Cosmetic agent containing adenosine

Abstract

The invention relates to a sprayable hair tonic in the form of an oil-in-water emulsion with a pH value of 3.0 to 7.0 at 20 °C, containing at least one water-insoluble oil component (A), at least one non-ionic emulsifier (B), at least one non-ionic co-emulsifier (C), water, and a buffer system for stabilizing the pH value, wherein the water content equals 60 - 90 wt.%, the component (A) is provided in a quantity of 1.5 to 20 wt.%, and the components (B) and (C) are provided in a total quantity of 1 to 12 wt.%. The invention is characterized in that adenosine is provided in a quantity of 0.01 to 3 wt.%, and urea and / or a urea derivative is provided in a total quantity of 1.0 to 25 wt.%. The invention additionally relates to a method for producing sprayable aqueous preparations of adenosine, in which an aqueous solution of adenosine is mixed with a finely dispersed emulsion of an oil component (A), said oil component (A) having an average droplet diameter of less than 1 µm (measured using a device based on the semi-elastic light scattering principle (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), in such a quantity that 1.5 to 20 wt.% of the emulsified oil component (A) is contained in the preparation. While being produced or after being produced and prior to being mixed with the adenosine solution, the emulsion is brought to a phase inversion temperature, and a urea and / or a urea derivative is added to the obtained mixture at room temperature. The invention also relates to the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative, comprising an ethanol content of less than 18 wt.%, for cosmetically treating the skin, in particular the scalp.

Description

[0001] Cosmetic product containing adenosine

[0002] The invention is an invention in the field of hair tonics. It relates to sprayable aqueous compositions with skin and hair care effects containing adenosine.

[0003] The present invention relates to a hair tonic with hair-care effects, such as preventing hair loss and promoting hair growth. Adenosine is an active ingredient used in various cosmetic preparations, such as hair tonics, to prevent hair loss and promote hair growth. Such preparations are preferably sprayed onto the scalp and hair for easy application and should be able to be applied without weighing down the hair.

[0004] It is desirable to be able to use high concentrations of adenosine in these products in order to achieve a satisfactory effect for the user. High concentrations of between 0.1 and 1.5 wt.% adenosine can currently only be delivered in sprayable products with an ethanol content of at least 20 wt.%. Adenosine cannot be incorporated stably into sprayable products with a significantly lower ethanol content. However, products with such a high alcohol content lead to severe drying of the consumer's scalp and to faster fading of colored hair. It is therefore desirable to provide a product that overcomes the aforementioned disadvantages.

[0005] It was therefore the aim of the present invention to provide stable sprayable aqueous compositions in which adenosine is present in a high concentration and which do not dry out the scalp.

[0006] Surprisingly, it was found that this task can be solved with an oil-in-water emulsion containing adenosine.

[0007] A first subject matter of the present application is therefore a sprayable hair tonic in the form of an oil-in-water emulsion with a pH of 3.0 to 7.0 at 20 °C containing at least one water-insoluble oil component (A), at least one non-ionic emulsifier (B), at least one non-ionic co-emulsifier (C), water and a buffer system for stabilizing the pH, wherein the water content is 60 - 90 wt.%, component (A) is present in an amount of 1.5 to 20 wt.%, components (B) and (C) are present in a total amount of 1 to 12 wt.%, characterized in that adenosine is present in an amount of 0.01 to 3 wt.% and urea and / or a urea derivative is present in a total amount of 1.0 to 25 wt.%.

[0008] The agent according to the invention contains a water-insoluble oil component (A) in an amount of 1.5 to 20 wt.%, preferably in an amount of 3.5 to 15, particularly preferably 5 to 10 wt.%. The water-insoluble oil component (A) is preferably selected from the group of fatty acid esters with a fatty acid alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons that are liquid at 20°C and 1013 mbar, and mixtures thereof.

[0009] The fatty acid esters with a fatty acid alkyl chain length of C8 to C36 are preferably those esterified with saturated alcohols with an alkyl chain length of C3 to C26. These are preferably, for example, caprylic acid (CaOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols and / or isopropyl myristic ester. These fatty acid esters are preferably used in amounts of 5 to 20 wt.%, particularly preferably 7 to 15 wt.%, based on the agent according to the invention.

[0010] The natural triglycerides can be vegetable triglycerides such as olive oil, almond oil, peanut oil, sunflower oil, soybean oil, rapeseed oil, palm oil, but also the liquid portions of coconut oil or palm kernel oil or mixtures thereof. The natural triglycerides can also be triglycerides of animal origin such as neatsfoot oil and / or the liquid portions of beef tallow. If natural triglycerides are used, it is preferred according to the invention that they are vegetable triglycerides. The synthetic triglycerides can be those obtained by esterifying glycerol with fatty acids having 8-22 C atoms, e.g. triglycerides of caprylic acid-capric acid mixtures, triglycerides from technical oleic acid or from palmitic acid-oleic acid mixtures or mixtures thereof.

