dyeing is completed at the first processing station 700, the adjacent second processing station 500 will not have all its material troughs dyed. To avoid the first processing station 700 waiting, the material hopper on the first processing station 700 will be fed out, and the material hopper in the second processing station 500 that has not completed its dyeing process will be pushed to the first processing station 700 via the discharge pushing mechanism 410. The first processing station 700 will then take over the remaining dyeing work from the second processing station 500 until all material troughs in the hopper are dyed. Similarly, at each of the second processing stations 500, if the preceding second processing station 500 is short of material, the hopper pushing mechanism 210 will push the material hopper in the following second processing station 500 that has not completed its dyeing process to the preceding second processing station 500, whereby the preceding second processing station 500 will take over the remaining dyeing work.

[0029] In other embodiments, the first processing station 700 may be omitted, and the discharge mechanism 400 may simply send the dyed material from the second processing station 500 to the discharge end 421.

[0030] The feeding and heating mechanism 300 includes a feeding mechanism 310, a heating mechanism 320, and a feeding and pushing mechanism 330, all respectively mounted on the machine base 100. The feeding mechanism 310 is connected to both the heating mechanism 320 and the feeding and pushing mechanism 330. During processing, the manual operator first places the hopper containing tissue slices onto the feeding mechanism 310, then the feeding mechanism 310 lifts the hopper to the heating position of the heating mechanism 320. The heating mechanism 320 heats the tissue slices in the hopper. After heating, the feeding mechanism 310 lowers the hopper to a height that matches the hopper flow channel 200. Finally, the feeding and pushing mechanism 330 pushes the hopper into the hopper flow channel 200, thus completing the heating and feeding process.

[0031] like Figure 5 As shown, the feeding mechanism 310 includes a feeding fixed base 311 and a feeding tray 312. The feeding fixed base 311 is fixedly connected to the machine base 100, and a feeding lifting motor 313 is fixedly installed on the feeding fixed base 311. The output end of the feeding lifting motor 313 is connected to a feeding lifting screw 314. A feeding lifting slider 315 is sleeved on the feeding lifting screw 314. A lifting plate 316 is fixedly fixed to the bottom of the feeding tray 312, and the lifting plate 316 is fixedly connected to the feeding lifting slider 315. During processing, the operator first places the hopper containing tissue slices onto the feeding tray 312; then, by controlling the operation of the feeding lifting motor 313, the operator can drive the feeding lifting slider 315 to slide up and down on the feeding lifting screw 314. The feeding lifting slider 315 drives the lifting plate 316 and the feeding tray 312 to move together, so that the feeding tray 312 can drive the hopper to extend into or out of the heating mechanism 320.

[0032] To limit and guide the lifting movement of the feeding tray 312, lifting guide sleeves 317 are respectively provided at the four corner positions of the lifting plate 316. Lifting guide rods 318 are respectively provided on the feeding fixing seat 311 at corresponding positions of each lifting guide sleeve 317. The lifting guide rods 318 pass through the corresponding lifting guide sleeves 317, and the two are slidably engaged. When the feeding lifting motor 313 is working, the lifting plate 316 drives the lifting guide sleeves 317 to slide on the lifting guide rods 318, thereby guiding and limiting the lifting plate 316.

[0033] In other embodiments, the number of lifting guide rods 318 can also be any other number; it is only necessary to ensure that the lifting guide rods 318 and the lifting guide sleeves 317 are set in a one-to-one correspondence.

[0034] like Figure 3 As shown, the heating mechanism 320 includes a heating mounting frame 321, which is fixedly connected to the machine base 100. A baking oven 322 is fixedly mounted on the heating mounting frame 321 and positioned directly above the feeding tray 312. The lower end of the baking oven 322 has a hollow structure, allowing the feeding tray 312 to lift the material hopper and extend it into the baking oven 322. The baking oven 322 then heats the tissue sections within the hopper, ensuring uniform heating. The baking oven 322 can be any existing type; its specific structure will not be described in detail here.

[0035] like Figure 6 As shown, the feeding mechanism 330 includes a feeding fixing frame 331, which is connected to the machine base 100. A feeding motor 332 and two feeding driven wheels 333 are mounted on the feeding fixing frame 331, with the two driven wheels 333 located at opposite ends of the feeding fixing frame 331. A feeding drive wheel 334 is mounted on the output end of the feeding motor 332. A feeding drive belt 335 is sleeved on the feeding drive wheel 334 and the feeding driven wheels 333, and a feeding push block 336 is fixedly mounted on the feeding drive belt 335. After the tissue slices are heated, the feeding lifting motor 313 drives the feeding tray 312 to descend to a height that matches the material flow channel 200. Then, the pushing motor 332 is controlled to work, driving the feeding push block 336 to move. The feeding push block 336 will connect with the material hopper on the feeding tray 312, thereby pushing the material hopper to slide on the feeding tray 312 until the material hopper carrying the tissue slices is pushed into the material flow channel 200.

[0036] To limit and guide the movement of the feeding push block 336, a feeding guide rail 337 is provided on the feeding fixing frame 331, and the feeding push block 336 is slidably engaged with the feeding guide rail 337. When the feeding motor 332 is working, the feeding push block 336 will slide on the feeding guide rail 337; the engagement between the two limits and guides the movement direction of the feeding push block 336, improves the stability of the feeding process, and ensures that the feeding push block 336 can push the hopper into the hopper flow channel 200.

