Controlling illumination and brain temperature in optogenetic activation

EP4727642A1Pending Publication Date: 2026-04-22MODULIGHT BIO LTD
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
MODULIGHT BIO LTD
Filing Date
2024-06-02
Publication Date
2026-04-22

AI Technical Summary

Technical Problem

Current neurological treatments, such as electrical stimulation and medication, lack precise spatial control and often result in adverse effects, while optogenetic methods offer improved precision but require precise temperature control to prevent tissue damage during optogenetic activation in the brain.

Method used

A device implanted in the brain that uses a resonance circuit to adjust the intensity of electrical power based on temperature changes, incorporating a magnetic field converter and light-emitting diodes to apply controlled illumination while maintaining temperature within a safe range, utilizing a processor for closed-loop temperature control.

Benefits of technology

Enables precise optogenetic activation with minimized tissue heating, reducing adverse effects and improving treatment efficacy for neurological conditions like Parkinson's disease and epilepsy by maintaining temperature within a safe 2°C limit.

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Abstract

A device (22) implanted in an organ, the device includes: (a) an energy consuming device (ECD) (44) configured to receive electrical power and to apply energy to the organ, and (b) a resonance circuit (21), which is configured to (i) receive a magnetic field (MF), and (ii) convert the MF to the electrical power, a resonance frequency (25) of the resonance circuit (21) depending on a temperature of the organ, and in response to a change in the temperature of the organ, the resonance circuit (21) is configured to change an intensity of the electrical power supplied to the ECD (44).
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