Sustained-release formulations for poorly permeable cyclic peptides

Abstract

The present disclosure provides orally administered pharmaceutical compositions that are effective in providing sustained plasma levels of a therapeutic peptide in a subject. The disclosed compositions are oral dosage forms comprising a large and / or poorly permeable cyclic peptide, a fatty acid salt, a cellulose-derived polymer, and one or more pharmaceutically acceptable excipients. Methods of preparing these compositions for oral administration, and methods of treatment comprising administering these compositions, are further provided. The disclosed methods and compositions provide for a sustained release of cyclic peptide drugs while also providing enhanced bioavailability relative to immediate-release formulations.

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