[0037] During processing, the hopper containing tissue sections is manually placed onto the feeding tray 312. The feeding lifting motor 313 starts, driving the feeding lifting slider 315 and lifting plate 316 upwards via the feeding lifting screw 314, causing the feeding tray 312 to carry the hopper into the baking oven 322 for heating. After heating, the feeding lifting motor 313 reverses, lowering the hopper to its initial position. The pushing motor 332 starts, pushing the feeding push block 336 along the feeding guide rail 337 via the pushing drive belt 335, pushing the hopper from the feeding tray 312 into the hopper flow channel 200, completing the feeding process.

[0038] like Figure 7 As shown, a blocking mechanism 220 and a positioning mechanism 230 are respectively provided on the material hopper flow channel 200 at positions corresponding to each of the second processing positions 500; the blocking mechanism 220 is used to prevent the material hopper from sliding in the material hopper flow channel 200, and the positioning mechanism 230 is used to limit the material hopper to the position corresponding to the second processing position 500 in the material hopper flow channel 200.

[0039] During actual processing, the feeding and heating mechanism 300 will transport the hopper to the first second processing position 500 in the hopper flow channel 200, and then push the hopper to the second second processing position 500 through the corresponding hopper pushing mechanism 210; at the same time, the feeding and heating mechanism 300 will transport the second hopper to the first second processing position 500 in the hopper flow channel 200; and so on, until all the second processing positions 500 are pushed to the hopper.

[0040] During the aforementioned material pushing process, the blocking mechanism 220 corresponding to the foremost second processing position 500 will activate first, blocking the hopper at the foremost second processing position 500. After the hopper is in place, the positioning mechanism 230 corresponding to the foremost second processing position 500 will activate to limit the hopper to the hopper flow channel 200 corresponding to the second processing position 500. After the hopper at the foremost second processing position 500 is pushed into place, the blocking mechanism 220 corresponding to the next second processing position 500 will activate, and after the hopper is in place, the positioning mechanism 230 of that second processing position 500 will activate to limit and fix the hopper to the hopper flow channel 200 corresponding to the second processing position 500. This process continues until all positioning mechanisms 230 have limited and fixed their respective hoppers to their corresponding second processing positions 500, thus completing the material transport process within the hopper flow channel 200.

[0041] To limit the sliding process of the hopper, two hopper limiting plates 240 are bolted parallel to each other on both sides of the upper end face of the hopper flow channel 200. The distance between these two hopper limiting plates 240 is slightly larger than the width of the hopper, thus guiding the movement of the hopper and preventing it from tipping over.

[0042] like Figure 8 As shown, the hopper pushing mechanism 210 is located on one side or below the hopper flow channel 200. The hopper pushing mechanism 210 includes a pushing frame 211, which is bolted to the machine base 100. A hopper pushing motor 212, a hopper pushing driven wheel 213, and a pushing guide rail 214 are mounted on the pushing frame 211. A hopper pushing drive wheel 215 is mounted on the output shaft of the hopper pushing motor 212. A hopper pushing transmission belt 216 is sleeved on the hopper pushing drive wheel 215 and the hopper pushing driven wheel 213. A hopper pushing slider 217 is fixedly mounted on the hopper pushing transmission belt 216, and the hopper pushing slider 217 is slidably engaged with the pushing guide rail 214. A hopper pusher block 218 is fixedly mounted on the hopper pushing slider 217, and the hopper pusher block 218 can extend out of the upper surface of the hopper flow channel 200 and abut against the side or end of the hopper. By controlling the hopper drive motor 212 to work, the hopper drive transmission belt 216 can drive the hopper drive slider 217 and the hopper push block 218 to move along the drive guide rail 214, thereby pushing the hopper in the hopper flow channel 200 and realizing the function of pushing the hopper from the previous station to the next station.

[0043] By sliding the hopper pusher 217 and the pusher rail 214 together, the movement direction of the hopper pusher 218 can be limited and guided, ensuring that it can push the hopper to slide within the hopper flow channel 200.

[0044] like Figure 9As shown, the blocking mechanism 220 includes a blocking lifting module. In this embodiment, the blocking lifting module is a vertically installed blocking electric push rod 221. The blocking electric push rod 221 is fixed on the pushing fixing frame 211. The output end of the blocking electric push rod 221 passes upward through a preset through hole in the flow channel and is connected to a wedge-shaped or square blocking block 222. After the material hoppers at the previous second processing position 500 are all pushed to the hopper, the control system will automatically control the blocking electric push rod 221 of the next second processing position 500 to move, pushing the blocking block 222 upward and protruding above the upper surface of the hopper flow channel 200, thus blocking the forward path of the next hopper and stopping it on the hopper flow channel 200 corresponding to the second processing position 500. When it is necessary to release the hopper, the electric push rod retracts, driving the blocking block 222 down below the plane of the hopper flow channel 200, and the hopper can continue to move forward.

