Electrochemical biosensor

Abstract

The present disclosure relates to a method of detecting the presence or absence of a target in a sample and a structure suitable for use in such a method. The structure comprises: a nucleic acid origami molecule and one or more capture moieties suitable for binding to a first position on a target. When present, the target is able to bind to the one or more capture moieties. The method comprises contacting (i) the structure; (ii) a working electrode comprising one or more probe moieties, which extend outwardly from a surface of the working electrode and are suitable for binding to a second position on the target; and (iii) the sample, in order to allow the target, when present, to interact with the one or more capture and one or more probe moieties. An electrical stimulus is applied to the working electrode; and an electrical response is detected.

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