Method for improving the ingestion of a liquid or viscous substance

Abstract

The present invention relates to a method for improving the ingestion of a liquid or viscous, preferably therapeutic, substance, in which - the substance and a palatable liquid or viscous matrix are collected simultaneously by means of a single instrument having two separate compartments, each for receiving only one of said substance and palatable matrix, - the substance and the palatable matrix are simultaneously delivered by means of the instrument, and - the substance and palatable matrix are kept separate during collection and distribution.

Description

Description Title: Method for improving the setting of a liquid or viscous substance Technical field

[0001] The present invention relates to a method for improving the uptake of a liquid or viscous substance, preferably therapeutic.

[0002] It also relates to an instrument for simultaneously collecting and dispensing at least two products, for the implementation of this method. Prior art

[0003] It is known that at some point in its life, a domestic animal such as a cat or a dog will need medication that will be administered orally.

[0004] For purely illustrative purposes, to maintain the health of a cat or dog, we know that it is necessary to regularly administer an oral dewormer such as a liquid dewormer. In other cases, the administration of an antibiotic will be necessary.

[0005] However, this oral administration, particularly in cats, can prove to be a real challenge.

[0006] It is indeed difficult to force a pet to swallow an unknown product which may also have low palatability.

[0007] It is then known to hide the medicine in a small amount of food in the hope that the pet will swallow it.

[0008] However, it is observed that these domestic animals, and especially cats, can, thanks to their highly developed sense of smell, detect the deception and leave aside the mouthful containing the medicine.

[0009] Furthermore, some of these medications in liquid form must be administered to the pet on an empty stomach, which makes it impossible to mask them with the smell of solid food.

[0010] We then know how to mix this medication in liquid form with another liquid product that is highly palatable to the domestic animal in order to ensure its absorption.

[0011] However, for some veterinary applications, these liquid products may be chemically incompatible, so preparing a ready-to-use mixture is not feasible. In addition, active ingredients are not always chemically stable in liquid media, and appetizing agents further destabilize these active ingredients in liquid media.

[0012] The preparation of this mixture by the owner of the domestic animal must therefore be carried out just before its administration.

[0013] Furthermore, it may be imperative to make the most accurate mixture possible, taking into account at least one parameter of the domestic animal, such as its weight.

[0014] This requirement therefore requires manipulations to measure and make the mixture before introducing it into a syringe, then administering it orally to the domestic animal.

[0015] This results in a longer preparation time, which can also be tedious for the preparer if repeated regularly.

[0016] In addition, dosage errors and losses of active product may occur during this preparation. Subject of the invention

[0017] The present invention relates to a method for improving the uptake of a liquid or viscous substance, preferably therapeutic, by a human being or an animal, simple in its design and in its implementation, making it possible to guarantee the stability, and consequently the properties, of this liquid or viscous substance. Statement of the invention

[0018] To this end, the invention relates to a therapeutic liquid or viscous substance for use in a method of therapeutic treatment in a subject, preferably an animal, to improve the uptake of said therapeutic substance, characterized in that said therapeutic substance and a liquid or viscous appetizing matrix are collected simultaneously by means of a single instrument comprising two separate compartments each to receive only one of said appetizing substance and matrix, and administered simultaneously by means of said instrument, such that said appetizing substance and matrix are kept separate during their collection and distribution.

[0019] The present application also relates to the use of a therapeutic liquid or viscous substance in the preparation of a medicament for a method of treatment in a subject, preferably an animal, to improve the uptake of said therapeutic substance, characterized in that said therapeutic substance and a liquid or viscous palatable matrix are withdrawn simultaneously by means of a single instrument comprising two separate compartments for each receiving only one of said substance and palatable matrix, and a therapeutically effective amount of said substance and matrix are administered simultaneously by means of said instrument, such that said substance and palatable matrix are kept separate during their withdrawal and their distribution.

[0020] The invention also relates to a method for improving the setting of a liquid or viscous substance, wherein - the said substance and a liquid or viscous appetizing matrix are simultaneously collected using a single instrument comprising two separate compartments each to receive only one of the said substance and appetizing matrix, - said substance and said appetizing matrix are delivered simultaneously by means of said instrument, and - the said substance and appetizing matrix are kept separate during their collection and distribution.

[0021] Advantageously, the present method makes it possible to simultaneously and separately collect at least two products, to separately contain these products and to deliver these products simultaneously, or concomitantly, while keeping them separate until they leave the instrument, for example to administer them directly into the mouth of the domestic animal or into the mouth of a riding, draft or grazing animal.

[0022] This prevents any possible degradation over time of one of these products by prolonged contact with the other product to be delivered.

[0023] Note that the present disclosure is not limited to the simultaneous collection and distribution of two liquid products, but is intended for other types of products, such as the simultaneous collection and distribution of a liquid product and a viscous product, or even two viscous products.

[0024] This liquid or viscous substance may be a substance comprising an active ingredient or be a non-therapeutic substance such as a nutritional composition, for example having a taste that is of low palatability to the mammal.

