1,2,4-triazole-3-thione inhibitors of trex2 for use in the treatment of psoriasis, atopic dermatitis or ichthyosis

Abstract

The present invention provides compounds of formula (I) for use in the treatment or prevention of a pathological condition related to an increase in TREX2 expression and activity, wherein: A1 is a group of formula (II); A2 is a ring system consisting of one or two rings, wherein each ring is saturated, partially saturated or unsaturated, and has 5 or 6 members selected from the group consisting of: N, O, S, C, NRp, CRz, and C(Rz)2; A3 represents X7-(X8)n; X1 represents CR1 or N; X2 represents CR2 or N; X3 represents CR3 or N; X4 represents CR4 or N; X5 represents CR5 or N; X6 represents CR6 or N; X7 represents CR7 or N; and X8 represents CR8 or N; provided that one, two or three of X1 to X8 are N; n is an integer number selected from 0 or 1. The present invention also provides compounds of formula (Ibis), as well as pharmaceutical compositions comprising thereof and processes for their preparation.

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