Chimeric molecule
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- Filing Date
- 2024-05-17
- Publication Date
- 2026-03-25
AI Technical Summary
Current approaches for targeting autophagy in cancer and neurodegenerative diseases face limitations, including the inability to effectively direct autophagic machinery to specific cellular targets and disrupt aberrant protein expression or organelle accumulation, with existing methods being either genetically challenging, time-consuming, or lacking local modulation and specificity.
Development of chimeric molecules comprising an autophagy-inducing moiety and a targeting moiety that co-locates autophagic machinery with deleterious targets such as aberrantly expressed proteins or dysfunctional organelles, initiating autophagosome formation and degradation at the site of the target, thereby treating the underlying cause of disease.
The chimeric molecules induce targeted autophagy, overcoming limitations of existing methods by increasing potency and specificity, creating new autophagosomes at the target site without disrupting cellular homeostasis, and demonstrating potential in treating cancers and neurodegenerative diseases like Parkinson’s disease.
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