ПРЕССОВАННЫЙ ПРОДУКТ, СОДЕРЖАЩИЙ ПРОБИОТИКИ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
EA054012B1Active Publication Date: 2026-07-13BLUESTONE PHARMA GMBH
Patent Information
- Authority / Receiving Office
- EA · EA
- Patent Type
- Patents
- Current Assignee / Owner
- BLUESTONE PHARMA GMBH
- Filing Date
- 2023-04-13
- Publication Date
- 2026-07-13
AI Technical Summary
Technical Problem
Existing methods for producing compressed tablets with probiotic bacteria often result in significant viability loss and produce hard, less stable products due to high compression forces, which are detrimental to the microorganisms.
Method used
A method involving a briquetting step where excipients are compressed into large briquettes, fractioned, and ground before adding probiotics, allowing for lower compression forces during final tablet pressing, thereby minimizing viability loss and enhancing product stability.
Benefits of technology
The method achieves a 7% viability loss of probiotic bacteria during tablet manufacturing, compared to 70% in traditional methods, while producing a softer, more stable product with similar water activity and disintegration time.
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Abstract
Provided is a method for producing a compressed product, in particular a tablet, which comprises probiotic bacteria as active ingredient. In particular, a method is provided which comprises a briquetting step in which the excipients are compressed to large briquettes and fractioned to the desired particle size before the probiotic bacteria are added for final compression.
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