[0025] Preferably, the liquid or viscous substance of the present disclosure is a therapeutic substance comprising an active ingredient. By way of non-limiting examples, the active ingredient may be chosen from: - antibiotics such as amoxicillin (7-[2-amino-2-(4-hydroxyphenyl)-acetyl]amino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo [3.2.0] heptane-4-carboxylic acid), or doxycycline ((4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)- 3,5,10,12,12a-pentahydroxy-6-methyl-1 ,11 -dioxo-1 ,4, 4a, 5, 5a, 6,11 ,12a- octahydrotetracene-2-carboxamide); - calcium channel blockers such as amlodipine ((RS)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 3-O-ethyl and 5-O-methyl), or diltiazem (cis-(+)-[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)- 3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]ethanoate); - aldosterone antagonists such as spironolactone (7a-acetylthio-3-oxo-17a-pregn-4-ene-21,17-carbolactone), or eplerenone; - antithyroid drugs such as thiamazole (1-methyl-3H-imidazole-2-thione) or carbimazole (3-methyl-2-sulfanylidene-imidazole-1-ethylcarboxylate); - angiotensin converting enzyme inhibitors such as benazepril (2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid), enalapril ((2S)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]pyrrolidine-2-carboxylic acid) or ramipril ((2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2- yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid); - a sodium / glucose cotransporter 2 (SGLT2) inhibitor such as dapagliflozin ((2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6- (hydroxymethyl)oxane-3,4,5-triol), velagliflozin (2-[(4-cyclopropylphenyl)methyl]- 4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]benzonitrile), bexagliflozin ((2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[4-(2-cyclopropyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol), canagliflozin ((2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4- methyl l-phenyl}-6-hyd roxy methyl l-tetra hyd ro-py ran-3,4,5-triol), l'i pragl iflozi ne ((1 S)- 1,5-Anhydro-1 -[3-(1 -benzothiophen-2-ylmethyl)-4-fluorophenyl]-D-glucitol), tofogliflozin ((1 S,3'R,4'S,5'S,6'R)-6-(4-Ethylbenzyl)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-3',4',5'-triol hydrate (1:1)), empagliflozin ((2S,3R,4R,5S,6R)-2-[4-Chloro-3-[[4-[(3S)-oxolan-3- yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol), ertugliflozin ((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol), or sotagliflozin and an anti-inflammatory agent such as prednisolone ((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13- dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one) or a combination thereof.

[0026] Preferably, the liquid or viscous substance for the use described in the present disclosure comprises one or more antibiotics such as amoxicillin, metronidazole and / or doxycycline for the treatment of a bacterial infection.

[0027] Preferably, the liquid or viscous substance for the use described in the present disclosure comprises a calcium channel blocker such as amlodipine or diltiazem, and / or an aldosterone antagonist such as spironolactone or eplerenone for the treatment of hypertension.

[0028] Preferably, the liquid or viscous substance for the use described in the present disclosure comprises an antithyroid agent such as thiamazole or carbimazole for the treatment of hyperthyroidism.

[0029] Preferably, the liquid or viscous substance for the use described in the present disclosure comprises an SGLT2 inhibitor such as dapagliflozin, velagliflozin, bexagliflozin, canagliflozin, lipragliflozin, tofogliflozin, empagliflozin, ertugliflozin, or sotagliflozin for the treatment of diabetes, preferably type 2 diabetes, a heart disorder such as heart failure, or a kidney problem such as chronic kidney disease.

[0030] Preferably, the liquid or viscous substance for the use described in the present disclosure comprises an anti-inflammatory agent such as prednisolone for the treatment of an inflammatory disease.

[0031] In the context of this disclosure, the term "treat" or "treatment," as used herein, means to reverse, alleviate, inhibit the progression of, or prevent the disorder or condition to which such term applies, or to reverse, alleviate, inhibit the progression of, or prevent one or more symptoms of the disorder or condition to which such term applies.

[0032] As used herein, a "therapeutically effective amount" or "effective amount" means the amount of a composition that, when administered to a subject to treat a condition, disorder, or state, is sufficient to effect treatment. The therapeutically effective amount varies depending on the compound, formulation, or composition, the disease and its severity, and the age, weight, physical condition, and responsiveness of the subject to be treated.

[0033] It will be appreciated that the specific dosage of the therapeutic substance in a given case will be adjusted depending on the composition administered, the volume of the composition that can be effectively delivered, the disease to be treated or inhibited, the condition of the subject, and other relevant medical factors that may alter the activity of the compositions or the response of the subject, as is well known to those skilled in the art.

[0034] Advantageously, the method or therapeutic use of the present disclosure allows the palatable matrix to be changed so that the human or animal does not become tired of it. This palatable matrix is ​​easily replaceable because it is not mixed with the liquid or viscous substance.

[0035] In particular, the appetizing matrix, with a liquid or creamy texture, is available in several flavors / several types of formulas to overcome the frequently encountered problem of cat weariness.

[0036] Advantageously, and in the case of the distribution of two products, the method of the present disclosure makes it possible to physically separate a matrix providing palatability or hyper-palatability and a substance containing an active ingredient, so that the latter remains stable over time, to ensure their collection and delivery simultaneously, using an instrument that is very easy to use for the animal owner.