[0045] like Figure 9 As shown, the positioning mechanism 230 includes a positioning lifting module. In this embodiment, the positioning lifting module uses a vertically mounted positioning electric push rod 231. The positioning electric push rod 231 is fixed on the push fixing frame 211, with its output end facing upwards and equipped with two positioning pins 232. In other embodiments, the number of positioning pins 232 can be any other number. Correspondingly, positioning holes 603 matching the shape of the positioning pins 232 are machined at the bottom of the hopper 600. When the hopper is stopped by the blocking mechanism 220, the control system commands the positioning electric push rod 231 to move, pushing the mounting block and positioning pins 232 upwards, so that the two positioning pins 232 are precisely inserted into the positioning holes at the bottom of the hopper, thereby constraining the hopper in the horizontal and vertical directions, achieving precise positioning and locking, and ensuring that the liquid injection mechanism 800 and the waste liquid recovery mechanism 900 can perform staining operations on the tissue sections in the hopper. After processing is completed, the positioning electric push rod 231 retracts, driving the positioning pin 232 to descend and separate from the hopper, thus releasing the lock.

[0046] In other embodiments, both the blocking lifting module and the positioning lifting module can be other linear drive devices such as cylinders and motor screw structures.

[0047] It should be noted that a positioning device is also provided on the machine tool 100 at the corresponding position of the first processing station 700. The positioning device has the same structure and function as the positioning mechanism 230 mentioned above.

[0048] like Figure 10 As shown, a dyeing mounting frame 1000 is fixedly installed on the machine base 100, and all the liquid injection mechanisms 800 and waste liquid recovery mechanisms 900 are installed on the dyeing mounting frame 1000.

[0049] The injection mechanism 800 includes an injection transverse module 810, which is fixedly connected to the dyeing mounting frame 1000. An injection lifting mounting plate 820 is provided on the output end of the injection transverse module 810. An injection lifting module 830 and a needle cleaning assembly 840 are provided on the injection lifting mounting plate 820. An injection needle 850 is provided on the output end of the injection lifting module 830, and one end of the injection needle 850 is externally connected to an injection pump. The injection lateral movement module 810 drives the injection needle 850 to move along the length of the hopper, aligning it with each material slot within the hopper. The injection lifting module 830 drives the injection needle 850 to descend or rise. Through the cooperation of the injection lateral movement module 810 and the injection lifting module 830, the injection needle 850 can be driven to extend into each material slot of the hopper, facilitating the staining of tissue sections within each slot. The injection needle 850, via an external injection pump, injects the drug solution into the material slot, staining the tissue sections within the hopper. The injection lifting module 830 also drives the injection needle 850 to connect to the needle cleaning assembly 840, which cleans the injection needle 850. Cleaning the injection needle 850 prevents different drugs from interfering with each other, enabling the injection mechanism 800 to be used for injecting different drugs and improving the equipment's versatility.

[0050] like Figure 11 As shown, the liquid injection transverse movement module 810 includes a liquid injection transverse movement fixing seat 811, which is connected to the dyeing mounting frame 1000. The liquid injection transverse movement fixing seat 811 is equipped with a lead screw assembly (not shown) and a liquid injection transverse movement motor 812. The output end of the liquid injection transverse movement motor 812 is connected to the lead screw assembly. A liquid injection transverse movement slider 813 is slidably mounted on the liquid injection transverse movement fixing seat 811 and is connected to the lead screw assembly. During operation, the liquid injection transverse movement motor 812 drives the lead screw assembly to rotate, thereby causing the liquid injection transverse movement slider 813 to slide laterally on the liquid injection transverse movement fixing seat 811. The liquid injection transverse movement slider 813 drives the liquid injection lifting mounting plate 820, the liquid injection lifting module 830, and the liquid injection needle 850 to move synchronously, thereby moving the liquid injection needle 850 to directly above each material trough in the material bin.

[0051] like Figure 12-13As shown, the liquid injection lifting module 830 includes a liquid injection lifting motor 831, which is fixedly connected to a liquid injection lifting mounting plate 820. The mounting plate 820 has a driven liquid injection wheel 832, and the output end of the motor 831 has a driving liquid injection wheel 833. A transmission belt 834 is fitted onto the driving wheel 833 and the driven wheel 832, and a slider 835 is mounted on the transmission belt 834. An injection needle 850 is connected to the slider 835. During operation, the motor 831 drives the driving wheel 833 to rotate, which in turn moves the transmission belt 834. The transmission belt 834 then drives the slider 835 and the injection needle 850 to move synchronously, causing the injection needle 850 to extend into or out of the material trough in the hopper.

[0052] To limit and guide the lifting movement of the injection needle 850, an injection lifting guide rail 836 is provided on the injection lifting mounting plate 820, and the injection lifting slider 835 is slidably engaged with the injection lifting guide rail 836. When the injection lifting motor 831 is working, it drives the injection lifting slider 835 to move; the injection lifting slider 835 is constrained by the injection lifting guide rail 836 and can only slide along the direction of the injection lifting guide rail 836, thereby driving the injection needle 850 to be accurately inserted into the material tank to complete the injection.

[0053] To improve control accuracy, a position sensor 837 is installed on the liquid injection lifting mounting plate 820, and a detection lever 838 is installed on the liquid injection lifting slider 835. The detection lever 838 can connect with the position sensor 837. Normally, the detection lever 838 and the position sensor 837 are in a separate state. When liquid injection is required, the liquid injection lifting motor 831 drives the liquid injection lifting slider 835 to descend, causing the liquid injection needle 850 to descend synchronously. As the liquid injection lifting slider 835 descends, the detection lever 838 on the liquid injection lifting slider 835 will connect with the position sensor 837. At this time, the liquid injection needle 850 has also been inserted into the material trough of the hopper. The position sensor 837 will send a feedback signal to the controller of the automatic dyeing machine, and the controller will immediately control the liquid injection lifting motor 831 to stop working. By cooperating with the detection lever 838 and the positioning sensor 837, the injection needle 850 can be accurately inserted into the material trough, avoiding the problem of inserting too much and breaking the injection needle 850 or piercing the material hopper, and also avoiding the problem of inaccurate injection due to incomplete insertion.