[0011] The natural or synthetic triglycerides, fatty acid esters, or mixtures thereof are preferably those that are liquid at 20°C and 1013 mbar. However, higher-melting triglycerides and esters corresponding to the formulas given can also be used in amounts such that the mixture of oil components remains liquid at 20°C and 1013 mbar. These triglycerides are preferably used in amounts of 1.5 to 20 wt.%, particularly preferably 3.5 to 15 wt.%, based on the composition according to the invention.

[0012] The hydrocarbons that are liquid at 20°C and 1013 mbar can be C11 to C16 hydrocarbons, for example, linear C11 to C16 hydrocarbons or branched C11 to C16 hydrocarbons. They are preferably, for example, mixtures of n-undecane and n-tridecane or isododecane and / or isohexadecane. These hydrocarbons are preferably used in amounts of 5 to 20 wt.%, particularly preferably 7 to 15 wt.%, based on the composition according to the invention.

[0013] A preferred subject matter is accordingly a composition as listed above, wherein the water-soluble oil component (A) is selected from the group of fatty acid esters with a fatty acid alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons liquid at 20°C and 1013 mbar, and mixtures thereof. A further preferred subject matter is a composition as listed above, wherein the water-soluble oil component (A) comprises a mixture of caprylic acid (C8OOH) esters / capric acid (C10OOH) esters of saturated C12-18 fatty alcohols and triglycerides of caprylic acid-capric acid mixtures, preferably in an amount of 2.0 to 10 wt.%.

[0014] The agent according to the invention contains at least one nonionic emulsifier (B) and at least one nonionic coemulsifier (C) in a total amount of 1 to 12 wt.%. The total amount of nonionic emulsifier (B) and nonionic coemulsifier (C) in the agent according to the invention is preferably 3.0 to 10 wt.%, particularly preferably 5.0 to 8.0 wt.%.

[0015] The at least one nonionic emulsifier (B) can preferably be one or more representatives from the group of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols. Particular preference is given to ethoxylated C8-C22 fatty alcohols with 8 to 26 EO, especially preferably ethoxylated C16-C18 fatty alcohols with 12 to 20 EO.

[0016] The at least one nonionic emulsifier (B) can preferably be one or more alkyl polyglucosides. In this case, they are preferably C8 to C18 polyglucosides, particularly preferably lauryl glucosides, decyl glucosides, and coco glucosides, or mixtures thereof.

[0017] It is further preferred that the at least one non-ionic emulsifier (B) has an HLB value of 10 to 18.

[0018] A preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic emulsifier (B) comprises one or more representatives from the group of alkoxylated C16-C22 fatty alcohols.

[0019] A further preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic emulsifier (B) comprises one or more alkyl polyglucosides.

[0020] A further preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic emulsifier (B) has an HLB value of 10 to 18.

[0021] A further preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic emulsifier (B) comprises a mixture of alkoxylated C8-C22 fatty alcohols and / or C8 to C16 polyglucosides.

[0022] Furthermore, articles comprising mixtures of different non-ionic emulsifiers (B) are also preferred.

[0023] Another preferred subject matter is an agent as listed above, wherein the nonionic emulsifier (B) comprises a mixture of polyethylene glycol ether (20EO) of cetylstearyl alcohol and polyethylene glycol ether (12EO) of cetylstearyl alcohol. The at least one nonionic co-emulsifier (C) can preferably be one or more representatives from the group consisting of C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitan, C12-C22 fatty alcohols, and mixtures thereof.

[0024] The at least one non-ionic co-emulsifier (C) may preferably be a C8-C22 monofatty acid ester of glycerol or mixtures thereof, particularly preferably glyceryl monostearate, glyceryl monolaurate, glyceryl caprylates or mixtures thereof.

[0025] The at least one nonionic co-emulsifier (C) can preferably be a C10-C18 monofatty acid ester of sorbitan or mixtures thereof, particularly preferably sorbitan monolaurates, sorbitan monooleates, sorbitan monostearates, or mixtures thereof. The at least one nonionic co-emulsifier (C) can preferably be a C12-C22 fatty alcohol, particularly preferably cetylstearyl alcohol, myristyl alcohol, behenyl alcohol, or mixtures thereof.

[0026] A preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic co-emulsifier (C) comprises one or more representatives from the group of C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitan, C12-C22 fatty alcohols, and mixtures thereof.

