METHOD FOR STRUCTURING AND SPATIAL ELECTROCHEMICAL IMAGE OF CELLS
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- PRESIDENT & FELLOWS OF HARVARD COLLEGE
- Filing Date
- 2021-06-16
- Publication Date
- 2026-05-27
AI Technical Summary
Existing methods for electrically assessing cells are limited in their ability to detect and map cell presence and adhesion non-invasively and with high spatial resolution, particularly due to interference from the surrounding medium and lack of sensitivity in impedance measurements.
Utilizing a CMOS-compatible electrode array with small electrode pitch and active circuitry to perform cross-electrode impedance measurements, which detect cell presence and adhesion by measuring changes in cross-electrode impedance caused by cells, allowing for high-resolution mapping and electrochemical reactions.
Enables non-invasive, high-resolution mapping of cell adhesion and spatially controlled electrochemical reactions, improving signal-to-background ratio and sensitivity, and facilitating real-time electrical assessment of cell properties.