Polyethylene glycol-saccharide-lipid conjugates

Abstract

This present disclosure provides various diamine centered PEG-saccharide-lipid conjugates. In various embodiments, the conjugates can safely be used as water solubility or bioavailability enhancers.. In one aspect, the present disclosure provides a PEG-saccharide- lipid conjugate having the structural formula (I) wherein m has a number-average value in the range of 2-10; S is a mono-, di- or trisaccharide group, in which each saccharide unit is a sugar, a sugar alcohol, an amino sugar or a sugar acid; L is -C(O)-R1 in which R1 is an alkanyl or alkenyl group having a number-average number of carbons in the range of 6-22, and / or is a steroid acyl group; P is -(CH2-CH2-O)nR2 in which "n" has a number-average value in the range of 5-50 (e.g., 8-45) and R2 is hydrogen and / or alkanyl and has a number average number of carbons in the range 0-4.

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