Whole blood cmp in a dmf device without dilution

EP4761859A1Pending Publication Date: 2026-06-24ABBOTT POINT OF CARE INC
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
ABBOTT POINT OF CARE INC
Filing Date
2024-12-18
Publication Date
2026-06-24

AI Technical Summary

Technical Problem

Current methods for analyzing biological samples, such as blood, often require separate cartridges and analyzers for cellular and chemical component testing, leading to increased costs and potential inconsistencies in results. Additionally, sample availability is limited, making efficient analysis of small sample volumes desirable.

Method used

The development of an analysis cartridge with integrated digital microfluidic (DMF) technology, which includes input chambers, reaction lanes with DMF electrodes, and detection chambers. This cartridge allows for the analysis of whole blood without dilution, enabling simultaneous testing of cellular and chemical components using a single device.

Benefits of technology

The proposed solution enables efficient and cost-effective analysis of biological samples by reducing the need for multiple devices and allowing for the analysis of small sample volumes. It achieves this by using DMF technology to manipulate and analyze samples within a single cartridge, improving consistency and reducing sample requirements.

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Abstract

Aspects of the present disclosure provide an analysis cartridge that allows analyzing clinical chemistry or cell types in a fluid sample, such as a blood sample. In certain embodiments, the analysis cartridge comprises a comprehensive metabolic panel (CMP) analysis module. Additional embodiments may further include a complete blood count (CBC) module for analyzing cells. In many embodiments, digital microfluidics (DMF) is used to move samples through the analysis cartridge. Additional embodiments define additional cuvette types and arrangements for detection. Also provided are systems and methods of analyzing fluid samples in the analysis cartridges provided herein.
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