[0037] For purely illustrative purposes, this method or therapeutic use may be implemented by means of an instrument for dispensing a first product and at least one second product, each of the products being liquid or viscous, this instrument comprising: - a first compartment having one end with a first outlet orifice and an opposite open end, a first compression piston being mounted in said first compartment, said first piston having a so-called actuating end, said first compression piston and said first compartment defining a first chamber for receiving the first product, - a second compartment separate from said first compartment, this second compartment having one end with a second outlet orifice and an opposite open end, a second compression piston being mounted in said second compartment, said second piston having a so-called actuating end, said second compression piston and said second compartment defining a second chamber for receiving the second product, - the first compartment comprising a barrier element to prevent purely manual actuation of said first piston, - a joining device for coupling the first and second pistons and thus forming a common actuating head of said pistons so that said pistons are moved simultaneously when a push or a pull is exerted on said common actuating head, and - said barrier element and said junction device being configured to allow the movement of said junction device through at least a portion of said barrier element, during the movement of said actuating head, in order to authorize the activation of said first piston.

[0038] By "purely manual actuation", or directly manual actuation, is meant that the movement of the first piston is carried out entirely, and only, manually, that is to say solely or directly by one or more of the operator's fingers.

[0039] In this sense, the barrier element therefore aims to prevent an operator from accessing at least the actuating end of the first piston to directly activate the latter with at least one of his fingers.

[0040] Note that according to a particular implementation method, this method allows these two products to be distributed at the same time to ensure their mixing directly in the mouth of the domestic animal or in the mouth of a riding, draft or grazing animal.

[0041] It should also be noted that the present disclosure is not limited to the simultaneous dispensing of only two products, but could very well relate to the dispensing of at least three products. What has, in fact, been presented for an assembly comprising a syringe assembled to the first compartment, could be adapted for at least one additional syringe assembled to the first compartment.

[0042] For purely illustrative purposes, another lateral opening could be added to another side of the first compartment and a joining device could be provided to enable the so-called actuating ends of the pistons mounted in the different compartments thus assembled to be assembled.

[0043] It should also be noted that these two compartments may be pre-assembled or may be initially separate compartments which may be assembled together by at least one assembly element of these compartments.

[0044] It is known that the so-called actuating, or proximal, end of a piston is also called the head and may have a finger rest surface, the piston thus comprising a rod, a head and a finger rest made from a single piece.

[0045] The features of the method for improving the uptake of a liquid or viscous substance of the present disclosure, described below, can be implemented as desired, separately or in combination with each other.

[0046] For purely illustrative purposes, this method or therapeutic use may be implemented by means of an instrument for dispensing a first product and at least one second product, each of the products being liquid or viscous, this instrument comprising: - a first compartment having one end with a first orifice of outlet and an open opposite end, a first compression piston being mounted in said first compartment, said first piston having a so-called actuating end, said first compression piston and said first compartment defining a first chamber for receiving the first product, - a second compartment separate from said first compartment, this second compartment having one end with a second outlet orifice and an opposite open end, a second compression piston being mounted in said second compartment, said second piston having a so-called actuating end, said second compression piston and said second compartment defining a second chamber for receiving the second product, - the first compartment being extended on the side of its open opposite end by an elongated hollow body partially surrounding the portion of said first piston located outside of said first compartment when this first piston is in a fully retracted position, said elongated hollow body being open at least partially on one of its sides to define a lateral opening extending longitudinally, - said instrument comprises a joining device for coupling the first and second pistons and thus forming a common actuating head of said pistons so that said pistons are moved simultaneously when a push or a pull is exerted on said common actuating head, and - said junction device is configured to travel through at least part of said lateral opening when a push or pull is exerted on said common actuating head.

[0047] Thus, the barrier element may comprise an elongated hollow body extending the first compartment on the side of its open opposite end.

[0048] According to a particular embodiment of the instrument for dispensing a first product and at least one second product, the joining device and the barrier-forming element are configured so that said joining device performs a translation during the movement of said actuating head.

[0049] Preferably, when the actuating head is moved under the manual impulse of an operator or an activation device, the joining device thus performs a translation in the barrier-forming element.

[0050] According to another particular embodiment of the instrument for dispensing a first product and at least one second product, the barrier-forming element surrounds said first piston to mask at least a portion of this first piston comprising said actuating end, at least in the fully retracted position of the latter and over an angular sector extending at a determined angle around an axis passing through said first piston, this angle delimiting an axial opening for passage of the junction device.

[0051] According to a particular embodiment of this method or of the therapeutic use for improving the intake of a liquid or viscous substance, preferably therapeutic, said substance and said appetizing matrix are delivered in ratios of between 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 or even 1:10. The ratio is variable depending on the dimensions of the first and second compartments.

[0052] According to another particular embodiment of this method or therapeutic use for improving the intake of a liquid or viscous substance, said substance and said appetizing matrix to be taken being initially contained in separate containers, each of these containers is first connected to a base comprising a first orifice for receiving and supporting a first container and a second orifice for receiving and supporting a second container, and - each compartment of this instrument comprising an outlet orifice and this base comprising a base comprising a connection means configured to receive the ends of said compartments and place their outlet orifice in fluid communication respectively with the first orifice and the second orifice, said instrument is connected to said connection means and said substance and a liquid or viscous appetizing matrix are simultaneously sampled.

