Microimprinting of antibodies and biomolecules for cell phenotyping and activation

EP4526428A1Pending Publication Date: 2025-03-26INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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Patent Information

Application Number
EP2023723218
Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2022-06-30
Filing Date
2023-05-17
Publication Date
2025-03-26

AI Technical Summary

Technical Problem

Current methods for rapidly visualizing immune system responses are inefficient, making it difficult to quickly detect infectious pathologies and monitor treatment effectiveness in clinical immunology, particularly in the quantification of lymphocyte functions and immune system responses.

Method used

A device with a substrate featuring two zones, one adsorbed with a protein binding to a specific membrane molecule and another with an antibody targeting a second membrane molecule, allowing cells to interact and adhere, enabling rapid optical detection of cell presence and phenotype through interferential optical reflection microscopy.

Benefits of technology

Enables rapid and efficient phenotyping and activation of immune cells, reducing the need for tedious immunostaining techniques and allowing real-time monitoring of immune function activation, particularly useful in clinical immunology and pharmaceutical research.

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Abstract

The device comprises a substrate comprising a first zone (1) on which is absorbed a protein capable of binding to a first membrane molecule and comprising a second zone (2), on which an antibody is absorbed, targeting a second membrane molecule, the first zone and the second zone extending together in length over a dimension comparable to the length of a cell.
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