METHOD FOR PRODUCING A MODIFIED TOXIN POLYPEPTID

DE602022039912T2Active Publication Date: 2026-07-15CHONGQING CLARUVIS PHARM CO LTD
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Patent Information

Authority / Receiving Office
DE · DE
Patent Type
Patents
Current Assignee / Owner
CHONGQING CLARUVIS PHARM CO LTD
Filing Date
2022-02-24
Publication Date
2026-07-15

AI Technical Summary

Technical Problem

The toxicity of toxin polypeptides necessitates the use of BL-3 environments for preparation, increasing production costs and making large-scale industrial production challenging due to safety concerns.

Method used

A method involving expressing a toxin polypeptide precursor with a specific protease cleavage site, enriching it using multiplex filtration, and activating it with proteases to reduce toxicity, allowing for safer and more efficient large-scale production without the need for isolators.

Benefits of technology

The method significantly reduces environmental and operational hazards while enhancing yield and purity, enabling high-purity toxin polypeptide production suitable for clinical applications.

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