[0053] For purely illustrative purposes, the base of this base includes internal conduits enabling each receiving and supporting orifice of an attached container, for example the orifice of which is screwed into the corresponding orifice, to be connected to the fluid with the orifice of a corresponding compartment of the instrument.

[0054] Preferably, the receiving and supporting base of this base can further be configured to maintain the first and second main axes of said compartments aligned or substantially aligned on the same reference axis, on which said actuating head is centered or substantially centered.

[0055] For purely illustrative purposes, this receiving and support base is made entirely of a plastic material compatible with the products intended to be received in the instrument compartments.

[0056] Preferably, each end of said compartments comprising an outlet nozzle receiving the corresponding outlet orifice, and said connection means comprising two connection orifices, the diameters of these outlet nozzles have been previously differentiated, and correspondingly the connection orifices, to individualize the fluid supply to each compartment. This guarantees that the liquid or viscous products are properly directed into their respective compartment.

[0057] According to yet another particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, each compartment of this instrument comprising a main axis and an outlet orifice, at least one of the outlet orifices of said compartments is off-center relative to its corresponding compartment main axis to spatially bring said outlet orifices closer to each other so that by simultaneously delivering said substance and said appetizing matrix, at least partial mixing of said substance and said matrix outside of said instrument is ensured.

[0058] In a particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic, and according to an embodiment of the instrument previously described, at least one of the outlet orifices of the compartments of this instrument is off-center relative to the main axis of the body of the corresponding compartment to spatially bring said outlet orifices closer to each other, so that the outlet orifices are spaced apart by a maximum distance of, for example, 1.5 cm, preferably 1 cm and more preferably 0.5 cm.

[0059] Preferably, the first compartment comprising at least one assembly element of said first and second compartments, this outlet orifice is placed on the side of said at least one assembly element so as to be close to the outlet of the second compartment thus assembled to the first compartment.

[0060] According to yet another particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic, each compartment comprising a device for collecting and dispensing a volume of liquid, these devices for collecting and dispensing a volume of liquid have been previously linked together to ensure their synchronous operation.

[0061] Preferably, each device for collecting and dispensing a liquid being a piston, the so-called actuating end of the piston of a first compartment comprising a female junction element, this female junction element is previously assembled to a male junction element of complementary shape placed at the so-called actuating end of the piston of the other compartment, to allow the simultaneous actuation of said pistons.

[0062] In a particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic and according to an embodiment of the instrument previously described, the so-called actuating ends of the first and second pistons are shaped to unite with each other and thus define said common actuating head of said pistons so that said pistons are moved simultaneously when a push or pull is exerted on said actuating head.

[0063] The lateral opening of the elongated hollow body then allows the instrument to operate by allowing the movement of the joining device, and consequently of the actuating head to push the pistons and simultaneously discharge the products contained in the corresponding compartments or to suck up products to fill these compartments.

[0064] Advantageously, the so-called actuating end of one of said pistons comprises a female joining element such as a hollow part, while the so-called actuating end of the other piston comprises a male joining element such as a projecting part of a shape complementary to the hollow part, said male and female joining elements having complementary shapes to ensure their assembly by shape engagement.

[0065] Alternatively, and according to the method or therapeutic use of the present disclosure, each device for collecting and dispensing a liquid being a piston comprising a rod, the rods of the pistons are previously assembled by means of a joining device connecting said rods.

[0066] In a particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, and according to an embodiment of the instrument previously described, this joining device is an added part, which is configured to couple said pistons.

[0067] Preferably, this joining device is placed close to the actuating ends of these pistons so as not to limit the stroke of the pistons in their respective compartment.

[0068] For purely illustrative purposes, this joining device may take the form of an arm having open rings at its ends to receive the piston rods by clipping.

[0069] According to yet another particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic, at least one of said compartments of the instrument being removable, said or at least one of said removable compartments is replaced after distribution by a new compartment, as well as possibly its corresponding piston, to receive a different appetizing substance or matrix.

[0070] This prevents, when changing a palatable matrix, the latter from being altered by residues from a previously taken matrix, contained in the corresponding compartment.

[0071] According to yet another particular embodiment of this method or therapeutic use for improving the intake of a liquid or viscous substance, preferably therapeutic, the appetizing matrix is ​​formed from hydrolyzed meat offal or fish meal, and / or based on hydrolyzed cereals and / or hydrolyzed legume seeds, and / or based on hydrolyzed fruits and / or hydrolyzed cheese and / or a liquid or thickened oil.

[0072] For purely illustrative purposes, this appetizing matrix can be formed from liver powder or fish meal.

[0073] This liquid or thickened oil is, for example, chosen from the group including olive oil, rapeseed oil, peanut oil or sunflower oil.

[0074] According to yet another particular embodiment of this method or therapeutic use for improving the intake of a liquid or viscous substance, the appetizing matrix comprises one or more additives chosen from flavorings, sweeteners, antioxidants, preservatives, pH regulators, etc.

[0075] For purely illustrative purposes, the aroma can be chosen from essential oils or terpene derivatives such as menthol.