[0027] A further preferred subject matter is accordingly an agent as listed above, wherein the at least one nonionic co-emulsifier (C) comprises a C12-C22 monofatty acid ester of glycerol or mixtures thereof, particularly preferably glycerol monostearate. A further preferred subject matter is accordingly an agent as listed above, wherein the at least one nonionic co-emulsifier (C) comprises a C10-C18 monofatty acid ester of sorbitan or mixtures thereof, particularly preferably sorbitan monolaurates, sorbitan monooleates, sorbitan monostearates, or mixtures thereof.

[0028] A further preferred subject matter is accordingly an agent as listed above, wherein the at least one non-ionic co-emulsifier (C) comprises a C12-C22 fatty alcohol or mixtures thereof, particularly preferably cetylstearyl alcohol.

[0029] Furthermore, articles comprising mixtures of different non-ionic co-emulsifiers (C) are also preferred.

[0030] A further preferred subject matter is accordingly an agent as listed above, wherein the non-ionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol, mainly of stearic (C18) and palmitic acid (C16) (INCI: glycerol monostearate) and cetylstearyl alcohol.

[0031] A further preferred subject matter is accordingly an agent as listed above, in which the non-ionic emulsifier (B) comprises a mixture of polyethylene glycol ether (20EO) of cetylstearyl alcohol and polyethylene glycol ether (12EO) of cetylstearyl alcohol, the non-ionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol, mainly of stearic (C18) and palmitic acid (C16) (INCI: glycerol monostearate) and cetylstearyl alcohol, and the total amount of components (B) and (C) is preferably 3.0 to 10% by weight, particularly preferably 5.0 to 8.0% by weight.

[0032] A further preferred subject matter is accordingly an agent as previously listed, in which the non-ionic emulsifier (B) comprises a mixture of polyethylene glycol ether (20EO) of cetylstearyl alcohol and polyethylene glycol ether (12EO) of cetylstearyl alcohol, the non-ionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol, mainly of stearic (C18) and palmitic acid (C16) (INCI: glycerol monostearate) and cetylstearyl alcohol, and the water-soluble oil component (A) comprises a mixture of caprylic acid (CaOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols and triglycerides of caprylic acid-capric acid mixtures or caprylic acid (CsOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols or a mixture of n-undecane and n-tridecane or isopropyl myristic acid.

[0033] The urea derivative can be used in combination with urea or instead thereof, the total amount being maintained at 1.0 to 25 wt.%. According to the invention, it is preferred that the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 8.0 wt.%, more preferably 3.0 to 6.0 wt.%. If a urea derivative is used, it is preferably 2-hydroxyethylurea. In these cases, 2-hydroxyethylurea is preferably used in amounts of 1.0 to 15 wt.%, particularly preferably in amounts of 2.0 to 7.0 wt.%, in particular of 2.0 to 5.0 wt.%. 2-Hydroxyethylurea is preferably used in combination with urea. In these cases, the preferred amount of urea is 0.05 to 3.0 wt.%, particularly preferably 0.1 to 1.0 wt.%, in particular 0.1 to 0.5 wt.%, and the preferred amount of 2-hydroxyethylurea is 1.0 to 15 wt.%, particularly preferably 1.5 to 7 wt.%, in particular 2.0 to 5.0 wt.%.In such combinations, the ratio of 2-hydroxyethylurea to urea is particularly preferably 20:1 to 10:1.

[0034] A preferred article is therefore an aforementioned hair tonic, wherein the urea derivative is 2-hydroxyethylurea.

[0035] A further preferred article is an aforementioned hair tonic, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 8.0 wt.%, more preferably 3.0 to 6.0 wt.%.

[0036] The claimed hair tonic contains adenosine in an amount of 0.01 to 3.0 wt.%. Adenosine is a nucleotide and consists of the nucleic base adenine and the sugar ß-D-ribose. Preferred agents contain adenosine in an amount of 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.1 to 1.0 wt.%. Furthermore, agents containing adenosine in amounts of 0.2 to 1.5 wt.%, in particular 0.5 to 1.0 wt.%, may be preferred.

[0037] It is therefore a preferred object if the hair tonic contains adenosine in an amount of 0.1 to 2.0 wt.%, in particular 0.1 to 1.0 wt.%.

[0038] The claimed hair tonic contains adenosine as an active ingredient. The hair tonic can also contain adenosine derivatives, such as adenosine 5'-phosphates. It is preferred that the claimed agent contains only a limited amount of adenosine derivatives, such as adenosine 5'-phosphates, e.g., adenosine monophosphate (INCI: Adenosine Phosphate), adenosine diphosphate, and / or adenosine triphosphate (INCI: Adenosine Triphosphate). It is preferred that the agent contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, and in particular less than 0.1% by weight, of the adenosine phosphate group. In particular, it may be preferred that the agent be free of adenosine phosphates. Free from adenosine phosphates in this context means that adenosine phosphate is neither added as a separate ingredient nor introduced into the claimed product via preparations of other ingredients, for example in amounts of up to 0.001 wt.-% based on the total mass of the product.

