PROCESS FOR THE PREPARATION OF (S)-2-(4-CHLORO-2-METHOXYPHENYL)-2-((3-METHOXY-5-(METHYLSULFONYL)PHENYL)AMINO)-1-(1H-INDOL-3-YL)ETHENONE DERIVATIVES
DE602022037529T2Active Publication Date: 2026-05-27KATHOLIEKE UNIV LEUVEN
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Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- KATHOLIEKE UNIV LEUVEN
- Filing Date
- 2022-06-28
- Publication Date
- 2026-05-27
AI Technical Summary
Technical Problem
Existing mono- or di-substituted indole compounds synthesized for combating flaviviruses like dengue virus lack chiral synthesis methods, necessitating separate enantiomer separation and industrial-scale processes.
Method used
A chiral synthesis process involving the reaction of a compound of formula (II) with 3-methoxy-5-methylsulfonyl-aniline followed by hydrogenation to produce compound of formula (I), optionally with chiral separation of intermediate compounds using phase transfer catalysts and specific hydrogenation catalysts and ligands.
Benefits of technology
Achieves stereoisomerically pure indole compounds with high enantiomeric excess, facilitating efficient industrial production of potent anti-dengue virus agents.
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