[0076] For example, the sweetener is chosen from aspartame, sodium saccharin, taumatin, polyols such as sorbitol, and mixtures thereof.

[0077] The antioxidant is chosen from ascorbic acid, its salts and its derivatives, sodium or potassium metabisulfite, sodium bisulfite, gallic acid and its derivatives such as propyl gallate and their mixtures.

[0078] For purely illustrative purposes, the flavor enhancer is sodium glutamate.

[0079] The preservative may be chosen from parabens, benzoic acid and its salts, sorbic acid and its salts, and mixtures thereof.

[0080] The pH regulator may be chosen from citric acid, its salts and derivatives, sodium carbonates, and their mixtures.

[0081] According to yet another particular embodiment of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic, said substance and said appetizing matrix are simultaneously delivered into the mouth or mouth of a mammal other than a human being, such as a domestic animal, for example a dog, a cat, a horse, etc.

[0082] In a particular embodiment, the volume of the chamber of a first compartment (intended to contain the composition comprising the active ingredient) is 5 to 60 mL, preferably 5 to 50 mL, and even better 10 to 50 mL, for example 18 mL, 20 mL, 25 mL or 50 mL.

[0083] The volume of the chamber of the other compartment (intended to contain the appetizing matrix) is 10 to 300 mL or 10 to 250 mL, or 20 to 200 mL, and even better from 40 to 180 mL and even more preferably from 60 to 120 mL, and for example from 60 mL, 80 mL, 100 mL, 240 mL, 300 mL.

[0084] In particular embodiments of this method or therapeutic use for improving the uptake of a liquid or viscous substance, preferably therapeutic, the instrument as previously described may have one or more of the following characteristics:

[0085] - the lateral opening being a slot defining a guide rail, said joining device is configured to be moved along said guide rail when said actuating head is actuated, thus guiding the movement of said pistons. This ensures rectilinear movement of the actuating head.

[0086] - at least a part of said lateral opening, preferably its end placed on the side of the so-called actuating end of the corresponding piston, has a foolproof shape, so that only a joining device formed by the joining of the so-called actuating ends of the pistons of two predetermined compartments, has the shape, or configuration, required to allow its movement over at least a part of said lateral opening during the actuation of said common actuating head. In other words, when this required shape or configuration is not obtained, the keyed shape of said lateral opening prevents the actuation of the pistons.

[0087] - said elongated hollow body is configured to prevent access to the so-called actuating end of said first piston, at least to one finger. The piston of the first compartment not being made accessible to the user's finger, it is thus ensured that the contents of the first compartment cannot be dispensed inadvertently, which prevents any loss of product for example. The junction device connecting the so-called actuating ends of the pistons, it is also ensured that the product contained in the first compartment cannot be delivered, or dispensed, alone. In addition, it is also ensured that the two products are withdrawn simultaneously, thanks to a single action, so that the ratio between each product is respected. Preferably, at least a part of said elongated hollow body then has a tubular shape, the lateral opening extending to the free end of said elongated hollow body, possibly, the latter having a flared shape.

[0088] - said first compartment defining a first main body axis and said second compartment defining a second main body axis, it comprises at least one assembly element of said first and second compartments, said at least one assembly element being configured to keep the first and second main axes aligned or substantially aligned on the same reference axis, on which said actuating head is centered or substantially centered.

[0089] Advantageously, this ensures that each piston is correctly centered on the axis of the compartment in which it is mounted, so as to avoid any untimely stopping of the advance of this piston in its compartment due to jamming. It is therefore possible to distribute the entire contents of the chamber of the corresponding compartment.

[0090] Preferably, the first compartment comprises lateral extensions defining a lateral housing for receiving and retaining said second compartment.

[0091] Advantageously, and purely for illustrative purposes, these lateral extensions define with the outer wall of the first compartment a housing having a substantially U-shaped cross-section of which each wing, or branch of the U, is flexible, or elastically deformable, to ensure access to the corresponding housing.

[0092] In a particular embodiment, these wings further form clipping means with said second compartment. In another embodiment, at least one additional attachment element is provided to assemble these two compartments and thus keep them connected to each other.

[0093] Such an embodiment also allows the use of conventional commercial syringes which are received and mounted on the first compartment. The junction device is then an added part.

[0094] - said first and second compartments are cylindrical. Preferably, at least a portion of the elongated hollow body is then also cylindrical.

[0095] - the first compartment and said elongated hollow body and / or said joining device and one of said pistons are formed from a single piece. Herein, the term "the first compartment and said elongated hollow body are formed of a single piece” or by “said joining device and one of said pistons are formed of a single piece”, that they are of a single piece. For purely illustrative purposes, they are obtained by molding a plastic material.