[0054] To facilitate cleaning of the injection needle 850, in this embodiment, the lower end face of the injection needle 850 is a sealed structure, and the outlet hole of the injection needle 850 is located on the side wall of the injection needle 850. Placing the outlet hole on the side wall of the injection needle 850 prevents the liquid from dripping when the injection needle 850 is raised, avoiding contamination of adjacent material tanks or equipment and improving operational cleanliness. Furthermore, during cleaning, cleaning fluid can be injected into the interior of the injection needle 850 through the outlet hole, thereby cleaning the interior of the injection needle 850.

[0055] Specifically, such as Figure 14 As shown, the syringe cleaning assembly 840 includes a cleaning mounting bracket 841, which is fixedly connected to the liquid injection lifting mounting plate 820. A cleaning tank 842 is mounted on the cleaning mounting bracket 841, and the cleaning tank 842 is made of a flexible material (such as silicone). The cleaning tank 842 has a needle-passing hole 843 at its center, penetrating both the upper and lower end faces. An injection needle 850 can pass through the needle-passing hole 843 and is clearance-fitted with it. During liquid injection, the injection needle 850 passes through the needle-passing hole 843 and extends into the material trough within the hopper. The side wall of the cleaning tank 842 is provided with a water inlet connector 844 and a water outlet connector 845, both of which communicate with the needle-passing hole 843. The water inlet connector 844 is connected to the cleaning liquid, and the water outlet connector 845 is connected to a negative pressure suction device.

[0056] When cleaning is required, the liquid injection horizontal movement module 810 and the liquid injection lifting module 830 work together to insert the liquid injection needle 850 into the needle hole 843 of the cleaning tank 842. Cleaning fluid is injected into the cleaning tank 842 through the water inlet connector 844. The cleaning fluid flows over the outer wall of the liquid injection needle 850, cleaning its outer wall. Simultaneously, because the liquid outlet of the liquid injection needle 850 is on the side wall, some cleaning fluid flows into the interior of the liquid injection needle 850 through the outlet, cleaning its interior. At the same time, the water outlet connector 845 generates negative pressure suction through an external negative pressure suction device, which can suck away the waste liquid generated during cleaning in the cleaning tank 842, preventing cleaning fluid overflow.

[0057] During operation, the hopper pushing mechanism 210 or the discharge pushing mechanism 410 pushes the hopper containing tissue sections to the injection station. The injection traverse motor 812 is controlled to move the injection traverse slider 813 via a lead screw assembly, aligning the injection needle 850 with one of the material slots within the hopper. The injection lifting motor 831 drives the injection lifting slider 835 downwards via a transmission belt, inserting the injection needle 850 into the material slot. The injection pump starts, and the solution is injected into the material slot from the outlet hole on the side wall of the injection needle 850. After injection, the injection lifting module 830 raises the injection needle 850. The solution then fully contacts the tissue sections in the material slot, achieving the purpose of staining the tissue sections in the hopper.

[0058] like Figure 10 As shown, the waste liquid recovery mechanism 900 includes a recovery transverse module 910, which is fixedly connected to the dyeing mounting frame 1000. The output end of the recovery transverse module 910 is provided with a recovery lifting module 920, and the output end of the recovery lifting module 920 is provided with a liquid extraction needle 930 and an air blowing assembly 940. The liquid extraction needle 930 is externally connected to a negative pressure suction device, and the air blowing assembly 940 is externally connected to an air source. During processing, after the drug solution in the material tank has stained the tissue section, the cooperation of the recovery horizontal movement module 910 and the recovery lifting module 920 drives the liquid extraction needle 930 to be inserted into the corresponding material tank. The negative pressure generated by the negative pressure suction device connected to the liquid extraction needle 930 draws away the waste liquid in the material tank. At the same time, the cooperation of the recovery horizontal movement module 910 and the recovery lifting module 920 drives the air blowing component 940 to move directly above each material tank in the material box flow channel. The air blowing component 940 blows air into the material tank to form a directional airflow, which drives the waste liquid remaining on the side wall of the material tank to gather towards the liquid extraction needle 930, so that the liquid extraction needle 930 can completely draw out the waste liquid in the material tank, effectively solving the problem of incomplete suction caused by liquid surface tension or liquid adhesion.

[0059] The recovery transverse movement module 910 has the same structure as the liquid injection transverse movement module 810, so the specific structure of the recovery transverse movement module 910 will not be described in detail in this article.

