Method for the production of readily water-soluble, colloidal, complex silver-tannin-protein compounds

Description

[0001] Method for the production of readily water-soluble, colloidal, complex silver-tannin-protein compounds. Patent 5i9 53I relates to a method for producing a silver-tannin-protein compound by dissolving diacetyltannin in small amounts of alkali and this Solution reacts with an aqueous solution of silver albumose.

[0002] The present invention relates to an embodiment of the method of patent 5-19 531 in that diacetyltannin is dissolved in diluted or pure alcohol, e.g. methyl, ethyl or other alcohols without the addition of alkali, dissolves this solution in an aqueous silver albumose solution, e.g., argentum proteinicum, is added and the combined solution is carefully concentrated under vacuum to dryness. The dry product thus obtained is in. Easily soluble in water.

[0003] The product obtained differs physically and in its reactions from the diacetyltannin as follows: The diacetyltannin is Water-insoluble, the obtained product is readily water-soluble. Diacetyltannin is soluble in pure alcohol or ethyl acetate. From the obtained Diacetyltannin cannot be extracted from this product with alcohol or ethyl acetate. Diacetyltannin reacts with ferric chloride in the known manner. It neither gives off this reaction itself, nor can a substance that gives off this reaction be extracted from it.

[0004] The presence of bound acetyl groups in the obtained product can be demonstrated, for example, by the acetic ester reaction (with alcohol and concentrated sulfuric acid).

[0005] From egg albumin, serum albumin, pea protein or casein and silver nitrate, corresponding silver- Protein compounds were produced and reacted in an analogous manner with diacetyltannin also dissolved in alcohol.

[0006] The products obtained using the silver compounds from egg albumin, serum albumin or pea protein are also Very easily water-soluble; the silver casein compound is somewhat less so. In the same way as when using Argentum. The proteinicum-derived compounds also do not give these products the reaction characteristic of diacetyltannin with ferric chloride. Here too, the Acetyl groups chemically bound.

[0007] The therapeutic advantage of the new process products is that they contain the entire amount of the tannin ester used. to the medicinal effect. Investigations of the substance described according to patent 519 531 or according to American patent I 653 087. The product showed that during the manufacturing process with alkali, approximately 17 to 18% of the tannin ester is broken down. This results in, among other things, the formation of... the loss of therapeutically effective substance byproducts, which may be undesirable This can lead to disruptions in therapeutic effectiveness.

[0008] @B.eispie,1 1 5 g of protein silver are dissolved in 50 cc of distilled water. 1 oz of diacetyltannin is added, which dissolves in approximately 30 cc. dissolved in 70% ethyl alcohol, if necessary with heating. The mixture is carefully concentrated to dryness under vacuum. The compound is Soluble up to 520 / 6 in water.

[0009] Examples: 6 g each of a silver albumose prepared from egg albumin, serum albumin, egg white, casein, and silver nitrate. are dissolved by sprinkling onto 25 g of water; this solution is dissolved by stirring with a solution of 15 g diacetyltannin. 20 cc of 95% alcohol or methyl alcohol is added. The resulting solution is then carefully concentrated to dryness under vacuum.

Claims

[0010] PATENT CLAIM: Process for the production of readily water-soluble, colloidal, complex silver-tannin-protein compounds, characterized in that, in a further development of the method of patent 519 531, aqueous solutions of silver albumoses are used here Allow alcoholic solutions of diacetyltannin to act and carefully concentrate the total solution under vacuum until dry.