Method for preparing glycolipids, glycolipids and uses thereof

EP4526316A1Pending Publication Date: 2025-03-26INSTITUT NATIONAL DE LA RECHERCHE POUR L AGRICULTURE, L ALIMENTATION ET L ENVIRONNEMENT +4
View PDF 0 Cites 0 Cited by

Patent Information

Application Number
EP2023730551
Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-05-18
Filing Date
2023-05-17
Publication Date
2025-03-26

AI Technical Summary

Technical Problem

Current methods for synthesizing glycolipids are inefficient, particularly in producing glycolipids with larger carbon chains and diverse molecular architectures, due to limitations in enzymatic processes and the use of acidic catalysts in chemical synthesis, which complicates the production of bolaamphiphilic structures needed for industrial applications.

Method used

An enzymatic process using a-transglucosylases of the GH70 family to glucosylate hydroxylated fatty acids with sucrose, enabling the production of glycolipids with large carbon chains and diverse structures, including bolaamphiphilic types, which are useful in various industrial fields.

Benefits of technology

This process allows for the efficient production of glycolipids with large hydrophobic parts and varied glucosidic structures, enhancing their surfactant and biological properties, making them suitable for applications in pharmacy, cosmetics, biocontrol, and other industries.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure IMGF000016_0001
    Figure IMGF000016_0001
  • Figure IMGF000018_0001
    Figure IMGF000018_0001
  • Figure IMGF000018_0002
    Figure IMGF000018_0002
Patent Text Reader

Abstract

The present invention relates to a method for preparing at least one glycolipid according to the following formula (I): [Glc]n-xOy-R (I) [Glc]n representing a linear or branched osidic motif comprising n glucosyl units, where n is between 1 and 7, with the condition that when the osidic motif comprises a plurality of glucosyl units, the latter are linked to one another by α-osidic bonds; R representing a fatty acid radical comprising between 4 and 24 carbon atoms, the carbon chain of which is linear or branched, saturated or unsaturated; -xOy- symbolising the attachment of the fatty acid radical to the osidic motif via an ether bond linking a carbon atom Cx of a glucosyl residue of the osidic motif, previously bearing a hydroxyl group, to a carbon atom Cy of the fatty acid radical, previously bearing a hydroxyl group, where Cx is the position of the atom of the glucosyl residue to which the bond is made, Cx representing the carbon atom C1 of the glucosyl residue, Cy being a carbon atom positioned along the carbon chain of the fatty acid radical or at the omega end thereof; the method comprising a step of glucosylating a hydroxylated fatty acid of formula (II): R-yOH (II) -yOH representing a hydroxyl group attached to a carbon atom Cy as defined above; the step comprising bringing the hydroxylated fatty acid of formula (II) into contact with at least one α-transglucosylase of the GH70 family in the presence of saccharose or a saccharose analogue.
Need to check novelty before this filing date? Find Prior Art