[0060] like Figure 15-16 As shown, the recovery lifting module 920 includes a recovery lifting mounting plate 921, which is connected to the output end of the recovery horizontal movement module 910. A recovery lifting motor 922 and a freely rotatable recovery lifting driven wheel 923 are mounted on the recovery lifting mounting plate 921. A recovery lifting drive wheel 924 is mounted on the output shaft of the recovery lifting motor 922. A recovery lifting transmission belt 925 is fitted onto the recovery lifting drive wheel 924 and the recovery lifting driven wheel 923. A recovery lifting slider 926 is fixedly mounted on the recovery lifting transmission belt 925; a liquid extraction needle 930 and an air blowing assembly 940 are respectively connected to the recovery lifting slider 926. When the recycling transverse module 910 drives the air blowing assembly 940 and the liquid extraction needle 930 to move directly above the material trough, the recycling lifting motor 922 is controlled to work. The recycling lifting motor 922 drives the recycling lifting slider 926 to move vertically through belt drive, thereby driving the liquid extraction needle 930 to insert into the corresponding material trough, so as to facilitate the extraction of waste liquid in the material trough. At the same time, the air blowing assembly 940 moves to the top of the material trough to facilitate air blowing into the material trough.

[0061] To limit and guide the direction of the lifting motion, a retrieval lifting guide rail 927 is fixedly installed on the retrieval lifting mounting plate 921, and the retrieval lifting slider 926 is slidably engaged with the retrieval lifting guide rail 927. When the retrieval lifting motor 922 is working, it can drive the retrieval lifting slider 926 to slide on the retrieval lifting guide rail 927. Through the sliding engagement between the retrieval lifting slider 926 and the retrieval lifting guide rail 927, the lifting direction of the suction needle 930 can be limited and guided to ensure smooth lifting motion.

[0062] To position the descent stroke of the suction needle 930, a second sensor 928 is installed on the recovery lifting mounting plate 921, and a second sensing tab 929 is installed on the recovery lifting slider 926. The second sensing tab 929 can connect with the second sensor 928. Normally, the second sensing tab 929 and the second sensor 928 are in a separate state. When waste liquid needs to be recovered, the recovery lifting motor 922 drives the recovery lifting slider 926 to descend, causing the suction needle 930 and the air blowing assembly 940 to descend synchronously. As the recovery lifting slider 926 descends, the second sensing tab 929 on the recovery lifting slider 926 will connect with the second sensor 928. At this time, the suction needle 930 has just been inserted into the material trough of the hopper, and the air blowing assembly 940 has just moved to the air blowing position above the hopper. The second sensor 928 will send a feedback signal to the control center of the automatic dyeing machine. The control center will then immediately control the recovery lifting motor 922 to stop working. The cooperation between the second sensing lever 929 and the second sensor 928 enables the liquid extraction needle 930 to be accurately inserted into the material trough, while simultaneously driving the air blowing assembly 940 to the air blowing position, thereby improving the stability of the processing and the accuracy of the control.

[0063] In actual operation, when the recovery transverse module 910 drives the suction needle 930 and the air blowing assembly 940 to move along the length of the material box, they may overlap with the position of the injection mechanism 800. Therefore, to avoid motion interference, a avoidance rotary motor 950 is installed on the recovery lifting slider 926. A rotary mounting block 960 is connected to the output end of the avoidance rotary motor 950, and the suction needle 930 and the air blowing assembly 940 are respectively connected to the rotary mounting block 960. During processing, if the position of the suction needle 930 and the air blowing assembly 940 overlaps with the injection needle 850 on the injection mechanism 800, the avoidance rotary motor 950 can drive the rotary mounting block 960 to rotate in the horizontal plane; this causes the suction needle 930 and the air blowing assembly 940 to rotate synchronously, thereby moving the position of the suction needle 930 and the air blowing assembly 940 away from directly above the material box, achieving avoidance and solving the problem of motion interference.

[0064] To improve the accuracy of the avoidance mechanism, a first sensor 970 is installed on the recovery lifting slider 926, and a first sensing lever 980 is fixed on the rotating mounting block 960. Normally, the first sensing lever 980 and the first sensor 970 are separate. When avoidance rotation is required, the avoidance rotation motor 950 drives the rotating mounting block 960 to rotate, causing the first sensing lever 980 to move together until it engages with the first sensor 970. The first sensor 970 then sends a feedback signal to stop the avoidance rotation motor 950. At this point, the rotating mounting block 960 has rotated by 90 degrees, precisely causing the suction needle 930 and the air blowing assembly 940 to rotate to a position misaligned with the injection needle 850 of the injection mechanism 800, thus achieving the avoidance function.

[0065] like Figure 17 As shown, the air blowing assembly 940 includes an air nozzle 941, which is fixedly mounted on the rotating mounting block 960. One end of the air nozzle 941 is connected to an external air source through a pipeline, and the other end is provided with a triangular air blowing section 942. Multiple air blowing holes 943 are provided on the end face of the air blowing section 942. During operation, the external air source supplies high-pressure gas to the air nozzle 941. The gas flows through the air nozzle 941 into each air blowing hole 943, and then blows into each material tank through each air blowing hole 943, blowing the liquid medicine in the material tank towards the liquid extraction needle 930 so that the liquid extraction needle 930 can extract all the liquid medicine.

[0066] In this embodiment, there are two extraction needles 930, which are symmetrically distributed on both sides of the air nozzle 941. The distance between the two extraction needles 930 is less than the length of the material trough, allowing both extraction needles 930 to be inserted into the same material trough simultaneously. Furthermore, by placing the two extraction needles 930 on both sides of the air nozzle 941, when the air nozzle 941 blows air into the material trough, the liquid in the trough will flow to both sides, flowing into the corresponding extraction needle 930. By using two extraction needles 930, the extraction efficiency can be improved, thereby increasing the processing efficiency.

