METHOD FOR DETECTING MULTIPLE PREDEFINED CONNECTIONS IN A SAMPLE
DE602014092823T2Active Publication Date: 2026-02-25THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK
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Patent Information
- Application Number
- DE602014092823
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2013-03-15
- Filing Date
- 2014-03-14
- Publication Date
- 2026-02-25
- Estimated Expiration
- 2034-03-14
AI Technical Summary
Technical Problem
Existing protein detection methods struggle with multiplex analysis, requiring high concentrations, variable antibody affinities, and fluorescence saturation, limiting sensitivity and dynamic range, especially for low copy number proteins.
Method used
A method using cleavable PEG tags attached to proteins via nanopores, where proteins are captured, tagged analytes are bound to antibodies near nanopores, and cleaved tags are detected electronically, generating unique current blockade signals for quantification.
Benefits of technology
Enables digital protein quantification at the single molecule level with a wide dynamic range, overcoming fluorescence limitations and providing scalable, high-throughput protein detection.
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