[0096] - this instrument allows you to correct / modify the dose. Brief description of the drawings

[0097] Other advantages, aims and particular characteristics of the present invention will emerge from the description which follows, given, for explanatory and in no way limiting purposes, with reference to the appended drawings, in which: Fig. 1

[0098] [Fig. 1] is a schematic representation of an instrument for dispensing a first product and at least one second product according to a particular embodiment of the present invention; Fig. 2

[0099] [Fig. 2] is an exploded perspective view of the instrument illustrated in Fig. 1 ; Fig. 3

[0100] [Fig. 3] is another side view of the instrument illustrated in Fig. 1; Fig. 4

[0101] [Fig. 4] is a sectional view of the instrument illustrated in Fig. 1; Fig. 5

[0102] [Fig. 5] is a schematic representation of an instrument for dispensing a first product and at least one second product according to another embodiment of the present invention; Fig. 6

[0103] [Fig. 6] is a sectional view of the instrument illustrated in Fig. 5; Fig. 7

[0104] [Fig. 7] shows a base for simultaneously loading the compartments of an instrument for dispensing a first product and at least one second product according to a first embodiment of the present invention; Fig. 8

[0105] [Fig. 8] is a perspective view of a base for simultaneously loading the compartments of an instrument for dispensing a first product and at least a second product, according to a second embodiment of the present invention; Fig. 9

[0106] [Fig. 9] is a side view and partially transparent of a base for simultaneously loading the compartments of an instrument for dispensing a first product and at least one second product, according to a third embodiment of the present invention; Fig. 10

[0107] [Fig. 10] is a perspective view of a base for simultaneously loading the compartments of an instrument for dispensing a first product and at least one second product, according to a fourth embodiment of the present invention; Fig. 11

[0108] [Fig. 11] is a bottom view of the base shown in Fig. 10 to show the internal conduits; Description of the embodiments

[0109] The drawings and the description below contain, for the most part, elements of a certain character. They may therefore not only serve to better understand the present invention, but also contribute to its definition, if necessary.

[0110] First of all, note that the figures are not to scale.

[0111] Figures 1 to 5 schematically represent an instrument for dispensing a first product and at least one second product according to a particular embodiment of the present invention.

[0112] This instrument is, for example, a veterinary instrument used to simultaneously distribute two liquid products, for example chemically incompatible, in order to ensure their mixing after their release from this instrument, in particular directly into the mouth of a pet such as a cat or a dog.

[0113] This instrument 10 comprises a first compartment 11 and a second compartment 16.

[0114] The first compartment 11 has for example one end with a first outlet orifice 12 and an open opposite end 13. A first piston 14 compression piston can be mounted in this first compartment in particular by making a sealed contact with the interior of this compartment. The first piston 14 can have a so-called actuating end 15, oriented opposite the first outlet orifice 12. Said first compression piston 14 and said first compartment 11 define for example a first chamber 23 for receiving a first liquid product. The first compartment 11 can be made of plastic or glass.

[0115] The second compartment 16 may be distinct and initially separate from the first compartment 11. The second compartment 16 has, for example, one end with a second outlet orifice 17 and an opposite open end 18. A second compression piston 19 may be mounted in this second compartment 16, in particular by making a sealing contact with the interior of this compartment. The second piston 19 may have a so-called actuating end 20, oriented opposite the second outlet orifice 17. The second compression piston 19 and the second compartment 16 define, for example, a second chamber 24 for receiving a second liquid product. The second compartment 16 may be made of plastic or glass.

[0116] The first and second compartments 11, 16 can be assembled by being arranged side by side or in parallel. For this, the first compartment 11, and more precisely the body of the first compartment, can comprise wing-shaped extensions 21 extending laterally to this first compartment 11 and placed opposite. A housing 27 is thus defined in which the second compartment 16 can be received, for example by clipping.

[0117] The instrument 10 comprises a barrier element 22 to prevent purely manual actuation of the first piston 14.

[0118] The barrier element 22 may comprise an elongated hollow body placed in the extension of the upper end, or even of the open opposite end 13, of the first compartment 11, and more precisely of the body of the first compartment.

[0119] The elongated hollow body 22 and the first compartment 11 may be formed from a single piece, for example made of plastic material, for example transparent.

[0120] The barrier element 22 and the first compartment 11 may be formed from a single piece, for example made of plastic material, for example transparent.

[0121] The elongated hollow body 22 may have a tubular shape, for example open on one of its sides so as to form a lateral opening 25. It may thus partially enclose a so-called external portion of the first piston 14. The so-called external portion corresponds to the part of the first piston located outside the first compartment 11. The first piston 14 is shown here in its fully retracted position.

[0122] The lateral opening 25 of the elongated hollow body 22 can extend above the so-called actuating end 15 of the first piston 14 when the latter is in its fully retracted position, so that it is impossible for the user to actuate this first piston 14 inadvertently.

[0123] The first chamber 23 of this first compartment 11 receives, for example, the appetizing matrix, thus ensuring no loss of appetizing matrix or that the latter cannot be delivered alone.

[0124] The so-called actuating ends 15, 20 of the first and second pistons 14, 19 have, for example, complementary shapes so that they can be assembled by shape engagement to form a common actuating head 26 allowing the simultaneous actuation of these pistons.

[0125] In addition, these so-called actuating ends 15, 20 can be shaped to ensure the movement of the common actuating head 26 for actuating the pistons 14, 19 through the lateral opening defined by the elongated hollow body 22.

[0126] Advantageously, there may be cooperation between the shape of the common actuating head 26 and the lateral opening 25 of the elongated hollow body 22 to guide the movement of the common actuating head 26.