[0067] During operation, once dyeing is completed in a particular tank, the recovery transverse module 910 is activated, moving the extraction needle 930 and air nozzle 941 directly above the tank. Subsequently, the recovery lifting motor 922 drives the recovery lifting slider 926 downwards via belt drive, lowering the extraction needle 930 and air nozzle 941 to a preset position. The negative pressure suction device is activated, drawing in waste liquid through the extraction needle 930; simultaneously, the air source supplies air to the air nozzle 941, and the airflow exits from the air blowing hole 943, agitating the waste liquid and causing it to converge towards the extraction needles 930 on both sides, ensuring thorough suction. After suction is complete, the recovery lifting module 920 rises, and the recovery transverse module 910 moves to the next tank position, repeating the above process until all tanks are processed.

[0068] During the process of pumping waste liquid, if it is necessary to avoid the injection needle 850 of the injection mechanism 800, the avoidance rotary motor 950 is controlled to drive the rotary mounting block 960 to rotate, so that the pumping needle 930 and the air nozzle 941 are deviated from the upper part of the silo flow channel 200 to achieve avoidance.

[0069] like Figure 18-19 As shown, the discharge pushing mechanism 410 includes a discharge pushing frame 411 fixedly mounted on the machine base 100, and a discharge driving mechanism is mounted on the discharge pushing frame 411. In this embodiment, the discharge driving mechanism includes a discharge motor 412 fixedly mounted on the discharge pushing frame 411, and a discharge driving wheel 413 is mounted on the output shaft of the discharge motor 412. Discharge driven wheels 414 are also mounted at both ends of the discharge pushing frame 411. A discharge transmission belt 415 is sleeved on the discharge driving wheel 413 and the two discharge driven wheels 414. A discharge pushing block 416 is fixedly connected to the discharge transmission belt 415. During processing, the material hopper channel 200 can transport the material hopper containing the tissue slices to the connection position between the material hopper channel 200 and the discharge channel 420; the discharge motor 412 drives the discharge drive wheel 413 to rotate, which in turn drives the discharge transmission belt 415 to drive the discharge push block 416 to move. The discharge push block 416 pushes the material hopper to slide within the material hopper channel 200 and the discharge channel 420, realizing the function of feeding and unloading materials to the first processing position 700.

[0070] In other embodiments, the discharge drive mechanism may also employ other linear drive devices such as a lead screw structure, an electric cylinder, or a pneumatic cylinder.

[0071] To ensure smooth movement of the discharge push block 416, a discharge guide rail 417 is installed on the discharge push frame 411, and a discharge slider 418 is installed at the bottom of the discharge push block 416. The discharge slider 418 is slidably engaged with the discharge guide rail 417, allowing the discharge push block 416 to reciprocate linearly along the discharge guide rail 417. The cooperation between the discharge guide rail 417 and the discharge slider 418 limits and guides the movement direction of the discharge push block 416, improving the accuracy and stability of the processing.

[0072] Two push blocks 419 are hinged to the discharge push block 416, located at opposite ends of the discharge push block 416. Each push block 419 can swing around its hinge point, passing through both the hopper flow channel 200 and the discharge flow channel 420, with one end passing through each channel abutting against the side wall of the hopper. A push limit post 440 is also fixedly installed on the discharge push block 416. The push limit post 440 restricts the swing angle of the push block 419 to only one direction, ensuring that the push block 419 maintains reliable contact with the hopper side wall when pushing the hopper. When the push block 419 encounters an obstacle during its return stroke, it can rotate and swing to avoid it.

[0073] Initially, the discharge pusher block 416 is located on the discharge channel 420, meaning the two pusher blocks 419 are located between the first processing position 700 and the hopper channel 200. During processing, when the hopper channel 200 transports the hopper to the position where it connects with the discharge channel 420, the discharge motor 412 is first controlled to drive the discharge pusher block 416 towards the hopper channel 200. The discharge pusher block 416 drives the pusher blocks 419 to move. After the pusher blocks 419 move and connect with the hopper in the hopper channel 200, the lower end face of the hopper will press against the pusher blocks 419, causing them to rotate and swing along the hinge, allowing the pusher blocks 419 to pass through the bottom surface of the hopper until they move to the other side of the hopper in the hopper channel 200. Then, the discharge motor 412 is controlled to reverse, driving the discharge pusher block 419 to move towards the hopper channel 200. The moving block 416 drives the pushing block 419 to move towards the discharge end 421 of the discharge channel 420. The discharge pushing block 416 drives the pushing block 419 to move synchronously. One end of the pushing block 419 extending into the hopper channel 200 will abut against the hopper in the hopper channel 200. At this time, the other end of the pushing block 419 will abut against the pushing limit post 440. Due to the constraint of the pushing limit post 440, the pushing block 419 cannot rotate or swing. It can only push the hopper from the hopper channel 200 into the discharge channel 420 until it slides to the position of the first processing position 700, thus completing the feeding work of the first processing position 700. Then, the tissue sections in the hopper on the first processing station 700 are stained by the liquid injection mechanism 800 and the waste liquid recovery mechanism 900. After the first processing station 700 is completed, the discharge motor 412 drives the pusher block 419 to push the hopper to slide on the discharge channel 420 until the hopper slides to the discharge end 421 of the discharge channel 420, thus completing the discharge of the hopper.

