Chromatography column with dual-purpose valve arrangement

DE602019070367T2Active Publication Date: 2025-05-21TOSOH CORP
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Patent Information

Application Number
DE602019070367
Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
Filing Date
2019-10-11
Publication Date
2025-05-21
Estimated Expiration
2039-10-11

AI Technical Summary

Technical Problem

Current chromatography column designs face challenges in achieving homogenous resin packing, uniform distribution of analytes, and maintaining aseptic conditions, particularly in disposable columns, due to issues like dead zones, bacterial contamination, and high manufacturing costs.

Method used

A dual-purpose valve assembly is introduced, featuring a hollow nozzle with moveable through holes and sealing means, allowing for both packing and operation of the column without retracting the nozzle, ensuring uniform distribution and easy cleaning to prevent bacterial growth, while maintaining cost-efficiency.

Benefits of technology

The dual-purpose valve assembly enables reproducible and efficient packing, prevents bacterial contamination, and ensures uniform analyte distribution, enhancing the separation efficiency and stability of the packed bed, while reducing manufacturing costs and complexity.

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Abstract

The present invention discloses methods for packing chromatography columns using dual- purpose valve assemblies. The key components of the dual-purpose valve comprise of the following; the inlet port (224) which sits on the first adaptor (212), the hollow nozzle (320) which passes through the first adaptor (212) cavity and is closed on the bottom end, and the internal movable plug (322). Different components of our device work in way that the mobile phase and analyte(s) distribution is not blocked in the centre of the column, allowing for a uniform and homogeneous fluid distribution. This simple yet novel design offers uniform fluid distribution, stable packed bed, eliminates any void volume, and prevents bacterial contamination / growth. Ease of use, scalability, ease of cleaning, cost-efficiency and fine-tuning packing conditions such as pressure are key features of this invention.
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