[0039] A preferred article is therefore a hair tonic which contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, in particular less than 0.1% by weight, of one or more ingredients from the group of adenosine 5'-phosphates.

[0040] A preferred article is therefore also a hair tonic which contains adenosine in an amount of 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.1 to 1.0 wt.%.

[0041] A further preferred subject matter is accordingly an agent as previously listed, in which the non-ionic emulsifier (B) comprises a mixture of polyethylene glycol ether (20EO) of cetylstearyl alcohol and polyethylene glycol ether (12EO) of cetylstearyl alcohol, the non-ionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol, mainly of stearic (C18) and palmitic acid (C16) (INCI: glycerol monostearate) and cetylstearyl alcohol, and the water-soluble oil component (A) comprises a mixture of caprylic acid (CaOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols and triglycerides of caprylic acid-capric acid mixtures or caprylic acid (CsOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols or a mixture of n-undecane and n-tridecane or myristic acid isopropyl ester and adenosine in an amount of 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.5 to 1.0 wt.-% is included.

[0042] A further preferred subject matter is accordingly an agent as previously listed, in which the non-ionic emulsifier (B) comprises a mixture of polyethylene glycol ether (20EO) of cetylstearyl alcohol and polyethylene glycol ether (12EO) of cetylstearyl alcohol, the non-ionic co-emulsifier (C) comprises a mixture of monofatty acid esters of glycerol, mainly of stearic (C18) and palmitic acid (C16) (INCI: glycerol monostearate) and cetylstearyl alcohol, and the water-soluble oil component (A) comprises a mixture of caprylic acid (CaOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols and triglycerides of caprylic acid-capric acid mixtures or caprylic acid (CsOOH) esters / capric acid (CioOOH) esters of saturated C12-18 fatty alcohols or a mixture of n-undecane and n-tridecane or myristic acid isopropyl ester and adenosine in an amount of 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.5 to 1.0 wt.-% and which contains less than 0.5 wt.%, particularly preferably less than 0.2 wt.%, in particular less than 0.1 wt.%, of one or more ingredients from the group of adenosine 5'-phosphates.

[0043] The aqueous embodiments contain water in an amount of 50 to 90 wt.%. Embodiments containing water in an amount of 70 to 80 wt.% are preferred. Water primarily serves to adjust the concentrations of the previously defined ingredients to a range suitable for the aqueous, sprayable hair tonic.

[0044] The claimed composition is stabilized by a buffer system. In particular, this enables storage at elevated temperatures, such as 40°C. The buffer substances and their concentrations are preferably selected such that the active ingredients contained are stabilized in the aqueous composition. Stabilization also occurs at elevated temperatures, such as 40°C; all pH values ​​stated in this application apply to measurements at 20°C. Any type of buffer system suitable for cosmetic products can be used that stabilizes the desired pH range and maintains it in the range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5. This is preferably a lactic acid / lactate buffer, for example containing sodium lactate, or a citric acid / disodium hydrogen phosphate buffer.

[0045] If a lactic acid / sodium lactate buffer is used, different concentrations are possible. It is preferred if the concentration of lactic acid is between 0.5 and 3.5 wt.% and that of sodium lactate between 1.5 and 20 wt.%, based on the total composition. In particular, it is preferred that the ratio of lactic acid to sodium lactate is between 0.02 and 2.3 within this range.

[0046] For some articles, the concentration of lactic acid is preferably 0.5 to 2 wt.% and of sodium lactate 1.5 to 2.5 wt.%, based on the total composition. In particular, it is preferred that in this range the ratio of lactic acid to sodium lactate is 0.3 to 0.8. For other articles, the concentration of lactic acid is preferably 2 to 3 wt.%, particularly preferably 2.2 to 2.6 wt.%, and of sodium lactate 13 to 20 wt.%, particularly preferably 15.5 to 17.0 wt.%, based on the total composition. In particular, it is preferred that in this range the ratio of lactic acid to sodium lactate is 0.1 to 0.2.

[0047] If a citric acid / disodium hydrogen phosphate buffer is used, the concentration of citric acid monohydrate is preferably 0.5 to 1.5 wt.% and of disodium hydrogen phosphate dihydrate is preferably 0.8 to 2.5 wt.%, based on the total composition. If citric acid and / or disodium hydrogen phosphate are used in anhydrous form, the concentrations must be reduced accordingly.