[0127] Thus, by pushing the common actuating head 26 from a fully retracted position to a discharge position of each piston, the liquid products contained in the first and second compartments 11, 16 are simultaneously dispensed, or discharged. By pulling the common actuating head 26 backward from the discharge position, product is simultaneously sucked into each of the compartments.

[0128] The outlet orifice 12 of the first compartment 11 may be off-center, or even offset to the side, to bring the outlet orifices 12, 17 of the two compartments 11, 16 closer together. Preferably, the spacing between these outlet orifices 12, 17 is less than or equal to 1.5 cm, preferably less than or equal to 1.0 cm or even more preferably, less than or equal to 0.5 cm.

[0129] The outlet orifices 12, 17 of the first and second compartments 11, 16 also have different diameters to differentiate these outlet orifices and form a foolproofing device. This prevents any error in filling the corresponding compartments.

[0130] The common actuating head 26 may comprise a main axis passing through the so-called actuating ends 15, 20 of the pistons 14, 19. The main axis may be arranged transversely or substantially transversely to the lateral opening 25.

[0131] The second compartment 16 makes it possible to take a quantity of second liquid product B adjustable to the weight of the animal in mL / kg while the first compartment 11 is controlled by the second compartment 16 so as to take a quantity of first liquid product A proportional to the second liquid product B in ratios B:A for example 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 or even 1:10. The ratio is variable according to the dimensions of the first and second compartments 11, 16.

[0132] For purely illustrative purposes, the volume of liquid product stored in the second compartment 16 receiving the liquid product B is between 1 - 10 mL or 1 - 5 mL or even 1 - 2 mL. The volume of liquid product stored in the second compartment is for example 5 mL or 1 mL.

[0133] The common piston actuation head 26 can be used to dose each liquid product at a rate of 0.05 - 0.25 mL / kg for the product contained in the second compartment 16 and 0.1 to 1 mL / kg for the liquid product contained in the first compartment 11. The instrument thus makes it possible to dose very precise volumes.

[0134] For purely illustrative purposes, the precision of the graduation for the dosage in the second compartment 16 is 0.05-0.25 mL, preferably 0.05 to 0.1 mL, for example 0.05 mL.

[0135] The instrument for dispensing a first product and at least one second product may comprise connection means, such as pipes 83, 84 illustrated with reference to FIG. 9. Note that these pipes 83, 84 are not necessarily integrated into a base such as illustrated in FIG. 9.

[0136] Figs. 5 and 6 are a schematic representation of an instrument 50 for dispensing a first product and at least one second product according to another embodiment of the present invention.

[0137] The elements of the instrument 50 shown in Figs. 5 and 6 bearing the same references as the elements of the instrument illustrated in Figs. 1 to 4 represent the same objects, which will not be described again below.

[0138] The instrument 50 shown in Figs. 5 and 6 differs from that illustrated in Figs. 1 to 4, in that the so-called actuating ends 51, 52 of the pistons have complementary shapes to ensure their assembly by engagement, which are of a different configuration. In particular, they are less wide, the lateral opening of the longitudinal hollow body 53 being narrower here.

[0139] The cross-section of the housing defined by the lateral extensions 54 and the outer wall of the first compartment is also significantly different in being more rounded and therefore closer to a C than to a U.

[0140] Figs. 7 to 9 illustrate a base 70, 80 for simultaneously loading the compartments of an instrument for dispensing a first product and a second product, called a double-compartment instrument, according to three embodiment variants.

[0141] Each of these bases 70, 80 may comprise supports for connecting thereto, for example, two containers 71, 72, 81, 82. Each base 70, 80 may comprise a base 88 for receiving and supporting a double-compartment instrument. Each base 70, 80 may comprise liquid supply circuits which are entirely separate, the liquid supply circuits being configured to be supplied by the containers 71, 72, 81, 82. Each of these liquid supply circuits may for example comprise a pipe 83, 84, opening at its other end onto a corresponding orifice 73, 74, 85, 86 of the base 88 for receiving and supporting a double-compartment instrument. The supply circuits and more particularly the pipes 83, 84, form means of connection of the first and second compartments 11, 16, to the containers 71, 72, 81, 82.

[0142] These liquid supply circuits 83, 84 are therefore completely separate so that each compartment 11, 16 to be filled with the instrument can only be loaded with a single corresponding liquid product.

[0143] The orifices 73, 74, 85, 86 of this receiving and supporting base 88 are intended to receive and be connected, for example by plugging, with the ends of the compartments comprising the outlet orifices 12, 17. The outlet orifices may be in the form of plugs or pins. The orifices 73, 74, 85, 86 may thus form a sort of socket to which the instrument to be filled is connected.

[0144] Note that the orifices 73, 74, 85, 86 of this receiving and support base 88 may have different diameters, each corresponding to the diameter of the outlet orifice 12, 17 of a respective compartment 11, 16 to ensure a foolproofing function.

[0145] The orifices 73, 74, 85, 86 of this receiving and support base 88 can be hermetically closed using a plug 87, for example screwed. This plug 87 can come from one of the containers 71, 72, 81, 82.

[0146] In a particular embodiment, at least one of the containers 71, 72, 81, 82 may be a solution storage bag.

