METHOD FOR THE TREATMENT OR PREVENTION OF CHOLESTEROL-RELATED DISEASES
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- AMGEN INC
- Filing Date
- 2012-05-10
- Publication Date
- 2026-07-15
AI Technical Summary
Current treatments for cholesterol-related disorders, such as hypercholesterolemia and heart disease, are inadequate for some patients, and there is a need for more aggressive therapies to lower LDL-C levels effectively, especially for those intolerant to or not responding to statin therapy.
Development of a monoclonal antibody specifically targeting PCSK9, administered at varying doses and schedules, to reduce serum LDL cholesterol levels by at least 15-90% in patients, potentially combined with other cholesterol-lowering agents.
The antibody effectively lowers LDL cholesterol levels by 15-90% in patients, providing a therapeutic option for those not responding to statins and addressing the need for more aggressive treatment of cholesterol-related disorders.