[0074] Two hopper guide blocks are fixed parallel to each other on the upper surface of the discharge channel 420. The distance between the two hopper guide blocks is slightly greater than the length of the hopper. The hopper guide blocks can guide the hopper to slide on the discharge channel 420 and prevent it from deviating, thereby improving the stability of the operation.

[0075] like Figure 20As shown, processing blocking mechanisms 430 are respectively provided at positions corresponding to the first processing station 700 on the machine tool 100. The processing blocking mechanism 430 can abut against the hopper on the discharge channel 420 to limit the hopper to the position on the discharge channel 420 corresponding to the first processing station 700. Specifically, the processing blocking mechanism 430 includes two blocking mounting seats 431 symmetrically fixed on both sides of the discharge channel 420. Each blocking mounting seat 431 is equipped with a blocking electric push rod 432. The output end of the blocking electric push rod 432 faces the center of the discharge channel 420, and a blocking block 433 is installed on the output end of the blocking electric push rod 432. When it is necessary to feed material to the first processing station 700, the blocking electric push rod 432 can drive the blocking block 433 to extend above the discharge channel 420. At this time, the hopper can be blocked by the blocking block 433, limiting it to the position of the first processing station 700, thus achieving precise feeding to the first processing station 700. Once the first processing station 700 has completed its processing, the blocking block 433 can be retracted by the blocking electric push rod 432 to release the material from the hopper.

[0076] This utility model has the following beneficial effects: 1. Fully Automated Multi-Station Parallel Processing: Through the coordinated operation of the feeding and heating mechanism 300, the material hopper channel 200, multiple processing stations, and the discharge mechanism 400, a fully automated production line operation is achieved for tissue sections, from heating and multi-station staining to discharge. Multiple processing stations can perform staining operations simultaneously, significantly improving the equipment's throughput and staining efficiency, making it suitable for large-volume sample processing.

[0077] 2. Improved staining quality and consistency: The use of a precise injection mechanism 800 and a waste liquid recovery mechanism 900 ensures the accuracy and consistency of drug addition and waste liquid extraction, reduces human error, and improves the reliability and repeatability of staining results.

[0078] 3. High degree of automation and reduced human intervention: From feeding, heating, conveying, positioning, liquid injection, waste liquid extraction to discharge, all operations are automated, which greatly reduces the labor intensity of operators, reduces reliance on skilled workers, and also reduces the risk of biological sample contamination.

[0079] 4. Optimized structural design and high space utilization: Through the ingenious design of the hopper flow channel 200, the pushing mechanism and the positioning and blocking mechanism, the orderly and accurate transmission and positioning of the hopper in a limited space is realized. The equipment has a compact structure and reasonable layout.

[0080] 5. Self-cleaning function to prevent cross-contamination: The injection mechanism 800 integrates a needle cleaning component 840, which can automatically clean the injection needle 850 before and after injection or when changing the drug solution, effectively preventing cross-contamination between different drugs and ensuring dyeing quality.

[0081] 6. Thorough waste liquid recovery: The waste liquid recovery mechanism 900 is equipped not only with a liquid extraction needle 930, but also with an air blowing component 940. The waste liquid remaining at the bottom of the material tank can be blown towards the liquid extraction needle 930 by air blowing, ensuring that the waste liquid is completely recovered and creating good conditions for the next dyeing step.

[0082] 7. Reliable operation and strong adaptability: Each module adopts mature drive methods such as motors and modules, ensuring precise and reliable movement. The articulated pusher block 419 design of the discharge push mechanism 410 allows it to push and return to its original position for obstacle avoidance in unidirectional movement, resulting in a simple and practical structure.

[0083] The above-described specific embodiments are preferred embodiments of this utility model, and are not intended to limit the specific scope of this utility model. The scope of this utility model includes but is not limited to the specific embodiments described above. All equivalent changes made in accordance with this utility model are within the protection scope of this utility model.

Claims

1. A multi-station fully automatic HE dyeing machine, characterized in that: The machine includes a feeding and heating mechanism, a hopper channel, and a discharging mechanism. One end of the hopper channel is connected to the feeding and heating mechanism, and the other end is connected to the discharging mechanism. The feeding and heating mechanism is used to heat the tissue slices in the hopper and transport the heated hopper into the hopper channel; The machine platform is provided with multiple second processing positions at the corresponding positions of the hopper flow channel. The hopper flow channel is provided with multiple hopper pushing mechanisms. The hopper pushing mechanisms are used to push the hopper to slide on the hopper flow channel, thereby moving the hopper to each of the second processing positions. The discharge mechanism includes a discharge pushing mechanism and a discharge channel mounted on the machine platform. One end of the discharge channel is the discharge end, and the other end is connected to the hopper channel. The discharge pushing mechanism is connected to the hopper channel and the discharge channel respectively, and the discharge pushing mechanism can push the hopper in the hopper channel to the discharge end of the discharge channel; The machine platform is equipped with a liquid injection mechanism and a waste liquid recovery mechanism at the corresponding positions of each second processing station. The liquid injection mechanism is used to inject liquid medicine into the hopper, and the waste liquid recovery mechanism is used to remove the waste liquid from the hopper.