[0048] In particular, it is preferred that in this amount range the ratio of citric acid monohydrate to disodium hydrogen phosphate dihydrate is 0.2 to 2.0.

[0049] It is therefore preferred that the claimed hair tonic comprises a lactic acid / sodium lactate buffer which stabilizes the pH of the agent and maintains it in a range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5.

[0050] It is also preferred for other claimed agents that the hair tonic contains a citric acid / disodium hydrogen phosphate buffer, which stabilizes the pH of the agent and keeps it in a range of 3.0 to 7.0, preferably 4.0 to 6.0, in particular 4.2 to 5.5.

[0051] A preferred article is therefore an agent as listed above, wherein the buffer system is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer.

[0052] Preferably, the above-mentioned amounts of buffer substances are used for all the above-mentioned and following compositions so that they can fulfill the stated purpose.

[0053] In order to ensure improved skin compatibility compared to compositions with a high ethanol content, the claimed hair tonic preferably contains less than 18 wt.%, particularly preferably a maximum of 10 wt.%, especially preferably a maximum of 5 wt.% ethanol.

[0054] A preferred article is therefore a hair tonic as described above, which contains less than 18% by weight, particularly preferably a maximum of 10% by weight, especially preferably a maximum of 5% by weight of ethanol.

[0055] Furthermore, it is preferred if the claimed hair tonic contains a maximum of 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, of ethanol or is free of ethanol.

[0056] In this context, "free from ethanol" means that ethanol is neither added as a separate ingredient nor introduced into the claimed product via preparations of other ingredients, for example, in amounts of up to 2% by weight based on the total mass of the product. Another preferred product is therefore a hair tonic as described above, which contains a maximum of 5% by weight, particularly preferably less than 1% by weight, especially preferably less than 0.5% by weight, and even more preferably less than 0.1% by weight, of ethanol, or which is free from ethanol.

[0057] The claimed hair tonic may contain one or more excipients. These optional excipients can further stabilize hair tonics with a very low ethanol content and ethanol-free hair tonics. A preferred article is therefore a hair tonic containing at least one excipient from the group of diols, glycol ethers, and glycerin, or mixtures thereof. A preferred article is also a hair tonic as described above, which contains a maximum of 5 wt.%, particularly preferably less than 1 wt.%, especially preferably less than 0.5 wt.%, even more preferably less than 0.1 wt.%, of ethanol and at least one excipient from the group of diols, glycol ethers, and glycerin, or mixtures thereof.

[0058] Hair tonics according to the invention which optionally contain such excipients preferably contain these excipients in a total amount of 1 to 20 wt.%, preferably up to 15 wt.%, in particular up to 10 wt.%.

[0059] A preferred subject matter is therefore a claimed hair tonic which additionally contains at least one diol as an optional excipient. The diol can preferably be ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,2-butylene glycol, 1,2-pentylene glycol, or dipropylene glycol, or mixtures thereof.

[0060] If at least one diol is used as an excipient, this diol or the mixture of several diols is preferably contained in the claimed agent in a total amount of 0.5 to 15 wt.%. The diol is particularly preferably 1,2-propylene glycol and / or 1,2-pentylene glycol. If 1,2-propylene glycol is used as an excipient, it is preferably contained in the claimed agent in an amount of 2 to 20 wt.%, particularly preferably 3 to 15 wt.%. If 1,2-pentylene glycol is used as an excipient, it is preferably contained in the claimed agent in an amount of 0.5 to 5 wt.%, particularly preferably 1 to 3.5 wt.%. A further preferred subject matter is therefore a claimed hair tonic which additionally contains at least one glycol ether as an optional excipient.The glycol ether can preferably be one or more compounds from the group of monomethyl ethers, monoethyl ethers, and monopropyl ethers, as well as mixtures thereof. If a glycol ether is used as an optional excipient, this glycol ether is preferably present in the claimed agent in a total amount of 0.5 to 15 wt.%. The optional glycol ether is particularly preferably diethylene glycol monoethyl ether. If used, it is preferably present in the claimed agent in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 5.0 to 10 wt.%.

[0061] A further preferred subject matter is therefore a claimed hair tonic which additionally contains glycerin as an optional excipient. If glycerin is used as an optional excipient, it is preferably present in the claimed agent in an amount of 0.5 to 15 wt.%, particularly preferably in an amount of 5.0 to 10 wt.%. To ensure the stability of the composition and to ensure a fine distribution of the ingredients, it is important that the oil component (A) is present as small droplets in the emulsion. It is preferred according to the invention that the mean droplet diameter of the oil components (A) is less than 1 pm (micrometer), preferably less than 600 nm (nanometer), more preferably less than 300 nm (nanometer) (measured with an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)).

