PROCESS FOR THE PREPARATION OF (S)-2-(4-CHLORO-2-METHOXYPHENYL)-2-((3-METHOXY-5-(METHYLSULFONYL)PHENYL)AMINO)-1-(1H-INDOL-3-YL)ETHENONE DERIVATIVES
DE602022037529T2Active Publication Date: 2026-05-27KATHOLIEKE UNIV LEUVEN
View PDF 0 Cites 0 Cited by
Patent Information
- Application Number
- DE602022037529
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2022-05-06
- Filing Date
- 2022-06-28
- Publication Date
- 2026-05-27
- Estimated Expiration
- 2042-06-28
AI Technical Summary
Technical Problem
Existing mono- or di-substituted indole compounds synthesized for combating flaviviruses like dengue virus lack chiral synthesis methods, necessitating separate enantiomer separation and industrial-scale processes.
Method used
A chiral synthesis process involving the reaction of a compound of formula (II) with 3-methoxy-5-methylsulfonyl-aniline followed by hydrogenation to produce compound of formula (I), optionally with chiral separation of intermediate compounds using phase transfer catalysts and specific hydrogenation catalysts and ligands.
Benefits of technology
Achieves stereoisomerically pure indole compounds with high enantiomeric excess, facilitating efficient industrial production of potent anti-dengue virus agents.
✦ Generated by Eureka AI based on patent content.
Need to check novelty before this filing date? Find Prior Art
No text content released.