Piperidine derivatives as inhibitors of nicotinamide N-methyltransferase.

Abstract

Certain piperidine derivatives of Formula (I), and pharmaceutically acceptable salts thereof, are described, along with compositions containing them and their use in therapy. These compounds are inhibitors of nicotinamide N-methyltransferase (NNMT) and are thus particularly useful in the treatment or prophylaxis of, for example, chronic kidney disease, acute kidney injury, or heart failure.