[0062] A preferred article is therefore a claimed hair tonic in which the mean droplet diameter of the oil components (A) is less than 1 pm, preferably less than 600 nm, more preferably less than 300 nm, measured with an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water).

[0063] The claimed aqueous sprayable hair tonic can be easily applied to the relevant areas by the user because it is sprayable and can therefore be distributed finely and evenly. In order to ensure good sprayability, the hair treatment composition according to the invention is preferably free from viscosity-increasing ingredients, such as the polyquaternium polymers known under the INCI names Polyquarternium-10 and Polyquarternium 37, as long as this is compatible with economical operation, i.e. as long as small amounts of corresponding substances are not introduced as minor components or impurities of customary ingredients. Such and comparable viscosity-increasing ingredients are preferably present in the hair treatment composition according to the invention in a concentration of no more than 2% by weight, furthermore preferably no more than 0.5% by weight, and particularly preferably no more than 0.1% by weight.-% based on the total weight of the hair treatment composition.

[0064] It is preferred according to the invention that the claimed hair tonic preferably has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM), in order to ensure good sprayability.

[0065] A preferred article is thus a claimed hair tonic as described above, which has a viscosity of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1.0 to 20.0 mPa*s, measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

[0066] The compositions that can achieve the aforementioned object are prepared in a specific way. Therefore, a further subject of the present application is a process for producing sprayable aqueous preparations of adenosine, in which an aqueous solution of adenosine is mixed with a finely divided emulsion of an oil component (A), wherein the oil component (A) has an average droplet diameter of less than 1 pm (measured using an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), in an amount such that the preparation contains 1.5 to 20 wt.-% of the emulsified oil component (A), wherein the emulsion was brought to phase inversion temperature during or after its preparation and before mixing with the adenosine solution and urea and / or a urea derivative is added to the resulting mixture at room temperature.

[0067] In preferred processes, the mean droplet diameter of the oil component (A) is preferably less than 600 nm, more preferably less than 300 nm.

[0068] Furthermore, processes are preferred in which the aqueous solution of adenosine has a temperature of at most 50 °C, preferably at most 45 °C, and / or the temperature of the finely divided emulsion of an oil component (A) is from 30 to 50 °C, preferably from 30 to 40 °C, measured directly before mixing the solution and the emulsion.

[0069] Furthermore, processes in which urea and / or a urea derivative is added in solid form are preferred.

[0070] Particularly preferred processes are those in which the finely divided emulsion of an oil component (A) is a PIT emulsion which further comprises at least one non-ionic emulsifier (B) and at least one non-ionic co-emulsifier (C).

[0071] Furthermore, methods according to the invention are preferred in which, after the addition of urea and / or urea derivative, the pH of the preparation is adjusted to a value between 3.0 and 7.0 and this is stabilized by the addition of a buffer system.

[0072] A preferred subject matter is therefore a claimed process as described above, in which the aqueous solution of adenosine has a temperature of at most 50 °C, preferably of at most 45 °C, and / or the temperature of the finely divided emulsion of an oil component (A) is from 30 to 50 °C, preferably from 30 to 40 °C, directly before mixing the solution and the emulsion.

[0073] A further preferred subject matter is therefore a claimed process as described above, in which urea and / or a urea derivative is added in solid form.

[0074] A further preferred subject matter is therefore a claimed process as described above, in which the finely divided emulsion of an oil component (A) is a PIT emulsion which further comprises at least one non-ionic emulsifier (B) and at least one non-ionic co-emulsifier (C).

[0075] A further preferred subject matter is therefore a claimed method as described above, in which, after adding urea and / or urea derivative, the pH of the preparation is adjusted to a value between 3.0 and 7.0 and this is stabilized by adding a buffer system.

[0076] A particularly preferred subject matter is therefore a claimed process as described above, in which the finely divided emulsion of an oil component (A) is a PIT emulsion which further comprises at least one non-ionic emulsifier (B) and at least one non-ionic co-emulsifier (C) and in which, after the addition of urea and / or urea derivative, the pH of the preparation is adjusted to a value between 3.0 and 7.0 and this is stabilized by the addition of a buffer system, wherein optionally the aqueous solution of adenosine has a temperature of not more than 50 °C, preferably of not more than 45 °C, and / or the temperature of the finely divided emulsion of an oil component (A) is from 30 to 50 °C, preferably from 30 to 40 °C, measured directly before mixing the solution and the emulsion, and wherein optionally urea and / or a urea derivative is added in solid form.

[0077] Stable aqueous compositions containing adenosine in high concentrations have been shown above. The present application therefore further relates to the use of urea and / or urea derivatives for stabilizing adenosine in aqueous emulsions having an ethanol content of less than 18% by weight. The present application therefore further relates to the use of urea and / or urea derivatives and optionally an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof, for stabilizing adenosine in aqueous emulsions having an ethanol content of less than 18% by weight.

