Tgf-beta switch receptor car t cells
EP4615864A1Pending Publication Date: 2025-09-17LEIBNIZ INSTITUT F R IMMUNTHERAPIE (LIT)
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Patent Information
- Application Number
- EP2023802189
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-11-07
- Filing Date
- 2023-11-06
- Publication Date
- 2025-09-17
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Figure 1.1
Abstract
The present invention provides recombinant T cells comprising switch receptors that protect the T cell from TGF-ß mediated repression and the same time produce an intracellular IL2 receptor signal, thereby increasing the functional efficacy of T cells triggered by a chimeric antigen receptor or T cell receptor co-expressed in the same T cell.
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