METHOD FOR ISSUING A BIOLOGICAL ENTITY
DE602021029089T2Active Publication Date: 2025-04-09CELL COPEDIA GMBH
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Patent Information
- Application Number
- DE602021029089
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2020-01-31
- Filing Date
- 2021-02-01
- Publication Date
- 2025-04-09
- Estimated Expiration
- 2041-02-01
AI Technical Summary
Technical Problem
Current cell separation techniques face limitations in yield, purity, viability, and functionality of isolated cells, particularly in recovering rare cells and improving throughput.
Method used
The method employs a chromatographic approach optimized with a dextran molecule as a carrier for ligand binding partners like Strep-Tactin, achieving an avidity effect through polymerization/multimerization, and using bivalent tagging agents or linking molecules to enhance cell isolation efficiency.
Benefits of technology
This approach results in high yields and purity of isolated cells, such as CD4+ cells, while maintaining cell viability and functionality, and is particularly effective for isolating cells with low abundant surface antigens.
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