[0078] The present application accordingly further relates to the use of a sprayable aqueous emulsion containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp. The present application accordingly further relates to the use of a sprayable aqueous emulsion containing adenosine, urea and / or a urea derivative and optionally an excipient selected from the group consisting of diols, polyethylene glycols, glycol ethers, glycerol, polymerized glycerol derivatives, amine oxides, betaines, amino alcohols, and lactate salts, or mixtures thereof, with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

[0079] A further subject matter of the present application is the use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

[0080] All information provided for the described agent is also directly applicable to the described processes and uses. This applies in particular, but not exclusively, to the data and characteristics of components (A), (B), and (C), buffer substances and systems, excipients, ethanol content, viscosity, pH, measurement methods, and other specified ingredients. The claimed subject matter is further described, but not exhaustively, by the following points:

[0081] Item 1: Sprayable hair tonic in the form of an oil-in-water emulsion with a pH of 3.0 to 7.0 at 20 °C containing at least one water-insoluble oil component (A), at least one non-ionic emulsifier (B), at least one non-ionic co-emulsifier (C), water and a buffer system for stabilizing the pH, wherein the water content is 60 - 90 wt.%, component (A) is present in an amount of 1.5 to 20 wt.%, components (B) and (C) are present in a total amount of 1 to 12 wt.%, characterized in that adenosine is present in an amount of 0.01 to 3 wt.% and urea and / or a urea derivative is present in a total amount of 1.0 to 25 wt.%.

[0082] Item 2: Agent according to item 1, wherein the agent contains less than 0.5% by weight, particularly preferably less than 0.2% by weight, in particular less than 0.1% by weight, of one or more ingredients from the group of adenosine 5'-phosphates.

[0083] Item 3: Agent according to one of the preceding items, wherein the buffer system is a lactic acid / sodium lactate buffer or a citric acid / disodium hydrogen phosphate buffer.

[0084] Item 4: Agent according to one of the above items, wherein the urea derivative is 2-hydroxyethylurea.

[0085] Item 5: Agent according to one of the preceding items, wherein the total amount of urea and / or a urea derivative is 1.0 to 15 wt.%, preferably 2.0 to 8.0 wt.%, more preferably 3.0 to 6.0 wt.%.

[0086] Item 6: Agent according to one of the preceding items, wherein the agent comprises at least one excipient from the group of diols, glycol ethers and glycerin.

[0087] Item 7: Agent according to item 6, wherein the excipient is selected from 1,2-propylene glycol or 1,2-pentylene glycol or mixtures thereof.

[0088] Item 8: Agents according to item 6 or 7, wherein the excipient is contained in a total amount of 1 to 20% by weight, preferably up to 15% by weight, in particular up to 10% by weight.

[0089] Item 9: Agent according to one of the preceding items, wherein the mean droplet diameter of the oil components (A) is less than 1 pm, preferably less than 600 nm, more preferably less than 300 nm, measured with an instrument based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water).

[0090] Item 10: Agent according to one of the preceding items, wherein the agent has a viscosity at 20 °C of at most 150 mPa*s, particularly preferably from 0.8 to 50 mPa*s, in particular 1 to 20 mPa*s, measured with a Brookfield rotational viscometer (type DV1, spindle 1, 20 RPM).

[0091] Item 11: Agent according to one of the preceding items, wherein the at least one water-soluble oil component (A) is selected from the group of fatty acid esters having a fatty acid alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons which are liquid at 20 °C and 1013 mbar, and mixtures thereof.

[0092] Item 12: Agent according to one of the preceding items, wherein the at least one non-ionic emulsifier (B) is one or more representatives from the group of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

[0093] Item 13: Agent according to one of the preceding items, wherein the at least one non-ionic emulsifier (B) is one or more representatives from the group of alkyl polyglucosides.

[0094] Item 14: Agent according to one of the preceding items, wherein the at least one non-ionic emulsifier (B) has an HLB value of 10 to 18.

[0095] Item 15: Agent according to one of the preceding items, wherein the at least one non-ionic co-emulsifier (C) is one or more representatives from the group of C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitan, C12-C22 fatty alcohols, and mixtures thereof.

[0096] Item 16: Agent according to one of the preceding items, wherein the agent contains less than 18% by weight, preferably at most 10% by weight, particularly preferably at most 5% by weight, more preferably less than 1% by weight of ethanol.

[0097] Item 15: Agent according to one of the preceding items, wherein the agent comprises 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.1 to 1.0 wt.%, of adenosine.