2. The multi-station fully automatic HE dyeing machine according to claim 1, characterized in that: The feeding and heating mechanism includes a feeding mechanism, a baking oven, and a feeding and pushing mechanism respectively installed on the machine platform; The feeding mechanism includes a feeding lifting module connected to the machine base. The output end of the feeding lifting module is equipped with a feeding tray for placing a hopper containing tissue sections. The feeding lifting module can drive the tray to move up and down, thereby causing the hopper to extend into or out of the baking oven. The baking oven is used to heat the tissue sections in the hopper. The feeding pushing mechanism is connected to the feeding mechanism and the hopper flow channel respectively, and is used to push the hopper on the feeding tray into the hopper flow channel.

3. The multi-station fully automatic HE dyeing machine according to claim 1, characterized in that: The material hopper flow channel is provided with a blocking mechanism and a positioning mechanism at positions corresponding to each of the second processing positions. The blocking mechanism is used to prevent the material hopper from sliding in the material hopper flow channel, and the positioning mechanism is used to limit the material hopper to the position corresponding to the second processing position in the material hopper flow channel.

4. The multi-station fully automatic HE dyeing machine according to claim 1, characterized in that: The hopper pushing mechanism includes a pushing fixed frame connected to the machine base. The pushing fixed frame is equipped with a hopper pushing motor and a hopper pushing driven wheel. The output end of the hopper pushing motor is equipped with a hopper pushing driving wheel. A hopper pushing transmission belt is sleeved on the hopper pushing driving wheel and the hopper pushing driven wheel. A hopper pushing slider is equipped on the hopper pushing transmission belt. A hopper pushing block is equipped on the hopper pushing slider. The hopper pushing block can abut against the hopper in the hopper flow channel.

5. The multi-station fully automatic HE dyeing machine according to any one of claims 1-4, characterized in that: The machine is equipped with a dyeing mounting frame. The liquid injection mechanism includes a liquid injection transverse movement module connected to the dyeing mounting frame. The output end of the liquid injection transverse movement module is equipped with a liquid injection lifting mounting plate. The liquid injection lifting mounting plate is equipped with a liquid injection lifting module and a needle cleaning assembly. The output end of the liquid injection lifting module is equipped with a liquid injection needle. One end of the liquid injection needle is externally connected to a liquid injection pump. The liquid injection transverse movement module and the liquid injection lifting module can drive the liquid injection needle to extend into each material trough of the hopper. The liquid injection lifting module can also drive the liquid injection needle to connect with the needle cleaning assembly, which is used to clean the liquid injection needle.

6. The multi-station fully automatic HE dyeing machine according to claim 5, characterized in that: The lower end face of the injection needle is a sealed structure, and the outlet hole of the injection needle is located on the side wall of the injection needle; The syringe cleaning assembly includes a cleaning mounting frame, which is connected to the liquid injection lifting mounting plate. The cleaning mounting frame is provided with a cleaning tank, and the cleaning tank has a needle hole that passes through the upper and lower end faces of the cleaning tank. The liquid injection needle can pass through the needle hole and is in clearance fit with the needle hole. The cleaning tank is provided with an inlet connector and an outlet connector on its side wall. The inlet connector and the outlet connector are respectively connected to the needle hole. The inlet connector is connected to the cleaning liquid, and the outlet connector is connected to the negative pressure suction device.

7. The multi-station fully automatic HE dyeing machine according to claim 5, characterized in that: The waste liquid recovery mechanism includes a recovery transverse module connected to the dyeing mounting frame. The output end of the recovery transverse module is equipped with a recovery lifting module, and the output end of the recovery lifting module is equipped with a liquid extraction needle and an air blowing assembly. The liquid extraction needle is externally connected to a negative pressure suction device, and the air blowing assembly is externally connected to an air source. The recovery transverse module and the recovery lifting module can drive the liquid extraction needle to extend into each material trough of the hopper, and the air blowing assembly is used to blow air into the material trough.

8. The multi-station fully automatic HE dyeing machine according to claim 7, characterized in that: The output end of the recovery lifting module is equipped with a positioning rotary motor, and the output end of the positioning rotary motor is equipped with a rotary mounting block. The positioning rotary motor can drive the rotary mounting block to rotate, and the liquid suction needle and the air blowing assembly are respectively connected to the rotary mounting block.

9. The multi-station fully automatic HE dyeing machine according to claim 7, characterized in that: The air blowing assembly includes an air nozzle, which is connected to the output end of the recovery lifting module. One end of the air nozzle is connected to an external air source, and the other end is provided with a triangular air blowing part. The end face of the air blowing part is provided with multiple air blowing holes. There are two liquid extraction needles, and the two liquid extraction needles are symmetrically distributed on both sides of the air nozzle. The distance between the two liquid extraction needles is less than the length of the material trough.

10. The multi-station fully automatic HE dyeing machine according to any one of claims 1-4 or any one of claims 6-9, characterized in that: The discharge pushing mechanism includes a discharge pushing frame, which is connected to the machine base. The discharge pushing frame is equipped with a discharge motor. The output end of the discharge motor is equipped with a discharge drive wheel. The two ends of the discharge pushing frame are respectively equipped with discharge driven wheels. A discharge transmission belt is fitted on the discharge drive wheel and the discharge driven wheel. A discharge pushing block is provided on the discharge transmission belt. The discharge pushing block is provided with a pushing block, which can pass through the hopper channel and the discharge channel respectively. The pushing block is hinged to the discharge pushing block and can swing around the hinge point as the axis. The discharge pushing block is provided with a pushing limiting post, which can abut against the pushing limiting post.

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