Novel methods for preparing semi-solid compositions and uses thereof

EP4770618A1Pending Publication Date: 2026-07-08F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Filing Date
2024-08-30
Publication Date
2026-07-08

AI Technical Summary

Technical Problem

Existing semi-solid pharmaceutical dosage forms for oral administration, particularly for patients with swallowing difficulties, face challenges in rapid gel formation, stability, homogeneity, and drug release profiles, especially without using gellan gum.

Method used

The use of novel combinations of alternative gel formers (such as kappa-carrageenan, polyethylene oxide, and sodium alginate) together with wicking agents (like calcium silicate) in dry solid compositions, which rapidly form stable, homogenous gels upon water addition, improving drug load and release profiles.

Benefits of technology

The described compositions achieve rapid gel formation within 30 seconds to 180 seconds, produce stable and homogenous gels, enhance drug load, and provide a favorable drug release profile, addressing the limitations of existing technologies.

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Abstract

The present application discloses methods and uses for preparation of a dry solid composition as a precursor for a stable gel body formation upon addition of water. The invention also discloses the compositions obtained from said methods and uses. Said gel bodies can, for example, be used in pharmaceutical compositions to administer drug substances to patients with difficulties to swallow.
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