[0098] Item 16: A process for the preparation of sprayable aqueous preparations of adenosine, in which an aqueous solution of adenosine is mixed with a finely divided emulsion of an oil component (A), the oil component (A) having an average droplet diameter of less than 1 pm (measured using an apparatus based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), in an amount such that the preparation contains 1.5 to 20% by weight of the emulsified oil component (A), the emulsion being brought to phase inversion temperature during or after its preparation and before mixing with the adenosine solution, and urea and / or a urea derivative being added to the resulting mixture at room temperature.

[0099] Item 17: Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

[0100] Examples of implementation:

[0101] For production, the (co-)emulsifiers were combined with the oil component and water to form a PIT emulsion. The emulsion was brought to phase inversion temperature during or after its preparation. The emulsion was then mixed at a temperature of 30 to 35 °C with an aqueous adenosine solution (1.5% to 2.5%) containing the buffer substances, excipients, and pH adjusters at approximately 50 °C. After cooling to room temperature (20 °C), perfume was added first (optional), followed by stirring urea as a solid into the cooled PIT emulsion.

[0102] The following compositions were provided:

[0103] 1 : INCI: Glyceryl Stearate (and) Ceteareth-20 (and) Ceteareth-12 (and) Cetearyl Alcohol (and)

[0104] Cetyl Palmitate

[0105] 2 : INCI: Ceteareth-12

[0106] 3 : INCI: Coco Caprylate / Caprate

[0107] It was shown that PIT emulsions containing urea or urea and an excipient can stabilize adenosine, resulting in sprayable compositions with a suitable viscosity. When this composition also contains a suitable buffer medium, adenosine is stabilized over the long term, even at elevated temperatures (E1-E4).

Claims

Patent claims:

1. Sprayable hair tonic in the form of an oil-in-water emulsion with a pH of 3.0 to 7.0 at 20 °C containing at least one water-insoluble oil component (A), at least one non-ionic emulsifier (B), at least one non-ionic co-emulsifier (C), water and a buffer system for stabilizing the pH, wherein the water content is 60 - 90 wt.%, component (A) is present in an amount of 1.5 to 20 wt.%, components (B) and (C) are present in a total amount of 1 to 12 wt.%, characterized in that adenosine is present in an amount of 0.01 to 3 wt.% and urea and / or a urea derivative is present in a total amount of 1.0 to 25 wt.%.

2. Agent according to one of the preceding claims, wherein the urea derivative is 2-hydroxyethylurea.

3. Agent according to one of the preceding claims, wherein the agent comprises at least one excipient from the group of diols, glycol ethers and glycerol and the excipient is preferably contained in a total amount of 1 to 20 wt.%, particularly preferably up to 15 wt.%, in particular up to 10 wt.%.

4. Agent according to one of the preceding claims, wherein the at least one water-soluble oil component (A) is selected from the group of fatty acid esters having a fatty acid alkyl chain length of C8 to C36, natural or synthetic triglycerides, hydrocarbons liquid at 20 °C and 1013 mbar, and mixtures thereof.

5. Agent according to one of the preceding claims, wherein the at least one non-ionic emulsifier (B) is one or more representatives from the group of alkoxylated C8-C22 fatty alcohols, preferably alkoxylated C16-C22 fatty alcohols.

6. Agent according to one of the preceding claims, wherein the at least one non-ionic co-emulsifier (C) is one or more representatives from the group of C8-C22 monofatty acid esters of glycerol, C10-C18 monofatty acid esters of sorbitan, C12-C22 fatty alcohols, and mixtures thereof.

7. Agent according to one of the preceding claims, wherein the agent contains less than 18% by weight, preferably at most 10% by weight, particularly preferably at most 5% by weight, more preferably less than 1% by weight of ethanol.

8. Agent according to one of the preceding claims, wherein the agent comprises 0.05 to 3.0 wt.%, particularly preferably 0.1 to 2 wt.%, in particular 0.1 to 1.0 wt.%, of adenosine.

9. A process for the preparation of sprayable aqueous preparations of adenosine, in which an aqueous solution of adenosine is mixed with a finely divided emulsion of an oil component (A), the oil component (A) having an average droplet diameter of less than 1 pm (measured with an apparatus based on the principle of quasi-elastic light scattering (Zetasizer Nano ZS, 25 °C, square polystyrene cuvette, 12 mm edge length (model DTS0012), dilution: 0.025% w / w in water)), in an amount such that the preparation contains 1.5 to 20 wt.% of the emulsified oil component (A), the emulsion being brought to phase inversion temperature during or after its preparation and before mixing with the adenosine solution, and urea and / or a urea derivative being added to the resulting mixture at room temperature.

10. Use of a sprayable aqueous preparation containing adenosine and urea and / or a urea derivative with an ethanol content of less than 18% by weight for the cosmetic treatment of the skin, in particular the scalp.

Images