[0147] Figs. 10 to 11 illustrate a base 90 for simultaneously loading the compartments of an instrument for dispensing a first product and a second product, called a dual-compartment instrument, according to a fourth embodiment.

[0148] The elements of the base 90 shown in Figs. 10 and 11 bearing the same references as those of the bases 70, 80 illustrated in Figs. 7 to 9 represent the same objects, which will not be described again below.

[0149] The base 90 shown in Figs. 10 and 11 differs essentially from those shown in Figs. 7 and 9 in that its receiving and supporting base 91 comprises a support 92 for receiving the instrument 10, 50 for dispensing a first product and at least one second product, between two uses of the latter. In addition, the conduits 93 of the receiving and supporting base 91 are removable so that they can be replaced at least in part by new conduits, when the instrument is intended to receive at least one new product.

Claims

Claims

1. A therapeutic liquid or viscous substance for use in a method of therapeutic treatment in a subject, preferably in an animal, for enhancing the uptake of a liquid or viscous substance, characterized in that said therapeutic substance and a liquid or viscous palatable matrix are collected simultaneously by means of a single instrument comprising two separate compartments for each receiving only one of said substance and palatable matrix, and administered simultaneously by means of said instrument, such that said substance and palatable matrix are kept separate during their collection and distribution.

2. Therapeutic liquid or viscous substance for use according to claim 1, characterized in that said substance and said appetizing matrix are delivered in ratios between 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9 and 1:

10.

3. Therapeutic liquid or viscous substance for use according to claim 1 or 2, characterized in that said substance and said appetizing matrix to be collected are initially contained in separate containers, each of these containers is first connected to a base comprising a first orifice (73, 85) for receiving and supporting a first container (71, 81) and a second orifice (74, 86) for receiving and supporting a second container (72, 82), and - each compartment of this instrument comprising an outlet orifice (12, 17) and this base comprising a base (91) comprising a connection means (83, 84) configured to place the outlet orifices in fluid communication respectively with the first orifice (73, 85) and the second orifice (74, 86), said instrument is connected to said connection means (83, 84) and said substance and said liquid or viscous appetizing matrix are simultaneously sampled.

4. Therapeutic liquid or viscous substance for use according to claim 3, characterized in that each compartment comprising one end comprising an outlet tip receiving the corresponding outlet orifice, and said connection means comprising two connection orifices, the diameters of these outlet tips, and correspondingly the connection orifices, have been previously differentiated to individualize the fluid supply to each compartment.

5. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that each compartment of this instrument comprising a main axis and an outlet orifice (12, 17), at least one of the outlet orifices (12, 17) of said compartments is off-center with respect to its corresponding compartment main axis to spatially bring said outlet orifices (12, 17) closer to each other so that by simultaneously delivering said substance and said appetizing matrix, at least partial mixing of said substance and said matrix outside of said instrument is ensured.

6. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that each compartment comprising a device for collecting and dispensing a volume of liquid, these devices for collecting and dispensing a volume of liquid have been previously linked together to ensure their synchronous operation.

7. Therapeutic liquid or viscous substance for use according to claim 6, characterized in that each device for withdrawing and dispensing a liquid being a piston, the so-called actuating end of the piston of a first compartment comprising a female junction element, this female junction element is previously assembled to a male junction element of complementary shape placed at the so-called actuating end of the piston of the other compartment, to allow the simultaneous actuation of said pistons.

8. Therapeutic liquid or viscous substance for use according to claim 6, characterized in that each sampling device and for dispensing a liquid being a piston comprising a rod, the rods of the pistons are previously assembled by means of a joining device configured to couple said rods.

9. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that at least one of said compartments of the instrument is removable, said or at least one of said removable compartments is replaced after dispensing by a new compartment, as well as possibly its corresponding piston, to receive a different appetizing substance or matrix.

10. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that the appetizing matrix is ​​formed from hydrolyzed meat offal or fish meal, and / or based on hydrolyzed cereals and / or hydrolyzed legume seeds, and / or based on hydrolyzed fruits and / or hydrolyzed cheese and / or a liquid or thickened oil.

11. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that said palatable matrix comprises one or more additives chosen from flavorings, sweeteners, antioxidants, preservatives and pH regulators.

12. A therapeutic liquid or viscous substance for use according to any preceding claim, characterized in that said substance and said palatable matrix are simultaneously delivered into the mouth or mouth of a mammal other than a human being, such as a domestic animal, for example a dog, a cat, or a horse.

13. Therapeutic liquid or viscous substance for use according to any one of the preceding claims, characterized in that said substance is chosen from: - antibiotics such as amoxicillin or doxycycline; - calcium channel blockers such as amlodipine or dilitiazem; - aldosterone antagonists such as spironolactone or eplerenone; - antithyroid drugs such as thiamazole or carbimazole; - angiotensin converting enzyme inhibitors such as benazepril, enalapril or ramipril; - a sodium / glucose cotransporter 2 (SGLT2) inhibitor such as dapagliflozin, velagliflozin, bexagliflozin, canagliflozin, ipragliflozin, tofogliflozin, empagliflozin, ertugliflozin, or sotagliflozin and - an anti-inflammatory agent such as prednisolone, or a combination of these.

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